The DOI matches its Crossref record.
Autonomic mechanisms in ventricular fibrillation induced by myocardial ischemia during exercise in dogs with healed myocardial infarction. An experimental preparation for sudden cardiac death.
Abstract
The relationship between activity of the autonomic nervous system, myocardial ischemia, and malignant arrhythmias has been investigated in a new experimental preparation for sudden death. Fifty-seven dogs were chronically instrumented and studied under control conditions (n = 15) and 1 month after production of an anterior myocardial infarction (n = 42). The protocol consisted in occluding the left circumflex coronary artery for 2 min, commencing at the last minute of an exercise stress test and extending through the first minute after cessation of exercise. With this protocol, ventricular fibrillation was observed in 40% of normal dogs and 66% of dogs with infarction. In 14 dogs with infarction, left stellectomy reduced the incidence of ventricular fibrillation to zero (p less than .001). The reflex changes in heart rate elicited within the first minute of ischemia during exercise in the animals that survived (from 204 +/- 14 to 198 +/- 31 beats/min, -6) were opposite those in animals that had ventricular fibrillation (from 208 +/- 24 to 229 +/- 30 beats/min, +21) (p less than .05). The ischemia-induced reduction in heart rate despite continuation of exercise suggests the presence in the dogs that survived of active vagal reflexes that may have played an important role in the maintenance of cardiac electrical stability. This preparation has the potential to induce ventricular fibrillation consistently in conscious animals by the interaction of a few clinically relevant factors (acute myocardial ischemia, submaximal exercise and its cessation, sympathetic and vagal reflexes, and heart rate) and offers the possibility of acquiring further insights into the mechanisms of malignant arrhythmias and evaluating novel strategies for targeted prevention.
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Citations
Cited by
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120
Self-citationVanoli, E., De Ferrari, G. M., Stramba-Badiale, M., Hull, S. S., Foreman, R. D., & Schwartz, P. J. (1991) · Circulation Research · doi:10.1161/01.res.68.5.1471 · Cited by 681
Self-citationAdverse consequences of high sympathetic nervous activity in the failing human heart
Kaye, D. M., Lefkovits, J., Jennings, G. L., Bergin, P., Broughton, A., & Esler, M. D. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00332-0 · Cited by 665
Prevention of Sudden Cardiac Death by Dietary Pure ω-3 Polyunsaturated Fatty Acids in Dogs
Billman, G. E., Kang, J. X., & Leaf, A. (1999) · Circulation · doi:10.1161/01.cir.99.18.2452 · Cited by 393
Self-citationPremchand, R. K., Sharma, K., Mittal, S., Monteiro, R., Dixit, S., Libbus, I., DiCarlo, L. A., Ardell, J. L., Rector, T. S., Amurthur, B., et al. (2014) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2014.08.009 · Cited by 377
Hull, S. S., Vanoli, E., Adamson, P. B., Verrier, R. L., Foreman, R. D., & Schwartz, P. J. (1994) · Circulation · doi:10.1161/01.cir.89.2.548 · Cited by 299
Self-citationde Geus, E. J. C., Gianaros, P. J., Brindle, R. C., Jennings, J. R., & Berntson, G. G. (2019) · Psychophysiology · doi:10.1111/psyp.13287 · Cited by 219
Aerobic exercise conditioning: a nonpharmacological antiarrhythmic intervention
Billman, G. E. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00874.2001 · Cited by 185
Self-citationVagus nerve stimulation: From pre-clinical to clinical application: Challenges and future directions
De Ferrari, G. M., & Schwartz, P. J. (2011) · Heart Failure Reviews · doi:10.1007/s10741-010-9216-0 · Cited by 169
Self-citationSchwartz, P. J., & De Ferrari, G. M. (2011) · Heart Failure Reviews · doi:10.1007/s10741-010-9179-1 · Cited by 158
Self-citationBillman, G. E. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.01.002 · Cited by 131
Self-citationNarita, K., Murata, T., Hamada, T., Takahashi, T., Omori, M., Suganuma, N., Yoshida, H., & Wada, Y. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.01.003 · Cited by 100
Animal models of ventricular arrhythmias
Hamlin, R. L. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.08.006 · Cited by 60
Pinter, A., Szatmari Jr, S., Horvath, T., Penzlin, A. I., Barlinn, K., Siepmann, M., & Siepmann, T. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s200360 · Cited by 53
Neijts, M., Van Lien, R., Kupper, N., Boomsma, D., Willemsen, G., & de Geus, E. J. C. (2014) · Psychophysiology · doi:10.1111/psyp.12246 · Cited by 29
Metadata
- Authors
- Schwartz, P. J., Billman, G. E., & Stone, H. L.
- Venue
- Circulation
- Published
- 1984-04
- Volume
- 69
- Issue
- 4
- Pages
- 790-800
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1970563581
- Cited by
- 434
- References
- 0
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
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