Cited by 327Angiogenesis and VEGF in CancerCancer, Hypoxia, and MetabolismLymphatic System and Diseases

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors

Open access

Yamakawa, Midori, Liu, Louis X., Date, Taro, Belanger, Adam J., Vincent, Karen A., Akita, Geoffrey Y., Kuriyama, Takayuki, Cheng, Seng H., Gregory, Richard J., Jiang, Canwen·2003·Circulation Research

DOI 10.1161/01.res.0000093984.48643.d7

Open this paper in CoChat — free account Open PDF

Abstract

Hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of vascular endothelial growth factor (VEGF) and other hypoxia-responsive genes. Transgenic expression of a constitutively stable HIF-1alpha mutant increases the number of vascular vessels without vascular leakage, tissue edema, or inflammation. This study aimed to investigate the molecular basis by which HIF-1 mediates the angiogenic response to hypoxia. In primary human endothelial cells, hypoxia, desferrioxamine, or infection with Ad2/HIF-1alpha/VP16, an adenoviral vector encoding a constitutively stable hybrid form of HIF-1alpha, increased the mRNA and protein levels of VEGF, angiopoietin-2 (Ang-2), and angiopoietin-4 (Ang-4). Infection with Ad2/CMVEV (a control vector expressing no transgene) had no effect. Angiopoietin-1 (Ang-1) expression was not detected in human endothelial cells. Ang-4 was also induced by hypoxia or Ad2/HIF-1alpha/VP16 in human cardiac cells, whereas Ang-1 expression remained unchanged. Recombinant Ang-4 protein protected endothelial cells against serum starvation-induced apoptosis and increased cultured endothelial cell migration and tube formation. Ad2/HIF-1alpha/VP16 stimulated endothelial cell proliferation and tube formation. Hypoxia- or Ad2/HIF-1alpha/VP16-induced tube formation was significantly reduced by a Tie-2 inhibitor. These results suggest that HIF-1 mediates the angiogenic response to hypoxia by upregulating the expression of multiple angiogenic factors. Ang-4 can function similarly as Ang-1 and substitute for Ang-1 to participate in hypoxia-induced angiogenesis. Activation of the angiopoietin/Tie-2 system may play a role in the ability of HIF-1 to induce hypervascularity without excessive permeability.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/01.res.0000093984.48643.d7

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Mechanisms of angiogenesis
Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
Holash, J. A., Maisonpierre, P. C., Compton, D. L., Boland, P., Alexander, C., Zagzag, D., Yancopoulos, G. D., & Wiegand, S. J. (1999) · Science · doi:10.1126/science.284.5422.1994 · Cited by 2,222
Purification and Characterization of Hypoxia-inducible Factor 1
Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094

Show all 48 references

Research works printed but not linked: 5

10.1161/circ.102.18.2255 · DOI
10.1161/res.83.3.233 · DOI
10.1161/res.83.8.852 · DOI
10.1161/res.87.5.370 · DOI
10.1161/circ.98.19.2081 · DOI

