The DOI matches its Crossref record, with a small difference in title or year; 129 of the 129 references it cites were found in a registry or an index.
Depression as a Risk Factor for Poor Prognosis Among Patients With Acute Coronary Syndrome: Systematic Review and Recommendations: A Scientific Statement From the American Heart Association
Open accessAbstract
Background—: Although prospective studies, systematic reviews, and meta-analyses have documented an association between depression and increased morbidity and mortality in a variety of cardiac populations, depression has not yet achieved formal recognition as a risk factor for poor prognosis in patients with acute coronary syndrome by the American Heart Association and other health organizations. The purpose of this scientific statement is to review available evidence and recommend whether depression should be elevated to the status of a risk factor for patients with acute coronary syndrome. Methods and Results—: Writing group members were approved by the American Heart Association’s Scientific Statement and Manuscript Oversight Committees. A systematic literature review on depression and adverse medical outcomes after acute coronary syndrome was conducted that included all-cause mortality, cardiac mortality, and composite outcomes for mortality and nonfatal events. The review assessed the strength, consistency, independence, and generalizability of the published studies. A total of 53 individual studies (32 reported on associations with all-cause mortality, 12 on cardiac mortality, and 22 on composite outcomes) and 4 meta-analyses met inclusion criteria. There was heterogeneity across studies in terms of the demographic composition of study samples, definition and measurement of depression, length of follow-up, and covariates included in the multivariable models. Despite limitations in some individual studies, our review identified generally consistent associations between depression and adverse outcomes. Conclusions—: Despite the heterogeneity of published studies included in this review, the preponderance of evidence supports the recommendation that the American Heart Association should elevate depression to the status of a risk factor for adverse medical outcomes in patients with acute coronary syndrome.
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“Elevated depressive and anxiety symptoms increase the risk for recurrent cardiac events and mortality after ACS [2].”
From Lower distress tolerance is associated with greater anxiety and depression symptoms among patients after acute coronary syndrome (2021) · cites this paper as [2]
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“One in five patients with ischaemic heart disease (IHD) develop comorbid depression or anxiety.”
From Efficacy and cost-effectiveness of a therapist-assisted web-based intervention for depression and anxiety in patients with ischemic heart disease attending cardiac rehabilitation [eMindYourHeart trial]: a randomised controlled trial protocol (2021) · cites this paper as [3]
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Borrione, L., Brunoni, A. R., Sampaio-Júnior, B., Aparicio, L. V. M., Kemp, A. H., Benseñor, I. M., Lotufo, P. A., & Fráguas, R. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.09.028 · Cited by 31
Risk factors for incident depression in patients at first acute coronary syndrome
Ossola, P., Paglia, F., Pelosi, A., Panfilis, C. D., Conte, G., Tonna, M., Ardissino, D., & Marchesi, C. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.063 · Cited by 29
“Depression in patients with ACS is associated with a worse cardiac outcome (Lichtman et al., 2014) due to an increase recurrence of cardiac events and mortality (Nicholson et al., 2006).”
BackgroundBerg, S. K., Rasmussen, T. B., Thrysoee, L., Thorup, C. B., Borregaard, B., Christensen, A. V., Mols, R. E., Juel, K., & Ekholm, O. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.07.002 · Cited by 30
Is Heart Failure Associated With Risk of Suicide?
Liu, C.-H., Wang, J., Weng, S., Cheng, Y.-H., Yeh, M., Bai, M., & Chang, J. (2018) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2018.07.006 · Cited by 30
Depressive Symptoms and Complications Early after Acute Myocardial Infarction: Gender Differences
AbuRuz, M. E., & Al-Dweik, G. A. (2018) · The Open Nursing Journal · doi:10.2174/1874434601812010205 · Cited by 28
Brinkmann, B., Payne, C., Kohler, I. V., Harling, G., Davies, J. I., Witham, M. D., Siedner, M. J., Sié, A., Bountogo, M., Ouèrmi, L., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-038199 · Cited by 30
Mousa, R. F., Smesam, H. N., Qazmooz, H. A., Al‐Hakeim, H. K., & Maes, M. H. J. (2021) · CNS Spectrums · doi:10.1017/s1092852921000432 · Cited by 30
“The American Heart Association, in a recent publication, states that depression predicts a poor prognosis in patients with the acute coronary syndrome.(47) Whang et al (2010) established that UA patients with depression have an increased risk of all-cause mortality at 42months even after adjusting for the Charlson com…”
BackgroundWu, M., Shen, L., Wang, Q., Liu, L., Lu, S., Jin, J., Dai, Z., & Shu, Z. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2021.758874 · Cited by 30
Systematic screening for anxiety and depression in cardiac rehabilitation – are we there yet?
