Cited by 441Cardiovascular Health and Disease PreventionCardiovascular Function and Risk FactorsCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Measures of Obesity Are Associated With Vascular Stiffness in Young and Older Adults

Wildman, Rachel P., Mackey, Rachel H., Bostom, Andrew, Thompson, Trina, Sutton-Tyrrell, Kim·2003·Hypertension

DOI 10.1161/01.hyp.0000090360.78539.cd

Open this paper in CoChat — free account

Abstract

Obesity has reached epidemic levels and carries a risk for cardiovascular disease. Obesity’s effects on the vascular systems of young adults and African Americans have not been well characterized. The aim of this study was to assess the association between measures of obesity and aortic stiffness in 186 young adults (20 to 40 years, 50% African American) and 177 older adults (41 to 70 years, 33% African American). Aortic stiffness was measured by aortic pulse-wave velocity. The median pulse-wave velocity value was 468 cm/s for young adults and 627 cm/s for older adults ( P <0.001). Higher body weight, body mass index, waist and hip circumferences, and waist-hip ratio were strongly correlated with higher pulse-wave velocity, independent of age, systolic blood pressure, race, and sex overall and among both age groups ( P <0.01 for all). Even among the 20- to 30-year-olds, obese individuals (body mass index>30) had a mean pulse-wave velocity value 47 cm/s higher than did nonobese individuals ( P <0.001). Obesity measures were among the strongest independent predictors of pulse-wave velocity overall and for both age groups. Results were consistent by race. In conclusion, excess body weight is associated with higher aortic stiffness in whites and African Americans as young as 20 to 30 years. The strength of the association, the early age at which it appears, and the prevalence of obesity among the young warn of substantially increased cardiovascular disease incidence as this cohort ages.

Integrity signals

Registry

Crossref · 10.1161/01.hyp.0000090360.78539.cd

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
Prevalence and Trends in Overweight Among US Children and Adolescents, 1999-2000
Ogden, C. L. (2002) · JAMA · doi:10.1001/jama.288.14.1728 · Cited by 4,060
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
McDonald's blood flow in arteries; theoretical, experimental and clinical principles
(1992) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(92)90079-y · Cited by 2,395
Biological Action of Leptin as an Angiogenic Factor
Sierra-Honigmann, M. R., Nath, A. K., Murakami, C., García‐Cardeña, G., Papapetropoulos, A., Sessa, W. C., Madge, L. A., Schechner, J. S., Schwabb, M. B., Polverini, P. J., et al. (1998) · Science · doi:10.1126/science.281.5383.1683 · Cited by 1,385
Relationship of Childhood Obesity to Coronary Heart Disease Risk Factors in Adulthood: The Bogalusa Heart Study
Freedman, D. S., Khan, L. K., Dietz, W. H., Srinivasan, S. R., & Berenson, G. S. (2001) · PEDIATRICS · doi:10.1542/peds.108.3.712 · Cited by 1,359
Effects of age and aerobic capacity on arterial stiffness in healthy adults.
Vaitkevicius, P. V., Fleg, J. L., Engel, J.-H., O’Connor, F. C., Wright, J. G., Lakatta, L. E., Yin, F. C. P., & Lakatta, E. G. (1993) · Circulation · doi:10.1161/01.cir.88.4.1456 · Cited by 1,085
The Prevention of Dementia With Antihypertensive Treatment<subtitle>New Evidence From the Systolic Hypertension in Europe (Syst-Eur) Study</subtitle>
Forette, F. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.18.2046 · Cited by 898

Show all 41 references

Research works printed but not linked: 6

10.1161/atvb.19.4.972 · DOI
10.1161/hyp.38.3.429 · DOI
10.1161/hyp.30.3.654 · DOI
10.1161/hyp.37.4.1075 · DOI
10.1161/res.83.10.1059 · DOI
10.1161/circ.88.4.8403292 · DOI

