Activation of Platelet Function Through G Protein–Coupled Receptors

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RHO GTPASES: Biochemistry and Biology

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The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

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A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

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Seven-transmembrane receptors

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Platelets in atherothrombosis

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Synthesis and Function of 3-Phosphorylated Inositol Lipids

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Platelets in inflammation and atherogenesis

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Thrombogenesis-associated genetic determinants as predictors of thromboembolism and prognosis in cervical cancer

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Platelet physiology and antiplatelet agents

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Ascorbate Reduces Mouse Platelet Aggregation and Surface P‐Selectin Expression in an Ex Vivo Model of Sepsis

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Novel Mouse Model for Studying Hemostatic Function of Human Platelets

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Nonsteroidal Anti-Inflammatory Drugs and Cardiovascular Risk

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Recent advances in microfluidic platelet function assays: Moving microfluidics into clinical applications

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Antiplatelet Agents Affecting GPCR Signaling Implicated in Tumor Metastasis

Rovati, G. E., Contursi, A., Bruno, A., Tacconelli, S., Ballerini, P., & Patrignani, P. (2022) · Cells · doi:10.3390/cells11040725 · Cited by 16

Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology

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Epigenetics and Gut Microbiota Crosstalk: A potential Factor in Pathogenesis of Cardiovascular Disorders

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Research development on gut microbiota and vulnerable atherosclerotic plaque

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Structure-based QSAR, molecule design and bioassays of protease-activated receptor 1 inhibitors

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Severe Trauma and Hemorrhage Leads to Platelet Dysfunction and Changes in Cyclic Nucleotides in The Rat

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Role of Kv1.3 Channels in Platelet Functions and Thrombus Formation

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RhoGAPs und Rho-GTPasen in Thrombozyten

Elvers, M. (2015) · Hämostaseologie · doi:10.5482/hamo-14-09-0046 · Cited by 15

Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease

Stockley, J., Nisar, S. P., Leo, V., Sabi, E. M., Cunningham, M., Eikenboom, J. C. J., Lethagen, S., Schneppenheim, R., Goodeve, A. C., Watson, S. P., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143913 · Cited by 15

Structure elucidation and inhibitory effects on human platelet aggregation of chlorogenic acid from Wrightia tinctoria

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Abnormal platelet kinetics are detected before the occurrence of thrombocytopaenia in HBV ‐related liver disease

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Inhibitory Effect of Allyl Isothiocyanate on Platelet Aggregation

Lee, D.-S., Kim, T., & Jung, Y. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4041518 · Cited by 15

Rare platelet GPCR variants: what can we learn?

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Interaction of angio-associated migratory cell protein with the TPα and TPβ isoforms of the human thromboxane A2 receptor

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A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivity

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Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y12 antagonist ticagrelor

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Revealing the Pharmacological Mechanism of Acorus tatarinowii in the Treatment of Ischemic Stroke Based on Network Pharmacology

Liu, F., Zhao, Q., Liu, S., Xu, Y., Zhou, D., Gao, Y., & Ling-qun, Z. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/3236768 · Cited by 15

Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia

Li, D., Peng, J., Li, T., Liu, Y., Chen, M., & Shi, X. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12088 · Cited by 14

Acute arterial thrombosis in the absence of inflammation: The stress-related anti-inflammatory hormone ACTH participates in platelet-mediated thrombosis

Pozzi, A. O., Bernardo, E., Coronado, M. T., Punchard, M. A., González, P., & Fantidis, P. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.08.023 · Cited by 14

Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif

Frey, A. J., Ibrahim, S., Gleim, S., Hwa, J., & Smyth, E. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m036673 · Cited by 16

Drospirenone enhances GPIb‐IX‐V‐mediated platelet activation

Fan, X., Chen, X., Wang, C., Dai, J., Lu, Y., Wang, K., Liu, J., Zhang, J., & Wu, X. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13109 · Cited by 14

