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Cited by 370Lipoproteins and Cardiovascular HealthAcute Ischemic Stroke ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Influence of total cholesterol, high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease: the Copenhagen city heart study

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Lindenstrom, E, Boysen, G, Nyboe, J·1994·BMJ
DOI 10.1136/bmj.309.6946.11PMC PMC2542648
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Abstract

Objective : To estimate the influence of plasma total cholesterol, high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease. Design : The Copenhagen city heart study is a prospective observational survey with two cardiovascular examinations at five year intervals. Non- fasting plasma lipids were measured in participants once at each examination, along with other variables. The Cox regression model was used to establish the effect of the factors recorded on cerebrovascular events of mostly, but not exclusively, ischaemic origin. Subjects — 19 698 women and men at least 20 years old, randomly selected after age stratification from an area of central Copenhagen. Main outcome measures : Initial cases of stroke and transient ischaemic attack recorded from hospital records and death certificates from 1976 through 1988. Results : 660 non-haemorrhagic and 33 haemorrhagic events were recorded. Total cholesterol was positively associated with risk of non-haemorrhagic events, but only for levels >8 mmol/l, correspaonding to the upper 5% of the distribution in the study population. For lower plasma cholesterol values the relative risk remained nearly constant. Plasma triglyceride concentration was significantly, positively associated with risk of non- haemorrhagic events. The relative risk corresponding to an increase of 1 mmol/l was 1.12 (95% confidence interval 1.07 to 1.16). There was a negative, log linear association between high density lipoprotein cholesterol and risk of non-haemorrhagic events (0.53 (0.34 to 0.83)). There was no indication that the20effects of plasma lipids were different in women and men. Conclusions : The pattern of the association between plasma cholesterol and risk of ischaemic cerebrovascular disease was not log linear, and the increased risk was confined to the upper 5% of the cholesterol distribution. Further studies should concentrate on the association between plasma cholesterol and varified haemorrhagic stroke.

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Authors
Lindenstrom, E., Boysen, G., & Nyboe, J.
Affiliations
Hvidovre Hospital (DK)
Venue
BMJ
Publisher
BMJ
Published
1994-07-02
Volume
309
Issue
6946
Pages
11-15
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.309.6946.11
PMC
PMC2542648
OpenAlex
W2033276124
Cited by
370
References
53
Citations by year
2026: 1 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 13 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 15 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 10
FWCI
10.34
Type
journal article
Language
en
Open access
Licence
www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
total cholesterol, HDL cholesterol, triglycerides, cerebrovascular disease, stroke, transient ischemic attack, ischemic stroke, hemorrhagic stroke, plasma lipids, cardiovascular risk factors, sex differences
MeSH terms
Adult, Aged, Ischemic Attack, Transient, Cerebrovascular Disorders, Cholesterol, Denmark, Female, Humans, Lipoproteins, HDL, Male, Middle Aged, Random Allocation, Regression Analysis, Risk Factors, Triglycerides

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