Helmark, C., Harrison, A. S., Pedersen, S. S., & Doherty, P. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.02.004 · Cited by 34
Dulfer, K., Hazemeijer, B. A. F., van Dijk, M. R., van Geuns, R., Daemen, J., van Domburg, R. T., & Utens, E. M. W. J. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.05.014 · Cited by 30
“On the other hand, larger studies (number of deaths between 123 and 192) [8,9] also did not find this association between type D personality and mortality in mainly heart failure (HF) patients and acute coronary syndrome [10].”
BackgroundTian, X., Wang, Q., Guo, R. J., Xu, L., Chen, Q., & Hou, Y. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s109880 · Cited by 30
“Introduction Depression is an independent risk factor for poor prognosis in patients suffering from an acute myocardial infarction (AMI).(1) Approximately 20% of AMI patients have depressive disorders.”
Balcan, B., Thunström, E. Ö., Strollo, P. J., & Peker, Y. (2018) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201803-174oc · Cited by 31
Yin, H., Liu, Y., Ma, H., Liu, G., Guo, L., & Geng, Q. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2061-3 · Cited by 30
Cardiovascular events, diabetes and guidelines: the virtue of simplicity
Esper, R. J., & Nordaby, R. A. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0844-y · Cited by 30
Pelletier, R., Bacon, S., Arsenault, A., Dupuis, J., Laurin, C., Blais, L., & Lavoie, K. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-006582 · Cited by 29
“Recently, results of a review of meta-analyses further supported the recommendation that the American Heart Association elevate depression to the status of an official risk factor for adverse medical outcomes in patients with acute coronary syndrome.(4) Studies have also found increased risks of morbidity and mortalit…”
ResultMajor Depression and Acute Coronary Syndrome-Related Factors
Figueiredo, J., Silva, N. A. D. S. E., Pereira, B. D. B., & de Oliveira, G. M. M. (2017) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20170028 · Cited by 29
Role of Stress and Psychosocial Determinants on Women's Cardiovascular Risk and Disease Development
Medina‐Inojosa, J. R., Vinnakota, S., Garcia, M. C., Calle, M. C. A., Mulvagh, S. L., López-Jiménez, F. A., & Bhagra, A. (2018) · Journal of Women s Health · doi:10.1089/jwh.2018.7035 · Cited by 28
Yang, H., Koh, E., & Kang, Y. (2021) · Biomolecules · doi:10.3390/biom11050708 · Cited by 33
“Several studies have suggested that DD is associated with greater sympathetic nervous system activation and decreased regulation of the parasympathetic nervous system of the heart rate and blood pressure [32,33].”
BackgroundDepressive and anxiety symptoms and illness perception among patients with acute coronary syndrome
Zou, H., Chair, S. Y., Zhang, C., & Bao, A. (2023) · Journal of Advanced Nursing · doi:10.1111/jan.15612 · Cited by 29
Initiation of β-blocker therapy and depression after acute myocardial infarction
Ranchord, A. M., Spertus, J. A., Buchanan, D. M., GOSCH, K. L., & Chan, P. S. (2015) · American Heart Journal · doi:10.1016/j.ahj.2015.11.018 · Cited by 29
Association Between Depressive Symptoms and Exercise Capacity in Patients With Heart Disease
Papasavvas, T., Alhashemi, M., & Micklewright, D. P. (2016) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000193 · Cited by 30
Carroll, A. J., Carnethon, M. R., Liu, K., Jacobs, D. R., Colangelo, L. A., Stewart, J. C., Carr, J. J., Widome, R., Auer, R., & Hitsman, B. L. (2016) · Health Psychology · doi:10.1037/hea0000425 · Cited by 29
Perez-Cornago, A., Mansego, M., Zulet, M., & Martinez, J. (2014) · Nutrients · doi:10.3390/nu6062387 · Cited by 28
“This psychiatric disease has been suggested to be often related to the metabolic syndrome (MetS), a state characterized by a combination of central obesity, peripheral insulin resistance, hypertension and serum lipid abnormalities [2,3].”
