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Cited by 142Smoking Behavior and CessationDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Long-term Use of Nicotine Gum Is Associated With Hyperinsulinemia and Insulin Resistance

Eliasson, Bjo¨rn, Taskinen, Marja-Riitta, Smith, Ulf·1996·Circulation
DOI 10.1161/01.cir.94.5.878
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Abstract

Background Insulin sensitivity and cardiovascular risk profile were examined in 20 healthy, nonobese, middle-aged men who were long-term users of nicotine-containing chewing gum and in 20 matched control subjects who did not use nicotine. Methods and Results Long-term use of nicotine-containing chewing gum was associated with insulin resistance and hyperinsulinemia. The degree of insulin sensitivity correlated negatively to the extent of nicotine use measured as plasma cotinine levels. Conclusions These findings suggest that nicotine is the major constituent in cigarette smoke that leads to insulin resistance, metabolic abnormalities associated with the insulin resistance syndrome, and increased cardiovascular morbidity. Thus, the use of nicotine replacement therapy during smoking cessation should be transient and limited.

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Crossref · 10.1161/01.cir.94.5.878

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  1. 10.1161/atv91.14.12.7981184 · DOI
  2. 10.1161/atvb.15.3.320 · DOI

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Metadata

Authors
Eliasson, B., Taskinen, M.-R., & Smith, U.
Affiliations
  • the Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Sahlgrenska University Hospital, Go¨teborg, Sweden, and the Department of Medicine, University of Helsinki (M.-R.T.), Finland.
  • University of Helsinki (FI)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1996-09
Volume
94
Issue
5
Pages
878-881
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.94.5.878
OpenAlex
W2065858852
Cited by
141
References
18
Citations by year
2025: 5 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 3 · 2013: 2 · 2012: 10
FWCI
3.15
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
nicotine gum, nicotine replacement therapy, hyperinsulinemia, insulin resistance, insulin sensitivity, cotinine, smoking cessation, cardiovascular risk, metabolic abnormalities, metabolic syndrome
MeSH terms
Adult, C-Peptide, Cotinine, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Nicotine

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