The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
MicroRNAs in Metabolic Disease
Open accessAbstract
Alterations in the metabolic control of lipid and glucose homeostasis predispose an individual to develop cardiometabolic diseases, such as type 2-diabetes mellitus and atherosclerosis. Work over the last years has suggested that microRNAs (miRNAs) play an important role in regulating these physiological processes. The contribution of miRNAs in regulating metabolism is exemplified by miR-33, an intronic miRNA encoded in the Srebp genes. miR-33 controls cellular cholesterol export and fatty acid degradation, whereas its host genes stimulate cholesterol and fatty acid synthesis. Other miRNAs, such as miR-122, also play a critical role in regulating lipid homeostasis by controlling cholesterol synthesis and lipoprotein secretion in the liver. This review article summarizes the recent findings in the field, highlighting the contribution of miRNAs in regulating lipid and glucose metabolism. We will also discuss how the modulation of specific miRNAs may be a promising strategy to treat metabolic diseases.
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“microRNAs can alter the expression of genes in insulin-producing and insulin-sensitive tissues, including the pancreas, liver, and vasculature.”
From The Vasculature in Prediabetes (2018) · cites this paper as [134]
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“The most abundant microRNA in the liver is miR-122.”
From The Vasculature in Prediabetes (2018) · cites this paper as [134]
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Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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The functions of animal microRNAs
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A pancreatic islet-specific microRNA regulates insulin secretion
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Hammond, S. M. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.001 · Cited by 1,324
“metabolism and transport, pancreatic islet function, and glucose metabolism[179].”
BackgroundBile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
Cardiovascular consequences of metabolic syndrome
Tune, J. D., Goodwill, A. G., Sassoon, D., & Mather, K. J. (2017) · Translational research · doi:10.1016/j.trsl.2017.01.001 · Cited by 645
Vienberg, S. G., Geiger, J., Madsen, S., & Dalgaard, L. T. (2016) · Acta Physiologica · doi:10.1111/apha.12681 · Cited by 385
“…targeting miR-122 results in significant reduction in plasma cholesterol levels (Kr€utzfeldt et al. 2005, Esau et al. 2006), but the effect on cholesterol metabolism by miR-122 seems to be indirect, as the exact targets of this particular miRNA are still unclear (Fernandez-Hernando et al. 2013).”
BackgroundControlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)
Sharpe, L. J., & Brown, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.479808 · Cited by 382
Metadata
- Authors
- Fernández-Hernando, C., Ramírez, C. M., Goedeke, L., & Suárez, Y.
- Affiliations
- From the Departments of Medicine and Cell Biology, Leon H. Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY.
- New York University (US)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2013-02
- Volume
- 33
- Issue
- 2
- Pages
- 178-185
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC3740757
- OpenAlex
- W2042714431
- Cited by
- 257
- References
- 67
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 12 · 2023: 12 · 2022: 21 · 2021: 15 · 2020: 18 · 2019: 21 · 2018: 24 · 2017: 25 · 2016: 21 · 2015: 21 · 2014: 30 · 2013: 21
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL105945, R01HL106063, R01HL107953)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- microRNA, metabolic disorders, lipid homeostasis, glucose homeostasis, type 2 diabetes, atherosclerosis, miR-33, SREBP, miR-122, cholesterol biosynthesis, lipoprotein secretion, liver, cholesterol export, fatty acid degradation, miRNA-based therapy
- MeSH terms
- Animals, Gene Expression Regulation, Glucose, Homeostasis, Humans, Insulin, Metabolic Diseases, Genetic Therapy, Signal Transduction, MicroRNAs, Carbohydrate Metabolism, Lipid Metabolism
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