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Cited by 304

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

Potential Antiatherogenic Mechanisms of Ascorbate (Vitamin C) and α-Tocopherol (Vitamin E)

Open access
Carr, Anitra C., Zhu, Ben-Zhan, Frei, Balz·2000·Circulation Research
DOI 10.1161/01.res.87.5.349
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Abstract

Abstract —The premise that oxidative stress, among several other factors, plays an important role in atherogenesis implies that the development and progression of atherosclerosis can be inhibited by antioxidants. In this minireview we discuss several mechanisms by which the antioxidants ascorbate (vitamin C) and α-tocopherol (vitamin E) may protect against atherosclerosis. These mechanisms include inhibition of LDL oxidation and inhibition of leukocyte adhesion to the endothelium and vascular endothelial dysfunction. Overall, ascorbate appears to be more effective than α-tocopherol in mitigating these pathophysiological processes, most likely as a result of its abilities to effectively scavenge a wide range of reactive oxygen and nitrogen species and to regenerate α-tocopherol, and possibly tetrahydrobiopterin, from its radical species. In contrast, α-tocopherol can act either as an antioxidant or a pro-oxidant to inhibit or facilitate, respectively, lipid peroxidation in LDL. However, this pro-oxidant activity of α-tocopherol is prevented by ascorbate acting as a coantioxidant. Therefore, an optimum vitamin C intake or body status may help protect against atherosclerosis and its clinical sequelae, whereas vitamin E may only be effective in combination with vitamin C.

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Metadata

Authors
Carr, A. C., Zhu, B.-Z., & Frei, B.
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-09
Volume
87
Issue
5
Pages
349-354
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/01.res.87.5.349
OpenAlex
W2131058177
Cited by
304
References
68
FWCI
14.18
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Potential Antiatherogenic Mechanisms of Ascorbate (Vitamin C) and α-Tocopherol (Vitamin E). https://app.cochat.ai/papers/10.1161/01.res.87.5.349
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Carr, A. C., Zhu, B.-Z., & Frei, B. (2000). Potential Antiatherogenic Mechanisms of Ascorbate (Vitamin C) and α-Tocopherol (Vitamin E). Circulation Research. https://doi.org/10.1161/01.res.87.5.349

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.