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Cited by 232

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Interplay Between Human Adipocytes and T Lymphocytes in Obesity: CCL20 as an Adipochemokine and T Lymphocytes as Lipogenic Modulators

Duffaut, Carine, Zakaroff-Girard, Alexia, Bourlier, Virginie, Decaunes, Pauline, Maumus, Marie, Chiotasso, Patrick, Sengenès, Coralie, Lafontan, Max, Galitzky, Jean, Bouloumié, Anne·2009·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/atvbaha.109.192583
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Abstract

Objective— Adipose tissue (AT) plays a major role in the low-grade inflammatory state associated with obesity. The aim of the present study was to characterize the human AT lymphocytes (ATLs) and to analyze their interactions with adipocytes. Methods and Results— Human ATL subsets were characterized by flow cytometry in subcutaneous ATs from 92 individuals with body mass index (BMI) ranging from 19 to 43 kg/m 2 and in paired biopsies of subcutaneous and visceral AT from 45 class II/III obese patients. CD3 + ATLs were composed of effector and memory CD4 + helper and CD8 + cytotoxic T cells. The number of ATLs correlated positively with BMI and was higher in visceral than subcutaneous AT. Mature adipocytes stimulated the migration of ATLs and released the chemokine CCL20, the receptor of which (CCR6) was expressed in ATLs. The expression of adipocyte CCL20 was positively correlated with BMI and increased in visceral compared to subcutaneous adipocytes. ATLs expressed inflammatory markers and released interferon gamma (IFNγ). Progenitor and adipocyte treatment with ATL-conditioned media reduced the insulin-mediated upregulation of lipogenic enzymes, an effect involving IFNγ. Conclusions— Therefore, crosstalk occurs between adipocytes and lymphocytes within human AT involving T cell chemoattraction by adipocytes and modulation of lipogenesis by ATLs.

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Metadata

Authors
Duffaut, C., Zakaroff-Girard, A., Bourlier, V., Decaunes, P., Maumus, M., Chiotasso, P., Sengenès, C., Lafontan, M., Galitzky, J., & Bouloumié, A.
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-10
Volume
29
Issue
10
Pages
1608-1614
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/atvbaha.109.192583
OpenAlex
W2098651296
Cited by
232
References
10
FWCI
12.54
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Interplay Between Human Adipocytes and T Lymphocytes in Obesity: CCL20 as an Adipochemokine and T Lymphocytes as Lipogenic Modulators. https://app.cochat.ai/papers/10.1161/atvbaha.109.192583
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Duffaut, C., Zakaroff-Girard, A., Bourlier, V., Decaunes, P., Maumus, M., Chiotasso, P., Sengenès, C., Lafontan, M., Galitzky, J., & Bouloumié, A. (2009). Interplay Between Human Adipocytes and T Lymphocytes in Obesity: CCL20 as an Adipochemokine and T Lymphocytes as Lipogenic Modulators. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.109.192583

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.