Functional links between Disabled‐2 Ser723 phosphorylation and thrombin signaling in human platelets

Tsai, H.-J., Chien, K., Liao, H. ‐., Shih, M. ‐., Lin, Y., Chang, Y. ‐., Cheng, J., & Tseng, C. (2017) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13785 · Cited by 14

NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet–Endothelial Cell Interaction in Pulmonary Hypertension

Wang, J., Yang, K., & Yuan, J. X. ‐. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202101-0007ed · Cited by 13

Is Antiplatelet Therapy Contraindicated After Platelet-Rich Plasma Treatment? A Narrative Review

Magruder, M. L., & Rodeo, S. A. (2021) · Orthopaedic Journal of Sports Medicine · doi:10.1177/23259671211010510 · Cited by 13

PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways Are Essential for Thrombin-Induced Morphological Changes in MEG-01 Cells

Heo, Y., Jeon, H., & Namkung, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020776 · Cited by 13

A Novel Antibody Targeting the Second Extracellular Loop of the Serotonin 5-HT2A Receptor Inhibits Platelet Function

Ramirez, J. E. M., Alarabi, A. B., Khasawneh, F. T., & Alshbool, F. Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158794 · Cited by 10

The Role of Platelets in Hypoglycemia-Induced Cardiovascular Disease: A Review of the Literature

Ali, A. A. G., Niinuma, S. A., Moin, A. S. M., Atkin, S. L., & Butler, A. E. (2023) · Biomolecules · doi:10.3390/biom13020241 · Cited by 13

Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation

Zhang, P., von Ungern‐Sternberg, S. N. I., Hastenplug, L., Solari, F. A., Sickmann, A., Kuijpers, M. J. E., Heemskerk, J. W. M., Walter, U., & Jurk, K. (2024) · Thrombosis and Haemostasis · doi:10.1055/a-2311-0117 · Cited by 13

LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis

Tranter, J. D., Mikami, R. T., Kumar, A., Brown, G., El‐Aziz, T. M. A., Zhao, Y., Arullampalam, P., Ashworth, K. J., Jha, V., Abraham, N., et al. (2025) · Blood · doi:10.1182/blood.2024026667 · Cited by 13

Inhibiting PAR-1 in the prevention and treatment of atherothrombotic events

Tomasello, S. D., Angiolillo, D. J., & Goto, S. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.521741 · Cited by 13

Interference with purinergic signalling

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Mechanisms of Hemostasis: Contributions of Platelets, Coagulation Factors, and the Vessel Wall

Mußbacher, M., Kral-Pointner, J. B., Salzmann, M., Schrottmaier, W. C., & Assinger, A. (2019) · Learning materials in biosciences · doi:10.1007/978-3-030-12270-6_8 · Cited by 13

Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis

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Microbiome in Behcet's syndrome

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Pathophysiologie und Biochemie der Thrombozyten

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Cyclic nucleotides inhibit MAP kinase activity in low-dose collagen-stimulated platelets

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Inhibitory Effect of Serotonin Antagonist on Leukocyte-Endothelial Interactions In Vivo and In Vitro

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Platelet biology: the role of shear

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Antithrombotic Agents: Platelet Inhibitors, Anticoagulants, and Fibrinolytics

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Antiplatelet and anti-proliferative action of disintegrin from Echis multisquamatis snake venom

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Role of Prednisolone in Platelet Activation by Inhibiting TxA2 Generation through the Regulation of cPLA2 Phosphorylation

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Storage of Transfusion Platelet Concentrates Is Associated with Complement Activation and Reduced Ability of Platelets to Respond to Protease-Activated Receptor-1 and Thromboxane A2 Receptor

Andersson, L. I., Sjöström, D. J., Quach, H. Q., Hägerström, K., Hurler, L., Kajdácsi, E., Cervenak, L., Prohászka, Z., Toonen, E. J. M., Mohlin, C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021091 · Cited by 12

Therapeutic effects and molecular mechanisms of natural products in thrombosis

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The Two Faces of Thrombosis: Coagulation Cascade and Platelet Aggregation. Are Platelets the Main Therapeutic Target?

