A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine
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Bioinformatic analyses of human tissue samples were used to build a database of rhythmically expressed genes across the body.
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Chronotherapeutic strategies of specifically timing the delivery of certain drugs are now being used in the treatment of certain cancers and may be therapeutically beneficial across various diseases.
“Chronotherapeutic strategies of specifically timing the delivery of certain drugs are now being used in the treatment of certain cancers325 and may be therapeutically beneficial across various diseases326.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [326]
Many of the most effective treatments for brain disorders and other diseases modulate clock function.
“Many of the most effective treatments for brain disorders and other diseases modulate clock function216,326,330,332,333.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [326]
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Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health
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Role of Circadian Transcription Factor Rev-Erb in Metabolism and Tissue Fibrosis
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Deciphering the relationship between temperature and immunity
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TimeTeller: A tool to probe the circadian clock as a multigene dynamical system
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The circadian clock protects against ionizing radiation‐induced cardiotoxicity
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Circadian Biology in Obstructive Sleep Apnea
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A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care
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Colonic Epithelial Circadian Disruption Worsens Dextran Sulfate Sodium–Induced Colitis
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GDF15: a potential therapeutic target for type 1 diabetes
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CNS Drug Delivery in Stroke: Improving Therapeutic Translation From the Bench to the Bedside
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Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease
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- Authors
- Ruben, M. D., Wu, G., Smith, D. F., Schmidt, R. E., Francey, L. J., Lee, Y. Y., Anafi, R. C., & Hogenesch, J. B.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- University of Pennsylvania (US)
- Corresponding author
- Hogenesch, John B.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2018-09-12
- Volume
- 10
- Issue
- 458
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8961342
- OpenAlex
- W2889589921
- Cited by
- 314
- References
- 44
- Citations by year
- 2026: 30 · 2025: 33 · 2024: 45 · 2023: 55 · 2022: 43 · 2021: 44 · 2020: 37 · 2019: 22 · 2018: 5
- FWCI
- 15.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Human Genome Research Institute (2R01HG005220)
- National Institute of Neurological Disorders and Stroke (2R01NS054794)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- circadian rhythm, tissue-specific gene expression, rhythmic gene expression, circadian clock, drug metabolism genes, drug transporters, therapeutic target, circadian medicine, drug response
- MeSH terms
- Adult, Aged, Circadian Rhythm, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Organ Specificity, Drug Delivery Systems, Databases, Genetic, Young Adult
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