Sorted by citations

Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.305697 · Cited by 1,360
Obesity, kidney dysfunction and hypertension: mechanistic links
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654
Endothelial Dysfunction, Arterial Stiffness, and Heart Failure
Marti, C. N., Gheorghiade, M., Kalogeropoulos, A. P., Georgiopoulou, V. V., Quyyumi, A. A., & Butler, J. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.082 · Cited by 500
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
Ren, J. T., Wu, N. N., Wang, S., Sowers, J. R., & Zhang, Y. (2021) · Physiological Reviews · doi:10.1152/physrev.00030.2020 · Cited by 388
Risk Factors Identified in Childhood and Decreased Carotid Artery Elasticity in Adulthood
Juonala, M., Järvisalo, M. J., Mäki-Torkko, N., Kähönen, M. A. P., Viikari, J. S. A., & Raitakari, O. T. (2005) · Circulation · doi:10.1161/circulationaha.104.502161 · Cited by 355
Sympathetic nervous activation in obesity and the metabolic syndrome—Causes, consequences and therapeutic implications
Lambert, G. W., Straznicky, N. E., Lambert, É., Dixon, J. B., & Schlaich, M. P. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.02.002 · Cited by 352
Obesity and cardiovascular disease: An ESC clinical consensus statement
Koskinas, K. C., Van Craenenbroeck, E. M., Antoniades, C., Blüher, M., Gorter, T. M., Hanssen, H., Marx, N., McDonagh, T. A., Mingrone, G., Rosengren, A., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae508 · Cited by 313
Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases
Montani, J.-P., Carroll, J. F., Dwyer, T. M., Antic, V., Yang, Z., & Dulloo, A. G. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802858 · Cited by 294
Obesity and hypertension: two epidemics or one?
Davy, K. P., & Hall, J. E. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00707.2003 · Cited by 280
Obesity is associated with increased arterial stiffness from adolescence until old age
Zebekakis, P. E., Nawrot, T. S., Thijs, L., Balkestein, E. J., Spek, J. J., Bortel, L. M. V., Struijker-Boudier, H. A. J., Safar, M. E., & Staessen, J. A. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000179511.93889.e9 · Cited by 276
Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus
Urbina, E. M., Kimball, T. R., Khoury, P. R., Daniels, S. R., & Dolan, L. M. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833a6132 · Cited by 253
Abdominal Obesity Is Associated With an Increased Risk of All-Cause Mortality in Patients With HFpEF
Tsujimoto, T., & Kajio, H. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.09.1111 · Cited by 228
Influence of Adiposity and Physical Activity on Arterial Stiffness in Healthy Children
Sakuragi, S., Abhayaratna, K., Gravenmaker, K. J., O’Reilly, C. M., Srikusalanukul, W., Budge, M. M., Telford, R. D., & Abhayaratna, W. P. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.123364 · Cited by 212
Obesity, arterial stiffness, and cardiovascular risk.
Safar, M., Czernichow, S., & Blacher, J. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005121321 · Cited by 209
Cardiorespiratory Fitness, Physical Activity, and Arterial Stiffness: The Northern Ireland Young Hearts Project
Boreham, C. A., Ferreira, I., Twisk, J. W., Gallagher, A. M., Savage, M. J., & Murray, L. J. (2004) · Hypertension · doi:10.1161/01.hyp.0000144293.40699.9a · Cited by 200
Visceral adiposity and arterial stiffness: echocardiographic epicardial fat thickness reflects, better than waist circumference, carotid arterial stiffness in a large population of hypertensives
Natale, F., TEDESCO, M., Mocerino, R., Simone, V. D., Marco, G. M. D., Aronne, L., Credendino, M., Siniscalchi, C., Calabrò, P., Cotrufo, M. F., et al. (2009) · European Journal of Echocardiography · doi:10.1093/ejechocard/jep002 · Cited by 192
