The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
MicroRNAs in Metabolic Disease
Open accessAbstract
Alterations in the metabolic control of lipid and glucose homeostasis predispose an individual to develop cardiometabolic diseases, such as type 2-diabetes mellitus and atherosclerosis. Work over the last years has suggested that microRNAs (miRNAs) play an important role in regulating these physiological processes. The contribution of miRNAs in regulating metabolism is exemplified by miR-33, an intronic miRNA encoded in the Srebp genes. miR-33 controls cellular cholesterol export and fatty acid degradation, whereas its host genes stimulate cholesterol and fatty acid synthesis. Other miRNAs, such as miR-122, also play a critical role in regulating lipid homeostasis by controlling cholesterol synthesis and lipoprotein secretion in the liver. This review article summarizes the recent findings in the field, highlighting the contribution of miRNAs in regulating lipid and glucose metabolism. We will also discuss how the modulation of specific miRNAs may be a promising strategy to treat metabolic diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“microRNAs can alter the expression of genes in insulin-producing and insulin-sensitive tissues, including the pancreas, liver, and vasculature.”
From The Vasculature in Prediabetes (2018) · cites this paper as [134]
In the citing paper
“The most abundant microRNA in the liver is miR-122.”
From The Vasculature in Prediabetes (2018) · cites this paper as [134]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., & Remaley, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2210 · Cited by 2,741
A pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082
LNA-mediated microRNA silencing in non-human primates
Elmén, J., Lindow, M., Schütz, S., Lawrence, M., Petri, A., Obad, S., Lindholm, M., Hedtjärn, M., Hansen, H. F., Berger, U., et al. (2008) · Nature · doi:10.1038/nature06783 · Cited by 1,589
Detection of microRNA Expression in Human Peripheral Blood Microvesicles
Hunter, M. P., Ismail, N., Zhang, X., Aguda, B. D., Lee, E. J., Yu, L., Xiao, T., Schafer, J., Lee, M. T., Schmittgen, T. D., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003694 · Cited by 1,476
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
Lanford, R. E., Hildebrandt-Eriksen, E. S., Petri, A., Persson, R., Lindow, M., Munk, M. E., Kauppinen, S., & Ørum, H. (2010) · Science · doi:10.1126/science.1178178 · Cited by 1,459
Selective Blockade of MicroRNA Processing by Lin28
Viswanathan, S. R., Daley, G. Q., & Gregory, R. I. (2008) · Science · doi:10.1126/science.1154040 · Cited by 1,449
Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
Zampetaki, A., Kiechl, S., Drozdov, I., Willeit, P., Mayr, U., Prokopi, M., Mayr, A., Weger, S., Oberhollenzer, F., Bonora, E., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.226357 · Cited by 1,283
MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
Rayner, K. J., Suárez, Y., Dávalos, A., Parathath, S., Fitzgerald, M. L., Tamehiro, N., Fisher, E. A., Moore, K. J., & Fernández-Hernando, C. (2010) · Science · doi:10.1126/science.1189862 · Cited by 1,260
Self-citationMicroRNA Pathways in Flies and Worms
Ambros, V. (2003) · Cell · doi:10.1016/s0092-8674(03)00428-8 · Cited by 1,218
MicroRNA-143 Regulates Adipocyte Differentiation
Esau, C., Kang, X., Peralta, E. R., Hanson, E. M., Marcusson, E. G., Ravichandran, L. V., Sun, Y., Koo, S., Perera, R. J., Jain, R., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400438200 · Cited by 1,023
MicroRNAs 103 and 107 regulate insulin sensitivity
Trajkovski, M., Hausser, J., Soutschek, J., Bhat, B., Akin, A., Zavolan, M., Heim, M. H., & Stoffel, M. (2011) · Nature · doi:10.1038/nature10112 · Cited by 1,000
MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
Najafi-Shoushtari, S. H., Kristo, F., Li, Y., Shioda, T., Cohen, D. E., Gerszten, R. E., & Näär, A. M. (2010) · Science · doi:10.1126/science.1189123 · Cited by 957
