Cited by 529Cardiovascular Disease and AdiposityCardiac Imaging and DiagnosticsAcute Myocardial Infarction Research

Association of Epicardial Fat With Cardiovascular Risk Factors and Incident Myocardial Infarction in the General Population

Open access
Mahabadi, Amir A., Berg, Marie H., Lehmann, Nils, Kälsch, Hagen, Bauer, Marcus, Kara, Kaffer, Dragano, Nico, Moebus, Susanne +3 more·2013·Journal of the American College of Cardiology

Abstract

Objectives This study sought to determine whether epicardial fat volume predicts coronary events in the general population.Background Epicardial adipose tissue (EAT) is suggested to promote plaque development in the coronary artery tree.Methods We quantified EAT volume in participants from the prospective population-based Heinz Nixdorf Recall cohort study free of cardiovascular disease. Incident coronary events were assessed during a follow-up period of 8.0 ± 1.5 years. Multivariable association of EAT with cardiovascular risk factors, coronary artery calcification (CAC), and coronary events was assessed using regression analysis.Results From the overall 4,093 participants (age 59.4 years, 47% male), 130 subjects developed a fatal or nonfatal coronary event. Incidence of coronary events increased by quartile of EAT (0.9% vs. 4.7% for 1(st) and 4th quartile, respectively, p < 0.001). Doubling of EAT was associated with a 1.5-fold risk of coronary events when adjusting for cardiovascular risk factors (hazard ratio [HR] [95% confidence interval (CI)]: 1.54 [1.09 to 2.19]), which remained unaltered after further adjustment for CAC score (HR [95% CI]: 1.50 [1.07 to 2.11]). For discrimination of subjects with events from those without, we observed a trend for improvement of Harrell's C and explained variance by EAT over traditional cardiovascular risk factors, which, however, did not reach statistical significance (0.720 to 0.730 for risk factors alone and with EAT added, respectively, p = 0.10, R(2) = 2.73% to R(2) = 2.92%, time-dependent integrated discrimination improvement = 0.196%).Conclusions Epicardial fat is associated with fatal and nonfatal coronary events in the general population independent of traditional cardiovascular risk factors and complements information from cardiac computed tomography above the CAC score.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2012.11.062

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Mahabadi, A. A., Berg, M. H., Lehmann, N., Kälsch, H., Bauer, M., Kara, K., Dragano, N., Moebus, S., Jöckel, K.-H., Erbel, R., & Möhlenkamp, S.
Affiliations
  • West German Heart and Vascular Center Essen (DE)
  • University of Duisburg-Essen (DE)
  • Düsseldorf University Hospital (DE)
Corresponding author
Mahabadi, Amir A.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2013-04
Volume
61
Issue
13
Pages
1388-1395
ISSN
0735-1097 (ISSN-L)
OpenAlex
W135321714
Cited by
529
References
33
Citations by year
2026: 34 · 2025: 39 · 2024: 42 · 2023: 31 · 2022: 44 · 2021: 50 · 2020: 49 · 2019: 40 · 2018: 40 · 2017: 51 · 2016: 30 · 2015: 47 · 2014: 21 · 2013: 10
FWCI
24.49
Type
journal article
Language
en
Open access
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
Funders
  • Bundesministerium für Bildung und Forschung
  • Heinz Nixdorf Stiftung
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords
epicardial adipose tissue, epicardial fat volume, myocardial infarction, coronary events, cardiovascular risk factors, coronary artery calcification, coronary artery disease, cardiac CT, risk prediction
MeSH terms
Adipose Tissue, Aged, Female, Humans, Life Style, Male, Middle Aged, Myocardial Infarction, Pericardium, Radiography, Risk Factors, Risk Assessment, Plaque, Atherosclerotic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review