The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy
Open accessAbstract
MicroRNAs are naturally existing, small, noncoding RNA molecules that downregulate posttranscriptional gene expression. Their expression pattern and function in the heart remain unknown. Here we report an array of microRNAs that are differentially and temporally regulated during cardiac hypertrophy. Significantly, the muscle-specific microRNA-1 (miR-1) was singularly downregulated as early as day 1 (0.56±0.036), persisting through day 7 (0.29±0.14), after aortic constriction–induced hypertrophy in a mouse model. Overexpression experiments showed that miR-1 inhibited its in silico–predicted, growth-related targets, including Ras GTPase–activating protein (RasGAP), cyclin-dependent kinase 9 (Cdk9), fibronectin, and Ras homolog enriched in brain (Rheb), in addition to protein synthesis and cell size. Thus, we propose that microRNAs play an essential regulatory role in the development of cardiac hypertrophy, wherein downregulation of miR-1 is necessary for the relief of growth-related target genes from its repressive influence and induction of hypertrophy.
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MicroRNA Gene Expression Deregulation in Human Breast Cancer
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Cited by
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thum, T., Gross, C., Fiedler, J., Fischer, T., Kissler, S., Bussen, M., Galuppo, P., Just, S., Rottbauer, W., Frantz, S., et al. (2008) · Nature · doi:10.1038/nature07511 · Cited by 2,349
MicroRNA as Biomarkers and Diagnostics
Wang, J., Chen, J., & Sen, S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25056 · Cited by 793
Non-coding RNAs as regulators of gene expression and epigenetics
Kaikkonen, M. U., Lam, M. T. Y., & Glass, C. K. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr097 · Cited by 764
Altered microRNA expression in human heart disease
Ikeda, S., Kong, S. W., Lu, J., Bisping, E., Zhang, H., Allen, P. D., Golub, T. R., Pieske, B., & Pu, W. T. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00144.2007 · Cited by 616
Microparticles: major transport vehicles for distinct microRNAs in circulation
Diehl, P., Fricke, A., Sander, L., Stamm, J., Bassler, N., Htun, N., Ziemann, M., Helbing, T., El-Osta, A., Jowett, J. B. M., et al. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs007 · Cited by 470
Metadata
- Authors
- Sayed, D., Hong, C., Chen, I.-Y., Lypowy, J., & Abdellatif, M.
- Venue
- Circulation Research
- Published
- 2007-02-16
- Volume
- 100
- Issue
- 3
- Pages
- 416-424
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W1999943920
- Cited by
- 776
- References
- 7
- FWCI
- 20.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sayed, D., Hong, C., Chen, I.-Y., Lypowy, J., & Abdellatif, M. (2007). MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy. Circulation Research. https://doi.org/10.1161/01.res.0000257913.42552.23
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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