The Lin28/let-7 Axis Regulates Glucose Metabolism
Zhu, H., Shyh‐Chang, N., Segrè, A. V., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J., Hagan, J. P., Kharas, M. G., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.033 · Cited by 916
Diabetes Mellitus and the β Cell: The Last Ten Years
Ashcroft, F. M., & Rorsman, P. (2012) · Cell · doi:10.1016/j.cell.2012.02.010 · Cited by 902
Regulation of glucose transport by insulin: traffic control of GLUT4
Leto, D., & Saltiel, A. R. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3351 · Cited by 848
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
Tsai, W.-C., Hsu, S., Hsu, C.-S., Lai, T., Chen, S.-J., Shen, R., Huang, Y., Chen, H., Lee, C.-H., Tsai, T., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63455 · Cited by 815
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
Hsu, S., Wang, B., Kota, J., Yu, J., Costinean, S., Kutay, H., Yu, L., Bai, S., Perle, K. L., Chivukula, R. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63539 · Cited by 794
miR-375 maintains normal pancreatic α- and β-cell mass
Poy, M. N., Hausser, J., Trajkovski, M., Braun, M., Collins, S., Rorsman, P., Zavolan, M., & Stoffel, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810550106 · Cited by 740
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
Newman, M. A., Thomson, J. M., & Hammond, S. M. (2008) · RNA · doi:10.1261/rna.1155108 · Cited by 708
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
Rayner, K. J., Esau, C. C., Hussain, F. N., McDaniel, A. L., Marshall, S. M., van Gils, J. M., Ray, T. D., Sheedy, F. J., Goedeke, L., Liu, X., et al. (2011) · Nature · doi:10.1038/nature10486 · Cited by 706
Self-citationRayner, K. J., Sheedy, F. J., Esau, C. C., Hussain, F. N., Temel, R. E., Parathath, S., van Gils, J. M., Rayner, A. J., Chang, A. N., Suarez, Y., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57275 · Cited by 690
Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
Cheung, O., Puri, P., Eicken, C., Contos, M. J., Mirshahi, F., Maher, J. W., Kellum, J. M., Min, H., Luketic, V. A., & Sanyal, A. J. (2008) · Hepatology · doi:10.1002/hep.22569 · Cited by 671
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
Dávalos, A., Goedeke, L., Smibert, P., Ramírez, C. M., Warrier, N. P., Andreo, U., Cirera-Salinas, D., Rayner, K., Suresh, U., Pastor-Pareja, J. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102281108 · Cited by 670
Self-citationCirculating MicroRNAs in Patients with Chronic Hepatitis C and Non-Alcoholic Fatty Liver Disease
Cermelli, S., Ruggieri, A., Marrero, J. A., Ioannou, G. N., & Beretta, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023937 · Cited by 564
miR-33 links SREBP-2 induction to repression of sterol transporters
Marquart, T. J., Allen, R. M., Ory, D. S., & Baldán, Á. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005191107 · Cited by 562
Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs
Frost, R. J., & Olson, E. N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118922109 · Cited by 461
A role of miR‐27 in the regulation of adipogenesis
Lin, Q., Gao, Z., Alarcon, R. M., Ye, J., & Yun, Z. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06967.x · Cited by 439
Hormonal regulation of hepatic glucose production in health and disease
Lin, H. V., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.003 · Cited by 429
Brunham, L. R., Kruit, J. K., Pape, T. D., Timmins, J. M., Reuwer, A. Q., Vasanji, Z., Marsh, B. J., Rodrigues, B. B., Johnson, J. D., Parks, J. S., et al. (2007) · Nature Medicine · doi:10.1038/nm1546 · Cited by 422
miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression
Kim, S., Kim, A., Lee, H. W., Son, Y. H., Lee, G. Y., Lee, J.-W., Lee, Y. S., & Kim, J. B. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.01.012 · Cited by 420
He, A., Zhu, L., Gupta, N., Chang, Y., & Fang, F. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0167 · Cited by 415
