The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Heart Valve Development: Endothelial Cell Signaling and Differentiation
Open accessAbstract
During the past decade, single gene disruption in mice and large-scale mutagenesis screens in zebrafish have elucidated many fundamental genetic pathways that govern early heart patterning and differentiation. Specifically, a number of genes have been revealed serendipitously to play important and selective roles in cardiac valve development. These initially surprising results have now converged on a finite number of signaling pathways that regulate endothelial proliferation and differentiation in developing and postnatal heart valves. This review highlights the roles of the most well-established ligands and signaling pathways, including VEGF, NFATc1, Notch, Wnt/β-catenin, BMP/TGF-β, ErbB, and NF1/Ras. Based on the interactions among and relative timing of these pathways, a signaling network model for heart valve development is proposed.
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Cites
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Metadata
- Authors
- Armstrong, E. J., & Bischoff, J.
- Venue
- Circulation Research
- Published
- 2004-09-03
- Volume
- 95
- Issue
- 5
- Pages
- 459-470
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2102103202
- Cited by
- 647
- References
- 10
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