Sorted by citations

Hypoxia-inducible factors and the response to hypoxic stress
Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N., & Semenza, G. L. (2005) · Blood · doi:10.1182/blood-2004-07-2958 · Cited by 1,154
MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3
Fasanaro, P., D'Alessandra, Y., Di Stefano, V., Melchionna, R., Romani, S., Pompilio, G., Capogrossi, M. C., & Martelli, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800731200 · Cited by 912
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
Kaur, B., Khwaja, F. W., Severson, E. A., Matheny, S. L., Brat, D. J., & Van Meir, E. G. (2005) · Neuro-Oncology · doi:10.1215/s1152851704001115 · Cited by 725
Therapeutic targeting of the angiopoietin–TIE pathway
Saharinen, P., Eklund, L., & Alitalo, K. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.278 · Cited by 620
Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1
Hsu, Y.-L., Hung, J.-Y., Chang, W.-A., Lin, Y. S., Pan, Y.-C., Tsai, P.-H., Wu, C.-Y., & Kuo, P.-L. (2017) · Oncogene · doi:10.1038/onc.2017.105 · Cited by 610
The cerebral effects of ascent to high altitudes
Wilson, M. H., Newman, S. P., & Imray, C. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70014-6 · Cited by 528
Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling
Anderson, J. D., Johansson, H. J., Graham, C. S., Vesterlund, M., Pham, M. T., Bramlett, C. S., Montgomery, E. N., Mellema, M., Bardini, R. L., Contreras, Z., et al. (2016) · Stem Cells · doi:10.1002/stem.2298 · Cited by 546
Signaling and Functions of Angiopoietin-1 in Vascular Protection
Brindle, N. P. J., Saharinen, P., & Alitalo, K. K. (2006) · Circulation Research · doi:10.1161/01.res.0000218275.54089.12 · Cited by 485
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
Kung, A. L., Zabludoff, S. D., France, D. S., Freedman, S. J., Tanner, E. A., Vieira, A., Cornell-Kennon, S., Lee, J., Wang, B., Wang, J., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.009 · Cited by 480
Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
Hammarstedt, A., Gogg, S., Hedjazifar, S., Nerstedt, A., & Smith, U. (2018) · Physiological Reviews · doi:10.1152/physrev.00034.2017 · Cited by 462
Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease
Grammas, P. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-26 · Cited by 432
The discovery of placenta growth factor and its biological activity
De Falco, S. (2012) · Experimental and Molecular Medicine · doi:10.3858/emm.2012.44.1.025 · Cited by 425
The role of the Angiopoietins in vascular morphogenesis
Thomas, M., & Augustin, H. G. (2009) · Angiogenesis · doi:10.1007/s10456-009-9147-3 · Cited by 418
Diabetic cardiomyopathy: mechanisms, diagnosis and treatment
Hayat, S. A., Patel, B., Khattar, R. S., & Malik, R. A. (2004) · Clinical Science · doi:10.1042/cs20040057 · Cited by 353
CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway
Liang, Z., Brooks, J., Willard, M. T., Liang, K., Yoon, Y., Kang, S., & Shim, H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.182 · Cited by 335
Defining Physiological Normoxia for Improved Translation of Cell Physiology to Animal Models and Humans
Keeley, T. P., & Mann, G. E. (2019) · Physiological Reviews · doi:10.1152/physrev.00041.2017 · Cited by 329
Hypoxic induction of an HIF-1α–dependent bFGF autocrine loop drives angiogenesis in human endothelial cells
Calvani, M., Rapisarda, A., Uranchimeg, B., Shoemaker, R. H., & Melillo, G. (2005) · Blood · doi:10.1182/blood-2005-09-3541 · Cited by 233
The use of hyperbaric oxygen therapy to treat chronic wounds: A review
Thackham, J. A., McElwain, D. L. S., & Long, R. J. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00372.x · Cited by 230
Regulation of Wound Healing and Fibrosis by Hypoxia and Hypoxia-Inducible Factor-1
Ruthenborg, R. J., Ban, J.-J., Wazir, A., Takeda, N., & Kim, J. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0150 · Cited by 230
The angiopoietin‐2 gene of endothelial cells is up‐regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA‐2 and Ets‐1
Simon, M., Tournaire, R., & Pouysségur, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21558 · Cited by 220
Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice
Shen, X., Wan, C., Ramaswamy, G., Mavalli, M. D., Wang, Y., Duvall, C. L., Deng, L. F., Guldberg, R. E., Eberhart, A., Clemens, T. L., et al. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.20886 · Cited by 215
Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel–Lindau syndrome
