The DOI matches its Crossref record, with a small difference in title or year; 129 of the 129 references it cites were found in a registry or an index.
Depression as a Risk Factor for Poor Prognosis Among Patients With Acute Coronary Syndrome: Systematic Review and Recommendations: A Scientific Statement From the American Heart Association
Open accessAbstract
Background—: Although prospective studies, systematic reviews, and meta-analyses have documented an association between depression and increased morbidity and mortality in a variety of cardiac populations, depression has not yet achieved formal recognition as a risk factor for poor prognosis in patients with acute coronary syndrome by the American Heart Association and other health organizations. The purpose of this scientific statement is to review available evidence and recommend whether depression should be elevated to the status of a risk factor for patients with acute coronary syndrome. Methods and Results—: Writing group members were approved by the American Heart Association’s Scientific Statement and Manuscript Oversight Committees. A systematic literature review on depression and adverse medical outcomes after acute coronary syndrome was conducted that included all-cause mortality, cardiac mortality, and composite outcomes for mortality and nonfatal events. The review assessed the strength, consistency, independence, and generalizability of the published studies. A total of 53 individual studies (32 reported on associations with all-cause mortality, 12 on cardiac mortality, and 22 on composite outcomes) and 4 meta-analyses met inclusion criteria. There was heterogeneity across studies in terms of the demographic composition of study samples, definition and measurement of depression, length of follow-up, and covariates included in the multivariable models. Despite limitations in some individual studies, our review identified generally consistent associations between depression and adverse outcomes. Conclusions—: Despite the heterogeneity of published studies included in this review, the preponderance of evidence supports the recommendation that the American Heart Association should elevate depression to the status of a risk factor for adverse medical outcomes in patients with acute coronary syndrome.
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“Elevated depressive and anxiety symptoms increase the risk for recurrent cardiac events and mortality after ACS [2].”
From Lower distress tolerance is associated with greater anxiety and depression symptoms among patients after acute coronary syndrome (2021) · cites this paper as [2]
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“One in five patients with ischaemic heart disease (IHD) develop comorbid depression or anxiety.”
From Efficacy and cost-effectiveness of a therapist-assisted web-based intervention for depression and anxiety in patients with ischemic heart disease attending cardiac rehabilitation [eMindYourHeart trial]: a randomised controlled trial protocol (2021) · cites this paper as [3]
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“Clarification remains pertinent, given the prevalence (15–31%) of depression in patients with coronary artery disease and its impact (Lesperance et al., 1996; Lichtman et al., 2014; Rudisch and Nemeroff, 2003).”
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“Depression in patients with acute coronary syndrome is associated with a worse cardiac outcome [19] due to an increase recurrence of cardiac events and mortality [20].”
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“서 우울 증상이 발생하는 것으로 보고한 체계적 문헌고찰 연구 [15,31]에 의해 지지 될 수 있다.”
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“Notably, the prevalence of depression increases the risk of developing vascular diseases, such as coronary heart disease and atherosclerosis, by activating inflammation and causing endothelial cell dysfunction (Lichtman et al., 2014; Newson et al., 2010).”
BackgroundSynergistic effects of depression and NR3C1 methylation on prognosis of acute coronary syndrome
Kang, H., Stewart, R. J., Kim, J., Kim, S.-W., Shin, I., Kim, M.-C., Hong, Y. J., Ahn, Y., Shin, M.-G., Jeong, M. H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62449-2 · Cited by 12
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Deter, H., Orth‐Gomér, K., Rauch‐Kröhnert, U., Albus, C., Ladwig, K., Söllner, W., de Zwaan, M., Grün, A.-S., Ronel, J., Hellmich, M., et al. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110659 · Cited by 10
Ski, C. F., Munian, S., Rolley, J. X., & Thompson, D. R. (2014) · Journal of Clinical Nursing · doi:10.1111/jocn.12703 · Cited by 10
Tylee, A. T., Barley, E. A., Walters, P., Achilla, E., Borschmann, R., Leese, M., McCrone, P., Palacios, J. E., Smith, A., Simmonds, R., et al. (2016) · Programme Grants for Applied Research · doi:10.3310/pgfar04080 · Cited by 12
Carroll, A. J., Auer, R., Colangelo, L. A., Carnethon, M. R., Jacobs, D. R., Stewart, J. C., Widome, R., Carr, J. J., Liu, K., & Hitsman, B. L. (2017) · Journal of Dual Diagnosis · doi:10.1080/15504263.2017.1287455 · Cited by 11
“…depressive symptom clusters; somatic symptoms; smoking; coronary artery calcification (CAC); cardiovascular disease risk; prospective study In 2014, the American Heart Association elevated depression to the level of risk factor for recurrent cardiovascular disease (CVD) (Lichtman et al., 2014).”
Simning, A., Seplaki, C. L., & Conwell, Y. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4684 · Cited by 11
“…syndrome, there is a “preponderance of evidence” (p. 1,357) that depression is a risk factor for adverse medical outcomes such as all-cause mortality (Lichtman et al., 2014), and post-stroke depression is likewise associated with increased mortality as well as disability and worse recovery of…”
BackgroundPeregrinova, L., & Jordan, J. (2017) · Heart and Mind · doi:10.4103/hm.hm_2_16 · Cited by 10
“[6] It is possible that PTSD might increase cardiovascular risk of morbidity and mortality in these patients as an independent factor which could already be shown for major depression.[9] The standard guidelines for the treatment of PTSD recommend evidence-based psychotherapeutic and psychopharmacological treatments.”
