Activation of Platelet Function Through G Protein–Coupled Receptors

Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

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The phosphoinositide 3-kinase pathway

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RHO GTPASES: Biochemistry and Biology

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The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

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A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

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Seven-transmembrane receptors

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Platelets in atherothrombosis

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Synthesis and Function of 3-Phosphorylated Inositol Lipids

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Platelets in inflammation and atherogenesis

Gawaz, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27196 · Cited by 1,484

ROLE OF REACTIVE OXYGEN SPECIES IN PLATELET FUNCTION IN NORMAL STATES AND CHRONIC MYELOPROLIFERATIVE DISORDERS

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Atopaxar

Wurster, T. H., & May, A. E. (2012) · Hämostaseologie · doi:10.5482/hamo-12-05-0009 · Cited by 2

Emerging Oral Antiplatelet Therapies for Acute Coronary Syndromes

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Effect of Atorvastatin Co-Treatment on Inhibition of Platelet Activation by Clopidogrel in Patients with Ischemic Stroke

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Antithrombotic potential of plant products

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Mouse Models of Thrombosis

Cherpokova, D., & Nieswandt, B. (2017) · Springer eBooks · doi:10.1007/978-3-319-47462-5_46 · Cited by 2

Aqueous Extract of Tournefortia sarmentosa Stem Inhibits ADP-induced Platelet Aggregation

Wang, L. K., Tsai, F., Chen, M. L., Wu, S., Lee, M. C., Tsai, T. C., Chou, W., & Wang, C. H. (2018) · Indian Journal of Pharmaceutical Sciences · doi:10.4172/pharmaceutical-sciences.1000337 · Cited by 2

The Role of Platelets in the Pathophysiology of Atherosclerosis and Its Complications

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Adrenoceptor α2A signalling countervails the taming effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation and aggregation

Fälker, K., Ljungberg, L. U., Kardeby, C., Lindkvist, M., Sirsjö, A., & Grenegård, M. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.03.019 · Cited by 2

Off-target drug effects on platelet function: Protecting an Achilles heel of drug development

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Genetic Polymorphisms Associated with Prothrombin Time and Activated Partial Thromboplastin Time in Chinese Healthy Population

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Investigation of platelet activation and calcium store release by a topical hemostatic xerogel dressing for improved blood clotting

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Manipulating integrin signaling for anti-thrombotic benefits

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Systems Biology to Study Platelet‐Related Bleeding Disorders

Akkerman, J. N., & de Bono, B. (2011) · Wiley eBooks · doi:10.1002/9780470940297.ch12 · Cited by 2

Free oscillation rheometry in the assessment of platelet quality

Tynngård, N. (2008) · DiVA (Linkoping University) · Cited by 2

Cytoskeletal reorganization in human blood platelets during spreading

Paknikar, A. K. (2017) · doi:10.53846/goediss-6360 · Cited by 2

A Sex-Specific Switch in Platelet Receptor Signaling Following Myocardial InfarctionPreprint

Kim, B. S., Auerbach, D. A., Sadhra, H., Ling, F. S. K., Toth, S., Mohan, A. M., Tura, S., Goldenberg, I., Rich, D. Q., & Cameron, S. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/580415 · Cited by 2

20(S)-Panaxadiol Enhances Hemostatic Effect on Activated Platelet by Affecting Calcium SignalingPreprint

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Platelets and coagulation

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Glycoprotein VI is Critical for the Detection and Progression of Abdominal Aortic AneurysmsPreprint

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Platelets, plasma, and proteostasis: a translation tightrope

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P2Y12–P-Selectin Mediated Platelet Activation Drives Dengue-Associated ThrombocytopeniaPreprint

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Inflammatory Mediator Serotonin Receptor (5-HT3AR) Gene Encoding Analysis in Patients with Psoriasis Vulgaris

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Chronic antiplatelet therapy in prevetion of cardiovascular diseases (in population of elderly) from the perspective of oral health: Cardiologic safety versus complications risk. Influence of oral diseases on global health risk in elderly

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Platelet Activation Through G-protein Coupled Receptors