Eisenhofer, G., Huynh, T.-T., Pacak, K., Brouwers, F. M., Walther, M. M., Linehan, W. M., Munson, P. J., Mannelli, M., Goldstein, D. S., & Elkahloun, A. G. (2004) · Endocrine-Related Cancer · doi:10.1677/erc.1.00838 · Cited by 207
Mechanisms of adaptive angiogenesis to tissue hypoxia
Fong, G. (2008) · Angiogenesis · doi:10.1007/s10456-008-9107-3 · Cited by 212
Innate Immunity and Angiogenesis
Frantz, S., Vincent, K. A., Féron, O., & Kelly, R. A. (2005) · Circulation Research · doi:10.1161/01.res.0000153188.68898.ac · Cited by 185
Self-citation
Biological characterization of angiopoietin‐3 and angiopoietin‐4
Lee, H. J., Cho, C., Hwang, S.-J., Choi, H.-H., Kim, K.-T., Ahn, S. Y., Kim, J., Oh, J.-L., Lee, G. M., & Koh, G. Y. (2004) · The FASEB Journal · doi:10.1096/fj.03-1466com · Cited by 176
Dexamethasone Induction of Keloid Regression through Effective Suppression of VEGF Expression and Keloid Fibroblast Proliferation
Wu, W.-S., Wang, F.-S., Yang, K. D., Huang, C.-C., & Kuo, Y.-R. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700274 · Cited by 174
Effects of Hypoxia-Inducible Factor-1α Overexpression in Pregnant Mice
Tal, R., Shaish, A., Barshack, I., Polak‐Charcon, S., Afek, A. B., Volkov, A., Feldman, B., Avivi, C., & Harats, D. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090800 · Cited by 173
The Pathogenesis of Adenomyosis vis-à-vis Endometriosis
Guo, S.-W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020485 · Cited by 165
Biology of bone marrow-derived endothelial cell precursors
Schatteman, G. C., Dunnwald, M., & Jiao, C. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00662.2006 · Cited by 160
Hypoxia Enhances the Angiogenic Potential of Human Dental Pulp Cells
Aranha, A. M. F., Zhang, Z., Neiva, K. G., Costa, C. A. D. S., Hebling, J., & Nor, J. E. (2010) · Journal of Endodontics · doi:10.1016/j.joen.2010.05.013 · Cited by 157
Hypoxia-Inducible Factor-1: A Novel Therapeutic Target for the Management of Cancer, Drug Resistance, and Cancer-Related Pain
Bui, B. P., Nguyen, P. L., Lee, K., & Cho, J. (2022) · Cancers · doi:10.3390/cancers14246054 · Cited by 178
Monocyte-endothelial cell interactions in vascular and tissue remodeling
Medrano-Bosch, M., Simón-Codina, B., Jiménez, W., Edelman, E. R., & Melgar‐Lesmes, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1196033 · Cited by 168
Preconditioning of adipose tissue-derived mesenchymal stem cells with deferoxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors: Potential application in the treatment of diabetic neuropathy
Oses, C., Olivares, B., Ezquer, M., Acosta, C. G., Bosch, P., Donoso, M., Léniz, P., & Ezquer, F. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178011 · Cited by 138
Cytokines and the regulation of hypoxia-inducible factor (HIF)-1α
Haddad, J. J., & Harb, H. L. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.11.009 · Cited by 139
Nanofibrous spongy microspheres for the delivery of hypoxia-primed human dental pulp stem cells to regenerate vascularized dental pulp
Kuang, R., Zhang, Z., Jin, X., Hu, J., Shi, S., Ni, L., & Ma, P. X. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.01.032 · Cited by 136
Role of Cytokines and Chemokines in Angiogenesis in a Tumor Context
Geindreau, M., Bruchard, M., & Végran, F. (2022) · Cancers · doi:10.3390/cancers14102446 · Cited by 151
Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor–Mediated Diabetic Nephropathy
Lin, C., Wang, F., Hsu, Y.-C., Chen, C., Tseng, M., Saleem, M. A., Chang, P., & Wang, J. (2010) · Diabetes · doi:10.2337/db09-0663 · Cited by 126
Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia
Shohet, R. V., & Garcia, J. A. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0279-x · Cited by 129
Hypoxic Signaling During Tissue Repair and Regenerative Medicine
Nauta, T. D., van Hinsbergh, V. W. M., & Koolwijk, P. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151119791 · Cited by 129
Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway
DeBusk, L. M., Hallahan, D. E., & Lin, P. C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.013 · Cited by 124
All‐trans retinoic acid preconditioning enhances proliferation, angiogenesis and migration of mesenchymal stem cell in vitro and enhances wound repair in vivo
Pourjafar, M., Saidijam, M., Mansouri, K., Ghasemibasir, H. R., Dermani, F. K., & Najafi, R. (2016) · Cell Proliferation · doi:10.1111/cpr.12315 · Cited by 105
Hemangioblastomas Share Protein Expression with Embryonal Hemangioblast Progenitor Cell
Gläsker, S., Li, J., Xia, J. B., Okamoto, H., Zeng, W., Lonser, R. R., Zhuang, Z., Oldfield, E. H., & Vortmeyer, A. O. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3505 · Cited by 100
Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells
Olszewska-Pazdrak, B., Hein, T. W., Olszewska, P., & Carney, D. H. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00533.2008 · Cited by 100
Hydrogen Peroxide Produced by Angiopoietin-1 Mediates Angiogenesis
Kim, Y., Kim, K. E., Koh, G. Y., Ho, Y.-S., & Lee, K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3640 · Cited by 100
A Central Role for Nicotinic Cholinergic Regulation of Growth Factor–Induced Endothelial Cell Migration
Ng, M., Wu, J., Chang, E., Wang, B., Katzenberg, R. H., Ishii‐Watabe, A., & Cooke, J. P. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000251517.98396.4a · Cited by 99
Expression of constitutively stable hybrid hypoxia-inducible factor-1α protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury
Date, T., Mochizuki, S., Belanger, A. J., Yamakawa, M., Luo, Z., Vincent, K. A., Cheng, S. H., Gregory, R. J., & Jiang, C. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00374.2004 · Cited by 98
Self-citation
Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells
Asikainen, T. M., Ahmad, A. M., Schneider, B. K., Ho, W., Arend, M., Brenner, M. C., Günzler, V., & White, C. W. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.004 · Cited by 96
Microtissue size and hypoxia in HTS with 3D cultures
Asthana, A., & Kisaalita, W. S. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.03.004 · Cited by 95
Hypoxia Mediates Tumor Malignancy and Therapy Resistance
Luo, W., & Wang, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12734-3_1 · Cited by 94
Na+/K+-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation
Bejček, J., Spiwok, V., Kmonı́čková, E., & Rimpelová, S. (2021) · Molecules · doi:10.3390/molecules26071905 · Cited by 96
Hyaluronic acid hydrogel stiffness and oxygen tension affect cancer cell fate and endothelial sprouting
Shen, Y., Abaci, H. E., Krupski, Y., Weng, L.-C., Burdick, J. A., & Gerecht, S. (2014) · Biomaterials Science · doi:10.1039/c3bm60274e · Cited by 95
Vascular Disruption and the Role of Angiogenic Proteins After Spinal Cord Injury
Ng, M., Stammers, A. T., & Kwon, B. K. (2011) · Translational Stroke Research · doi:10.1007/s12975-011-0109-x · Cited by 87
Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor α/retinoid X receptor
Belanger, A. J., Luo, Z., Vincent, K. A., Akita, G. Y., Cheng, S. H., Gregory, R. J., & Jiang, C. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.062 · Cited by 81
Self-citation
Angiopoietin 2 expression is related to histological grade, vascular density, metastases, and outcome in prostate cancer
Lind, A., Wikström, P., Granfors, T., Egevad, L., Stattin, P. E., & Bergh, A. R. J. (2004) · The Prostate · doi:10.1002/pros.20163 · Cited by 81
Cell Signaling Associated with Na+/K+-ATPase: Activation of Phosphatidylinositide 3-Kinase IA/Akt by Ouabain Is Independent of Src
Wu, J., Akkuratov, E. E., Bai, Y., Gaskill, C. M., Askari, A., & Liu, L. (2013) · Biochemistry · doi:10.1021/bi4011804 · Cited by 80
Self-citation
Up-Regulation of Vascular Endothelial Growth Factor (VEGF) in Small-for-Size Liver Grafts Enhances Macrophage Activities through VEGF Receptor 2-Dependent Pathway
Yang, Z. F., Poon, R. T. P., Luo, Y., Cheung, C. K. Y., Ho, D. W., Lo, C. M., & Fan, S. T. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2507 · Cited by 78
Hypoxia-Inducible Factor Activation in Myeloid Cells Contributes to the Development of Liver Fibrosis in Cholestatic Mice
Copple, B. L., Kaska, S., & Wentling, C. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.189340 · Cited by 78
Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development
Licht, A. H., Müller-Holtkamp, F., Flamme, I., & Breier, G. (2005) · Blood · doi:10.1182/blood-2005-07-3033 · Cited by 76
In Vivo Acceleration of Skin Growth Using a Servo-Controlled Stretching Device
Chin, M. S., Ogawa, R., Lancerotto, L., Pietramaggiori, G., Schomacker, K. T., Mathews, J. C., Scherer, S. S., Duyn, P. V., Prsa, M. J., Ottensmeyer, M. P., et al. (2009) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2009.0185 · Cited by 76
Endothelial dysfunction in pregnancy metabolic disorders
Echeverría, C., Eltit, F., Santibanez, J. F., Gatica, S., Cabello‐Verrugio, C., & Simón, F. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.02.009 · Cited by 84
Blood-Brain Barrier Changes in High Altitude
Lafuente, J. V., Bermúdez, G., Camargo-Arce, L., & Bulnes, S. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160920123911 · Cited by 73
