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Single-Unit Sympathetic Discharge: Quantitative Assessment in Human Hypertensive Disease
Abstract
Background —Reports demonstrating sympathetic hyperactivity in hypertension with the use of microneurography have been inconsistent. One possible reason is that previous studies have assessed muscle sympathetic nerve activity (MSNA) from integrated voltage waves (“bursts”) recorded from multiunit discharges. We studied single units with defined vasoconstrictor properties (s-MSNA) to further characterize sympathetic output in hypertensive disease. Methods and Results —We examined 74 subjects with a wide range of arterial blood pressure that were considered to be either normal (NT), high normal (HN), or stages 1 to 3 essential hypertension (EHT-1, EHT-2/3). All had their peripheral sympathetic activity measured from both multiunit bursts and single-unit vasoconstrictor impulses. There was a significant correlation between s-MSNA and MSNA, and results of variability studies were similar. The EHT-1 and EHT-2/3 groups had greater s-MSNA and MSNA than did the matched NT group (always P <0.01). The HN group also had greater s-MSNA and MSNA than did the NT group (mean±SEM; 43±5 vs 29±2 impulses/100 beats, P <0.05; 36±4 vs 24±2 bursts/100 beats, P <0.05). In addition, the EHT-1 group had significantly greater s-MSNA than did the EHT-2/3 group (63±6 vs 51±3 impulses/100 beats, P <0.05), which could not be demonstrated with MSNA bursts. Conclusions —Quantification from single vasoconstrictor units has provided additional evidence in established essential hypertension of increased central sympathetic output. Furthermore, in the mild or early stages of hypertension, this technique has provided new evidence of augmented sympathetic output compared with more severe hypertension.
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“Finally, although the technique of microneurography is selective for the particular unit(s) studied, under resting conditions the variability between repeat recordings of both s-MSNA and MSNA is <8% (16).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]
In the citing paper
“The results obtained from MSNA recordings in this study were similar to those previously published in age-comparable hypertensive subjects (15,16,25,26,28).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]
In the citing paper
“more recently, we have shown that, in stage 1 hypertensive disease, the peripheral sympathetic drive is, in fact, higher than that found in the more severe degrees of hypertension (16).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]
In the citing paper
“More recently, we have shown that patients with moderate to severe hypertension had either lower or equal sympathetic output compared with matched groups with milder hypertension, depending on whether single units or multiunits were examined (16).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]
In the citing paper
“Finally, and perhaps most importantly, subjects with severe hypertension in the former study had a high LVMI, whereas, in the latter study, LVH was excluded.”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]
In the citing paper
“Only vasoconstrictor activity was accepted and examined, the criteria of acceptance being appropriate responses to spontaneous changes in arterial blood pressure, the Valsalva maneuver and isometric hand-grip exercise, as previously described (16,17).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [16]
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Metadata
- Authors
- Greenwood, J. P., Stoker, J. B., & Mary, D. A. S. G.
- Affiliations
- University of Leeds (GB)
- ORCID
- Greenwood, John P.
- Venue
- Circulation
- Published
- 1999-09-21
- Volume
- 100
- Issue
- 12
- Pages
- 1305-1310
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2001261464
- Cited by
- 174
- References
- 29
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 8 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 14 · 2012: 10
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- British Heart Foundation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- essential hypertension, sympathetic nervous system, muscle sympathetic nerve activity, sympathetic hyperactivity, early hypertension, high-normal blood pressure, microneurography
- MeSH terms
- Action Potentials, Adult, Female, Humans, Hypertension, Male, Middle Aged, Sympathetic Nervous System, Vasoconstriction
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