Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers
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OBJECTIVE: This study investigated the relationship between physical activity and the obesity-related inflammatory markers C-reactive protein, interleukin-6, and soluble tumor necrosis factor receptors (sTNF-Rs) 1 and 2. Furthermore, we examined the relationship between physical activity and insulin sensitivity (insulin, C-peptide, and hemoglobin A(1c) levels) and whether inflammatory markers mediate this association. RESEARCH METHODS AND PROCEDURES: Biomarkers were measured in 405 healthy men and 454 healthy women from two large ongoing prospective studies. Information about physical activity and other variables was assessed by questionnaires. RESULTS: After adjustment for other predictors of inflammation, physical activity was inversely associated with plasma levels of sTNF-R1, sTNF-R2, interleukin-6, and C-reactive protein (p = 0.07, p = 0.004, p = 0.04, and p = 0.009). After further adjustment for BMI and leptin, as a surrogate for fat mass, most of these associations were no longer significant. Physical activity was also inversely related to insulin and C-peptide levels (p = 0.008 and p < 0.001); however, in contrast to BMI and leptin, levels of inflammatory markers explained only very little of this inverse relationship. DISCUSSION: These results suggest that frequent physical activity is associated with lower systemic inflammation and improved insulin sensitivity. These associations can partially be explained by a lower degree of obesity in physically active subjects. Although inflammatory markers may mediate obesity-dependent effects of physical activity on inflammatory related diseases such as type 2 diabetes or coronary heart disease, our study suggests that they do not directly account for the beneficial effects of physical activity on insulin resistance.
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Increased intake of long-chain n-3 PUFA results in increased proportions of those fatty acids in inflammatory cell phospholipids.
“Increased intake of long-chain n-3 PUFA results in increased proportions of those fatty acids in inflammatory cell phospholipids (610 -614) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [613]
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- Authors
- Pischon, T., Hankinson, S. E., Hotamisligil, G. S., Rifai, N., & Rimm, E. B.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Corresponding author
- Pischon, Tobias
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 2003-09
- Volume
- 11
- Issue
- 9
- Pages
- 1055-1064
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W2018048986
- Cited by
- 245
- References
- 58
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 7 · 2018: 11 · 2017: 7 · 2016: 13 · 2015: 12 · 2014: 8 · 2013: 15 · 2012: 17
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Research (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- Deutscher Akademischer Austauschdienst
- National Institutes of Health (DK46200, CA67262, CA55075)
- National Institute on Alcohol Abuse and Alcoholism (AA-11181, R01AA011181)
- National Heart, Lung, and Blood Institute (R01HL035464, HL35464)
- National Cancer Institute (CA-55075, CA67262)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- leisure-time physical activity, obesity-associated inflammation, C-reactive protein, interleukin-6, soluble tumor necrosis factor receptor, insulin sensitivity, insulin resistance, C-peptide, HbA1c, leptin, body mass index, type 2 diabetes, coronary artery disease
- MeSH terms
- Adult, C-Peptide, C-Reactive Protein, Cross-Sectional Studies, Female, Glycated Hemoglobin, Humans, Insulin, Male, Middle Aged, Obesity, Prospective Studies, Cohort Studies, Biomarkers, Exercise, Interleukin-6, Body Mass Index, Receptors, Tumor Necrosis Factor, Leptin
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