The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress
Abstract
Accumulating evidence suggests that oxidant stress alters many functions of the endothelium, including modulation of vasomotor tone. Inactivation of nitric oxide (NO(.)) by superoxide and other reactive oxygen species (ROS) seems to occur in conditions such as hypertension, hypercholesterolemia, diabetes, and cigarette smoking. Loss of NO(.) associated with these traditional risk factors may in part explain why they predispose to atherosclerosis. Among many enzymatic systems that are capable of producing ROS, xanthine oxidase, NADH/NADPH oxidase, and uncoupled endothelial nitric oxide synthase have been extensively studied in vascular cells. As the role of these various enzyme sources of ROS become clear, it will perhaps be possible to use more specific therapies to prevent their production and ultimately correct endothelial dysfunction.
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“Xdh-derived ROS are proinflammatory in the vasculature as they increase vascular permeability and arteriolar tone [57] and thus promote hypertension, cardiovascular diseases, and atherosclerosis [58,59].”
From Genetic variation in CCDC93 is associated with elevated central systolic blood pressure, impaired arterial relaxation, and mitochondrial dysfunction (2024) · cites this paper as [57]
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“Both enzymes have been implicated as important prooxidant enzymes contributing to hypertension [32,50,51].”
From Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension (2011) · cites this paper as [50]
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Cites
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
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Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
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Self-citationHypercholesterolemia increases endothelial superoxide anion production.
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Self-citationSuperoxide generation by endothelial nitric oxide synthase: The influence of cofactors
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Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
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Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension
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Self-citationGeneration of superoxide by purified brain nitric oxide synthase
Pou, S., Pou, W. S., Bredt, D. S., Snyder, S. H., & Rosen, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35745-4 · Cited by 750
Research works printed but not linked: 21
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Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
PLEIOTROPIC EFFECTS OF STATINS
Liao, J. K., & Laufs, U. (2005) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095748 · Cited by 1,994
Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T. (2001) · Circulation · doi:10.1161/hc4601.099485 · Cited by 1,961
Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
Taylor, A. L., Ziesche, S., Yancy, C., Carson, P., D'Agostino, R., Ferdinand, K., Taylor, M., Adams, K., Sabolinski, M., Worcel, M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042934 · Cited by 1,773
Angiotensin-converting enzyme 2 is an essential regulator of heart function
Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., et al. (2002) · Nature · doi:10.1038/nature00786 · Cited by 1,733
Metadata
- Authors
- Cai, H., & Harrison, D. G.
- Affiliations
- Emory University (US)
- Venue
- Circulation Research
- Published
- 2000-11-10
- Volume
- 87
- Issue
- 10
- Pages
- 840-844
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2148637873
- Cited by
- 3,839
- References
- 48
- Citations by year
- 2026: 61 · 2025: 66 · 2024: 84 · 2023: 99 · 2022: 114 · 2021: 115 · 2020: 125 · 2019: 136 · 2018: 143 · 2017: 167 · 2016: 163 · 2015: 171 · 2014: 197 · 2013: 195 · 2012: 208
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (HL39006, HL58000)
- National Heart, Lung, and Blood Institute (HL59243, HL 58000, R01HL039006, R01HL39006, P01HL058000)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- endothelial dysfunction, oxidative stress, reactive oxygen species, nitric oxide, superoxide, xanthine oxidase, NADPH oxidase, uncoupled nitric oxide synthase, hypertension, hypercholesterolemia, diabetes mellitus, cigarette smoking, atherosclerosis, vascular tone
- MeSH terms
- Animals, Cardiovascular Diseases, Endothelium, Vascular, Humans, NADH, NADPH Oxidoreductases, Nitric Oxide, Xanthine Oxidase, Reactive Oxygen Species, Oxidative Stress, Nitric Oxide Synthase, Nitric Oxide Synthase Type III
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