Overweight, physical activity and high blood pressure in children: a review of the literature.
Torrance, B. D., McGuire, K. A., Lewanczuk, R. Z., & McGavock, J. (2007) · PubMed · Cited by 182
Vascular stiffening and arterial complianceImplications for systolic blood pressure
SCHIFFRIN, E. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.08.019 · Cited by 183
Metabolic syndrome: a sympathetic disease?
Schlaich, M., Straznicky, N., Lambert, E., & Lambert, G. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70033-6 · Cited by 171
Weight Change Is Associated With Change in Arterial Stiffness Among Healthy Young Adults
Wildman, R. P., Farhat, G. N., Patel, A. S., Mackey, R. H., Brockwell, S. E., Thompson, T., & Sutton-Tyrrell, K. (2005) · Hypertension · doi:10.1161/01.hyp.0000152200.10578.5d · Cited by 176
Self-citation
Local adipose tissue depots as cardiovascular risk factors
Thalmann, S., & MEIER, C. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.008 · Cited by 166
Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction
Samson, R., Jaiswal, A., Ennezat, P. V., Cassidy, M. M., & Jemtel, T. H. L. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002477 · Cited by 149
Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive
the Vasorisk group, Recio-Rodriguez, J. I., Gómez-Marcos, M. Á., Patino-Alonso, M. C., Agudo‐Conde, C., Rodríguez‐Sánchez, E., & García‐Ortiz, L. (2012) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-12-3 · Cited by 144
Early Signs of Cardiovascular Disease in Youth With Obesity and Type 2 Diabetes
Gungor, N., Thompson, T., Sutton‐Tyrrell, K., Janosky, J. J., & Arslanian, S. A. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1219 · Cited by 142
Self-citation
Abdominal obesity is associated with arterial stiffness in middle-aged adults
Strasser, B., Arvandi, M., Pasha, E. P., Haley, A. P., Stanforth, P. R., & Tanaka, H. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.01.002 · Cited by 140
Obesity, Metabolic Syndrome, and Cardiovascular Disease
Aggoun, Y. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e31805d8a8c · Cited by 135
Endothelial dysfunction in obesity: etiological role in atherosclerosis
Meyers, M. R., & Gokce, N. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282be90a8 · Cited by 134
Regional Adiposity and Heart Failure with Preserved Ejection Fraction
Rao, V. N., Fudim, M., Mentz, R. J., Michos, E. D., & Felker, G. M. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1956 · Cited by 131
Fatness Is a Better Predictor of Cardiovascular Disease Risk Factor Profile Than Aerobic Fitness in Healthy Men
Christou, D. D., Gentile, C. L., DeSouza, C. A., Seals, D. R., & Gates, P. E. (2005) · Circulation · doi:10.1161/01.cir.0000161818.28974.1a · Cited by 131
Prevalence and determinants of isolated systolic hypertension among young adults: the 1999–2004 US National Health And Nutrition Examination Survey
Grebla, R. C., Rodríguez, C. J., Borrell, L. N., & Pickering, T. G. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e328331b7ff · Cited by 127
Obesity and cardiovascular disease: an ESC clinical consensus statement
Koskinas, K. C., Craenenbroeck, E. M. V., Antoniades, C. A., Blüher, M., Gorter, T. M., Hanssen, H., Marx, N., McDonagh, T. A., Mingrone, G., Rosengren, A., et al. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae279 · Cited by 134
Body composition and fat repartition in relation to structure and function of large arteries in middle-aged adults (the SU.VI.MAX study)
Czernichow, S., Bertrais, S., Oppert, J., Galan, P., Blacher, J., Ducimetière, P., Herçberg, S., & Zureik, M. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802986 · Cited by 120
Impact of obesity on the risk of heart failure and survival after the onset of heart failure