Cimmino, G., & Fischetti, S. (2017) · Journal of Thrombosis and Circulation Open Access · doi:10.4172/2572-9462-3-117 · Cited by 12

The Molecular Aspects of Disturbed Platelet Activation through ADP/P2Y12 Pathway in Multiple Sclerosis

Dziedzic, A., Miller, E. D., Saluk, J., Niwald, M., & Bijak, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126572 · Cited by 12

Platelet functional responses and signalling: the molecular relationship. Part 2: receptors.

Martyanov, A. A., & Panteleev, M. A. (2021) · System Biology and Physiology Reports · doi:10.52455/sbpr.01.202103013 · Cited by 12

Nicotinic acid impairs assembly of leading edge in glioma cells

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Blood-device interaction

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New Insights into Platelet Signalling Pathways by Functional and Proteomic Approaches

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Regulation of platelet function by natural bioactive compounds

Fernandez-Rojas, M., Rodríguez, L., Trostchansky, A., & Eduardo Fuentes, Q. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101742 · Cited by 12

The neurokinin 1 receptor: a potential new target for anti-platelet therapy?

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Characterization of the In Vivo Antiplatelet Activity of the Antihypertensive Agent Losartan

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Characterization of Platelet Receptors and Their Involvement in Immune Activation of These Cells

Tokarz–Deptuła, B., Baraniecki, Ł., Palma, J., Stosik, M. P., & Deptuła, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312611 · Cited by 11

Potassium 2-(1-hydroxypentyl)-benzoate inhibits ADP-induced rat platelet aggregation through P2Y1-PLC signaling pathways

Yang, H., Xu, S., Li, J., Wang, L., & Wang, X. (2015) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-015-1113-6 · Cited by 11

Differential proteomic analysis of platelets suggested target-related proteins in rabbit platelets treated with Rhizoma Corydalis

Li, C., Chen, C., Zhang, Q., Tan, C.-N., Yuanjia, H., Li, P., Wan, J., Feng, G., Xia, Z., & Yang, F. Q. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1229340 · Cited by 11

Inherited Platelet Disorders

Tsai, F. D., & Battinelli, E. M. (2021) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2021.07.003 · Cited by 11

Urine and Plasma Markers of Platelet Activation and Respiratory Symptoms in COPD

Fawzy, A., Putcha, N., Raju, S., Woo, H., Lin, C. T., Brown, R. H., Williams, M. S., Faraday, N. R., McCormack, M. C., & Hansel, N. N. (2022) · Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation · doi:10.15326/jcopdf.2022.0326 · Cited by 11

Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists

Sadek, B. S., Dar, A., & Khan, N. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s84335 · Cited by 11

Regulatory mechanisms of cAMP levels as a multiple target for antiplatelet activity and less bleeding risk

Eduardo Fuentes, Q., & Palomo, I. F. (2014) · Thrombosis Research · doi:10.1016/j.thromres.2014.04.027 · Cited by 11

Characterization of a new peptide agonist of the protease-activated receptor-1

Mao, Y., Jin, J., & Kunapuli, S. P. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.09.002 · Cited by 11

Platelet Biology and Implications for Antiplatelet Therapy in Atherothrombotic Disease

Montalescot, G. (2010) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029610373366 · Cited by 11

The Diagnostic Assessment of Platelet Function Defects - Part 2: Update on Platelet Disorders

Althaus, K., Hoepner, G., Zieger, B., Prüller, F., Pavlova, A. V., Boeckelmann, D., Birschmann, I., Müller, J., Rühl, H., Sachs, U. J., et al. (2025) · Hämostaseologie · doi:10.1055/a-2404-0216 · Cited by 10

Phospholipid polymer electrodeposited on titanium inhibits platelet adhesion

Fukuhara, Y., Kyuzo, M., Tsutsumi, Y., Nagai, A., Chen, P., & Hanawa, T. (2015) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33423 · Cited by 10

The G-protein βγ subunits regulate platelet function

Alarabi, A. B., Karim, Z. A., Hinojos, V., Lozano, P. A., Hernandez, K. R., Ramirez, J. E. M., Ali, H. E. A., Khasawneh, F. T., & Alshbool, F. Z. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118481 · Cited by 10

A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis

Majima, M., Hosono, K., Ito, Y., Amano, H., Nagashima, Y., Matsuda, Y., Watanabe, S.-I., & NISHIMURA, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114831 · Cited by 10

Inhibition of Platelet Adhesion from Surface Modified Polyurethane Membranes

Chou, S. (2020) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2020.32.005247 · Cited by 10

Transcriptomic responses to yam ( Dioscorea oppositifolia L .) extract dietary supplementation in rainbow trout ( Oncorhynchus mykiss ) liver

Wang, F., Liu, F., Wang, X., Wan-guang, C., & Meng, X. (2019) · Aquaculture Research · doi:10.1111/are.14438 · Cited by 10

The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets

Makhoul, S., Kumm, E. J., Zhang, P., Walter, U., & Jurk, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238939 · Cited by 10

Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?

Laudani, S., Godos, J., Romano, G. L., Gozzo, L., Domenico, F. D., Azpíroz, I. D., Diaz, R. M., Giampieri, F., Quiles, J. L., Battino, M. A., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17020236 · Cited by 10

Roles of G proteins and their GTPase-activating proteins in platelets

O’Donoghue, L., & Smolenski, A. (2024) · Bioscience Reports · doi:10.1042/bsr20231420 · Cited by 9

The role of protease-activated receptors (PARs) in the functioning of platelets and platelet-derived microparticles (PMPs)

Jakobsche-Policht, U., Bronowicka-Szydełko, A., Adamiec, R., Bednarska-Chabowska, D., Mierzchała-Pasierb, M., Lewandowski, Ł., Gostomska‐Pampuch, K., Adamiec-Mroczek, J., Rabczyński, M., Kuźnik, E., et al. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1636893 · Cited by 10

Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study

Seecheran, N. A., Sukha, D. A., Grimaldos, K., Grimaldos, G., Richard, S., Ishmael, A., Gomes, C., Kampradi, L., Seecheran, R. V., Seecheran, V. K., et al. (2022) · Open Heart · doi:10.1136/openhrt-2022-002066 · Cited by 9

Neutrophil Phagocytosis of Platelets in the Early Phase of 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced Dermatitis in Mice

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Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase

Reddi, B. A. J., Iannella, S., O’Connor, S. N., Deane, A. M., Willoughby, S. R., & Wilson, D. P. (2015) · Intensive Care Medicine Experimental · doi:10.1186/s40635-014-0037-7 · Cited by 9

Advances in the Pharmacogenomics of Antiplatelet Therapy

Akhtar, T., Bandyopadhyay, D., Ghosh, R. K., Aronow, W. S., Lavie, C. J., & Yadav, N. (2019) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000001013 · Cited by 9

The Roles of GRKs in Hemostasis and Thrombosis

Chen, X., Zhao, X., Cooper, M., & Ma, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155345 · Cited by 9

Metabolic systems analysis identifies a novel mechanism contributing to shock in patients with endotheliopathy of trauma (EoT) involving thromboxane A2 and LTC4

Henriksen, H., de Mas, I. M., Herand, H., Krocker, J. D., Wade, C. E., & Johansson, P. I. (2022) · Matrix Biology Plus · doi:10.1016/j.mbplus.2022.100115 · Cited by 9

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Constitutive surface expression of the thromboxane A2 receptor is Pim kinase-dependent

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REVIEW ARTICLE Platelet G protein-coupled receptors in hemostasis and thrombosis

Woulfe, D. S. (2016)