The role of adrenomedullin in angiogenesis
Ribatti, D., Nico, B., Spinazzi, R., Vacca, A., & Nussdorfer, G. G. (2005) · Peptides · doi:10.1016/j.peptides.2005.02.017 · Cited by 70
The Opening Act
Jin, S., & Patterson, C. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.161539 · Cited by 81
Expression of hypoxia-inducible factor-1 and the protein products of its target genes in diabetic fibrovascular epiretinal membranes
El‐Asrar, A. M. A., Missotten, L., & Geboes, K. J. (2007) · British Journal of Ophthalmology · doi:10.1136/bjo.2006.109876 · Cited by 70
Stabilization of Hypoxia Inducible Factor Rather than Modulation of Collagen Metabolism Improves Cardiac Function After Acute Myocardial Infarction in Rats
Philipp, S., Jürgensen, J. S., Fielitz, J., Bernhardt, W. M., Weidemann, A., Schiche, A., Pilz, B., Dietz, R., Regitz‐Zagrosek, V., Eckardt, K., et al. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2005.10.009 · Cited by 73
IL-1β induces VEGF, independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells
Solà-Villà, D., Camacho, M., Solà, R., Soler, M., Diaz, J.-M., & Vila, L. (2006) · Kidney International · doi:10.1038/sj.ki.5001948 · Cited by 68
Neurovascular Factors in Wound Healing in the Foot Skin of Type 2 Diabetic Subjects
Krishnan, S. T. M., Quattrini, C., Jeziorska, M., Malik, R. A., & Rayman, G. A. (2007) · Diabetes Care · doi:10.2337/dc07-1421 · Cited by 68
Cell-specific and hypoxia-dependent regulation of human HIF-3α: inhibition of the expression of HIF target genes in vascular cells
Augstein, A., Poitz, D. M., Braun-Dullaeus, R. C., Strasser, R. H., & Schmeißer, A. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0575-4 · Cited by 69
Myocardial hypoxia-inducible HIF-1α, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia
Bateman, R. M., Tokunaga, C., Kareco, T., Dorscheid, D. R., & Walley, K. R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00035.2007 · Cited by 67
Angiogenesis — a self-adapting principle in hypoxia
Marti, H. H. (2005) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7311-3_12 · Cited by 66
Hypoxic stress simultaneously stimulates vascular endothelial growth factor via hypoxia-inducible factor-1 and inhibits stromal cell-derived factor-1 in human endometrial stromal cells
Tsuzuki, T., Okada, H., Cho, H., Tsuji, S., Nishigaki, A., Yasuda, K., & Kanzaki, H. (2011) · Human Reproduction · doi:10.1093/humrep/der405 · Cited by 64
BMK1/ERK5 Is a Novel Regulator of Angiogenesis by Destabilizing Hypoxia Inducible Factor 1α
Pi, X., Garin, G., Xie, L., Zheng, Q., Wei, H., Abe, J., Chen, Y., & Berk, B. C. (2005) · Circulation Research · doi:10.1161/01.res.0000168802.43528.e1 · Cited by 62
Repetitive acute intermittent hypoxia increases growth/neurotrophic factor expression in non-respiratory motor neurons
Satriotomo, I., Nichols, N. L., Dale, E. A., Emery, A. T., Dahlberg, J. M., & Mitchell, G. S. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.060 · Cited by 60
Left Ventricular Assist Devices (LVADS): History, Clinical Application and Complications
Eisen, H. J. (2019) · Korean Circulation Journal · doi:10.4070/kcj.2019.0161 · Cited by 60
Differential Regulation of Pulmonary Vascular Cell Growth by Hypoxia-Inducible Transcription Factor–1α and Hypoxia-Inducible Transcription Factor–2α
Ahmad, A. M., Ahmad, S., Malcolm, K. C., Miller, S. M., Hendry‐Hofer, T. B., Schaack, J. B., & White, C. W. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0107oc · Cited by 57
Angiogenesis in the human heart: Gene and cell therapy
Tı̂rziu, D., & Simons, M. (2005) · Angiogenesis · doi:10.1007/s10456-005-9011-z · Cited by 58
Digoxin Is Associated With a Decreased Incidence of Angiodysplasia-Related Gastrointestinal Bleeding in Patients With Continuous-Flow Left Ventricular Assist Devices
Vukelic, S., Vlismas, P. P., Patel, S. R., Xue, X., Shitole, S. G., Saeed, O., Sims, D. B., Chinnadurai, T., Shin, J. J., Forest, S., et al. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.118.004899 · Cited by 57
Improvement of myocardial perfusion in coronary patients after intermittent hypobaric hypoxia
Valle, M. D., García-Godos, F., Woolcott, O. O., Marticorena, J. M., Rodríguez, V., Gutiérrez, I., Fernández-Dávila, L., Contreras, A., Valdivia, L., Robles, J., et al. (2006) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2005.11.008 · Cited by 57
The effect of deferoxamine on angiogenesis and bone repair in steroid-induced osteonecrosis of rabbit femoral heads
