Association of Epicardial Fat With Cardiovascular Risk Factors and Incident Myocardial Infarction in the General Population
Open accessAbstract
Objectives This study sought to determine whether epicardial fat volume predicts coronary events in the general population.Background Epicardial adipose tissue (EAT) is suggested to promote plaque development in the coronary artery tree.Methods We quantified EAT volume in participants from the prospective population-based Heinz Nixdorf Recall cohort study free of cardiovascular disease. Incident coronary events were assessed during a follow-up period of 8.0 ± 1.5 years. Multivariable association of EAT with cardiovascular risk factors, coronary artery calcification (CAC), and coronary events was assessed using regression analysis.Results From the overall 4,093 participants (age 59.4 years, 47% male), 130 subjects developed a fatal or nonfatal coronary event. Incidence of coronary events increased by quartile of EAT (0.9% vs. 4.7% for 1(st) and 4th quartile, respectively, p < 0.001). Doubling of EAT was associated with a 1.5-fold risk of coronary events when adjusting for cardiovascular risk factors (hazard ratio [HR] [95% confidence interval (CI)]: 1.54 [1.09 to 2.19]), which remained unaltered after further adjustment for CAC score (HR [95% CI]: 1.50 [1.07 to 2.11]). For discrimination of subjects with events from those without, we observed a trend for improvement of Harrell's C and explained variance by EAT over traditional cardiovascular risk factors, which, however, did not reach statistical significance (0.720 to 0.730 for risk factors alone and with EAT added, respectively, p = 0.10, R(2) = 2.73% to R(2) = 2.92%, time-dependent integrated discrimination improvement = 0.196%).Conclusions Epicardial fat is associated with fatal and nonfatal coronary events in the general population independent of traditional cardiovascular risk factors and complements information from cardiac computed tomography above the CAC score.
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EAT has been associated with fatal and nonfatal coronary events regardless of traditional cardiovascular risk factors.
“Epicardial adipose tissue has been associated with fatal and nonfatal coronary events regardless of the traditional cardiovascular risk factors [21].”
From Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity (2020) · cites this paper as [21]
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- Authors
- Mahabadi, A. A., Berg, M. H., Lehmann, N., Kälsch, H., Bauer, M., Kara, K., Dragano, N., Moebus, S., Jöckel, K.-H., Erbel, R., & Möhlenkamp, S.
- Affiliations
- West German Heart and Vascular Center Essen (DE)
- University of Duisburg-Essen (DE)
- Düsseldorf University Hospital (DE)
- Corresponding author
- Mahabadi, Amir A.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 61
- Issue
- 13
- Pages
- 1388-1395
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W135321714
- Cited by
- 529
- References
- 33
- Citations by year
- 2026: 34 · 2025: 39 · 2024: 42 · 2023: 31 · 2022: 44 · 2021: 50 · 2020: 49 · 2019: 40 · 2018: 40 · 2017: 51 · 2016: 30 · 2015: 47 · 2014: 21 · 2013: 10
- FWCI
- 24.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Heinz Nixdorf Stiftung
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- epicardial adipose tissue, epicardial fat volume, myocardial infarction, coronary events, cardiovascular risk factors, coronary artery calcification, coronary artery disease, cardiac CT, risk prediction
- MeSH terms
- Adipose Tissue, Aged, Female, Humans, Life Style, Male, Middle Aged, Myocardial Infarction, Pericardium, Radiography, Risk Factors, Risk Assessment, Plaque, Atherosclerotic
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