Magnetic determination of the relationship between the S-T segment shift and the injury current produced by coronary artery occlusion.
Abstract
Both the S-T segment shift and the injury current were measured using the direct-current magnetocardiogram (d-c MCG) in seven dogs undergoing coronary artery occlusion. The purpose of the measurements was to clarify the origin of the S-T shift in acute ischemia and infarction. Previous measurements, consisting of d-c electrograms recorded from the exposed epicardial surface in situ, are partially inconsistent; also, they are not necessarily representative of the surface electrocardiogram (ECG), which sums broadly over the myocardium. The d-c MCG allows steady myocardial currents in the intact torso to the measured externally; because the d-c MCG sums broadly over these currents, conclusions drawn from it are applicable to the ECG. Coronary artery occlusion was produced by inflating a tube which, about 1 week earlier, had been surgically installed around the artery and exteriorized. During occlusions carried out in the MIT magnetically shielded room, a sensitive magnetometer recorded the d-c MCG at various locations around the torso. Within 20 seconds after occlusion, equal and opposite S-T segment and base-line (d-c) shifts appeared on the d-c MCG; these shifts were maintained for at least 15 minutes, after which they slowly decreased. Therefore, during the acute ischemia produced by these occlusions, the S-T shift is a secondary result of a primary injury current that is interrupted during the S-T interval.
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MCG can provide additional diagnostic information not achievable with electrocardiography alone.
“although theory and experimental research suggest and confirm that it can provide additional diagnostic information not achievable with electrocardiography alone (1, 2, 4–6, 9, 16, 107).”
From Clinical magnetocardiography: the unshielded bet—past, present, and future (2023) · cites this paper as [16]
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Clinical application of magnetocardiography
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Clinical magnetocardiography: the unshielded bet—past, present, and future
Brisinda, D., Fenici, P., & Fenici, R. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1232882 · Cited by 71 · see citing works
Hänninen, H., Takala, P., Korhonen, P., Oikarinen, L., Mäkijärvi, M., Nenonen, J., Katila, T., & Toivonen, L. (2002) · Annals of Medicine · doi:10.1080/07853890252953518 · Cited by 49 · see citing works
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Self-citationPark, J.-W., Shin, E.-S., Ann, S. H., Gödde, M., Park, L. S.-I., Brachmann, J., Vidal-Lopez, S., Wierzbinski, J., Lam, Y.-Y., & Jung, F. (2015) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-141912 · Cited by 29 · see citing works
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Magnetocardiography and exercise testing
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Shin, E.-S., Chung, J.-H., Park, S. G., Saleh, A., Lam, Y.-Y., Bhak, J., Jung, F., Morita, S., & Brachmann, J. (2019) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-180485 · Cited by 20 · see citing works
Brisinda, D., Fenici, R., & Smars, P. (2022) · Contemporary Cardiology · doi:10.1007/978-3-031-05520-1_17 · Cited by 6 · see citing works
- Authors
- Cohen, D., & Kaufman, L. A.
- ORCID
- Cohen, D
- Venue
- Circulation Research
- Published
- 1975-03
- Volume
- 36
- Issue
- 3
- Pages
- 414-424
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W1979866488
- Cited by
- 131
- References
- 1
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2016: 1 · 2015: 5 · 2013: 2 · 2012: 1
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- injury current, coronary artery occlusion, myocardial ischemia, myocardial infarction, acute myocardial ischemia
- MeSH terms
- Animals, Constriction, Coronary Disease, Coronary Vessels, Dogs, Electrocardiography, Electromagnetic Phenomena
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