CoChat
Sign Up
Cited by 593Heart Rate Variability and Autonomic ControlCardiovascular Syncope and Autonomic DisordersBlood Pressure and Hypertension Studies

Role of the Baroreceptor Reflex in Daily Control of Arterial Blood Pressure and Other Variables in Dogs

Open access
COWLEY, ALLEN W., LIARD, JEAN FRANCOIS, GUYTON, ARTHUR C.·1973·Circulation Research
DOI 10.1161/01.res.32.5.564
Open this paper in CoChat — free accountOpen PDF

Abstract

Normal and sinoaortic baroreceptor-denervated dogs were monitored continuously (24 hours a day) to quantify the role of the baroreceptors in determining the average level and the variability of arterial blood pressure, heart rate, cardiac output, and total peripheral resistance. The frequency of occurrence over 24-hour periods was obtained for each variable using a fiber optic curve-scanning system to read the variables from continuously recorded charts and a digital computer system to plot curves. The results indicate that the degree of hypertension previously reported for this preparation has been highly exaggerated, presumably due to the methods of study. The average 24-hour mean arterial blood pressure was 101.6 mm Hg in normal dogs and only 112.7 mm Hg in baroreceptor-denervated dogs. The normal dogs exhibited narrowly distributed 24-hour frequency distribution curves for blood pressure; in contrast the denervated dogs exhibited curves with twice the 24-hour standard deviation. Similar analysis indicated that the baroreceptors exerted less influence on the daily stabilization of heart rate than they did on arterial blood pressure and that they had very little if any influence on the daily stabilization of cardiac output and total peripheral resistance. Hemodynamic variables during postural changes were studied along with diurnal rhythms. We concluded that the primary function of the baroreceptor reflex is not to set the chronic level of arterial blood pressure but, instead, to minimize variations in systemic arterial blood pressure, whether these variations are caused by postural changes of the animal, excitement, diurnal rhythm, or even spontaneous fluctuations of unknown origin.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/01.res.32.5.564

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. SACAWA, K.: Analysis of the CNS ischemic feedback regulation of the circulation. In Physical Bases of Circulatory Transport Regulation and Exchange edited by A. C. Guyton and A. A. Reeves. Philadelphia, W. B. Saunders Company, 1967, p 129.

Cited by

Sorted by citations

Related

Authors
COWLEY, A. W., LIARD, J. F., & GUYTON, A. C.
Affiliations
University of Mississippi Medical Center (US)
ORCID
COWLEY, ALLEN W.
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1973-05
Volume
32
Issue
5
Pages
564-576
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/01.res.32.5.564
OpenAlex
W2163685664
Cited by
593
References
34
Citations by year
2026: 3 · 2025: 5 · 2024: 8 · 2023: 3 · 2022: 9 · 2021: 15 · 2020: 6 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 15 · 2015: 13 · 2014: 18 · 2013: 15 · 2012: 17
FWCI
9.81
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
baroreflex, sinoaortic denervation, blood pressure regulation, blood pressure variability, heart rate, cardiac output, systemic vascular resistance, diurnal cycle, postural changes, hypertension, dogs
MeSH terms
Analog-Digital Conversion, Animals, Aorta, Blood Flow Velocity, Blood Pressure, Cardiac Output, Carotid Sinus, Circadian Rhythm, Computers, Denervation, Dogs, Heart Rate, Posture, Potassium, Pressoreceptors, Pulse, Radioimmunoassay, Renin, Sodium, Time Factors, Vagotomy, Vascular Resistance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review