The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes.
Abstract
We report the cloning of cDNAs encoding two different human nonmuscle myosin heavy chains designated NMMHC-A and NMMHC-B. The mRNAs encoding NMMHC-A and NMMHC-B are both 7.5 kb in size but are shown to be the products of different genes, which are localized to chromosome 22q11.2 and chromosome 17q13, respectively. In aggreement with previously reported results using avian tissues, we show that the mRNAs encoding the two myosin heavy chain isoforms are differentially expressed in rat nonmuscle and muscle tissues as well as in a number of human cell lines. The cDNA sequence encoding the 5' portion of the NMMHC-A isoform completes the previously published 3' cDNA sequence encoding a human myosin heavy chain, thus providing the cDNA sequence encoding the entire NMMHC-A amino acid sequence. Comparison of this sequence to cDNA clones encoding the amino-terminal one third of the NMMHC-B sequence (amino acids 58-718) shows them to be 89% identical at the amino acid level and 74% identical at the nucleotide level.
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 46,426
The Pathogenesis of Atherosclerosis — An Update
Ross, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602203140806 · Cited by 4,877
Disruption of the Dictyostelium Myosin Heavy Chain Gene by Homologous Recombination
De Lozanne, A., & Spudich, J. A. (1987) · Science · doi:10.1126/science.3576222 · Cited by 983
Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization
Harper, M. E., & Saunders, G. F. (1981) · Chromosoma · doi:10.1007/bf00327364 · Cited by 825
Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.
Kozak, M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.9.2850 · Cited by 687
Antisense RNA Inactivation of Myosin Heavy Chain Gene Expression in Dictyostelium discoideum
Knecht, D. A., & Loomis, W. F. (1987) · Science · doi:10.1126/science.3576221 · Cited by 676
[20] Isolation of RNA using guanidinium salts
MacDonald, R. J., Swift, G. H., Przybyla, A. E., & Chirgwin, J. M. (1987) · Methods in Enzymology · doi:10.1016/0076-6879(87)52023-7 · Cited by 599
Austin, G. E., Ratliff, N. B., Hollman, J., Tabei, S., & Phillips, D. F. (1985) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(85)80174-1 · Cited by 574
Myosin Structure and Function in Cell Motility
Warrick, H. M., & Spudich, J. A. (1987) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.03.110187.002115 · Cited by 482
Cited by
Komarova, Y. A., Kruse, K., Mehta, D., & Malik, A. B. (2017) · Circulation Research · doi:10.1161/circresaha.116.306534 · Cited by 503
Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes
Syndrome Consortium, T. M.-H. (2000) · Nature Genetics · doi:10.1038/79063 · Cited by 448
THE MAMMALIAN MYOSIN HEAVY CHAIN GENE FAMILY
Weiss, A., & Leinwand, L. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.417 · Cited by 358
Zhou, P., Li, Y., Li, B., Zhang, M., Liu, Y., Yao, Y., & Li, D. (2019) · Oncogene · doi:10.1038/s41388-019-0806-6 · Cited by 108
Bond, J. E., Ho, T. Q., Selim, M. A., Hunter, C. L., Bowers, E. V., & Levinson, H. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2010.181 · Cited by 46
Metadata
- Authors
- Simons, M., Wang, M., McBride, O. W., Kawamoto, S., Yamakawa, K., Gdula, D., Adelstein, R. S., & Weir, L.
- Venue
- Circulation Research
- Published
- 1991-08
- Volume
- 69
- Issue
- 2
- Pages
- 530-539
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W1981429363
- Cited by
- 272
- References
- 34
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Simons, M., Wang, M., McBride, O. W., Kawamoto, S., Yamakawa, K., Gdula, D., Adelstein, R. S., & Weir, L. (1991). Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. Circulation Research. https://doi.org/10.1161/01.res.69.2.530
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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