Cited by 83Heart Rate Variability and Autonomic ControlCircadian rhythm and melatoninBlood Pressure and Hypertension Studies

Twenty-four-hour rhythms of plasma catecholamines and their relation to cardiovascular parameters in healthy young men

Schofl, C, Becker, C, Prank, K, von zur Muhlen, A, Brabant, G·1997·European Journal of Endocrinology

Abstract

Diurnal and ultradian rhythms of plasma norepinephrine and epinephrine and their role in the regulation of cardiovascular parameters were investigated over 24 h of recumbency in a group of five men. Catecholamines were measured at 10 min intervals, and blood pressure and heart rate were recorded continuously. Norepinephrine and epinephrine rapidly fluctuated in each subject, with no obvious diurnal rhythm. Spectral analysis suggested two ultradian rhythms with periods of around 12 h and 50-100 min for both catecholamines. The pulse detection programs PULSAR and CLUSTER revealed 20-30 pulses/24 h for norepinephrine and epinephrine, with a significant correlation between the two rhythms (r = 0.63-0.80, P < 0.001). Neither the frequency nor the amplitude of these rapid fluctuations differed between day and night. Arousal in the morning caused a small increase in plasma catecholamines and getting out of bed a large increase. Thus changes in posture and activity are the main influences on the diurnal variations of plasma catecholamines reported previously, while the ultradian rhythms of sympathoadrenomedullary activity appear to be of intrinsic origin. Blood pressure and heart rate exhibited a diurnal rhythm with a nightly decrease. Arousal and rising from bed increased blood pressure and heart rate significantly. Although the amplitude of the rapid fluctuations of plasma catecholamines at times exceeded those caused by postural changes in the morning, when both plasma norepinephrine and epinephrine levels correlated highly with all cardiovascular parameters, correlations were not significant during recumbency. Thus the intrinsic ultradian fluctuations of plasma catecholamines appear not to be involved in the control of cardiovascular parameters during recumbency, and the increase in blood pressure and heart rate in the morning appears to be controlled by direct sympathetic neural input to the heart and vasculature in response to changes in activity and posture rather than by an endogenous surge of plasma catecholamines.

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Crossref · 10.1530/eje.0.1370675

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31 of 31 references verified0 citation errors · 0 not checkable

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  • The preponderance of TPP attacks in the morning may stem from higher plasma catecholamines and sympathetic tone in the late morning.

    “The preponderance of TPP attacks in the morning may also stem from higher plasma catecholamines and sympathetic tone in the late morning (35).”
  • The preponderance of TPP attacks in the morning may stem from higher plasma catecholamines and sympathetic tone in the late morning.

    “The preponderance of TPP attacks in the morning may also stem from higher plasma catechol-amines and sympathetic tone in the late morning [14].”

    From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [14]

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Authors
Schofl, C., Becker, C., Prank, K., von zur Muhlen, A., & Brabant, G.
Affiliations
Medizinische Hochschule Hannover (DE)
Corresponding author
Brabant, G
Venue
European Journal of Endocrinology
Published
1997-12-01
Volume
137
Issue
6
Pages
675-683
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
OpenAlex
W2106101254
Cited by
83
References
31
Citations by year
2025: 1 · 2024: 4 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 10 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 2
FWCI
0.49
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
plasma catecholamines, norepinephrine, epinephrine, ultradian rhythms, diurnal cycle, cardiovascular parameters, blood pressure, heart rate, sympathoadrenal activity, postural changes, arousal, circadian rhythm, spectral analysis, young men
MeSH terms
Adult, Blood Pressure, Circadian Rhythm, Epinephrine, Heart Rate, Humans, Male, Norepinephrine, Posture, Wakefulness

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