CoChat
Sign Up
Cited by 372Cardiovascular Health and Risk FactorsCardiac Health and Mental HealthLipoproteins and Cardiovascular Health

Attenuated Progression of Coronary Artery Disease After 6 Years of Multifactorial Risk Intervention: Role of Physical Exercise

Niebauer, Josef, Hambrecht, Rainer, Velich, Tamás, Hauer, Klaus, Marburger, Christian, Kälberer, Barbara, Weiss, Claus, von Hodenberg, Eberhard +4 more·1997·Circulation
DOI 10.1161/01.cir.96.8.2534
Open this paper in CoChat — free account

Abstract

Background It was the aim of this study to assess the long-term effects of physical exercise and low-fat diet on the progression of coronary artery disease. At the beginning of the study, 113 male patients with coronary artery disease were randomized to an intervention group (n=56) or a control group (n=57); 90 patients (80%) could be reevaluated after 6 years. Methods and Results Patients in the intervention group (n=40) showed a reduction in total serum cholesterol (6.03±1.03 versus 5.67±1.01 mmol/L; P <.03) and triglyceride levels (1.94±0.8 versus 1.6±0.89 mmol/L; P <.005) and maintained their initial body mass index (26±2 versus 27±2 kg/m 2 ; P =NS), but results were not statistically different from the control group (n=50) (total serum cholesterol, 6.05±1.02 versus 5.79±0.88 mmol/L; triglycerides, 2.25±1.28 versus 1.85±0.96 mmol/L [both P =NS]; body mass index, 26±2 versus 28±3 kg/m 2 [ P <.0001]). In the intervention group, there was a significant 28% increase in physical work capacity (166±59 versus 212±89 W; P <.001), whereas values remained essentially unchanged in the control group (165±51 versus 170±60 W; P =NS; between groups, P <.05). In the intervention group, coronary stenoses progressed at a significantly slower rate than in the control group ( P <.0001). Energy expenditure during exercise was assessed in a subgroup; patients with regression of coronary stenoses spent an average of 1784±384 kcal/wk (≈4 hours of moderate aerobic exercise per week). Multivariate regression analysis identified only physical work capacity as independently contributing to angiographic changes. Conclusions After 6 years of multifactorial risk intervention, there is significant and persistent improvement in lipoprotein levels and physical work capacity, which results in a significant retardation of disease progression. These beneficial effects appear to be largely due to chronic physical exercise.

Integrity signals

Registry

Crossref · 10.1161/01.cir.96.8.2534

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 43 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Niebauer, J., Hambrecht, R., Velich, T., Hauer, K., Marburger, C., Kälberer, B., Weiss, C., von Hodenberg, E., Schlierf, G., Schuler, G., Zimmermann, R., & Kübler, W.
Affiliations
  • Heidelberg University (DE)
  • From Medizinische Universitätsklinik Heidelberg, Abteilung Innere Medizin III–Kardiologie (J.N., T.V., K.H., C.M., B.K., C.W., G. Schlierf, R.Z., W.K.), Heidelberg, Germany; Herzzentrum der Universität Leipzig (R.H., G. Schuler), Abteilung Innere Medizin–Kardiologie, Leipzig, Germany; and Herzzentrum Lahr (E. von H.), Abteilung Kardiologie, Lahr, Germany.
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1997-10-21
Volume
96
Issue
8
Pages
2534-2541
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.96.8.2534
OpenAlex
W2085122671
Cited by
372
References
43
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 14 · 2015: 13 · 2014: 13 · 2013: 12 · 2012: 18
FWCI
5.71
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
coronary artery disease, physical activity, low-fat diet, coronary stenosis progression, physical work capacity, serum cholesterol, triglycerides, body mass index, energy expenditure, male patients, lipoproteins, aerobic exercise, energy balance, smoking cessation, alcohol consumption reduction, blood pressure reduction, lipid lowering
MeSH terms
Adult, Aged, Cholesterol, Coronary Disease, Dietary Fats, Energy Metabolism, Cardiac Catheterization, Hemodynamics, Humans, Male, Middle Aged, Nicotine, Risk Factors, Smoking, Triglycerides, Exercise, Body Mass Index, Coronary Angiography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review