Chaudhary, P. K., Kim, S., & Kim, S. (2024) · Clinical & Experimental Thrombosis and Hemostasis · doi:10.14345/ceth.24002 · Cited by 1

Illicit drug N-ethylpentylone potentiates platelet activation through 5-hydroxytryptamine2A receptor-mediated mitogen-activated protein kinase signaling

Cai, J., Zhang, W., Wang, J., Zhang, S., Huang, Z., Jia, X., Han, L., Zhong, H., Wei, Z., Zhang, Y., et al. (2026) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2025.12.013 · Cited by 1

Diacylglycerol kinases: Molecular mechanism of cellular and physiological functions

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Identification of Protein Signatures Reflecting Latent Variation in Aptamer-Based Affinity Proteomics

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Thromboxane A2 synthase is an off target of the CES1 small-molecule inhibitor WWL113

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Metal-based complexes as emerging antiplatelet and antithrombotic agents: Mechanistic insights and therapeutic perspective

Sheu, J., Hsieh, C., Hsia, C., Saravanabhavan, P., Velusamy, M., & Jayakumar, T. (2026) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2026.116707 · Cited by 1

Oxylipin-mediated metabolic signatures of symbiosis homeostasis and thermal stress in a model sea anemone

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Beyond Hemostasis: Platelets’ Multifaceted Functions in Immune Responses

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Platelets as localized conduits of TGF-β1 in the tumor microenvironment: implications for cancer progression and therapy

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Characterization and Targeting of Thromboxane Receptor Dimerization: A Gateway to Novel Therapeutic Developments

Frey, A. J. (2013) · ScholarlyCommons (University of Pennsylvania) · Cited by 1

The effects of clopidogrel, acetyl salicylic acid and tirofiban on acetylcholine-induced dilation in rat thoracic aorta segments

Özkısacık, E. A. (2012) · Turkish Journal of Thoracic and Cardiovascular Surgery · doi:10.5606/tgkdc.dergisi.2012.111 · Cited by 1

Kinetic Modeling of Thrombin Induced and Collagen Induced Platelet Aggregation Pathway–A System Biology Approach

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Overview, Measurement and Point-of-Care Testing of Platelet Function

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PI3K-Dependent Platelet Signaling in Vascular Inflammation and Atherothrombosis

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Selective activation of platelets by surfaces and soluble agonists

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In vitro Research of the Concentration Dependence of Effect of Adrenaline on Platelets Aggregation.

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GTPases

Stefanini, L., Lee, R. H., & Bergmeier, W. (2017) · Springer eBooks · doi:10.1007/978-3-319-47462-5_20 · Cited by 1

СУЧАСНІ УЯВЛЕННЯ ПРО СИСТЕМУ ГЕМОСТАЗУ

Савицький, І., Карабут, Л., Савицький, В. В., & Александріна, Т. (2022) · Clinical Anesthesiology and intensive Care · doi:10.31379/2411.2616.18.2.6 · Cited by 1

PI3K Isoform Signalling in Platelets

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The therapeutic role of microbial metabolites in human health and diseases

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Proteome of Personalized Tissue-Engineered Veins

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Mechanism of Ascorbate Protection Against Sepsis-Induced Capillary Blood Flow Impairment

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Antiplatelet therapy for atherothrombotic disease: How can we improve the outcomes?

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Platelets — Allies of Tumour Cells

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Normal Mechanisms of Vascular Hemostasis

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Alterations in Platelet Activity and Elastic Modulus of Healthy Subjects, Carriers of G20210A Polymorphism in the Prothrombin Gene

Komsa‐Penkova, R., Todinova, S. J., Andreeva, T. D., Krumova, S., Taneva, S. G., Golemanov, G. M., Georgieva, G. A., Mihaylova, N., Tchorbanov, A. I., & Tonchev, P. (2016) · Journal of Biomedical and Clinical Research · doi:10.1515/jbcr-2016-0011 · Cited by 1

Resistencia a la aspirina: un problema latente de alto riesgo

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Morphofunctional Properties of Human Platelets, Treated with Low Doses of Hydrogen Peroxide

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Preliminary Investigation about the Expression of G Protein-Coupled Receptors in Platelets from Patients with Chronic Immune Thrombocytopenic Purpura

