The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Pericardial Adipose Tissue Determined by Dual Source CT Is a Risk Factor for Coronary Atherosclerosis
Abstract
Objectives— Pericardial fat as a visceral fat depot may be involved in the pathogenesis of coronary atherosclerosis. To gain evidence for that concept we sought to investigate the relation of pericardial fat volumes to risk factors, serum adiponectin levels, inflammatory biomarkers, and the quantity and morphology of coronary atherosclerosis. Methods and Results— Using Dual source CT angiography pericardial fat volume and coronary atherosclerosis were assessed simultaneously. Plaques were classified as calcified, mixed, and noncalcified, and the number of affected segments served as quantitative score. Patients with atherosclerotic lesions had significant larger PAT volumes (226 cm 3 ±92 cm 3 ) than patients without atherosclerosis (134 cm 3 ±56 cm 3 ; P >0.001). No association was found between BMI and coronary atherosclerosis. PAT volumes >300 cm 3 were the strongest independent risk factor for coronary atherosclerosis (odds ratio 4.1; CI 3.63 to 4.33) also significantly stronger compared to the Framingham score. We furthermore demonstrated that elevated PAT volumes are significantly associated with low adiponectin levels, low HDL levels, elevated TNF-α levels, and hsCRP. Conclusion— In the present study we demonstrated that elevated PAT volumes are associated with coronary atherosclerosis, hypoadiponectinemia, and inflammation and represent the strongest risk factor for the presence of atherosclerosis and may be important for risk stratification and monitoring.
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Citations
Cites
Epicardial fat from echocardiography: A new method for visceral adipose tissue prediction
Iacobellis, G., Assael, F., Ribaudo, M. C., Zappaterreno, A., Alessi, G., Di Mario, U., & Leonetti, F. (2003) · Obesity Research · doi:10.1038/oby.2003.45 · Cited by 779
Epicardial adipose tissue and insulin resistance in obese subjects
Iacobellis, G., & Leonetti, F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1087 · Cited by 355
Myocardial infarction and coronary pathology in severely obese people examined at autopsy
Kortelainen, M.-L. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801852 · Cited by 49
Cited by
Obesity and inflammation: the linking mechanism and the complications
Ellulu, M. S., Patimah, I., Khaza’ai, H., Rahmat, A., & Abed, Y. (2017) · Archives of Medical Science · doi:10.5114/aoms.2016.58928 · Cited by 1,982
Echocardiographic epicardial fat: a review of research and clinical applications
Iacobellis, G., & Willens, H. J. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2009.10.013 · Cited by 700
Mahabadi, A. A., Berg, M. H., Lehmann, N., Kälsch, H., Bauer, M., Kara, K., Dragano, N., Moebus, S., Jöckel, K.-H., Erbel, R., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.062 · Cited by 529
Perivascular adipose tissue inflammation in vascular disease
Nosalski, R., & Guzik, T. J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13705 · Cited by 398
Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions.
Snel, M., Jonker, J. T., Schoones, J., Lamb, H., de Roos, A., Pijl, H., Smit, J. W. A., Meinders, A. E., & Jazet, I. M. (2012) · International Journal of Endocrinology · doi:10.1155/2012/983814 · Cited by 368
Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis
Alexopoulos, N., Katritsis, D., & Raggi, P. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.12.023 · Cited by 332
Fitzgibbons, T. P., & Czech, M. P. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000582 · Cited by 331
Epicardial adipose tissue and coronary artery plaque characteristics
Alexopoulos, N., McLean, D. S., Janik, M., Arepalli, C. D., Stillman, A. E., & Raggi, P. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.11.020 · Cited by 329
Lehrke, M., Becker, A., Greif, M., Stark, R., Laubender, R. P., von Ziegler, F., Lebherz, C., Tittus, J., Reiser, M., Becker, C., et al. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0380 · Cited by 299
Self-citationGaborit, B., Kober, F., Jacquier, A., Moro, P. J., Cuisset, T., Boullu, S., Dadoun, F., Alessi, M.-C., Morange, P., Clément, K., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.117 · Cited by 116
Snel, M., Jonker, J. T., Hammer, S., Kerpershoek, G., Lamb, H. J., Meinders, A. E., Pijl, H., de Roos, A., Romijn, J. A., Smit, J. W. A., et al. (2012) · Obesity · doi:10.1038/oby.2011.390 · Cited by 80
Metadata
- Authors
- Greif, M., Becker, A., von Ziegler, F., Lebherz, C., Lehrke, M., Broedl, U. C., Tittus, J., Parhofer, K., Becker, C., Reiser, M., Knez, A., & Leber, A. W.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2009-05
- Volume
- 29
- Issue
- 5
- Pages
- 781-786
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2146361547
- Cited by
- 272
- References
- 3
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- closed
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