Kenchaiah, S., Gaziano, J. M., & Vasan, R. S. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.011 · Cited by 120
Global impairment of brachial, carotid, and aortic vascular function in young smokers
Wiesmann, F., Petersen, S. E., Leeson, P., Francis, J. M., Robson, M. D., Wang, Q., Choudhury, R. P., Channon, K. M., & Neubauer, S. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.08.033 · Cited by 120
Effect of Weight Loss on Pulse Wave Velocity
Petersen, K. S., Blanch, N., Keogh, J. B., & Clifton, P. M. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304798 · Cited by 119
Type 2 Diabetes Mellitus in Youth: The Complete Picture to Date
Gungor, N., Hannon, T. S., Libman, I. M., Bacha, F. F., & Arslanian, S. A. (2005) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2005.07.009 · Cited by 116
Weight loss after bariatric surgery improves aortic elastic properties and left ventricular function in individuals with morbid obesity: a 3-year follow-up study
Ikonomidis, I., Mazarakis, A., Papadopoulos, C., Patsouras, N., Kalfarentzos, F., Lekakis, J., Kremastinos, D. T., & Alexopoulos, D. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3280115bfb · Cited by 118
Relationship between low-grade inflammation and arterial stiffness in patients with essential hypertension
Pietri, P. G., Vyssoulis, G. P., Vlachopoulos, C. V., Zervoudaki, A., Gialernios, T. P., Aznaouridis, K. A., & Stefanadis, C. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000249701.49854.21 · Cited by 118
Adiposity, Obesity, and Arterial Aging
Brunner, E. J., Shipley, M. J., Ahmadi‐Abhari, S., Tabák, Á. G., McEniery, C. M., Wilkinson, I. B., Marmot, M. G., Singh‐Manoux, A., & Mika Kivimaki, B. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05494 · Cited by 116
Blood pressure categories, hypertensive subtypes, and the metabolic syndrome
Franklin, S. S., Barboza, M. G., Pio, J. R., & Wong, N. D. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000244950.72664.02 · Cited by 116
Endothelial dysfunction: role in obesity-related disorders and the early origins of CVD
Singhal, A. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004404 · Cited by 115
Association between serum C-reactive protein levels and pulse wave velocity: a population-based cross-sectional study in a general population
Nagano, M., Nakamura, M., Sato, K., Tanaka, F., Segawa, T., & Hiramori, K. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.11.019 · Cited by 108
Carotid Stiffness in Young Adults: A Life-Course Analysis of its Early Determinants
Ferreira, I., van de Laar, R. J., Prins, M. H., Twisk, J. W. R., & Stehouwer, C. D. A. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.156109 · Cited by 102
Whole-body vibration training reduces arterial stiffness, blood pressure and sympathovagal balance in young overweight/obese women
Figueroa, A., Gil, R., Wong, A., Hooshmand, S., Park, S., Vicil, F., & Sanchez‐Gonzalez, M. A. (2012) · Hypertension Research · doi:10.1038/hr.2012.15 · Cited by 100
Adiposity and Incidence of Heart Failure Hospitalization and Mortality
Levitan, E. B., Yang, A. Z., Wolk, A., & Mittleman, M. A. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.794099 · Cited by 98
Associations of large artery structure and function with adiposity: Effects of age, gender, and hypertension. The SardiNIA Study
Scuteri, A., Orrù, M., Morrell, C. H., Tarasov, K. V., Schlessinger, D., Uda, M., & Lakatta, E. G. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.11.045 · Cited by 97
Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial
Joris, P. J., Plat, J., Bakker, S. J. L., & Mensink, R. P. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.131466 · Cited by 98
The Association between Abdominal Visceral Fat and Carotid Stiffness Is Mediated by Circulating Inflammatory Markers in Uncomplicated Type 2 Diabetes