Integration of microRNA miR-122 in hepatic circadian gene expressionPreprint
Gatfield, D., Martelot, G. L., Vejnar, C. E., Gerlach, D., Schaad, O., Fleury-Olela, F., Ruskeepää, A., Orešič, M., Esau, C., Zdobnov, E. M., et al. (2009) · Genes & Development · doi:10.1101/gad.1781009 · Cited by 393
Horie, T., Ono, K., Horiguchi, M., Nishi, H., Nakamura, T., Nagao, K., Kinoshita, M., Kuwabara, Y., Marusawa, H., Iwanaga, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008499107 · Cited by 384
Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*
Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
Wahrle, S. E., Jiang, H., Parsadanian, M., Kim, J., Li, A., Knoten, A., Jain, S., Hirsch-Reinshagen, V., Wellington, C. L., Bales, K. R., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33622 · Cited by 370
A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13
Grueter, C. E., van Rooij, E., Johnson, B. A., DeLeon, S. M., Sutherland, L. B., Qi, X., Gautron, L., Elmquist, J. K., Bassel‐Duby, R., & Olson, E. N. (2012) · Cell · doi:10.1016/j.cell.2012.03.029 · Cited by 368
MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse
Lynn, F. C., Skewes-Cox, P., Kosaka, Y., McManus, M. T., Harfe, B. D., & German, M. S. (2007) · Diabetes · doi:10.2337/db07-0175 · Cited by 351
Plaisance, V., Abderrahmani, A., Perret-Menoud, V., Jacquemin, P., Lemaigre, F., & Regazzi, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601225200 · Cited by 350
Li, S., Zhu, J., Zhang, W., Chen, Y., Zhang, K., Popescu, L. M., Ma, X., Lau, W. B., Rong, R., Yu, X., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.012237 · Cited by 334
Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease
Wahrle, S. E., Jiang, H., Parsadanian, M., Hartman, R. E., Bales, K. R., Paul, S. M., & Holtzman, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508780200 · Cited by 325
MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism
Iliopoulos, D., Drosatos, K., Hiyama, Y., Goldberg, I. J., & Zannis, V. I. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m004812 · Cited by 308
Melkman‐Zehavi, T., Oren, R., Kredo‐Russo, S., Shapira, T., Mandelbaum, A. D., Rivkin, N., Nir, T., Lennox, K. A., Behlke, M. A., Dor, Y., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.361 · Cited by 280
MicroRNA let-7 regulates 3T3-L1 adipogenesis.
Sun, T.-W., Fu, M., Bookout, A., Kliewer, S., & Mangelsdorf, D. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0298 · Cited by 277
Lee, J., Padhye, A., Sharma, A., Song, G., Miao, J., Mo, Y.-Y., Wang, L., & Kemper, J. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.094524 · Cited by 269
Pullen, T. J., da Silva Xavier, G., Kelsey, G., & Rutter, G. A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01433-10 · Cited by 258
Lovis, P., Gattesco, S., & Regazzi, R. (2008) · bchm · doi:10.1515/bc.2008.026 · Cited by 257
Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis
Gerin, I., Bommer, G. T., McCoin, C. S., Sousa, K. M., Krishnan, V., & MacDougald, O. A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00179.2010 · Cited by 256
The role of FOXO in the regulation of metabolism
Gross, D. N., Wan, M., & Birnbaum, M. J. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0034-5 · Cited by 244
Ramirez, C. M., Dávalos, A., Goedeke, L., Salerno, A. G., Warrier, N., Cirera-Salinas, D., Suárez, Y., & Fernández-Hernando, C. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.232066 · Cited by 242
Self-citationMicrorna-27b Is a Regulatory Hub in Lipid Metabolism and Is Altered in Dyslipidemia
Vickers, K. C., Shoucri, B. M., Levin, M. G., Wu, H., Pearson, D. S., Osei-Hwedieh, D. O., Collins, F. S., Remaley, A. T., & Sethupathy, P. (2012) · Hepatology · doi:10.1002/hep.25846 · Cited by 239
Ramachandran, D., Roy, U., Garg, S., Ghosh, S., Pathak, S., & Kolthur‐Seetharam, U. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08042.x · Cited by 180
Nakanishi, N., Nakagawa, Y., Tokushige, N., Aoki, N., Matsuzaka, T., Ishii, K., Yahagi, N., Kobayashi, K., Yatoh, S., Takahashi, A., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.058 · Cited by 178
miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression
Kim, J., Yoon, H., Ramírez, C. M., Lee, S.-M., Hoe, H.-S., Fernández-Hernando, C., & Kim, J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.010 · Cited by 173
Self-citationAllen, R. M., Marquart, T. J., Albert, C. J., Suchy, F. J., Wang, D. Q. ‐., Ananthanarayanan, M., Ford, D. A., & Baldán, Á. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201228 · Cited by 159
Protein kinase B: signalling roles and therapeutic targeting
Sale, E. M., & Sale, G. J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7274-9 · Cited by 148
MiR‐26 controls LXR‐dependent cholesterol efflux by targeting ABCA1 and ARL7
Sun, D., Zhang, J., Xie, J., Wei, W., Chen, M., & Zhao, X. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.068 · Cited by 138
Zile, M. R., Mehurg, S. M., Arroyo, J. E., Stroud, R. E., DeSantis, S. M., & Spinale, F. G. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.959841 · Cited by 138
Wijesekara, N., Zhang, L.-H., Kang, M. H., Abraham, T., Bhattacharjee, A., Warnock, G. L., Verchere, C. B., & Hayden, M. R. (2012) · Diabetes · doi:10.2337/db11-0944 · Cited by 130
RNA-Binding Protein HuD Controls Insulin Translation
Lee, E. K., Kim, W., Tominaga, K., Martindale, J. L., Yang, X., Subaran, S. S., Carlson, O. D., Mercken, E. M., Kulkarni, R. N., Akamatsu, W., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.016 · Cited by 108
Kojima, S., Gatfield, D., Esau, C., & Green, C. B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011264 · Cited by 93
Flagged first, then by citations
Cited by
Sorted by citations
Hammond, S. M. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.001 · Cited by 1,324
“metabolism and transport, pancreatic islet function, and glucose metabolism[179].”
BackgroundBile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
Cardiovascular consequences of metabolic syndrome
Tune, J. D., Goodwill, A. G., Sassoon, D., & Mather, K. J. (2017) · Translational research · doi:10.1016/j.trsl.2017.01.001 · Cited by 645
Vienberg, S. G., Geiger, J., Madsen, S., & Dalgaard, L. T. (2016) · Acta Physiologica · doi:10.1111/apha.12681 · Cited by 385
“…targeting miR-122 results in significant reduction in plasma cholesterol levels (Kr€utzfeldt et al. 2005, Esau et al. 2006), but the effect on cholesterol metabolism by miR-122 seems to be indirect, as the exact targets of this particular miRNA are still unclear (Fernandez-Hernando et al. 2013).”
BackgroundControlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)
Sharpe, L. J., & Brown, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.479808 · Cited by 382
Metadata
- Authors
- Fernández-Hernando, C., Ramírez, C. M., Goedeke, L., & Suárez, Y.
- Affiliations
- From the Departments of Medicine and Cell Biology, Leon H. Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY.
- New York University (US)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2013-02
- Volume
- 33
- Issue
- 2
- Pages
- 178-185
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC3740757
- OpenAlex
- W2042714431
- Cited by
- 257
- References
- 67
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 12 · 2023: 12 · 2022: 21 · 2021: 15 · 2020: 18 · 2019: 21 · 2018: 24 · 2017: 25 · 2016: 21 · 2015: 21 · 2014: 30 · 2013: 21
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL105945, R01HL106063, R01HL107953)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- microRNA, metabolic disorders, lipid homeostasis, glucose homeostasis, type 2 diabetes, atherosclerosis, miR-33, SREBP, miR-122, cholesterol biosynthesis, lipoprotein secretion, liver, cholesterol export, fatty acid degradation, miRNA-based therapy
- MeSH terms
- Animals, Gene Expression Regulation, Glucose, Homeostasis, Humans, Insulin, Metabolic Diseases, Genetic Therapy, Signal Transduction, MicroRNAs, Carbohydrate Metabolism, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