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PLATELETS FUNCTIONS, ORGANIZATION, AND THEIR ASSOCIATED DISEASES: A BRIEF REVIEW

Agarwal, D. A. (2023) · Era s journal of medical research · doi:10.24041/ejmr2023.39 · Cited by 1

A study of coagulation potential in pre-eclampsia

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Platelet responsiveness and function during storage : implications for platelet transfusion therapy

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The influence of P2Y12 antagonists on vascular NO signalling

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Fysiologie van de hemostase

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Role of eosinophils and muscarinic receptors in paradoxical airway hyperreactivity associated with antigen challenge

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Platelet Interactions with the Blood Vessel Wall

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Immobilised collagen prevents shedding and induces sustained GPVI clustering and signalling in plateletsPreprint

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Tyrosine kinase inhibitors for cancer treatment

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Antiplatelet Agents

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Effect of non-esterified fatty acids on insulin resistance and cardiovascular risk in polycystic ovary syndrome

Aye, M. M. (2013) · Repository@Hull (Worktribe) (University of Hull) · Cited by 1

Early Aging of Endothelial Function and Platelet–Vessel Wall Interactions

Regnault, V., Lagrange, J., & Lacolley, P. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801387-8.00010-7

Individual Platelet Adhesion (iPA): A novel assay of platelet function

Alonso, A. L. (2014) · Figshare · doi:10.25419/rcsi.10806629

Хемилюминесценция тромбоцитов. Использование метода хемилюминесценции для определения активности тромбоцитов

Кривохижина, Л. В., Абдулхакович, К. С., Ермолаева, Е. Н., & Николаевич, К. Д. (2013) · Вестник Тюменского государственного университета. Социально-экономические и правовые исследования

Thrombin, thrombus, thrombi mechanisms of thrombus formation under flow

Berny‐Lang, M. A. (2013) · doi:10.6083/m4jq0z0m

Antiplatelet Therapies: Aspirin, Clopidogrel and Thienopyridines, and Glycoprotein IIb/IIIa Inhibitors for the Management of ST-Segment Elevation Myocardial Infarction

Weiner, R. B., & Sabatine, M. S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-235-3_11

The role of platelet thrombin receptors PAR1 and PAR4 in health and disease

Nylander, M. (2011) · DiVA (Linkoping University)

Critical Role of the Liver in Coagulation

Fathke, R. L., Peng, Z., Golding, B., & Kimchi‐Sarfaty, C. (2009) · doi:10.1002/9780470747919.ch41

Targeting Platelet G Protein‐Coupled Receptors for Antithrombotic Therapy

Fälker, K., Nazaré, M., Wonerow, P., & Kozian, D. H. (2013) · Drug Development Research · doi:10.1002/ddr.21101

Gastrointestinal absorption of heparins

Moazed, B. (2009) · University Library - University of Saskatchewan (University of Saskatchewan)

Prasugrel erhöht die endotheliale Bioverfügbarkeit von NO im Vergleich zu Clopidogrel bei Patienten mit instabiler Angina Pectoris

Schlichting, A. (2014)

Análise da expressão e atividade de receptores ativados por proteases em plaquetas de pacientes com hipertensão arterial pulmonar

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The effect of the flavonols quercetin and 3', 4' dihydroxyflavonol on platelet function in vitro and in vivo

Mosawy, S. (2013) · RMIT Research Repository (RMIT University Library) · doi:10.25439/rmt.27580971

The Effects of vanilloid-like agents on platelet aggregation

Almaghrabi, S. (2012) · eCite Digital Repository (University of Tasmania) · doi:10.25959/23205209

Platelet reactivity and comorbidities in acute coronary syndrome

Björklund, F. (2012)

Basics of Antithrombotic Therapy for Cardiovascular Disease

Capranzano, P., & Angiolillo, D. J. (2013) · Interventional Cardiology Clinics · doi:10.1016/j.iccl.2013.06.003

Komórkowa odpowiedź na działanie trombiny

Bijak, M., Ponczek, M. B., & Nowak, P. (2012)

