Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization

Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E., & Hsu, C.-Y. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041031 · Cited by 11,369 · see citing works

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works

Functional interactions between the gut microbiota and host metabolism

Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk

Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works

Coronary Artery Calcium Score Combined With Framingham Score for Risk Prediction in Asymptomatic Individuals

Greenland, P. (2004) · JAMA · doi:10.1001/jama.291.2.210 · Cited by 1,825 · see citing works

Assessment of Coronary Artery Disease by Cardiac Computed Tomography

Budoff, M. J., Achenbach, S. S., Blumenthal, R. S., Carr, J. J., Goldin, J. G., Greenland, P., Guerci, A. D., Lima, J. A. C., Rader, D. J., Rubin, G. D., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.178458 · Cited by 1,391 · see citing works

Gut Microbiota-Dependent Trimethylamine <i>N</i> -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Tang, W. H. W., Wang, Z., Kennedy, D. J., Wu, Y., Buffa, J. A., Agatisa-Boyle, B., Li, X. S., Levison, B. S., & Hazen, S. L. (2015) · Circulation Research · doi:10.1161/circresaha.116.305360 · Cited by 1,223 · see citing works

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

Durham, A. L., Speer, M. Y., Scatena, M., Giachelli, C. M., & Shanahan, C. M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy010 · Cited by 1,131 · see citing works

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice

Marques, F. Z., Nelson, E., Chu, P.-Y., Horlock, D., Fiedler, A., Ziemann, M., Tan, J. K., Kuruppu, S., Rajapakse, N. W., El-Osta, A., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024545 · Cited by 1,065 · see citing works

Bone morphogenetic protein expression in human atherosclerotic lesions.

Boström, K. I., Watson, K. E., Horn, S. E. V., Wortham, C., Herman, I. M., & Demer, L. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116391 · Cited by 1,020 · see citing works

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926 · see citing works

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

Seldin, M. M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S. L., Lusis, A. J., & Shih, D. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002767 · Cited by 911 · see citing works

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

Abderrazak, A., Syrovets, T., Couchie, D., Hadri, K. E., Friguet, B., Simmet, T., & Rouis, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.008 · Cited by 737 · see citing works

Abdominal Aortic Calcific Deposits Are an Important Predictor of Vascular Morbidity and Mortality

Wilson, P. W. F., Kauppila, L. I., O’Donnell, C. J., Kiel, D. P., Hannan, M. T., Polak, J. F., & Cupples, L. A. (2001) · Circulation · doi:10.1161/01.cir.103.11.1529 · Cited by 668 · see citing works

The Clinical Epidemiology of Cardiac Disease in Chronic Renal Failure

Parfrey, P. S., & Foley, R. N. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1071606 · Cited by 652 · see citing works

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

Chen, M., Zhu, X., Ran, L., Lang, H., Yi, L., & Mi, M. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006347 · Cited by 600 · see citing works

Tumor Necrosis Factor-α Promotes In Vitro Calcification of Vascular Cells via the cAMP Pathway

Tintut, Y., Patel, J., Parhami, F., & Demer, L. L. (2000) · Circulation · doi:10.1161/01.cir.102.21.2636 · Cited by 528 · see citing works

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

Sun, X., Jiao, X., Ma, Y., Liu, Y., Zhang, L., He, Y., & Chen, Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.017 · Cited by 507 · see citing works

Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

Stubbs, J. R., House, J. A., Ocque, A. J., Zhang, S., Johnson, C., Kimber, C., Schmidt, K., Gupta, A., Wetmore, J. B., Nolin, T. D., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014111063 · Cited by 450 · see citing works

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart Failure

Organ, C. L., Otsuka, H., Bhushan, S., Wang, Z., Bradley, J., Trivedi, R., Polhemus, D. J., Tang, W. H. W., Wu, Y., Hazen, S. L., et al. (2016) · Circulation: Heart Failure · doi:10.1161/circheartfailure.115.002314 · Cited by 382 · see citing works

Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair

Tang, T. W. H., Chen, H.-C., Chen, C.-Y., Yen, C. Y. T., Lin, C.-J., Prajnamitra, R. P., Chen, L.-L., Ruan, S.-C., Lin, J.-H., Lin, P.-J., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.035235 · Cited by 348 · see citing works

Smooth Muscle Cell–Specific Runx2 Deficiency Inhibits Vascular Calcification

Sun, Y., Byon, C. H., Yuan, K., Chen, J., Mao, X., Heath, J. M., Javed, A., Zhang, K., Anderson, P. G., & Chen, Y. (2012) · Circulation Research · doi:10.1161/circresaha.112.267237 · Cited by 344 · see citing works

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease

Missailidis, C., Hällqvist, J., Qureshi, A. R., Barany, P., Heimbürger, O., Lindholm, B., Stenvinkel, P., & Bergman, P. (2016) · PLOS ONE · doi:10.1371/journal.pone.0141738 · Cited by 338 · see citing works

Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry

Wang, Z., Levison, B. S., Hazen, J. E., Donahue, L., Li, X.-M., & Hazen, S. L. (2014) · Analytical Biochemistry · doi:10.1016/j.ab.2014.03.016 · Cited by 320 · see citing works

Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis

Bain, M. A., Faull, R., Fornasini, G., Milne, R. W., & Evans, A. M. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfk056 · Cited by 282 · see citing works

NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension

Sun, H., Ren, X., Xiong, X., Chen, Y.-Z., Zhao, M., Wang, J., Zhou, Y., Han, Y., Chen, Q., Li, Y., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.470 · Cited by 244 · see citing works

Inflammation and the Osteogenic Regulation of Vascular Calcification

Shao, J.-S., Cheng, S., Sadhu, J. S., & Towler, D. A. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.134205 · Cited by 223 · see citing works

Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis

Li, Z., Wu, Z., Yan, J., Liu, H., Liu, Q., Deng, Y., Ou, C., & Chen, M. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0091-y · Cited by 218 · see citing works

Mitochondrial reactive oxygen species promote p65 nuclear translocation mediating high-phosphate-induced vascular calcification in vitro and in vivo

Zhao, M.-M., Xu, M., Cai, Y., Zhao, G., Guan, Y., Kong, W., Tang, C., & Wang, X. (2011) · Kidney International · doi:10.1038/ki.2011.18 · Cited by 216 · see citing works

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

Li, T., Chen, Y., Gua, C., & Li, X. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00350 · Cited by 216 · see citing works

Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia

Yamada, S., Tokumoto, M., Tatsumoto, N., Taniguchi, M., Noguchi, H., Nakano, T., Masutani, K., Ooboshi, H., Tsuruya, K., & Kitazono, T. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00633.2013 · Cited by 182 · see citing works

Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice

Brunt, V. E., Gioscia‐Ryan, R. A., Richey, J. J., Zigler, M. C., Cuevas, L. M., Gonzalez, A., Vázquez‐Baeza, Y., Battson, M. L., Smithson, A. T., Gilley, A. D., et al. (2019) · The Journal of Physiology · doi:10.1113/jp277336 · Cited by 182 · see citing works

Inflammatory Cytokines and Reactive Oxygen Species as Mediators of Chronic Kidney Disease-Related Vascular Calcification

Agharazii, M., St-Louis, R., Gauthier-Bastien, A., Ung, R., Mokas, S., Larivière, R., & Richard, D. E. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu225 · Cited by 180 · see citing works

Interaction between gut microbiome and cardiovascular disease

Peng, J., Xiao, X., Hu, M., & Zhang, X. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.10.063 · Cited by 175 · see citing works

Microbiota‐Dependent Metabolite Trimethylamine N‐Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)

Meyer, K. A., Benton, T. Z., Bennett, B. J., Jacobs, D. R., Lloyd‐Jones, D. M., Gross, M. D., Carr, J. J., Gordon‐Larsen, P., & Zeisel, S. H. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003970 · Cited by 167 · see citing works

Associations of Trimethylamine N-Oxide With Nutritional and Inflammatory Biomarkers and Cardiovascular Outcomes in Patients New to Dialysis

Kaysen, G. A., Johansen, K. L., Chertow, G. M., Dalrymple, L. S., Kornak, J., Grimes, B., Dwyer, T., Chassy, A. W., & Fiehn, O. (2015) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2015.02.006 · Cited by 164 · see citing works

Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression

Zhao, G., Xu, M., Zhao, M., Dai, X.-Y., Kong, W., Wilson, G. M., Guan, Y., Wang, C., & Wang, X. (2012) · Kidney International · doi:10.1038/ki.2012.40 · Cited by 160 · see citing works

Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation

Zhang, P., Tsuchiya, K., Kinoshita, T., Kushiyama, H., Suidasari, S., Hatakeyama, M., Imura, H., Katô, N., & Suda, T. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.743815 · Cited by 143 · see citing works

1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar®/Mimpara®) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism

Henley, C. M., Colloton, M., Cattley, R. C., Shatzen, E. M., Towler, D. A., Lacey, D. L., & Martin, D. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh834 · Cited by 138 · see citing works

Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production

Ceneri, N. M., Zhao, L., Young, B. D., Healy, A. L., Coşkun, S., Vasavada, H. H., Yarovinsky, T. O., Ike, K., Pardi, R., Qin, L., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308507 · Cited by 122 · see citing works

Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation

Lin, M.-E., Chen, T. M., Wallingford, M. C., Nguyen, N. B., Yamada, S., Sawangmake, C., Zhang, J., Speer, M. Y., & Giachelli, C. M. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw205 · Cited by 116 · see citing works

Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification

Wen, C., Yang, X., Yan, Z., Zhao, M., Yue, X., Cheng, X., Zheng, Z., Guan, K., Dou, J., Xu, T., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.01.211 · Cited by 110 · see citing works

Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study

Mafune, A., Iwamoto, T., Tsutsumi, Y., Nakashima, A., Yamamoto, I., Yokoyama, K., Yokoo, T., & Urashima, M. (2016) · Clinical and Experimental Nephrology · doi:10.1007/s10157-015-1207-y · Cited by 103 · see citing works

TLR4/NF-κB/Ceramide signaling contributes to Ox-LDL-induced calcification of human vascular smooth muscle cells

Song, Y., Hou, M., Li, Z., Luo, C., Ou, J., Yu, H., Yan, J., & Lu, L. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.11.029 · Cited by 99 · see citing works

Cell-specific effects of TNF-α and IL-1β on alkaline phosphatase: implication for syndesmophyte formation and vascular calcification

Lencel, P., Delplace, S., Pilet, P., Leterme, D., Miellot, F., Sourice, S., Caudrillier, A., Hardouin, P., Guicheux, J., & Magne, D. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.83 · Cited by 86 · see citing works

Intermedin1–53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of α-Klotho

Chang, J. R., Guo, J. F., Wang, Y., Hou, Y., Lu, W., Zhang, J. S., Yu, Y. R., Xu, M. J., Liu, X., Wang, X. J., et al. (2016) · Kidney International · doi:10.1016/j.kint.2015.12.029 · Cited by 80 · see citing works

Decorin GAG Synthesis and TGF-β Signaling Mediate Ox-LDL–Induced Mineralization of Human Vascular Smooth Muscle Cells

Yan, J., Stringer, S. E., Hamilton, A., Charlton-Menys, V., Götting, C., Muller, B. Z., Aeschlimann, D. P., & Alexander, M. Y. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.220749 · Cited by 79 · see citing works

Targeted Reduction of Vascular <i>Msx1</i> and <i>Msx2</i> Mitigates Arteriosclerotic Calcification and Aortic Stiffness in <i>LDLR</i>-Deficient Mice Fed Diabetogenic Diets

Cheng, S.-L., Behrmann, A., Shao, J.-S., Ramachandran, B., Krchma, K., Bello Arredondo, Y., Kovacs, A., Mead, M., Maxson, R., & Towler, D. A. (2014) · Diabetes · doi:10.2337/db14-0326 · Cited by 77 · see citing works

Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation

Benz, K., Hilgers, K., Daniel, C., & Amann, K. (2018) · International Journal of Nephrology · doi:10.1155/2018/4310379 · Cited by 73 · see citing works

Prevention of aortic calcification by etidronate in the renal failure rat model

Tamura, K., Suzuki, Y., Matsushita, M., Fujii, H., Miyaura, C., Aizawa, S., & Kogo, H. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.12.006 · Cited by 55 · see citing works

CDC42 promotes vascular calcification in chronic kidney disease

Li, Z., Ji, W., Zhang, X., Ou, C., Zhong, X., Chen, Y., Lu, L., Liu, H., Li, Y., Liu, X., et al. (2019) · The Journal of Pathology · doi:10.1002/path.5334 · Cited by 53 · see citing works

Inhibition of Vascular Calcification

Liu, L., Zeng, P., Yang, X., Duan, Y., Zhang, W., Ma, C., Zhang, X., Yang, S., Li, X., Yang, J. A., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311546 · Cited by 52 · see citing works

Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia

Awan, Z. A., Denis, M., Roubtsova, A., Essalmani, R., Marcinkiewicz, J., Awan, A., Gram, H., Seidah, N. G., & Genest, J. J. (2015) · Angiology · doi:10.1177/0003319715583205 · Cited by 51 · see citing works

AT2 receptor stimulation inhibits phosphate-induced vascular calcification

Kukida, M., Mogi, M., Kan‐no, H., Tsukuda, K., Bai, H., Shan, B., Yamauchi, T., Higaki, A., Min, L., Iwanami, J., et al. (2018) · Kidney International · doi:10.1016/j.kint.2018.07.028 · Cited by 45 · see citing works

Curcumin attenuates osteogenic differentiation and calcification of rat vascular smooth muscle cells

Hou, M., Song, Y., Li, Z., Luo, C., Ou, J., Yu, H., Yan, J., & Lu, L. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2778-y · Cited by 42 · see citing works

Hyaluronan negatively regulates vascular calcification involving BMP2 signaling

Kong, Y., Liang, Q., Chen, Y., Yang, P., Liu, X., Li, Y., Feng, S., Ji, W., Liu, W., Tang, J., et al. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0076-x · Cited by 38 · see citing works

Interleukin-1β Is a Key Biomarker and Mediator of Inflammatory Vascular Calcification

Shobeiri, N., & Bendeck, M. P. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308724 · Cited by 30 · see citing works

Gut Microbiota in Vascular Disease: Therapeutic Target?

Anbazhagan, A. N., Priyamvada, S., & Priyadarshini, M. (2017) · Current Vascular Pharmacology · doi:10.2174/1570161115666170105095834 · Cited by 23 · see citing works

Gut microbiota and cardiovascular disease.

Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051 · see citing works

Gut-liver axis: Pathophysiological concepts and clinical implications

Tilg, H., Adolph, T. E., & Trauner, M. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.017 · Cited by 843 · see citing works

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

Targher, G., Byrne, C. D., & Tilg, H. (2020) · Gut · doi:10.1136/gutjnl-2020-320622 · Cited by 848 · see citing works

Vascular Calcification—New Insights into Its Mechanism

Lee, S., Lee, I. K., & Jeon, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082685 · Cited by 451 · see citing works

Role of the gut microbiota in type 2 diabetes and related diseases

Yang, G., Wei, J., Liu, P., Zhang, Q., Tian, Y., Hou, G., Meng, L., Xin, Y., & Jiang, X. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154712 · Cited by 418 · see citing works

Uremic Toxins in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Mechanisms and Therapeutic Targets

Lim, Y. J., Sidor, N. A., Tonial, N. C., Che, A., & Urquhart, B. L. (2021) · Toxins · doi:10.3390/toxins13020142 · Cited by 381 · see citing works

Repression of the antiporter SLC7A11/glutathione/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification

Ye, Y., Chen, A., Li, L., Liang, Q., Wang, S., Dong, Q., Fu, M., Lan, Z., Li, Y., Liu, X., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.07.034 · Cited by 358 · see citing works

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Jiang, S., Shui, Y., Cui, Y., Tang, C., Wang, X., Qiu, X., Hu, W., Fei, L., Li, Y., Zhang, S., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102115 · Cited by 237 · see citing works

Programmed cell death in atherosclerosis and vascular calcification

Li, M., Wang, Z., Fang, L., Cheng, S.-Q., Wang, X., & Liu, N. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04923-5 · Cited by 229 · see citing works

Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases

Sandireddy, R., Sakthivel, S., Gupta, P., Behari, J., Tripathi, M., & Singh, B. K. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1433857 · Cited by 229 · see citing works

Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease

Pang, Q., Wang, P., Pan, Y., Dong, X., Zhou, T., Song, X., & Zhang, A. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04735-7 · Cited by 159 · see citing works

Gut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis

Li, X., Shan, Q., Wu, X., Miao, H., & Zhao, Y. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05532-5 · Cited by 157 · see citing works

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

Saaoud, F., Liu, L., Xu, K., Cueto, R., Shao, Y., Lu, Y., Sun, Y., Snyder, N. W., Wu, S., Yang, L., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158183 · Cited by 153 · see citing works

Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling

Yan, J., Pan, Y., Shao, W., Wang, C., Wang, R., He, Y., Zhang, M., Wang, Y., Li, T., Wang, Z., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01390-0 · Cited by 148 · see citing works

Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis

Gong, B., Wang, C., Meng, F., Wang, H., Song, B., Yang, Y., & Shan, Z. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.774362 · Cited by 121 · see citing works

Trimethylamine N-Oxide Exacerbates Renal Inflammation and Fibrosis in Rats With Diabetic Kidney Disease

Fang, Q., Zheng, B., Liu, N., Liu, J., Liu, W., Huang, X., Zeng, X., Chen, L., Li, Z., & Ouyang, D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.682482 · Cited by 116 · see citing works

Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis

Witkowski, M., Witkowski, M., Friebel, J., Buffa, J. A., Li, X. S., Wang, Z., Sangwan, N., Li, L., DiDonato, J. A., Tizian, C., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab263 · Cited by 116 · see citing works

Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development

Simó, C., & García‐Cañas, V. (2020) · Food & Function · doi:10.1039/d0fo01237h · Cited by 110 · see citing works

Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway

Liu, X., Chen, A., Liang, Q., Yang, X., Dong, Q., Fu, M., Wang, S., Li, Y., Ye, Y., Lan, Z., et al. (2021) · Aging Cell · doi:10.1111/acel.13377 · Cited by 104 · see citing works

Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy

Wang, B., Qiu, J., Lian, J., Yang, X., & Zhou, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.723886 · Cited by 108 · see citing works

Biomimetic Grapefruit-Derived Extracellular Vesicles for Safe and Targeted Delivery of Sodium Thiosulfate against Vascular Calcification

Feng, W., Teng, Y., Zhong, Q., Zhang, Y., Zhang, J., Zhao, P., Chen, G., Wang, C., Liang, X., & Ou, C. (2023) · ACS Nano · doi:10.1021/acsnano.3c05261 · Cited by 99 · see citing works

TMAO as a potential biomarker and therapeutic target for chronic kidney disease: A review

Ye, Z., Lulu, C., Xiangchang, Z., Fang, Q., Binjie, Z., Chunyang, L., Rao, T., & Dongsheng, O. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.929262 · Cited by 90 · see citing works

Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention

Benincasa, G., Coscioni, E., & Claudio Napoli, A. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115108 · Cited by 83 · see citing works

Inflammation: a putative link between phosphate metabolism and cardiovascular disease

Voelkl, J. G. J., Egli-Spichtig, D., Alesutan, I., & Wagner, C. A. (2021) · Clinical Science · doi:10.1042/cs20190895 · Cited by 83 · see citing works

Gut Microbial Metabolite Trimethylamine N -Oxide Aggravates Pulmonary Hypertension

Huang, Y., Lin, F., Tang, R., Bao, C., Zhou, Q., Ye, K., Shen, Y., Liu, C., Hong, C., Yang, K., et al. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0414oc · Cited by 82 · see citing works

Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study

Wang, M., Wang, Z., Lee, Y., Lai, H. T. M., Otto, M. C. D. O., Lemaître, R. N., Fretts, A. M., Sotoodehnia, N., Budoff, M. J., DiDonato, J. A., et al. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316533 · Cited by 81 · see citing works

Trimethylamine N-oxide is associated with long-term mortality risk: the multi-ethnic study of atherosclerosis

Wang, M., Li, X. S., Wang, Z., Otto, M. C. D. O., Lemaître, R. N., Fretts, A. M., Sotoodehnia, N., Budoff, M. J., Nemet, I., DiDonato, J. A., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad089 · Cited by 80 · see citing works

The roles of trimethylamine-N-oxide in atherosclerosis and its potential therapeutic aspect: A literature review

Oktaviono, Y. H., Lamara, A. D., Saputra, P. B. T., Arnindita, J. N., Pasahari, D., Saputra, M. E., & Suasti, N. M. A. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2023.8893 · Cited by 87 · see citing works

Indoleamine 2,3-Dioxygenase 1 Deletion–Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification

Ouyang, L., Yu, C., Xie, Z., Su, X., Xu, Z., Song, P., Li, J., Huang, H., Ye, D., & Zou, M. (2022) · Circulation · doi:10.1161/circulationaha.121.057868 · Cited by 75 · see citing works

Inflammation and gut dysbiosis as drivers of CKD–MBD

Evenepoel, P., Stenvinkel, P., Shanahan, C. M., & Pacifici, R. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00736-7 · Cited by 78 · see citing works

Trimethylamine N -oxide: heart of the microbiota–CVD nexus?

Naghipour, S., Cox, A. J., Peart, J. N., Toit, E. F. D., & Headrick, J. P. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422420000177 · Cited by 75 · see citing works

Role of the Microbiome in Gut-Heart-Kidney Cross Talk

Glorieux, G., Nigám, S. K., Vanholder, R. C., & Verbeke, F. (2023) · Circulation Research · doi:10.1161/circresaha.123.321763 · Cited by 75 · see citing works

TMAO Promotes NLRP3 Inflammasome Activation of Microglia Aggravating Neurological Injury in Ischemic Stroke Through FTO/IGF2BP2

Ge, P., Duan, H., Tao, C., Niu, S., Hu, Y., Duan, R., Shen, A., Sun, Y., & Sun, W. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s399480 · Cited by 74 · see citing works

Roles of Gut Microbial Metabolites in Diabetic Kidney Disease

Fang, Q., Liu, N., Zheng, B., Guo, F., Zeng, X., Huang, X., & Ouyang, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.636175 · Cited by 69 · see citing works

The Role of NLRP3 Inflammasome Activities in Bone Diseases and Vascular Calcification

Yu, C., Zhang, C., Kuang, Z., & Zheng, Q. (2020) · Inflammation · doi:10.1007/s10753-020-01357-z · Cited by 67 · see citing works

Uremic Toxins and Cardiovascular Risk in Chronic Kidney Disease: What Have We Learned Recently beyond the Past Findings?

Chamieh, C. E., Liabeuf, S., & Massy, Z. A. (2022) · Toxins · doi:10.3390/toxins14040280 · Cited by 69 · see citing works

Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite

Querio, G., Antoniotti, S., Geddo, F., Levi, R. C., & Gallo, M. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065806 · Cited by 70 · see citing works

Interactions between gut microbes and NLRP3 inflammasome in the gut-brain axis

Ding, Y., Wang, Z., Chen, Y., Guo, Q., & Dong, Y. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.03.017 · Cited by 65 · see citing works

Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease

Yang, X., Chen, A., Liang, Q., Dong, Q., Fu, M., Liu, X., Wang, S., Li, Y., Ye, Y., Lan, Z., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.020 · Cited by 63 · see citing works

Trimethylamine-N-Oxide Promotes Osteoclast Differentiation and Bone Loss via Activating ROS-Dependent NF-κB Signaling Pathway

Wang, N., Hao, Y., & Fu, L. (2022) · Nutrients · doi:10.3390/nu14193955 · Cited by 64 · see citing works

Vascular Calcification in Chronic Kidney Disease: An Update and Perspective

Ren, S., Mao, N., Si, Y., Ma, X., Zou, J., Tang, X., & Fan, J. (2022) · Aging and Disease · doi:10.14336/ad.2021.1024 · Cited by 60 · see citing works

The short-chain fatty acid butyrate accelerates vascular calcification via regulation of histone deacetylases and NF-κB signaling

Zhong, H., Yu, H., Chen, J., Mok, S. W. F., Tan, X., Zhao, B., He, S., Lan, L., Fu, X., Chen, G., et al. (2022) · Vascular Pharmacology · doi:10.1016/j.vph.2022.107096 · Cited by 58 · see citing works

Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway

Hao, Q.-Y., Yan, J., Wei, J., Zeng, Y.-H., Feng, L., Que, D., Li, S.-C., Guo, J., Fan, Y., Ding, Y.-F., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2351532 · Cited by 57 · see citing works

Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD

Li, X., Hong, J. W., Wang, Y., Pei, M., Wang, L., & Gong, Z. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.733507 · Cited by 58 · see citing works

Gut microbiome and its meta-omics perspectives: profound implications for cardiovascular diseases

Xu, J., & Yang, Y. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1936379 · Cited by 56 · see citing works

Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification

Lan, Z., Chen, A., Li, L., Ye, Y., Liang, Q., Dong, Q., Wang, S., Fu, M., Li, Y., Liu, X., et al. (2022) · The Journal of Pathology · doi:10.1002/path.5992 · Cited by 54 · see citing works

Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease

Rodrigues, F. G., Ormanji, M. S., Heilberg, I. P., Bakker, S. J. L., & de Borst, M. H. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13588 · Cited by 50 · see citing works

The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis

Wang, Z., Hazen, J. E., Jia, X., Org, E., Zhao, Y., Osborn, L. J., Nimer, N. A., Buffa, J. A., Culley, M. K., Krajcik, D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413477 · Cited by 52 · see citing works

Gut microbial metabolism in Alzheimer's disease and related dementias

Kang, J. W., Vemuganti, V., Kuehn, J. F., Ulland, T. K., Rey, F. E., & Bendlin, B. B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00470 · Cited by 49 · see citing works

Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1α (Hypoxic-Inducible Factor-1 Alpha)

Luo, D., Li, W., Xie, C., Yin, L., Su, X., Chen, J., & Huang, H. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18778 · Cited by 46 · see citing works

Role of gut microbiota‐derived metabolites on vascular calcification in CKD

Yin, L., Li, X.-X., Ghosh, S., Xie, C., Chen, J., & Huang, H. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16230 · Cited by 46 · see citing works

Regulated vascular smooth muscle cell death in vascular diseases

Yin, Z., Zhang, J., Shen, Z., Qin, J., Wan, J., & Wang, M. (2024) · Cell Proliferation · doi:10.1111/cpr.13688 · Cited by 45 · see citing works

Cardiovascular Consequences of Uremic Metabolites: an Overview of the Involved Signaling Pathways

Curaj, A., Vanholder, R. C., Loscalzo, J., Quach, K., Wu, Z., Jankowski, V., & Jankowski, J. (2024) · Circulation Research · doi:10.1161/circresaha.123.324001 · Cited by 46 · see citing works

Intestinal microbiota regulates the gut-thyroid axis: the new dawn of improving Hashimoto thyroiditis

Zhu, X., Zhang, C., Feng, S., He, R., & Zhang, S. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01304-4 · Cited by 46 · see citing works

Contribution of Gut Microbiota-Derived Uremic Toxins to the Cardiovascular System Mineralization

Filipska, I., Winiarska, A., Knysak, M., & Stompór, T. P. (2021) · Toxins · doi:10.3390/toxins13040274 · Cited by 42 · see citing works

Microbiota metabolites in bone: Shaping health and Confronting disease

Han, D., Wang, W., Gong, J., Ma, Y.-P., & Li, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28435 · Cited by 46 · see citing works

Trimethylamine N-oxide reduction is related to probiotic strain specificity: A systematic review

Cantero, M. A., Guedes, M. R. A., Fernandes, R., & Lollo, P. C. B. (2022) · Nutrition Research · doi:10.1016/j.nutres.2022.04.001 · Cited by 41 · see citing works

Gut-brain axis: Mechanisms and potential therapeutic strategies for ischemic stroke through immune functions

Zhou, S., Guo, Z., Yang, Y., Qu, Y., & Jin, H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1081347 · Cited by 42 · see citing works

Interactions between the gut microbiota and immune cell dynamics: novel insights into the gut-bone axis

You, Y., Xiang, T., Yang, C. H., Xiao, S., Tang, Y., Luo, G., Ling, Z., Luo, F., & Chen, Y. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2545417 · Cited by 43 · see citing works

Phosphate, Microbiota and CKD

Favero, C., Carriazo, S. M., Cuarental, L., Fernández-Prado, R., Gomá-Garcés, E., Pérez-Gómez, M. V., Ortíz, A., Fernández‐Fernández, B., & Sánchez-Niño, M. D. (2021) · Nutrients · doi:10.3390/nu13041273 · Cited by 41 · see citing works

Lipoprotein (a)-mediated vascular calcification: population-based and in vitro studies

Peng, J., Liu, M., Liu, H., Xu, R., Zhu, C., Guo, Y., Wu, N., Dong, Q., Cui, C.-J., & Li, J. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154960 · Cited by 38 · see citing works

Insights into bone morphogenetic proteins in cardiovascular diseases

Ye, D., Liu, Y., Pan, H., Feng, Y., Lu, X., Gan, L., Wan, J., & Ye, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1125642 · Cited by 37 · see citing works

Endoplasmic Reticulum Stress and Pathogenesis of Vascular Calcification

Rao, Z., Zheng, Y., Xu, L., Wang, Z., Zhou, Y., Chen, M., Dong, N., Cai, Z., & Li, F. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.918056 · Cited by 36 · see citing works

Role of Uremic Toxins in Vascular Inflammation Associated with Chronic Kidney Disease

Chermiti, R., Burtey, S., & Dou, L. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13237149 · Cited by 36 · see citing works

Acute Myocardial Infarction: Molecular Pathogenesis, Diagnosis, and Clinical Management

Zhu, M., Li, Y., Xu, Q., Wang, W., Liu, Y., & Liu, Y. (2025) · MedComm · doi:10.1002/mco2.70418 · Cited by 40 · see citing works

Sugar Fructose Triggers Gut Dysbiosis and Metabolic Inflammation with Cardiac Arrhythmogenesis

Cheng, W., Li, S., Lee, T.-I., Lee, T., Chung, C., Kao, Y., & Chen, Y. (2021) · Biomedicines · doi:10.3390/biomedicines9070728 · Cited by 38 · see citing works

Bibliometric and Visual Analysis of Vascular Calcification Research

Dong, Q., Liang, Q., Chen, Y., Li, J., Lu, L., Huang, X., & Zhou, Q. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.690392 · Cited by 35 · see citing works

Bone Homeostasis and Gut Microbial-Dependent Signaling Pathways

Zhong, X., Zhang, F., Yin, X., Cao, H., Wang, X., Liu, D., Chen, J., & Chen, X. (2021) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2104.04016 · Cited by 34 · see citing works

Role of gut microbiota in doxorubicin-induced cardiotoxicity: from pathogenesis to related interventions

Huang, C., Li, X., Li, H., Chen, R., Li, Z., Li, D., Xu, X., Zhang, G., Qin, L., Li, B., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05232-5 · Cited by 35 · see citing works

Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease: current knowledge and new insights

Song, Y., Wei, H., Zhou, Z., Wang, H., Hang, W., Wu, J., & Wang, D. W. (2024) · Frontiers of Medicine · doi:10.1007/s11684-024-1055-9 · Cited by 32 · see citing works

Uremic Vascular Calcification: The Pathogenic Roles and Gastrointestinal Decontamination of Uremic Toxins

Chao, C., & Lin, S. (2020) · Toxins · doi:10.3390/toxins12120812 · Cited by 31 · see citing works

The gut-cardiovascular connection: new era for cardiovascular therapy

Cheng, C. K., & Huang, Y. (2021) · Medical Review · doi:10.1515/mr-2021-0002 · Cited by 31 · see citing works

Association Between Trimethylamine N-Oxide and Prognosis of Patients with Acute Myocardial Infarction and Heart Failure

Li, N., Zhou, J., Wang, Y., Chen, R., Li, J., Zhao, X., Zhou, P., Liu, C., Song, L., Liao, Z., et al. (2022) · ESC Heart Failure · doi:10.1002/ehf2.14009 · Cited by 32 · see citing works

Gut microbiota and atherosclerosis

Fusco, W. G., Adolph, T. E., Cammarota, G., Gasbarrini, A., Ianiro, G., & Tilg, H. (2025) · Gut · doi:10.1136/gutjnl-2025-335610 · Cited by 35 · see citing works

25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress

Dong, Q., Chen, Y., Liu, W., Liu, X., Chen, A., Yang, X., Li, Y., Wang, S., Fu, M., Ou, J., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173165 · Cited by 30 · see citing works

Increased circulating phenylacetylglutamine concentration elevates the predictive value of cardiovascular event risk in heart failure patients

Wei, H., Wu, J., Wang, H., Huang, J., Li, C., Zhang, Y., Song, Y., Zhou, Z., Sun, Y., Xiao, L., et al. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13653 · Cited by 30 · see citing works

Dendrobium officinale polysaccharide inhibits vascular calcification via anti‐inflammatory and anti‐apoptotic effects in chronic kidney disease

Jiang, W., Ruan, W., & Wang, Z. (2022) · The FASEB Journal · doi:10.1096/fj.202200353rrr · Cited by 29 · see citing works

Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears

Ebert, T., Painer, J., Bergman, P., Qureshi, A., Giroud, S., Stalder, G., Kublickiene, K., Göritz, F., Vetter, S. G., Bieber, C., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76346-1 · Cited by 24 · see citing works

Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair

Wang, S., Li, L., Liang, Q., Ye, Y., Lan, Z., Dong, Q., Chen, A., Fu, M., Li, Y., Liu, X., et al. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.10.009 · Cited by 27 · see citing works

Hydrogen sulfide attenuates TMAO‑induced macrophage inflammation through increased SIRT1 sulfhydration

Liu, M., Lin, X., & Xiao, L. (2023) · Molecular Medicine Reports · doi:10.3892/mmr.2023.13016 · Cited by 27 · see citing works

Trimethylamine N-Oxide Promotes Abdominal Aortic Aneurysm Formation by Aggravating Aortic Smooth Muscle Cell Senescence in Mice

Hu, J., Xu, J., Shen, S., Zhang, W., Chen, H., Sun, X., Qi, Y., Zhang, Y., Zhang, Q., Guo, M., et al. (2022) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-022-10211-6 · Cited by 27 · see citing works

Vascular calcification: from the perspective of crosstalk

Yang, S., Zeng, Z., Yuan, Q., Chen, Q., Zuo, W., Xie, H., & Liu, J. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00146-y · Cited by 26 · see citing works

Oxidized phospholipid POVPC contributes to vascular calcification by triggering ferroptosis of vascular smooth muscle cells

Lu, L., Ye, Y., Chen, Y., Feng, L., Huang, J., Liang, Q., Lan, Z., Dong, Q., Liu, X., Li, Y., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202302570r · Cited by 26 · see citing works

From heart failure and kidney dysfunction to cardiorenal syndrome: TMAO may be a bridge

Zhang, J., Zhu, P., Li, S., Gao, Y., & Xing, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1291922 · Cited by 26 · see citing works

The role of the gut microbiome and its metabolites in cerebrovascular diseases

Xu, H., Xu, Z., Long, S., Li, Z., Jiang, J., Zhou, Q., Huang, X., Wu, X., Wei, W., & Li, X. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1097148 · Cited by 26 · see citing works

Trimethylamine N-Oxide (TMAO) Inducing Endothelial Injury: UPLC-MS/MS-Based Quantification and the Activation of Cathepsin B-Mediated NLRP3 Inflammasome

Lei, D., Yu, W., Liu, Y. F., Jiang, Y., Li, X., Lv, J., & Li, Y. (2023) · Molecules · doi:10.3390/molecules28093817 · Cited by 24 · see citing works

Therapeutic Modulation of Gut Microbiome in Cardiovascular Disease: A Literature Review

Suresh, M. G., Mohamed, S., Yukselen, Z., Hatwal, J., Venkatakrishnan, A., Metri, A. A., Bhardwaj, A., Singh, A., Bush, N., & Batta, A. (2024) · Heart and Mind · doi:10.4103/hm.hm-d-24-00044 · Cited by 26 · see citing works

Ecklonia cava extracts decrease hypertension-related vascular calcification by modulating PGC-1α and SOD2

Byun, K.-A., Oh, S., Yang, J. Y., Lee, S., Son, K. H., & Byun, K. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113283 · Cited by 24 · see citing works

Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles

Lu, W., Yan, J., Wang, C., Qin, W., Han, X., Qin, Z., Wei, Y., Xu, H., Gao, J., Gao, C., et al. (2024) · Bone Research · doi:10.1038/s41413-023-00310-8 · Cited by 23 · see citing works

Elevated serum trimethylamine oxide levels as potential biomarker for diabetic kidney disease

Huang, Y., Zhu, Z., Huang, Z., & Zhou, J. (2023) · Endocrine Connections · doi:10.1530/ec-22-0542 · Cited by 24 · see citing works

The microbial metabolite trimethylamine N-oxide and the kidney diseases

Su, J. Q., Wu, X., Wang, Q., Xie, B.-Y., Xiao, C.-Y., Su, H.-Y., Tang, J., & Yao, C. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1488264 · Cited by 25 · see citing works

Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling

Feng, L., Que, D., Li, Z., Zhong, X., Yan, J., Wei, J., Zhang, X., Yang, P., Ou, C., & Chen, M. (2021) · Clinical Science · doi:10.1042/cs20210259 · Cited by 22 · see citing works

Uremic Toxins and Vascular Calcification–Missing the Forest for All the Trees

Rapp, N., Evenepoel, P., Stenvinkel, P., & Schurgers, L. J. (2020) · Toxins · doi:10.3390/toxins12100624 · Cited by 22 · see citing works

Multi-metabolomics and intestine microbiome analysis: YZC extract ameliorates septic-ALI by modulating intestine microbiota to reduce TMAO/NLRP3 signaling

Cao, X., Zhao, M., Wang, X., Lin, J., Yang, M., Zhong, L., Liang, L., Yue, Y., Du, J., Li, J., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155345 · Cited by 21 · see citing works

Trimethylamine-N-oxide accelerates osteoporosis by PERK activation of ATF5 unfolding

Lin, Y.-H., Lian, W., Wu, R., Chen, Y., Wu, S.-L., Ko, J., Wang, S., Jahr, H., & Wang, F. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05501-y · Cited by 21 · see citing works

The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of the TET2/NLRP3 inflammasome signaling pathway

Fu, M., Lan, Z., Ye, Y., Gong, Y., Liang, Q., Li, M., Feng, L., Chen, A., Dong, Q., Li, Y., et al. (2025) · Kidney International · doi:10.1016/j.kint.2025.04.016 · Cited by 21 · see citing works

Serum Trimethylamine N-Oxide Level Is Associated with Peripheral Arterial Stiffness in Advanced Non-Dialysis Chronic Kidney Disease Patients

Hsu, B., Wang, C., Lin, Y., Lai, Y.-H., & Tsai, J. (2022) · Toxins · doi:10.3390/toxins14080526 · Cited by 21 · see citing works

Insights into the intestinal toxicity of foodborne mycotoxins through gut microbiota: A comprehensive review

Ruan, H., Huang, Y., Yue, B., Zhang, Y., Lv, J., Miao, K., Zhang, D., Luo, J., & Yang, M. (2023) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13242 · Cited by 23 · see citing works

Biomolecular Actions by Intestinal Endotoxemia in Metabolic Syndrome

Charitos, I. A., Aliani, M., Tondo, P., Venneri, M. G., Castellana, G., Scioscia, G., Castellaneta, F., Lacedonia, D., & Carone, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052841 · Cited by 21 · see citing works

The role of gut-dependent molecule trimethylamine N-oxide as a novel target for the treatment of chronic kidney disease

Pan, S., Zhao, D., Duan, S., & Chen, X. (2023) · International Urology and Nephrology · doi:10.1007/s11255-023-03500-9 · Cited by 20 · see citing works

Oral supplementation of TMAO Promotes Vascular Calcification in db/db Mice by Regulating the SIRT1/NF-κB p65/NLRP3 Signaling Axis and the Intestinal Microbiota

Huang, L., Wu, W., He, T., Chen, K., Wang, J., Xie, S., Li, H., Yao, Y., 谭周进, & Wang, X. (2026) · Food Science and Human Wellness · doi:10.26599/fshw.2026.9251123

Correlation between serum trimethylamine oxide and vascular calcification in patients with chronic kidney disease

Gao, P.-R., Cui, C.-X., Wu, X.-P., & Chen, W.-D. (2024) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.3969/j.issn.1671-2390.2024.08.004

Research progress on the association between TMAO and vascular calcification in patients with chronic kidney disease

Zhang, Y., Huang, L., & Ou, S. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2435485 · Cited by 6 · see citing works

Nitric oxide regulates vascular calcification by interfering with TGF-b signalling

Kanno, Y., Into, T., Lowenstein, C. J., & Matsushita, K. (2015)

The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of the TET2/NLRP3 inflammasome signaling pathway

Fu, M., Lan, Z., Ye, Y., Gong, Y., Liang, Q., Li, M., Feng, L., Chen, A., Dong, Q., Li, Y., et al. (2025) · Kidney International · doi:10.1016/j.kint.2025.04.016 · Cited by 21 · see citing works