Diamant, M., Lamb, H. J., van de Ree, M. A., Endert, E. L., Groeneveld, Y., Bots, M. L., Kostense, P. J., & Radder, J. K. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1579 · Cited by 98
Insulin resistance and arterial stiffness in healthy adolescents and young adults
Urbina, E. M., Gao, Z., Khoury, P. R., Martin, L. J., & Dolan, L. M. (2011) · Diabetologia · doi:10.1007/s00125-011-2412-1 · Cited by 98
Pulse Wave Velocity Assessment by External Noninvasive Devices and Phase-Contrast Magnetic Resonance Imaging in the Obese
Joly, L., Perret‐Guillaume, C., Kearney‐Schwartz, A., Salvi, P., Mandry, D., Marie, P., Karcher, G., Rossignol, P., Zannad, F. M., & Bénétos, A. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.133645 · Cited by 96
Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study
Brown, O. I., Drozd, M., McGowan, H., Giannoudi, M., Conning-Rowland, M. S., Gierula, J., Straw, S., Wheatcroft, S. B., Bridge, K., Roberts, L. D., et al. (2023) · Diabetes Care · doi:10.2337/dc23-0294 · Cited by 101
The role of obesity in the pathogenesis of hypertension
Bogaert, Y. E., & Linas, S. L. (2008) · Nature Reviews Nephrology · doi:10.1038/ncpneph1022 · Cited by 95
Body Fat Is Associated With Reduced Aortic Stiffness Until Middle Age
Corden, B., Keenan, N., de Marvao, A., Dawes, T. J. W., Cesare, A. D., Diamond, T., Durighel, G., Hughes, A. D., Cook, S. A., & O’Regan, D. P. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01177 · Cited by 92
Large Artery Stiffening With Weight Gain in Humans
Orr, J. S., Gentile, C. L., Davy, B. M., & Davy, K. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.112946 · Cited by 94
Effects of exercise modalities on central hemodynamics, arterial stiffness and cardiac function in cardiovascular disease: Systematic review and meta-analysis of randomized controlled trials
Zhang, Y., Qi, L., Xu, L., Sun, X., Liu, W., Zhou, S., van de Vosse, F. N., & Greenwald, S. E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200829 · Cited by 93
Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity
Hanssen, H., Nickel, T., Drexel, V., Hertel, G., Emslander, I., Sisic, Z., Lorang, D., Schuster, T., Kotliar, K. E., Preßler, A., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.02.009 · Cited by 94
Metabolic Syndrome in Relation to Structure and Function of Large Arteries: A Predominant Effect of Blood PressureA Report From the SU.VI.MAX. Vascular Study
Czernichow, S., Bertrais, S., Blacher, J., Oppert, J., Galan, P., Ducimetière, P., Herçberg, S., Safar, M. E., & Zureik, M. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.04.006 · Cited by 90
Insulin resistance is associated with subclinical vascular disease in humans
Adeva‐Andany, M. M., Ameneiros-Rodríguez, E., Fernández‐Fernández, C., Domínguez-Montero, A., & Funcasta-Calderón, R. (2019) · World Journal of Diabetes · doi:10.4239/wjd.v10.i2.63 · Cited by 91
Effect of Weight Loss and Nutritional Intervention on Arterial Stiffness in Type 2 Diabetes
Barinas‐Mitchell, E., Kuller, L. H., Sutton‐Tyrrell, K., Hegazi, R. A. F., Harper, P. H., Mancino, J., & Kelley, D. E. (2006) · Diabetes Care · doi:10.2337/dc06-0665 · Cited by 89
Self-citation
Modulatory influences on ageing of the vasculature in healthy humans
Seals, D. R., Moreau, K. L., Gates, P. E., & Eskurza, I. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.001 · Cited by 86
Effects of Diet and/or Low-Intensity Resistance Exercise Training on Arterial Stiffness, Adiposity, and Lean Mass in Obese Postmenopausal Women
Figueroa, A., Vicil, F., Sanchez-Gonzalez, M. A., Wong, A., Ormsbee, M. J., Hooshmand, S., & Daggy, B. (2013) · American Journal of Hypertension · doi:10.1093/ajh/hps050 · Cited by 97
Assessing the Causal Role of Body Mass Index on Cardiovascular Health in Young Adults