A FLOW–CYTOMETRIC ANALYSIS OF THE INHIBITION OF PLATELET REACTIVITY WITH NITRITE REDUCTION BY DEOXYGENATED ERYTHROCYTES

Akrawinthawong, K., Park, J., Piknova, B., Sibmooh, N., Fucharoen, S., & Schechter, A. N. (2013) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(13)62067-7

Dynamic regulation of thrombus stability : focus on platelet receptors and downstream signaling

Cosemans, J. M. E. M. (2009) · doi:10.26481/dis.20090129jc

Oral antiplatelet agents: new insights in managing patients with acute coronary syndromes

Bonaca, M. P., & Giugliano, R. P. (2010) · Hot Topics in Cardiology · doi:10.4147/htc-102000

Future directions in antiplatelet therapy: efficacy versus safety

Kuzniatsova, N., Shantsila, E., & Lip, G. Y. H. (2009) · Future Prescriber · doi:10.1002/fps.52

Antithrombotic Strategies in Endovascular Interventions

Shishehbor, M. H., & Katzen, B. T. (2013) · Interventional Cardiology Clinics · doi:10.1016/j.iccl.2013.06.005

Clinically Relevant Concentrations of Dopamine Do Not Amplify Agonist-induced Human Platelet Ca2+ Mobilization or GP IIb IIIa Activation and Do Not Accelerate Acute Coronary Thrombosis in Dogs

Sill, J. C., Bertha, B. G., Berger, I. H., Southorn, V., & Folts, J. D. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31819c74f4

Phospholipase D in human blood platelets

Vorland, M. (2008) · NORA - Norwegian Open Research Archives

α1-acid glycoprotein modulates the function of human neutrophils and platelets

Gunnarsson, P. (2009) · DiVA (Linkoping University)

Receptor-mediated inhibitory mechanisms and the regulation of platelet function

Cheng, Z., & Liu, J. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4966-5

The effects of clopidogrel, acetyl salicylic acid and tirofiban on acetylcholine-induced dilation in rat thoracic aorta segments Klopidogrel, asetilsalisilik asit ve tirofibanin siçan torasik aort segmentlerinde asetilkolin ile uyarilan gevşeme üzerine etkisi

Özkısacık, E. A., & Durmaz, S. (2012)

Platelet Activation After Lung Transplantation

Sternberg, D. I., & Sonett, J. R. (2013) · Springer eBooks · doi:10.1007/978-1-4471-4429-8_46

Estudo da atividade plaquetaria na asma alergica em ratos

Baldissera, L. (2009) · doi:10.47749/t/unicamp.2009.465545

Herpesvirus mediated activation of coagulation and fibrinolytic proteins

Gershom, E. S. (2011) · cIRcle (University of British Columbia) · doi:10.14288/1.0072315

Aspirin in diabetes mellitus: mechanisms and clinical implications

Kurdee, Z. (2015) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)

Dual roles for polo-like kinase 3 in the regulation of platelet function

Bachman, B. (2025) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/x45x-c925

The Discovery of Vorapaxar (SCH 530348), a Thrombin Receptor (Protease Activated Receptor-1) Antagonist with Potent Antiplatelet Effects

Chackalamannil, S. (2010) · Royal Society of Chemistry eBooks · doi:10.1039/9781849731980-00025

Basics of Antithrombotic Therapy for Cardiovascular Disease Targets of Platelet Inhibitors

Capranzano, P., & Angiolillo, D. J. (2013)

Platelet–Vessel Wall Interactions

Diacovo, T. G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00119-0

The role of GPVI and CLEC-2 in platelet activation by miscellaneous ligands

Alshehri, O. M. (2016) · University of Birmingham Institutional Research Archive (University of Birmingham)

Receptor-mediated inhibitory mechanisms and the regulation of platelet function

Cheng, Z., & Liu, J. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4966-5

G-protein Dependent Platelet Signaling - Perspectives for Therapy

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The Role of Heterotrimeric G Proteins in Platelet Activation

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Thrombin and Platelet Activation

Brass, L. F. (2003) · CHEST Journal · doi:10.1378/chest.124.3_suppl.18s · Cited by 408

REVIEW ARTICLE Platelet G protein-coupled receptors in hemostasis and thrombosis

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