Li, J., Fan, L., Yu, Z., Dang, X., & Wang, K. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214553906 · Cited by 55
Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis
Yamakawa, M., Liu, L. X., Belanger, A. J., Date, T., Kuriyama, T., Goldberg, M. A., Cheng, S. H., Gregory, R. J., & Jiang, C. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00028.2004 · Cited by 55
Self-citation
Angiopoietin-2 Is an Early Indicator of Acute Pancreatic-Renal Syndrome in Patients with Acute Pancreatitis
Sporek, M., Dumnicka, P., Gala‐Błądzińska, A., Ceranowicz, P., Warzecha, Z., DEMBINSKI, A. B., Stępień, E. Ł., Walocha, J. A., Drożdż, R., Kuźniewski, M., et al. (2016) · Mediators of Inflammation · doi:10.1155/2016/5780903 · Cited by 54
Growth factors for therapeutic angiogenesis in peripheral arterial disease
Jones, W. S., & Annex, B. H. (2007) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328236741b · Cited by 53
Angiogenesis as an immunopharmacologic target in inflammation and cancer
Bian, X. W., Chen, J. H., Jiang, X. F., Bai, J. S., Wang, Q. L., & Zhang, X. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.07.017 · Cited by 53
Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure
Schiekofer, S., Shiojima, I., Sato, K., Galasso, G., Oshima, Y., & Walsh, K. X. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00234.2005 · Cited by 53
Increased endogenous angiogenic response and hypoxia-inducible factor-1α in human critical limb ischemia
Ho, T. K., Rajkumar, V. S., Ponticos, M., Leoni, P., Black, D. C., Abraham, D., & Baker, D. (2006) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.08.042 · Cited by 52
Hypoxia‐inducible factor 1α modulates adhesion, migration, and FAK phosphorylation in vascular smooth muscle cells
Corley, K. M., Taylor, C. J., & Lilly, B. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20559 · Cited by 52
Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?”
Pinilla, L. L., Ugun‐Klusek, A., Rutella, S., & Girolamo, L. A. D. (2021) · Biology · doi:10.3390/biology10080723 · Cited by 52
Therapeutic Angiogenesis in Critical Limb Ischemia
Ouma, G. O., Zafrir, B., Mohler, E. R., & Flugelman, M. Y. (2012) · Angiology · doi:10.1177/0003319712464514 · Cited by 52
Angiogenesis in cutaneous disease: Part I
Nguyen, A., Hoang, V., Laquer, V. T., & Kelly, K. M. (2009) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.05.052 · Cited by 49
Col4a1 mutations cause progressive retinal neovascular defects and retinopathy
Alavi, M. V., Mao, M., Pawlikowski, B. T., Kvezereli, M., Duncan, J. L., Libby, R. T., John, S. W. M., & Gould, D. B. (2016) · Scientific Reports · doi:10.1038/srep18602 · Cited by 50
Function and Dysfunction of Adipose Tissue
Matafome, P. N., & Seiça, R. M. F. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_1 · Cited by 51
Hypoxia induces angiogenic factors in brain microvascular endothelial cells
Luo, J., Martinez, J. M., Yin, X., Sanchez, A. C., Tripathy, D., & Grammas, P. (2011) · Microvascular Research · doi:10.1016/j.mvr.2011.11.004 · Cited by 50
Decoding Noncoding RNAs: Role of MicroRNAs and Long Noncoding RNAs in Ocular Neovascularization
Zhang, Y., Cai, S., Jia, Y., Chen, Q., Sun, J., Zhang, H., Wang, F., Cao, Y., & Li, X. (2017) · Theranostics · doi:10.7150/thno.19646 · Cited by 49
Cefalea de elevada altitud y mal de altura
Carod-Artal, F. J. (2012) · Neurología · doi:10.1016/j.nrl.2012.04.015 · Cited by 47
A COMPARISON OF HYPOXIA-INDUCIBLE FACTOR-α IN SURGICALLY EXCISED NEOVASCULAR MEMBRANES OF PATIENTS WITH DIABETES COMPARED WITH IDIOPATHIC EPIRETINAL MEMBRANES IN NONDIABETIC PATIENTS
Lim, J. I., Spee, C. K., & Hinton, D. R. (2010) · Retina · doi:10.1097/iae.0b013e3181d6df09 · Cited by 47
Prolyl Hydroxylase Domain 2 Protein Suppresses Hypoxia-Induced Endothelial Cell Proliferation
Takeda, K., & Fong, G. (2006) · Hypertension · doi:10.1161/01.hyp.0000251360.40838.0f · Cited by 49
Circadian influences on myocardial infarction
Virag, J. A. I., & Lust, R. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00422 · Cited by 47
Apoptosis Contributes to Vascular Lumen Formation and Vascular Branching in Human Placental Vasculogenesis1
Tertemiz, F., Kayisli, U. A., Arici, A. M., & Demir, R. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.034975 · Cited by 46
The Heterogeneity of the Tumor Microenvironment as Essential Determinant of Development, Progression and Therapy Response of Pancreatic Cancer
Group Young Researchers in Inflammatory Carcinogenesis, Wandmacher, A. M., Mehdorn, A., & Sebens, S. (2021) · Cancers · doi:10.3390/cancers13194932 · Cited by 48