Wade, K. H., Chiesa, S. T., Hughes, A. D., Chaturvedi, N., Charakida, M., Rapala, A., Muthurangu, V., Khan, T. A., Finer, N., Sattar, N. A., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.033278 · Cited by 86
Increased Aortic Stiffness and Attenuated Lysyl Oxidase Activity in Obesity
Chen, J., Tsai, P.-J., Tai, H.-C., Tsai, R.-L., Chang, Y., Wang, M.-C., Chiou, Y.-W., Yeh, M., Tang, M., Lam, C.-F., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300036 · Cited by 82
Effects of resistance training on central blood pressure in obese young men
Croymans, D. M., Krell, S. L., Oh, C. S., Katiraie, M., Lam, C. Y., Harris, R. A., & Roberts, C. K. (2013) · Journal of Human Hypertension · doi:10.1038/jhh.2013.81 · Cited by 86
The relationship between various measures of obesity and arterial stiffness in morbidly obese patients
Nordstrand, N., Gjevestad, E. S., Dinh, K., Hofsø, D., Røislien, J., Saltvedt, E., Os, I., & Hjelmesaeth, J. S. (2011) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-11-7 · Cited by 81
Metabolic and vascular insulin resistance: partners in the pathogenesis of cardiovascular disease in diabetes
Horton, W. B., Love, K. M., Gregory, J. M., Liu, Z., & Barrett, E. J. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00826.2024 · Cited by 95
Aortic stiffness and calcification in men in a population-based international study
Sekikawa, A. M., Shin, C., Curb, J. D., Barinas‐Mitchell, E., Masaki, K., El‐Saed, A., Seto, T. B., Mackey, R. H., Choo, J., Fujiyoshi, A., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.03.027 · Cited by 80
Self-citation
Whole-body vibration training in obese subjects: A systematic review
Zago, M., Capodaglio, P., Ferrario, C., Tarabini, M., & Galli, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202866 · Cited by 79
Increased Arterial Stiffness in Subjects with Impaired Glucose Tolerance and Newly Diagnosed Diabetes But Not Isolated Impaired Fasting Glucose
Li, C., Wu, J., Yang, Y., Shih, C.-C., Lu, F., & Chang, C. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2595 · Cited by 79
INDICES OF VASCULAR STIFFNESS AND WAVE REFLECTION IN RELATION TO BODY MASS INDEX OR BODY FAT IN HEALTHY SUBJECTS
Wykrętowicz, A., Adamska, K., Guzik, P., Krauze, T., & Wysocki, H. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04666.x · Cited by 75
Arterial Stiffness and Vascular Load in Heart Failure
Ooi, H., Chung, W. B., & Biolo, A. (2008) · Congestive Heart Failure · doi:10.1111/j.1751-7133.2008.07210.x · Cited by 76
Brain structure and cognitive correlates of body mass index in healthy older adults
Bolzenius, J. D., Laidlaw, D. H., Cabeen, R. P., Conturo, T. E., McMichael, A. R., Lane, E., Heaps, J. M., Salminen, L. E., Baker, L. M., Scott, S. E., et al. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.010 · Cited by 76
High body mass alters colonic sensory-motor function and transit in humans
Delgado-Aros, S., Camilleri, M., Garcia, M. A., Burton, D. D., & Busciglio, I. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90286.2008 · Cited by 73
The two faces of hypertension: role of aortic stiffness
Smulyan, H., Mookherjee, S., & Safar, M. E. (2015) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2015.11.012 · Cited by 73
Association between body fat parameters and arterial stiffness
Kim, H., Ahn, D.-W., Kim, S. H., Lee, D. S., Yoon, S. H., Zo, J., Kim, M., & Jeong, J. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-00175-z · Cited by 69
Body Mass Index Is Not Independently Associated With Increased Aortic Stiffness in a Brazilian Population
Rodrigues, S. L., Baldo, M. P., Lani, L., Nogueira, L. D. O., Mill, J. G., & Cunha, R. S. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.91 · Cited by 68
Effect of Habitual Aerobic Exercise on Body Weight and Arterial Function in Overweight and Obese Men
