The DOI matches its Crossref record, with a small difference in title or year; 129 of the 129 references it cites were found in a registry or an index.
Depression as a Risk Factor for Poor Prognosis Among Patients With Acute Coronary Syndrome: Systematic Review and Recommendations: A Scientific Statement From the American Heart Association
Open accessAbstract
Background—: Although prospective studies, systematic reviews, and meta-analyses have documented an association between depression and increased morbidity and mortality in a variety of cardiac populations, depression has not yet achieved formal recognition as a risk factor for poor prognosis in patients with acute coronary syndrome by the American Heart Association and other health organizations. The purpose of this scientific statement is to review available evidence and recommend whether depression should be elevated to the status of a risk factor for patients with acute coronary syndrome. Methods and Results—: Writing group members were approved by the American Heart Association’s Scientific Statement and Manuscript Oversight Committees. A systematic literature review on depression and adverse medical outcomes after acute coronary syndrome was conducted that included all-cause mortality, cardiac mortality, and composite outcomes for mortality and nonfatal events. The review assessed the strength, consistency, independence, and generalizability of the published studies. A total of 53 individual studies (32 reported on associations with all-cause mortality, 12 on cardiac mortality, and 22 on composite outcomes) and 4 meta-analyses met inclusion criteria. There was heterogeneity across studies in terms of the demographic composition of study samples, definition and measurement of depression, length of follow-up, and covariates included in the multivariable models. Despite limitations in some individual studies, our review identified generally consistent associations between depression and adverse outcomes. Conclusions—: Despite the heterogeneity of published studies included in this review, the preponderance of evidence supports the recommendation that the American Heart Association should elevate depression to the status of a risk factor for adverse medical outcomes in patients with acute coronary syndrome.
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“Elevated depressive and anxiety symptoms increase the risk for recurrent cardiac events and mortality after ACS [2].”
From Lower distress tolerance is associated with greater anxiety and depression symptoms among patients after acute coronary syndrome (2021) · cites this paper as [2]
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“One in five patients with ischaemic heart disease (IHD) develop comorbid depression or anxiety.”
From Efficacy and cost-effectiveness of a therapist-assisted web-based intervention for depression and anxiety in patients with ischemic heart disease attending cardiac rehabilitation [eMindYourHeart trial]: a randomised controlled trial protocol (2021) · cites this paper as [3]
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Nygren, A., Reutfors, J., Karlsson, P., Tiger, M., Faxén, J., & Brenner, P. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119419 · Cited by 1
Thurmann, K. E., Mukherjee, T. G., Dantin, J. G., Kang, P. T., & White, M. (2025) · Cureus · doi:10.7759/cureus.86933 · Cited by 1
“For instance, depression is associated with autonomic dysfunction, inflammation, and platelet hyperreactivity, all of which may exacerbate CV outcomes [27].”
Fi, B., Veltishchev, D. Y., Volel, B. A., Garganeeva, N. P., Kopylov, F. Y., Lareva, N. V., Medvedev, V. E., Mosolov, S. N., Petrova, M. M., Петрунько, О. В., et al. (2025) · Kardiologiia · doi:10.18087/cardio.2025.6.n2921 · Cited by 2
Xu, X., Liu, Z., Liu, Z., Li, Z., Zhou, Y., Zhou, H., Tan, W., Peng, C., Cheng, S., Wang, Y., et al. (2025) · International Journal of Cardiology · doi:10.1016/j.ijcard.2025.133634 · Cited by 1
Epigenetica e psiconeuroimmunoendocrinologia: una rivoluzione che integra psicologia e medicina
Bottaccioli, F. (2014) · PSICOTERAPIA E SCIENZE UMANE · doi:10.3280/pu2014-004003 · Cited by 1
Piamjariyakul, U., & Smith, C. E. (2014) · Sigma Theta Tau International's 25th International Nursing Research Congress · Cited by 1
Henriksson, C., Hallberg, T., & Johnston, N. (2015) · Journal of Cardiovascular Diseases & Diagnosis · doi:10.4172/2329-9517.1000230 · Cited by 1
“It is also known that both anxiety and depression increases the risk of cardiovascular morbidity and mortality [4-6], while decreasing quality of life (QoL) [7,8].”