BackgroundCardiology and lifestyle medicine
Rozanski, A., Blumenthal, J. A., Hinderliter, A. L., Cole, S. W., & Lavie, C. J. (2023) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2023.04.004 · Cited by 29
Self-citationManagement of Depression After Myocardial Infarction
Shapiro, P. A. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0634-4 · Cited by 29
The role of medical and psychosocial factors for unfavourable coronary risk factor control
Munkhaugen, J., Sverre, E., Peersen, K., Gjertsen, E., Gullestad, L. L., Moum, T., Otterstad, J. E., Perk, J., Husebye, E., & Dammen, T. (2015) · Scandinavian Cardiovascular Journal · doi:10.3109/14017431.2015.1111408 · Cited by 28
“depression) have previously been reported as being modifiable in cardiac patients.[17] However, whether modification will be associated with improved drug adherence and risk factor control has previously not yet been tested.”
BackgroundDepression, treatable cardiovascular risk factors and incident cardiac events in the Gazel cohort
Hamieh, N. M., Meneton, P., Wiernik, E., Limosin, F., Zins, M., Goldberg, M., Melchior, M., & Lemogne, C. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.10.013 · Cited by 29
“Approximately 30-45% of patients with CVD suffer from elevated levels of depressive symptoms [7] and while depression predicts CVD onset (i.e. depressed individuals are 1.5 times higher to develop CVD compared to non-depressed [8]), the opposite can also be the case.”
BackgroundInfluentialMental health disorders among patients with acute myocardial infarction in the United States
Sreenivasan, J., Khan, M. S., Khan, S. U., Hooda, U., Aronow, W. S., Panza, J. A., Levine, G. N., Commodore-Mensah, Y. Y., Blumenthal, R. S., & Michos, E. D. (2020) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2020.100133 · Cited by 28
“However, it is intriguing that those patients who suffer from MHD have developed acute MI at an early age compared to their non-MHD counterparts and this seems to be likely due to premature CVD associated with various MHD [2,33].”
BackgroundDoyle, F., Freedland, K. E., Carney, R. M., de Jonge, P., Dickens, C. M., Pedersen, S. S., Sørensen, J. R., & Dempster, M. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000944 · Cited by 27
Self-citation
Metadata
- Authors
- Lichtman, J. H., Froelicher, E. S., Blumenthal, J. A., Carney, R. M., Doering, L. V., Frasure-Smith, N., Freedland, K. E., Jaffe, A. S., Leifheit-Limson, E. C., Sheps, D. S., Vaccarino, V., & Wulsin, L.
- ORCID
- Venue
- Circulation
- Published
- 2014-03-25
- Volume
- 129
- Issue
- 12
- Pages
- 1350-1369
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2137977071
- Cited by
- 1,208
- References
- 129
- Citations by year
- 2026: 65 · 2025: 87 · 2024: 95 · 2023: 106 · 2022: 107 · 2021: 100 · 2020: 108 · 2019: 105 · 2018: 112 · 2017: 90 · 2016: 113 · 2015: 86 · 2014: 32
- FWCI
- 17.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- depression, acute coronary syndrome, cardiovascular risk factors, prognosis, all-cause mortality, cardiac mortality
- MeSH terms
- American Heart Association, Cardiology, Depression, Humans, Prognosis, Risk Factors, United States, Practice Guidelines as Topic, Evidence-Based Medicine, Acute Coronary Syndrome
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