Miyaki, A., Maeda, S., Yoshizawa, M., Misono, M., Saito, Y., Sasai, H., Kim, M.-K., Nakata, Y., Tanaka, K., & Ajisaka, R. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.04.057 · Cited by 68
Changes in Arterial Stiffness But Not Carotid Intimal Thickness in Acromegaly
Paisley, A. N., Banerjee, M., Rezai, M. R., Schofield, R. E., Balakrishnan-Nair, S., Herbert, A., Lawrance, J., Trainer, P. J., & Cruickshank, J. K. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2225 · Cited by 66
Long Sleep Duration Associated With a Higher Risk of Increased Arterial Stiffness in Males
Tsai, T.-C., Wu, J., Yang, Y., Huang, Y., Lu, F.-H., & Chang, C. (2014) · SLEEP · doi:10.5665/sleep.3920 · Cited by 62
Arterial stiffness is associated to cardiorespiratory fitness and body mass index in young Swedish adults: The Lifestyle, Biomarkers, and Atherosclerosis study
Fernberg, U., Fernström, M., & Hurtig‐Wennlöf, A. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317720796 · Cited by 64
Diet-Induced Obesity Promotes Kidney Endothelial Stiffening and Fibrosis Dependent on the Endothelial Mineralocorticoid Receptor
Aroor, A. R., Habibi, J., Nistala, R., Ramirez‐Perez, F. I., Martinez‐Lemus, L. A., Jaffe, I. Z., Sowers, J. R., Jia, G., & Whaley‐Connell, A. T. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12198 · Cited by 64
Effect of Aerobic Exercise Training on Arterial Stiffness in Obese Populations
Montero, D., Roberts, C. K., & Vinet, A. (2014) · Sports Medicine · doi:10.1007/s40279-014-0165-y · Cited by 63
Impaired Vascular Function in Obese Adolescents with Insulin Resistance
Mahmud, F. H., Hill, D. J., Cuerden, M. S., & Clarson, C. L. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.04.060 · Cited by 62
Prevention and Treatment of Type 2 Diabetes in Youth
Libman, I. M., & Arslanian, S. A. (2006) · Hormone Research in Paediatrics · doi:10.1159/000095981 · Cited by 62
Common carotid arterial interadventitial distance (diameter) as an indicator of the damaging effects of age and atherosclerosis, a cross-sectional study of the Atherosclerosis Risk in Community Cohort Limited Access Data (ARICLAD), 1987–89
Eigenbrodt, M. L., Bursac, Z., Rose, K. M., Couper, D. J., Tracy, R. E., Evans, G. W., Brancati, F. L., & Mehta, J. L. (2006) · Cardiovascular Ultrasound · doi:10.1186/1476-7120-4-1 · Cited by 60
Leptin is independently associated with systolic blood pressure, pulse pressure and arterial compliance in hypertensive African women with increased adiposity: the POWIRS study
Schutte, R., Huisman, H. W., Schutte, A. E., & Malan, N. T. (2005) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001856 · Cited by 61
Pedometer‐determined physical activity is linked to low systemic inflammation and low arterial stiffness in Type 2 diabetes
Jennersjö, P. E. S., Ludvigsson, J., Länne, T., Nyström, F. H., Ernerudh, J., & Östgren, C. J. (2012) · Diabetic Medicine · doi:10.1111/j.1464-5491.2012.03621.x · Cited by 60
Regional variation in arterial stiffening and dysfunction in Western diet-induced obesity
Bender, S. B., Castorena‐Gonzalez, J. A., Garro, M., Reyes‐Aldasoro, C. C., Sowers, J. R., DeMarco, V. G., & Martinez‐Lemus, L. A. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00155.2015 · Cited by 58
Relationship between measures of central and general adiposity with aortic stiffness in the general population
Wohlfahrt, P., Somers, V. K., Cífková, R., Filipovský, J., Seidlerová, J., Krajčoviechová, A., Sochor, O., Kullo, I. J., & López-Jiménez, F. A. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.05.958 · Cited by 59
Comparison of the ability to identify arterial stiffness between two new anthropometric indices and classical obesity indices in Chinese adults
Zhang, J., Fang, L., Qiu, L., Huang, L., Zhu, W., & Yu, Y. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.06.031 · Cited by 58