BackgroundPsychological and Behavioral Contributions to Rehabilitation and Recovery in Heart Disease
Clarke, D. M., Perera, D. N., & Casey, M. F. (2016) · Springer eBooks · doi:10.1007/978-981-287-206-7_49 · Cited by 1
In-Hospital Management of Psychological Responses to Acute Cardiac Events
Worcester, M. U. C. (2016) · Springer eBooks · doi:10.1007/978-981-287-206-7_51 · Cited by 1
Depression, Anxiety, and Cardiovascular Disease in Chinese: A Review for a Bigger Picture
Pan, X., Meng, R., Liu, N., & Pan, A. (2017) · Cardiovascular Innovations and Applications · doi:10.15212/cvia.2016.0059 · Cited by 1
“In particular, a review qualitatively assessed the available literature for depression’s negative impact on the prognosis for acute coronary syndrome, and found that depression was associated with all-cause and cardiac death, as well as composite outcomes that combined death and nonfatal cardiac events [36].”
BackgroundAnksioznost in koronarna bolezen srca
Palandačić, A. K., & Šarotar, B. N. (2018) · Slovenian Medical Journal · doi:10.6016/zdravvestn.2430 · Cited by 3
USO DA ESCALA DE DEPRESSÃO GERIÁTRICA NO CONTEXTO DA ATENÇÃO PRIMÁRIA À SAÚDE
Monteiro, L. H. B., Nobre, J. N. P., de Mello, P. F., Cambraia, R. P., & de Andrade, R. A. (2018) · Enciclopédia Biosfera · doi:10.18677/encibio_2018b106 · Cited by 1
Carney, R. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319845122 · Cited by 1
Self-citationDepression, cardiovascular disease, and related pathophysiologic mechanisms in women
Gegenava, T., & Gegenava, M. (2019) · Cor et Vasa · doi:10.33678/cor.2019.028 · Cited by 1
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Depression in the Elderly: Prevalence, Clinical and Psychopathological Features
Hryn, K. V. (2020) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs05.03.040 · Cited by 1
Psychotherapy and Psychological Support for Severe Heart Conditions
Sommaruga, M., & Pierobon, A. (2020) · Springer eBooks · doi:10.1007/978-3-319-90305-7_26-2 · Cited by 1
La dépression unipolaire comme facteur de risque et pronostic des maladies somatiques
Lemogne, C. (2018) · French Journal of Psychiatry · doi:10.1016/s2590-2415(19)30230-2 · Cited by 1
World Mental Health Day: hearts and minds
Thompson, D. R. (2020) · British Journal of Cardiac Nursing · doi:10.12968/bjca.2020.0098 · Cited by 1
“US guidelines (Lichtman et al., 2014) recognise depression as a factor contributing to poor prognosis among people with CVD. European guidelines (Piepoli et al., 2016) recognise that low carry a worse prognosis of CVD.”
BackgroundGender aspects of cardiovascular disease
Долженко, М. М., & Yakovenko, L. I. (2019) · Medicine of Ukraine · doi:10.37987/1997-9894.2019.8(234).187187 · Cited by 2
Cardiovascular Disease and Mental Health in Men
Thompson, D., & Ski, C. (2021) · Comprehensive Men's Mental Health · doi:10.1017/9781108646765.021
Metadata
- Authors
- Lichtman, J. H., Froelicher, E. S., Blumenthal, J. A., Carney, R. M., Doering, L. V., Frasure-Smith, N., Freedland, K. E., Jaffe, A. S., Leifheit-Limson, E. C., Sheps, D. S., Vaccarino, V., & Wulsin, L.
- ORCID
- Venue
- Circulation
- Published
- 2014-03-25
- Volume
- 129
- Issue
- 12
- Pages
- 1350-1369
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2137977071
- Cited by
- 1,208
- References
- 129
- Citations by year
- 2026: 65 · 2025: 87 · 2024: 95 · 2023: 106 · 2022: 107 · 2021: 100 · 2020: 108 · 2019: 105 · 2018: 112 · 2017: 90 · 2016: 113 · 2015: 86 · 2014: 32
- FWCI
- 17.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- depression, acute coronary syndrome, cardiovascular risk factors, prognosis, all-cause mortality, cardiac mortality
- MeSH terms
- American Heart Association, Cardiology, Depression, Humans, Prognosis, Risk Factors, United States, Practice Guidelines as Topic, Evidence-Based Medicine, Acute Coronary Syndrome
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