Authors: Yamakawa, M., Liu, L. X., Date, T., Belanger, A. J., Vincent, K. A., Akita, G. Y., Kuriyama, T., Cheng, S. H., Gregory, R. J., & Jiang, C.
Affiliations: Chiba University (JP)
ORCID: Vincent, Karen A.
Gregory, Richard J.
Jiang, Canwen
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-10-03
Volume: 93
Issue: 7
Pages: 664-673
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.0000093984.48643.d7
OpenAlex: W2171354819
Cited by: 327
References: 48
Citations by year: 2026: 7 · 2025: 13 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 12 · 2019: 13 · 2018: 12 · 2017: 13 · 2016: 21 · 2015: 15 · 2014: 12 · 2013: 17 · 2012: 15
FWCI: 6.55
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords: HIF-1, HIF-1α, angiogenesis, hypoxia, vascular endothelial cells, vascular endothelial growth factor, angiopoietin-2, angiopoietin-4, angiopoietin-1, Tie2, endothelial cell migration, tube formation, endothelial cell proliferation, apoptosis, deferoxamine, hypervascularity, vascular permeability
MeSH terms: Placenta Growth Factor, Blood Vessels, Cell Division, Cell Membrane Permeability, Cell Movement, Cells, Cultured, Deferoxamine, DNA-Binding Proteins, Endothelium, Vascular, Enzyme Activation, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Genetic Vectors, Humans, Lymphokines, Nuclear Proteins, Platelet-Derived Growth Factor, Pregnancy Proteins, RNA, Messenger, Transcription Factors, Cell Hypoxia, Endothelial Growth Factors, Apoptosis, Caspases, Receptor Protein-Tyrosine Kinases, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Angiopoietins, Angiopoietin-2, Receptor, TIE-2, Angiogenesis Inducing Agents, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, Caspase 3

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks