Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice
Open accessAbstract
Key points: Age‐related arterial dysfunction, characterized by oxidative stress‐ and inflammation‐mediated endothelial dysfunction and arterial stiffening, is the primary risk factor for cardiovascular diseases. To investigate whether age‐related changes in the gut microbiome may mediate arterial dysfunction, we suppressed gut microbiota in young and old mice with a cocktail of broad‐spectrum, poorly‐absorbed antibiotics in drinking water for 3–4 weeks. In old mice, antibiotic treatment reversed endothelial dysfunction and arterial stiffening and attenuated vascular oxidative stress and inflammation. To provide insight into age‐related changes in gut microbiota that may underlie these observations, we show that ageing altered the abundance of microbial taxa associated with gut dysbiosis and increased plasma levels of the adverse gut‐derived metabolite trimethylamine N ‐oxide. The results of the present study provide the first proof‐of‐concept evidence that the gut microbiome is an important mediator of age‐related arterial dysfunction and therefore may be a promising therapeutic target for preserving arterial function with ageing, thereby reducing the risk of cardiovascular diseases. Oxidative stress‐mediated arterial dysfunction (e.g. endothelial dysfunction and large elastic artery stiffening) is the primary mechanism driving age‐related cardiovascular diseases. Accumulating evidence suggests the gut microbiome modulates host physiology because dysregulation (‘gut dysbiosis’) has systemic consequences, including promotion of oxidative stress. The present study aimed to determine whether the gut microbiome modulates arterial function with ageing. We measured arterial function in young and older mice after 3–4 weeks of treatment with broad‐spectrum, poorly‐absorbed antibiotics to suppress the gut microbiome. To identify potential mechanistic links between the gut microbiome and age‐related arterial dysfunction, we sequenced microbiota from young and older mice and measured plasma levels of the adverse gut‐derived metabolite trimethylamine N ‐oxide (TMAO). In old mice, antibiotics reversed endothelial dysfunction [area‐under‐the‐curve carotid artery dilatation to acetylcholine in young: 345 ± 16 AU vs . old control (OC): 220 ± 34 AU, P < 0.01; vs . old antibiotic‐treated (OA): 334 ± 15 AU; P < 0.01 vs . OC] and arterial stiffening (aortic pulse wave velocity in young: 3.62 ± 0.15 m s −1 vs . OC: 4.43 ± 0.38 m s −1 ; vs . OA: 3.52 ± 0.35 m s −1 ; P = 0.03). These improvements were accompanied by lower oxidative stress and greater antioxidant enzyme expression. Ageing altered the abundance of gut microbial taxa associated with gut dysbiosis. Lastly, plasma TMAO was higher with ageing (young: 2.6 ± 0.4 μmol L −1 vs . OC: 7.2 ± 2.0 μmol L −1 ; P < 0.0001) and suppressed by antibiotic treatment (OA: 1.2 ± 0.2 μmol L −1 ; P < 0.0001 vs . OC). The results of the present study provide the first evidence for the gut microbiome being an important mediator of age‐related arterial dysfunction and oxidative stress and suggest that therapeutic strategies targeting gut microbiome health may hold promise for preserving arterial function and reducing cardiovascular risk with ageing in humans.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Suppression of the gut microbiome using broad-spectrum antibiotics restored arterial function in old mice (20-24 months old) to levels observed in young animals (8-10 weeks old), coupled with normalization of oxidative stress and inflammation.
“suppression of the gut microbiome using broad-spectrum antibiotics restored arterial function in old mice (20-24 months old) to levels observed in young animals (8-10 weeks old), which was coupled with normalization of both oxidative stress and inflammation”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Brunt et al., 2019
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredIn animal models, gut microbiota suppression with oral poorly absorbed antibiotics is associated with decreased TMAO levels, improved endothelial function, reduced arterial stiffness, and lower oxidative stress.
“In other animal model studies, gut microbiota suppression with oral poorly absorbed antibiotics was associated with decreased TMAO levels, improved endothelial function, reduced arterial stiffness, and lower oxidative stress129.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [129]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
DADA2: High–resolution sample inference from Illumina amplicon data
Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016) · Nature Methods · doi:10.1038/nmeth.3869 · Cited by 35,698 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Self-citationHeart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
VSEARCH: a versatile open source tool for metagenomics
(2016) · doi:10.7717/peerj.2584 · Cited by 10,773 · see citing works
Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample
Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Lozupone, C., Turnbaugh, P. J., Fierer, N., & Knight, R. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000080107 · Cited by 9,633 · see citing works
Self-citationUniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227 · see citing works
Self-citationConservation evaluation and phylogenetic diversity
Faith, D. (1992) · Biological Conservation · doi:10.1016/0006-3207(92)91201-3 · Cited by 5,495 · see citing works
Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing
Bokulich, N. A., Subramanian, S., Faith, J. J., Gevers, D., Gordon, J. I., Knight, R. D., Mills, D. A., & Caporaso, J. G. (2012) · Nature Methods · doi:10.1038/nmeth.2276 · Cited by 4,406 · see citing works
Self-citationIntestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710 · see citing works
Self-citationIntestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244 · see citing works
Analysis of composition of microbiomes: a novel method for studying microbial composition
Mandal, S., Van Treuren, W., White, R. A., Eggesbø, M., Knight, R., & Peddada, S. D. (2015) · Microbial Ecology in Health & Disease · doi:10.3402/mehd.v26.27663 · Cited by 1,942 · see citing works
Self-citationDeblur Rapidly Resolves Single-Nucleotide Community Sequence Patterns
Amir, A., McDonald, D., Navas-Molina, J. A., Kopylova, E., Morton, J. T., Zech Xu, Z., Kightley, E. P., Thompson, L. R., Hyde, E. R., Gonzalez, A., et al. (2017) · mSystems · doi:10.1128/msystems.00191-16 · Cited by 1,881 · see citing works
Self-citationMechanisms, Pathophysiology, and Therapy of Arterial Stiffness
Zieman, S. J., Melenovsky, V., & Kass, D. A. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000160548.78317.29 · Cited by 1,854 · see citing works
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755 · see citing works
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754 · see citing works
Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322 · see citing works
Wang, Z., Roberts, A. B., Buffa, J. A., Levison, B. S., Zhu, W., Org, E., Gu, X., Huang, Y., Zamanian-Daryoush, M., Culley, M. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.055 · Cited by 1,317 · see citing works
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises
Lakatta, E. G. (2003) · Circulation · doi:10.1161/01.cir.0000048894.99865.02 · Cited by 1,086 · see citing works
Bennett, B. J., Vallim, T. Q. D. A., Wang, Z., Shih, D. M., Meng, Y., Gregory, J., Allayee, H., Lee, R., Graham, M., Crooke, R., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.011 · Cited by 1,070 · see citing works
Akkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044 · cited 1× · see citing works
“Because these taxa are typically reported to be health beneficial and anti-inflammatory (Derrien et al. 2017), future studies are needed to further explore these differing findings.”
BackgroundMueller, S., Saunier, K., Hanisch, C., Norin, E., Alm, L., Midtvedt, T., Cresci, A., Silvi, S., Orpianesi, C., Verdenelli, M. C., et al. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.2.1027-1033.2006 · Cited by 1,006 · see citing works
Seldin, M. M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S. L., Lusis, A. J., & Shih, D. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002767 · Cited by 911 · see citing works
Mechanisms of inflammation-driven bacterial dysbiosis in the gut
Zeng, M. Y., Inohara, N., & Núñez, G. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.75 · Cited by 872 · see citing works
IBD—what role do Proteobacteria play?
Mukhopadhya, I., Hansen, R., El-Omar, E. M., & Hold, G. L. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.14 · Cited by 810 · see citing works
Grundy, D. (2015) · The Journal of Physiology · doi:10.1113/jp270818 · Cited by 767 · see citing works
Aging and vascular endothelial function in humans
Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725 · see citing works
Self-citationMicrobial conversion of choline to trimethylamine requires a glycyl radical enzyme
Craciun, S., & Balskus, E. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215689109 · Cited by 701 · see citing works
Qiita: rapid, web-enabled microbiome meta-analysis
Gonzalez, A., Navas-Molina, J. A., Kościółek, T., McDonald, D. T., Vázquez‐Baeza, Y., Ackermann, G. L., DeReus, J., Janssen, S., Swafford, A. D.-E., Orchanian, S. B., et al. (2018) · Nature Methods · doi:10.1038/s41592-018-0141-9 · Cited by 594 · see citing works
Self-citationHopkins, M. J., Sharp, R., & Macfarlane, G. T. (2001) · Gut · doi:10.1136/gut.48.2.198 · Cited by 577 · see citing works
Phylogenetic Placement of Exact Amplicon Sequences Improves Associations with Clinical Information
Janssen, S., McDonald, D., Gonzalez, A., Navas-Molina, J. A., Jiang, L., Xu, Z. Z., Winker, K., Kado, D. M., Orwoll, E., Manary, M., et al. (2018) · mSystems · doi:10.1128/msystems.00021-18 · Cited by 536 · see citing works
Self-citationDepletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression
Reikvam, D. H., Erofeev, A. S., Sandvik, A., Grcic, V., Jahnsen, F. L., Gaustad, P., McCoy, K. D., Macpherson, A. J., Meza‐Zepeda, L. A., & Johansen, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017996 · Cited by 531 · see citing works
Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation
Gregory, J. C., Buffa, J. A., Org, E., Wang, Z., Levison, B. S., Zhu, W., Wagner, M. A., Bennett, B. J., Li, L., DiDonato, J. A., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.618249 · Cited by 486 · see citing works
Microbial shifts in the aging mouse gut
Langille, M. G., Meehan, C. J., Koenig, J. E., Dhanani, A. S., Rose, R. A., Howlett, S. E., & Beiko, R. G. (2014) · Microbiome · doi:10.1186/s40168-014-0050-9 · Cited by 437 · see citing works
Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice
Fransen, F., van Beek, A. A., Borghuis, T., Aidy, S. E., Hugenholtz, F., van der Gaast – de Jongh, C., Savelkoul, H. F. J., De Jonge, M. I., Boekschoten, M. V., Smidt, H., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01385 · Cited by 403 · see citing works
Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction
Karbach, S. H., Schönfelder, T., Brandão, I., Wilms, E., Hörmann, N., Jäckel, S., Schüler, R., Finger, S., Knorr, M., Lagrange, J., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003698 · Cited by 378 · see citing works
Vitamin D Regulates the Gut Microbiome and Protects Mice from Dextran Sodium Sulfate–Induced Colitis
Ooi, J. H., Li, Y., Rogers, C. J., & Cantorna, M. T. (2013) · Journal of Nutrition · doi:10.3945/jn.113.180794 · Cited by 359 · see citing works
Wang, Z., Levison, B. S., Hazen, J. E., Donahue, L., Li, X.-M., & Hazen, S. L. (2014) · Analytical Biochemistry · doi:10.1016/j.ab.2014.03.016 · Cited by 320 · see citing works
Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice
Carvalho, B. M., Guadagnini, D., Tsukumo, D. M. L., Schenka, A. A., Latuf-Filho, P., Vassallo, J., Dias, J. C., Kubota, L. T., Carvalheira, J. B. C., & Saad, M. J. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2648-4 · Cited by 314 · see citing works
Kuczynski, J., Liu, Z. Z., Lozupone, C., McDonald, D. T., Fierer, N., & Knight, R. D. (2010) · Nature Methods · doi:10.1038/nmeth.1499 · Cited by 285 · see citing works
Self-citationSEPP: SATé-Enabled Phylogenetic Placement
MIRARAB, S., NGUYEN, N., & WARNOW, T. (2011) · Biocomputing 2012 · doi:10.1142/9789814366496_0024 · Cited by 251 · see citing works
Stull, V. J., Finer, E., Bergmans, R. S., Febvre, H. P., Longhurst, C. A., Manter, D. K., Patz, J. A., & Weir, T. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-29032-2 · Cited by 250 · see citing works
Self-citationMechanisms Involved in the Aging-Induced Vascular Dysfunction
Fuente, M. E. A. D. L., Angulo, J., Fernán, S. E., Peiró, C., Sánchez‐Ferrer, C. F., & Rodríguez‐Mañas, L. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00132 · Cited by 226 · see citing works
Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00679.x · Cited by 218 · see citing works
Self-citationLi, T., Chen, Y., Gua, C., & Li, X. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00350 · Cited by 216 · see citing works
Fleenor, B. S., Marshall, K. D., Durrant, J., Lesniewski, L. A., & Seals, D. R. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.194753 · Cited by 212 · see citing works
Self-citationThe autophagy enhancer spermidine reverses arterial aging
LaRocca, T. J., Gioscia‐Ryan, R. A., Hearon, C. M., & Seals, D. R. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.004 · Cited by 207 · see citing works
Self-citationRevisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202 · see citing works
The exogenous origin of trimethylamine in the mouse
Al-Waiz, M., Mikov, M., Mitchell, S. C., & Smith, R. L. (1992) · Metabolism · doi:10.1016/0026-0495(92)90140-6 · Cited by 196 · see citing works
Catry, E., Bindels, L. B., Tailleux, A., Lestavel, S., Neyrinck, A. M., Goossens, J.-F., Lobysheva, I., Plovier, H., Essaghir, A., Demoulin, J.-B., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313316 · Cited by 194 · see citing works
Intestinal TM7 bacterial phylogenies in active inflammatory bowel disease
Kuehbacher, T., Rehman, A., Lepage, P., Hellmig, S., Fölsch, U. R., Schreiber, S., & Ott, S. J. (2008) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47719-0 · Cited by 190 · see citing works
Rippe, C., Lesniewski, L. A., Connell, M. L., LaRocca, T. J., Donato, A. J., & Seals, D. R. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00557.x · Cited by 158 · see citing works
Self-citationLammers, S. R., Kao, P. H., Qi, H. J., Hunter, K. S., Lanning, C. J., Albietz, J. A., Hofmeister, S., Mecham, R. P., Stenmark, K. R., & Shandas, R. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00127.2008 · Cited by 153 · see citing works
Curcumin ameliorates arterial dysfunction and oxidative stress with aging
Fleenor, B. S., Sindler, A. L., Marvi, N. K., Howell, K. L., Zigler, M. L., Yoshizawa, M., & Seals, D. R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.10.008 · Cited by 145 · see citing works
Self-citationProbiotic supplementation and trimethylamine‐<i>N</i>‐oxide production following a high‐fat diet
Boutagy, N. E., Neilson, A. P., Osterberg, K. L., Smithson, A. T., Englund, T. R., Davy, B. M., Hulver, M. W., & Davy, K. P. (2015) · Obesity · doi:10.1002/oby.21212 · Cited by 127 · see citing works
Self-citationMitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice
Gioscia‐Ryan, R. A., Battson, M. L., Cuevas, L. M., Eng, J. S., Murphy, M. P., & Seals, D. R. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00670.2017 · Cited by 124 · see citing works
Self-citationVikram, A., Kim, Y., Kumar, S., Li, Q., Kassan, M., Jacobs, J. S., & Irani, K. (2016) · Nature Communications · doi:10.1038/ncomms12565 · Cited by 120 · see citing works
Absorption of Orally Administered Neomycin and Kanamycin
Kunin, C. M., Chalmers, T. C., Leevy, C. M., Sebastyen, S. C., Lieber, C. S., & Finland, M. (1960) · New England Journal of Medicine · doi:10.1056/nejm196002252620802 · Cited by 114 · see citing works
Short-term high-fat diet increases postprandial trimethylamine- N -oxide in humans
Boutagy, N. E., Neilson, A. P., Osterberg, K. L., Smithson, A. T., Englund, T. R., Davy, B. M., Hulver, M. W., & Davy, K. P. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.07.002 · Cited by 102 · see citing works
Self-citationSystemic absorption of oral vancomycin in patients with Clostridium difficile infection
Rao, S., Kupfer, Y. Y., Pagala, M. K. D., Chapnick, E. K., & Tessler, S. (2011) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2010.544671 · Cited by 92 · see citing works
Fleenor, B. S., Sindler, A. L., Eng, J. S., Nair, D. P., Dodson, R. B., & Seals, D. R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.05.004 · Cited by 85 · see citing works
Self-citationSuppression of gut dysbiosis reverses Western diet-induced vascular dysfunction
Battson, M. L., Lee, D. M., Jarrell, D. K., Hou, S., Ecton, K. E., Weir, T. L., & Gentile, C. L. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00187.2017 · Cited by 85 · see citing works
Self-citationmyPhyloDB: a local web server for the storage and analysis of metagenomic data
Manter, D. K., Korsa, M., Tebbe, C., & Delgado, J. A. (2016) · Database · doi:10.1093/database/baw037 · Cited by 30 · see citing works
Mitsuyama, T., Hidaka, K., Furuno, T., & Hara, N. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006894301389 · Cited by 21 · see citing works
Impact of antibiotics on the microcirculation in local and systemic inflammation
Al-Banna, N., Pavlović, D., Gründling, M., Zhou, J., Kelly, M. E. M., Whynot, S., Hung, O. R., Johnston, B., Issekutz, T. B., Kern, H., et al. (2013) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2012-1583 · Cited by 21 · see citing works
Chronic Exposure to Subtherapeutic Antibiotics Aggravates Ischemic Stroke Outcome in Mice
Dong, X., Peng, C., Zhang, Y.-Y., Tao, Y., Tao, X., Zhang, C., Chen, A. F., & Xie, H. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.002 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,107 · see citing works
Gut microbiota and cardiovascular disease.
Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051 · see citing works
The gut microbiome as a modulator of healthy ageing
Ghosh, T. S., Shanahan, F., & O’Toole, P. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00605-x · Cited by 817 · see citing works
Intestinal Microbiota in Cardiovascular Health and Disease
Tang, W. H. W., Bäckhed, F., Landmesser, U., & Hazen, S. L. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.024 · Cited by 508 · see citing works
Yang, S., Li, X., Yang, F., Zhao, R., Pan, X., Liang, J., Tian, L., Li, X., Liu, L., Xing, Y., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01360 · Cited by 347 · see citing works
Abdolmaleky, H. M., & Zhou, J. (2024) · Antioxidants · doi:10.3390/antiox13080985 · Cited by 311 · see citing works
Zhang, X., Li, Y., Yang, P., Liu, X., Lu, L., Chen, Y., Zhong, X., Li, Z., Liu, H., Ou, C., et al. (2020) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.313414 · Cited by 291 · see citing works
Brunt, V. E., Gioscia‐Ryan, R. A., Casso, A. G., VanDongen, N. S., Ziemba, B. P., Sapinsley, Z. J., Richey, J. J., Zigler, M. C., Neilson, A. P., Davy, K. P., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14759 · Cited by 285 · see citing works
Self-citationLivshits, G., & Kalinkovich, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100980 · Cited by 239 · see citing works
Liu, Y., & Dai, M. (2020) · Mediators of Inflammation · doi:10.1155/2020/4634172 · Cited by 232 · see citing works
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy
Herzog, M. J., Müller, P., Lechner, K., Stiebler, M., Arndt, P., Kunz, M., Ahrens, D., Schmeißer, A., Schreiber, S., & Braun-Dullaeus, R. C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02346-0 · Cited by 246 · see citing works
Brunt, V. E., LaRocca, T. J., Bazzoni, A. E., Sapinsley, Z. J., Miyamoto-Ditmon, J., Gioscia-Ryan, R. A., Neilson, A. P., Link, C. D., & Seals, D. R. (2021) · GeroScience · doi:10.1007/s11357-020-00257-2 · Cited by 197 · see citing works
Self-citationZanoli, L., Briet, M. B., Empana, J. P., Cunha, P., Maki-Petaja, K. M., Protogerou, A. D., Tedgui, A., Touyz, R. M., Schiffrin, E. L., Spronck, B., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002508 · Cited by 194 · see citing works
Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing
Conway, J., & Duggal, N. A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101323 · Cited by 194 · see citing works
Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review
Anik, M. I., Mahmud, N., Masud, A. A., Khan, M. I., Islam, M. N., Uddin, S., & Hossain, M. K. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00411 · Cited by 156 · see citing works
Reactive oxygen species in hypertension
Camargo, L. L., Rios, F. J. O., Montezano, A. C. I., & Touyz, R. M. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01062-6 · Cited by 154 · see citing works
Obesity-related cognitive impairment: The role of endothelial dysfunction
Buie, J. N. J., Watson, L. S., Smith, C. J., & Sims‐Robinson, C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104580 · Cited by 133 · see citing works
Muralitharan, R. R., Jama, H. A., Xie, L., Peh, A., Snelson, M., & Marques, F. Z. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14473 · Cited by 131 · see citing works
Xu, L., Zhang, Y., Li, X., Li, C., Hu, H., Hu, J., Liu, M., Yang, Q. Z., Gu, P., Li, J., et al. (2025) · iMeta · doi:10.1002/imt2.270 · Cited by 138 · see citing works
Li, L., Chen, B., Zhu, R., Li, R., Tian, Y., Liu, C., Jia, Q., Wang, L., Tang, J., Zhao, D., et al. (2019) · Aging · doi:10.18632/aging.102376 · Cited by 128 · see citing works
The role of gut microbiota in intestinal disease: from an oxidative stress perspective
Sun, Y., Wang, X., Li, L., Zhong, C., Zhang, Y., Yang, X., Li, M., & Yang, C. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1328324 · Cited by 130 · see citing works
Arterial Stiffness in Aging: Does It Have a Place in Clinical Practice?
Mitchell, G. F. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.14515 · Cited by 119 · see citing works
Inflammation in Coronary Microvascular Dysfunction
Sagris, M., Theofilis, P., Antonopoulos, A. S., Oikonomou, E., Paschaliori, C., Galiatsatos, N., Tsioufis, K., & Tousoulis, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413471 · Cited by 115 · see citing works
Brunt, V. E., Casso, A. G., Gioscia‐Ryan, R. A., Sapinsley, Z. J., Ziemba, B. P., Clayton, Z. S., Bazzoni, A. E., VanDongen, N. S., Richey, J. J., Hutton, D. A., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16895 · Cited by 110 · see citing works
Self-citationMahoney, S. A., Venkatasubramanian, R., Darrah, M. A., Ludwig, K. R., VanDongen, N. S., Greenberg, N., Longtine, A. G., Hutton, D. A., Brunt, V. E., Campisi, J., et al. (2023) · Aging Cell · doi:10.1111/acel.14060 · Cited by 107 · see citing works
Self-citationClayton, Z. S., Rossman, M. J., Mahoney, S. A., Venkatasubramanian, R., Maurer, G. S., Hutton, D. A., VanDongen, N. S., Greenberg, N. T., Longtine, A. G., Ludwig, K. R., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21392 · Cited by 84 · see citing works
“Old mice also had greater aortic intima-media thickness relative to young (old vehicle versus young vehicle; P= 0.03), which is similar to previous reports from our laboratory, 20,28 S1A).”
BackgroundResultInfluentialSelf-citationInflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging
Barbu, E., Popescu, M.-R., Popescu, A.-C., & Balanescu, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020963 · Cited by 91 · see citing works
Clinical approach to the inflammatory etiology of cardiovascular diseases
Ruscica, M., Corsini, A., Ferri, N., Banach, M., & Sirtori, C. R. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104916 · Cited by 87 · see citing works
Janiak, M. C., Montague, M. J., Villamil, C. I., Stock, M. K., Trujillo, A. E., DePasquale, A. N., Orkin, J. D., Bauman, S. E., González, O., Platt, M. L., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01009-w · Cited by 79 · see citing works
Age-dependent remodeling of gut microbiome and host serum metabolome in mice
Wu, C., Muthyala, S. D. V., Klemashevich, C. L., Ufondu, A., Menon, R., Chen, Z., Devaraj, S., Jayaraman, A., & Sun, Y. (2021) · Aging · doi:10.18632/aging.202525 · Cited by 80 · see citing works
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2022) · Kompass Nutrition & Dietetics · doi:10.1159/000523712 · Cited by 79 · see citing works
How Oxidative Stress Induces Depression?
Ji, N., Lei, M., Chen, Y., Tian, S., Li, C., & Zhang, B. (2023) · ASN NEURO · doi:10.1177/17590914231181037 · Cited by 82 · see citing works
Trimethylamine N -oxide: heart of the microbiota–CVD nexus?
Naghipour, S., Cox, A. J., Peart, J. N., Toit, E. F. D., & Headrick, J. P. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422420000177 · Cited by 75 · see citing works
Clayton, Z. S., Hutton, D. A., Brunt, V. E., VanDongen, N. S., Ziemba, B. P., Casso, A. G., Greenberg, N., Mercer, A. N., Rossman, M. J., Campisi, J., et al. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00118.2021 · Cited by 73 · see citing works
Self-citationRole of the Gut Microbiome in the Development of Atherosclerotic Cardiovascular Disease
Samarraie, A. A., Pichette, M., & Rousseau, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065420 · Cited by 76 · see citing works
Flavonifractor plautii Protects Against Elevated Arterial Stiffness
Luo, S., Zhao, Y., Zhu, S., Liu, L., Cheng, K., Ye, B., Han, Y., Fan, J., & Xia, M. (2022) · Circulation Research · doi:10.1161/circresaha.122.321975 · Cited by 68 · see citing works
Smart capsules for sensing and sampling the gut: status, challenges and prospects
Rehan, M., Al-Bahadly, I. H., Thomas, D. G., Young, W., Cheng, L. K., & Avci, E. (2023) · Gut · doi:10.1136/gutjnl-2023-329614 · Cited by 68 · see citing works
Mudimela, S., Vishwanath, N. K., Pillai, A., Morales, R., Marrelli, S. P., Barichello, T., & Giridharan, V. V. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.08.002 · Cited by 70 · see citing works
Balancing the Equation: A Natural History of Trimethylamine and Trimethylamine-N-oxide
Loo, R. L., Chan, Q. M., Nicholson, J. K., & Holmes, E. C. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00851 · Cited by 60 · see citing works
Allostatic load and ageing: linking the microbiome and nutrition with age-related health
Shiels, P. G., Buchanan, S. J., Selman, C., & Stenvinkel, P. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190110 · Cited by 60 · see citing works
TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies
Zhang, W., Wang, Y., Zhang, A., Ding, Y., Zhang, X., Jia, Q.-J., Zhu, Y., Li, Y., Lv, S., & Zhang, J. (2021) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-021-10115-x · Cited by 59 · see citing works
Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases
Mutalub, Y. B., Abdulwahab, M., Mohammed, A., Yahkub, A. M., Al-Mhanna, S. B., Yusof, W., Tang, S. P., Rasool, A. H. G., & Mokhtar, S. S. (2022) · Foods · doi:10.3390/foods11172575 · Cited by 60 · see citing works
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59 · see citing works
Gámez-Macías, P. E., Félix‐Soriano, E., Samblas, M., Sáinź, N., Moreno-Aliaga, M. J., & González‐Muniesa, P. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae045 · Cited by 56 · see citing works
The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease
Hage, R. E., Al-Arawe, N., & Hinterseher, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032399 · Cited by 55 · see citing works
Rath, S., Rox, K., Bardenhorst, S. K., Schminke, U., Dörr, M., Mayerle, J. V., Frost, F., Lerch, M. M., Karch, A., Brönstrup, M., et al. (2021) · mSystems · doi:10.1128/msystems.00945-21 · Cited by 53 · see citing works
Microbiota of the gastrointestinal tract: Friend or foe?
Senchukova, M. A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i1.19 · Cited by 55 · see citing works
Gut microbial metabolism in Alzheimer's disease and related dementias
Kang, J. W., Vemuganti, V., Kuehn, J. F., Ulland, T. K., Rey, F. E., & Bendlin, B. B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00470 · Cited by 49 · see citing works
Targeting mitochondrial fitness as a strategy for healthy vascular aging
Rossman, M. J., Gioscia‐Ryan, R. A., Clayton, Z. S., Murphy, M. P., & Seals, D. R. (2020) · Clinical Science · doi:10.1042/cs20190559 · Cited by 50 · see citing works
Self-citationHu, C., Yan, Y., Ji, F., & Zhou, H. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.671347 · Cited by 48 · see citing works
Oxidative stress and metabolic diseases: Relevance and therapeutic strategies
Manzoor, M. F., Arif, Z., Kabir, A., Mehmood, I., Munir, D., Razzaq, A., Ali, A., Gökşen, G., Coşier, V., Aḥmad, N., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.994309 · Cited by 48 · see citing works
Mo, X., Shen, L., Cheng, R., Wang, P., Lin, W. Y., Sun, Y., Wang, Q., Chen, J., Lin, S., Liao, Y., et al. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13294 · Cited by 47 · see citing works
The Gut–Heart Axis: Molecular Perspectives and Implications for Myocardial Infarction
Rivera, K., González, L., Bravo, L., Manjarres, L., & Andía, M. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212465 · Cited by 50 · see citing works
Gut microbiota: a promising target against cardiometabolic diseases
Warmbrunn, M. V., Herrema, H., Aron‐Wisnewsky, J., Soeters, M. R., van Raalte, D. H., & Nieuwdorp, M. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2020.1720511 · Cited by 48 · see citing works
Hashim, H. M., & Makpol, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1007166 · Cited by 46 · see citing works
Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?
Ren, J., Li, H., Zeng, G., Pang, B., Wang, Q., & Wei, J.-P. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1178596 · Cited by 44 · see citing works
Anthracycline chemotherapy‐mediated vascular dysfunction as a model of accelerated vascular aging
Clayton, Z. S., Hutton, D. A., Mahoney, S. A., & Seals, D. R. (2021) · Aging and Cancer · doi:10.1002/aac2.12033 · Cited by 43 · see citing works
Self-citationAlmeida, H. M., Sardeli, A. V., Conway, J., Duggal, N. A., & Cavaglieri, C. R. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101773 · Cited by 43 · see citing works
Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health
Semenova, N. V., Евгеньевна, Г. Н., Kolesnikov, S. I., Darenskaya, M. A., & Kolesnikova, L. (2024) · Pathophysiology · doi:10.3390/pathophysiology31030023 · Cited by 43 · see citing works
Qiao, C.-M., Quan, W., Zhou, Y., Niu, G.-Y., Hong, H., Wu, J., Zhao, L.-P., Li, T., Cui, C., Zhao, W.-J., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03392-x · Cited by 45 · see citing works
Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation
Iglesias‐Carres, L., Hughes, M. D., Steele, C. N., Ponder, M. A., Davy, K. P., & Neilson, A. P. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108600 · Cited by 42 · see citing works
Self-citationLuo, Z., Yu, X., Wang, C., Zhao, H., Wang, X., & Guan, X. (2023) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-023-00984-y · Cited by 41 · see citing works
Krueger, E. S., Lloyd, T. S., & Tessem, J. S. (2021) · Nutrients · doi:10.3390/nu13082873 · Cited by 40 · see citing works
Clayton, Z. S., Brunt, V. E., Hutton, D. A., Casso, A. G., Ziemba, B. P., Melov, S., Campisi, J., & Seals, D. R. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16759 · Cited by 40 · see citing works
Self-citationFarini, A., Tripodi, L., Villa, C., Strati, F., Facoetti, A., Baselli, G., Troisi, J., Landolfi, A., Lonati, C., Molinaro, D., et al. (2022) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00445-1 · Cited by 40 · see citing works
RetractedEvidence for the Contribution of Gut Microbiota to Age-Related Anabolic Resistance
Watson, M. D., Cross, B. L., & Grosicki, G. J. (2021) · Nutrients · doi:10.3390/nu13020706 · Cited by 39 · see citing works
Li, C., Zhu, L., Dai, Y., Zhang, Z., Huang, L., Wang, T. J., Fu, P., Li, Y., Wang, J., & Jiang, C. Q. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1599747 · Cited by 37 · see citing works
Tracy, E. P., Hughes, W. E., Beare, J. E., Rowe, G., Beyer, A., & LeBlanc, A. J. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0031 · Cited by 38 · see citing works
A grass carp model with an antibiotic-disrupted intestinal microbiota
Sun, B.-Y., Yang, H., He, W., Tian, D.-Y., Kou, H.-Y., Wu, K., Yang, C.-G., Cheng, Z., & Song, X. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736790 · Cited by 35 · see citing works
Kang, K., Xia, A., Meng, F., Chunyu, J., Sun, X., Ren, G., Yu, D., Jiang, X., Tang, L., Xiao, W. L., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107634 · Cited by 34 · see citing works
Resveratrol and the Interaction between Gut Microbiota and Arterial Remodelling
Man, A. W. C., Li, H., & Xia, N. (2020) · Nutrients · doi:10.3390/nu12010119 · Cited by 34 · see citing works
Iglesias‐Carres, L., Essenmacher, L. A., Racine, K. C., & Neilson, A. P. (2021) · Nutrients · doi:10.3390/nu13051466 · Cited by 34 · see citing works
Self-citationThe Gut Microbiota and Vascular Aging: A State-of-the-Art and Systematic Review of the Literature
Agnoletti, D., Piani, F., Cicero, A. F. G., & Borghi, C. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123557 · Cited by 36 · see citing works
Krueger, E. S., Beales, J. L., Russon, K. B., Elison, W. S., Davis, J., Hansen, J. M., Neilson, A. P., Hansen, J. M., & Tessem, J. S. (2021) · Biomolecules · doi:10.3390/biom11121892 · Cited by 32 · see citing works
Self-citationCasso, A. G., VanDongen, N. S., Gioscia‐Ryan, R. A., Clayton, Z. S., Greenberg, N., Ziemba, B. P., Hutton, D. A., Neilson, A. P., Davy, K. P., Seals, D. R., et al. (2022) · The Journal of Physiology · doi:10.1113/jp283581 · Cited by 31 · see citing works
Self-citationThe Influence of Antioxidants on Oxidative Stress-Induced Vascular Aging in Obesity
Sharebiani, H., Keramat, S., Chavoshan, A., Fazeli, B., & Stanek, A. (2023) · Antioxidants · doi:10.3390/antiox12061295 · Cited by 30 · see citing works
Mihuţa, M. S., Paul, C., Borlea, A., Roi, C. M., Pescari, D., Velea-Barta, O.-A., Mozos, I. M., & Stoian, D. L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1253584 · Cited by 31 · see citing works
Que, Y., Zhang, Y., Liang, F., Wang, L., Yang, Y., Zhang, J., Wang, W., Sun, Y., Zhong, C., Zhang, H., et al. (2024) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2024.107085 · Cited by 29 · see citing works
Inflammation and Arterial Stiffness as Drivers of Cardiovascular Risk in Kidney Disease
Cicero, L. L., Lentini, P. L. M., Sessa, C., Castellino, N., D’anca, A., Torrisi, I., Marcantoni, C., Castellino, P., Santoro, D., & Zanoli, L. (2024) · Cardiorenal Medicine · doi:10.1159/000542965 · Cited by 29 · see citing works
Targeting gut microbiota in aging-related cardiovascular dysfunction: focus on the mechanisms
Liu, S., He, Y., Zhang, Y., Zhang, Z., Huang, K., Deng, L., Liao, B., Zhong, Y., & Feng, J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2290331 · Cited by 31 · see citing works
Yu, J., Jiang, W., Wang, S., Liu, S., Shi, D., Wang, H., & Chang, X. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105255 · Cited by 27 · see citing works
Chittimalli, K., Jahan, J., Sakamuri, A., McAdams, Z. L., Ericsson, A. C., & Jarajapu, Y. P. R. (2023) · Clinical Science · doi:10.1042/cs20220904 · Cited by 25 · see citing works
Guo, X., Dong, Z., Li, Q., Wan, D., Zhong, J., Dongzhi, D., & Huang, M. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154270 · Cited by 27 · see citing works
Balmuș, I.-M., Lefter, R. M., Ciobica, A. S., Cojocaru, S. I., Guenné, S., Timofte, D. V., Stanciu, C., Trifan, A. V., & Hrițcu, L. D. (2019) · Medicina · doi:10.3390/medicina55120776 · Cited by 25 · see citing works
Chen, L., He, J.-T., Pan, M., Liu, J.-L., Zhang, K.-K., Li, J.-H., Wang, L., Xu, L., Chen, Y.-K., Zhang, Q.-Y., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716703 · Cited by 25 · see citing works
Hu, J., Zou, H., Qiao, X., Wang, Y., Lv, M., Zhang, K., & Wang, F. (2024) · BMC Public Health · doi:10.1186/s12889-024-18683-8 · Cited by 24 · see citing works
Woolf, E. K., Lee, S. Y., Ghanem, N., Vazquez, A. R., & Johnson, S. A. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.09.007 · Cited by 24 · see citing works
Perivascular fat tissue and vascular aging: A sword and a shield
Wang, Y., Wang, X., chen, Y., Zhang, Y., Zhen, X., Tao, S., Dou, J., Li, P., & Jiang, G. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107140 · Cited by 23 · see citing works
Ganapathy, T. P., Yuan, J.-T., Ho, M. Y.-M., Wu, K. K.-L., Hoque, M. M., Wang, B., Li, X., Wang, K., Wabitsch, M., Feng, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63905-1 · Cited by 22 · see citing works
de la Visitación, N., Robles‐Vera, I., Moleón, J., González‐Correa, C., Aguilera-Sánchez, N., Toral, M., Gómez‐Guzmán, M., Sánchez, M., Jiménez, R., Martín‐Morales, N., et al. (2021) · Antioxidants · doi:10.3390/antiox10091426 · Cited by 20 · see citing works
Fleenor, B. S., Carlini, N. A., Ouyang, A., & Harber, M. P. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106150 · Cited by 20 · see citing works
Role of gut microbiome in suppression of cancers
Xu, Y., Gao, Z., Liu, J., Yang, Q., & Xu, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2495183 · Cited by 21 · see citing works
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies
Wang, X., Fan, L., Meng, C., Wang, Y., Deng, L.-E., Yuan, Z., Zhang, J., Li, Y., & Lv, S. (2023) · Biogerontology · doi:10.1007/s10522-023-10082-7 · Cited by 20 · see citing works
Inflammation as a mediator of arterial ageing
Trott, D. W., & Fadel, P. J. (2019) · Experimental Physiology · doi:10.1113/ep087499 · Cited by 19 · see citing works
The Gut-Arterial Stiffness Axis: Is TMAO a Novel Target to Prevent Age-Related Aortic Stiffening?
Pierce, G. L., Roy, S. J., & Gimblet, C. J. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.17487 · Cited by 19 · see citing works
Microvascular endothelial dysfunction in vascular senescence and disease
Kasal, D. A. B., Sena, V., Huguenin, G. V. B., Lorenzo, A. D., & Tibiriçá, E. V. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1505516 · Cited by 21 · see citing works
Gut microbiota-derived metabolites: Potential targets for cardiorenal syndrome
Lai, Y.-C., Zhu, Y., Zhang, X., Ding, S., Wang, F., Hao, J., Wang, Z., Shi, C., Xu, Y., Zheng, L., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107672 · Cited by 21 · see citing works
Iglesias‐Carres, L., Krueger, E. S., Herring, J. A., Tessem, J. S., & Neilson, A. P. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c00247 · Cited by 18 · see citing works
Self-citationMicrobial disruption in the gut promotes cerebral endothelial dysfunction
Rustia, A. J., Paterson, J. S., Best, G., & Sokoya, E. M. (2021) · Physiological Reports · doi:10.14814/phy2.15100 · Cited by 17 · see citing works
- Authors
- Brunt, V. E., Gioscia‐Ryan, R. A., Richey, J. J., Zigler, M. C., Cuevas, L. M., Gonzalez, A., Vázquez‐Baeza, Y., Battson, M. L., Smithson, A. T., Gilley, A. D., Ackermann, G., Neilson, A. P., Weir, T., Davy, K. P., Knight, R., & Seals, D. R.
- Affiliations
- University of Colorado Boulder (US)
- Department of Pediatrics University of California San Diego La Jolla CA USA
- University of California San Diego (US)
- Colorado State University (US)
- Virginia Tech (US)
- Corresponding author
- Brunt, Vienna E.
- ORCID
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2019-02-27
- Volume
- 597
- Issue
- 9
- Pages
- 2361-2378
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC6487935
- OpenAlex
- W2919947473
- Cited by
- 182
- References
- 69
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 33 · 2023: 25 · 2022: 28 · 2021: 35 · 2020: 14 · 2019: 12
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (F31 AG047784)
- National Heart, Lung, and Blood Institute (F32 HL140875)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- gut microbiota, endothelial dysfunction, arterial stiffness, oxidative stress, gut dysbiosis, trimethylamine N-oxide, antibiotic-induced microbiota depletion, cardiovascular aging, aortic pulse wave velocity, inflammation, cardiovascular risk, mice, gut-heart axis, gut microbiota metabolites
- MeSH terms
- Gastrointestinal Microbiome, Aging, Animals, Anti-Bacterial Agents, Carotid Arteries, Endothelium, Vascular, Male, Methylamines, Mice, Inbred C57BL, Vasodilation, Oxidative Stress, Mice, Vascular Stiffness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