Overweightness, obesity and arterial stiffness in healthy subjects: a systematic review and meta-analysis of literature studies
Li, P., Wang, L., & Liu, C. (2016) · Postgraduate Medicine · doi:10.1080/00325481.2017.1268903 · Cited by 56
The influence of obesity on arterial compliance in adult men and women
Acree, L. S., Montgomery, P. S., & Gardner, A. W. (2007) · Vascular Medicine · doi:10.1177/1358863x07079323 · Cited by 57
Inverse relationship of cardioankle vascular index with BMI in healthy Japanese subjects: a cross-sectional study
Nagayama, D., Imamura, H., Sato, Y., Yamaguchi, T., Ban, N., Kawana, H., Ohira, M., Saiki, A., Shirai, K., & Tatsuno, I. (2016) · Vascular Health and Risk Management · doi:10.2147/vhrm.s119646 · Cited by 57
Novel and traditional anthropometric indices for identifying arterial stiffness in overweight and obese adults
Li, G., Yao, T., Wu, X., Cao, Z., Tu, Y., Ma, Y., Li, B., Peng, Q.-Y., Wu, B., & Hou, J. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.03.029 · Cited by 55
Relationship between body mass index and arterial stiffness in a health assessment Chinese population
Tang, B., Luo, F., Zhao, J., Ma, J., Tan, I., Butlin, M., Avolio, A. P., & Zuo, J. (2020) · Medicine · doi:10.1097/md.0000000000018793 · Cited by 54
Arterial stiffness, lifestyle intervention and a low‐calorie diet in morbidly obese patients—A nonrandomized clinical trial
Nordstrand, N., Gjevestad, E. S., Hertel, J. K., Johnson, L. K., Saltvedt, E., Røislien, J., & Hjelmesaeth, J. S. (2013) · Obesity · doi:10.1002/oby.20099 · Cited by 51
Sex differences in fat distribution influence the association between BMI and arterial stiffness
van den Munckhof, I., Holewijn, S., Graaf, J. D., & Rutten, J. H. W. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001297 · Cited by 50
Obesity and Overweight Associated With Increased Carotid Diameter and Decreased Arterial Function in Young Otherwise Healthy Men
Kappus, R. M., Fahs, C. A., Smith, D. L., Horn, G. P., Agiovlasitis, S., Rossow, L., Jae, S. Y., Heffernan, K. S., & Fernhall, B. (2013) · American Journal of Hypertension · doi:10.1093/ajh/hpt152 · Cited by 49
Beneficial Effect of Statin Therapy on Arterial Stiffness
Alidadi, M., Montecucco, F., Jamialahmadi, T., Al‐Rasadi, K., Johnston, T. P., & Sahebkar, A. (2021) · BioMed Research International · doi:10.1155/2021/5548310 · Cited by 49
Adipokines and Arterial Stiffness in Obesity
Para, I., Albu, A., & Porojan, M. D. (2021) · Medicina · doi:10.3390/medicina57070653 · Cited by 53

Authors: Wildman, R. P., Mackey, R. H., Bostom, A., Thompson, T., & Sutton-Tyrrell, K.
Affiliations: University of Pittsburgh (US)
ORCID: Mackey, Rachel H.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-10
Volume: 42
Issue: 4
Pages: 468-473
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/01.hyp.0000090360.78539.cd
OpenAlex: W2091786740
Cited by: 441
References: 41
Citations by year: 2026: 9 · 2025: 12 · 2024: 15 · 2023: 16 · 2022: 17 · 2021: 23 · 2020: 17 · 2019: 20 · 2018: 15 · 2017: 25 · 2016: 22 · 2015: 28 · 2014: 31 · 2013: 32 · 2012: 25
FWCI: 9.44
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ag014108-05)
National Institute on Aging (AG14108)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: obesity, vascular stiffness, aortic stiffness, pulse wave velocity, body mass index, waist circumference, waist-to-hip ratio, African Americans, young adults, older adults, cardiovascular risk, body weight
MeSH terms: Adult, Age Factors, Aged, Aorta, Compliance, Female, Humans, Male, Middle Aged, Obesity, Pulsatile Flow

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Measures of Obesity Are Associated With Vascular Stiffness in Young and Older Adults

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks