Cited by 400Adipokines, Inflammation, and Metabolic DiseasesBlood Pressure and Hypertension StudiesCardiovascular Disease and Adiposity

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Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

Ohashi, Koji, Kihara, Shinji, Ouchi, Noriyuki, Kumada, Masahiro, Fujita, Koichi, Hiuge, Aki, Hibuse, Toshiyuki, Ryo, Miwa, Nishizawa, Hitoshi, Maeda, Norikazu, Maeda, Kazuhisa, Shibata, Rei, Walsh, Kenneth, Funahashi, Tohru, Shimomura, Iichiro·2006·Hypertension

DOI 10.1161/01.hyp.0000222368.43759.a1

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Abstract

Patients with obesity are susceptible to hypertension. We have reported that the plasma adiponectin levels are decreased in obesity and that adiponectin has many defensive properties against obesity-related diseases, such as type 2 diabetes and coronary artery disease. The aim of this study was to determine the relationship between adiponectin and hypertension in mice. We measured blood pressure and heart rate directly by a catheter in the carotid artery and indirectly by automatic sphygmomanometer at the tail artery. Obese KKAy mice had significantly lower plasma adiponectin levels and higher systolic blood pressure than control C57BL/6J mice at 21 weeks of age. Adenovirus-delivered adiponectin significantly decreased blood pressure in KKAy mice. The direct role of adiponectin on blood pressure regulation under insulin resistance–free state was investigated in adiponectin-knockout (KO) mice. Adiponectin KO mice developed hypertension when maintained on a high-salt diet (8% NaCl) without insulin resistance. The hypertension of salt-fed adiponectin KO mice was associated with reduced mRNA levels of endothelial NO synthase (eNOS) and prostaglandin I 2 synthase in aorta and low metabolite levels of endothelial NO synthase and prostaglandin I 2 synthase in plasma. Adiponectin therapy lowered the elevated blood pressure and corrected the above mRNA levels to those of the wild type. Our results suggest that hypoadiponectinemia contributes to the development of obesity-related hypertension, at least in part, directly, in addition to its effect via insulin resistance, and that adiponectin therapy can be potentially useful for hypertension in patients with the metabolic syndrome.

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Self-citation
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Authors: Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., Maeda, K., Shibata, R., Walsh, K., Funahashi, T., & Shimomura, I.
Affiliations: Boston University (US)
ORCID: Ohashi, Koji
Kihara, Shinji
Ouchi, Noriyuki
Fujita, Koichi
Nishizawa, Hitoshi
Maeda, Norikazu
Maeda, Kazuhisa
Shibata, Rei
Walsh, Kenneth
Shimomura, Iichiro
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-06
Volume: 47
Issue: 6
Pages: 1108-1116
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/01.hyp.0000222368.43759.a1
OpenAlex: W2166751358
Cited by: 400
References: 36
Citations by year: 2026: 5 · 2025: 11 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 61 · 2019: 13 · 2018: 6 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 25 · 2013: 22 · 2012: 30
FWCI: 24.90
Type: journal article
Language: en
Update notices: correction (2006-12-26)
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adiponectin, obesity-related hypertension, hypoadiponectinemia, KK-Ay mice, adiponectin knockout mice, high-salt diet, endothelial nitric oxide synthase, PTGIS, nitric oxide, insulin resistance, metabolic syndrome, blood pressure regulation
MeSH terms: Adenoviridae, Animals, Aorta, Blood Pressure, Cytochrome P-450 Enzyme System, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Enzyme Inhibitors, Genetic Vectors, Hypertension, Insulin Resistance, Male, Mice, Inbred Strains, Obesity, RNA, Messenger, Sodium Chloride, Dietary, Gene Transfer Techniques, Mice, Knockout, NG-Nitroarginine Methyl Ester, Intramolecular Oxidoreductases, Mice, Adiponectin, Nitric Oxide Synthase Type III

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Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

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