BackgroundMulick, A., Walker, J., Puntis, S., Symeonides, S., Gourley, C., Burke, K., Wanat, M., Frost, C., & Sharpe, M. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.11.008 · Cited by 7
Marzolini, S., & Colella, T. J. F. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.08.019 · Cited by 11
Thomas, E. E., Grande, M. R. L., Phillips, S., Cartledge, S. H., Poulter, R. S., & Murphy, B. M. (2024) · Heart Lung and Circulation · doi:10.1016/j.hlc.2024.08.002 · Cited by 9
Hussain, A., Wani, Z. A., Shah, H., Zarġar, A., Margoob, M. A., & Qureshi, W. (2020) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_46_19 · Cited by 9
“65%) in our study in comparison to other debilitating disorders such as cancer (16·5%), coronary heart disease prevalence (15%–30%), and stroke (30%) suggests the strong association between diabetes and depression.[29-31]”
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Wang, J., Wang, Q., Bao, Z., Peng, Y.-Y., Liu, S., Yu, T., Wang, L., Yang, G., Gao, M., & Sun, G. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.761149 · Cited by 8
Greco, A., Brugnera, A., Adorni, R., Tasca, G. A., Compare, A., Viganò, A., Fattirolli, F., Giannattasio, C., D'Addario, M., & Steca, P. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.110974 · Cited by 11
Feng, Z., Tong, W. K., & Tang, Z. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.943165 · Cited by 9
Reis, J., Brizido, C., Madeira, S., Ramos, R. B., Almeida, M., & Cacela, D. (2023) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2022.05.010 · Cited by 9
Darvishzadehdaledari, S., Harrison, A. S., Gholami, F., & Azadnia, A. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03640-x · Cited by 9
“A systematic review indicated a strong association between depression and both cardiac-related mortality and low participation in CR interventions [48].”
Backgroundde Jong, R., van Hout, G. P. J., Houtgraaf, J. H., Takashima, S., Pasterkamp, G., Hoefer, I. E., & Duckers, H. J. (2015) · BioMed Research International · doi:10.1155/2015/209315 · Cited by 9
“At the same time, therapy optimization has also resulted in an increased incidence of HF, since patients survive with severely deteriorated cardiac function [13].”
The year in cardiology 2014: prevention
Backer, G. D., Kastelein, J. J. P., & Landmesser, U. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu482 · Cited by 9
Translation and validation of the Cardiac Depression Scale to Arabic
Papasavvas, T., Al-Amin, H. A., Ghabrash, H. F., & Micklewright, D. P. (2016) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2016.05.001 · Cited by 9
“Based on the consistency of evidence relating depression to adverse outcomes after cute coronary syndrome, the American Heart Association has elevated depression to the status of a risk factor for poor prognosis in patients with acute coronary syndrome (Lichtman et al., 2014).”
BackgroundYamashita, A., Noguchi, H., Hamazaki, K., Sato, Y., Narisawa, T., Kawashima, Y., Usuki, M., Nishi, D., Yoshimasu, H., Horikawa, N., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.062 · Cited by 9
Grippo, A. J., Scotti, M. L., Wardwell, J., McNeal, N., Bates, S. L., Chandler, D. L., Ihm, E., & Jadia, N. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.08.002 · Cited by 9
Storm, V., Reinwand, D. A., Wienert, J., Tan, S. L., & Lippke, S. (2018) · JMIR Mental Health · doi:10.2196/11124 · Cited by 9
Non-ST Elevation Myocardial Infarction: Diagnosis and Management
Alahmad, Y., & Ali, M. T. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.76241 · Cited by 9
Petry, N., Lupu, R. A., Gohar, A., Larson, E. A., Peterson, C., Williams, V. R., Zhao, J., Wilke, R. A., & Hines, L. J. (2019) · Pharmacogenomics · doi:10.2217/pgs-2018-0156 · Cited by 9
Metadata
- Authors
- Lichtman, J. H., Froelicher, E. S., Blumenthal, J. A., Carney, R. M., Doering, L. V., Frasure-Smith, N., Freedland, K. E., Jaffe, A. S., Leifheit-Limson, E. C., Sheps, D. S., Vaccarino, V., & Wulsin, L.
- ORCID
- Venue
- Circulation
- Published
- 2014-03-25
- Volume
- 129
- Issue
- 12
- Pages
- 1350-1369
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2137977071
- Cited by
- 1,208
- References
- 129
- Citations by year
- 2026: 65 · 2025: 87 · 2024: 95 · 2023: 106 · 2022: 107 · 2021: 100 · 2020: 108 · 2019: 105 · 2018: 112 · 2017: 90 · 2016: 113 · 2015: 86 · 2014: 32
- FWCI
- 17.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- depression, acute coronary syndrome, cardiovascular risk factors, prognosis, all-cause mortality, cardiac mortality
- MeSH terms
- American Heart Association, Cardiology, Depression, Humans, Prognosis, Risk Factors, United States, Practice Guidelines as Topic, Evidence-Based Medicine, Acute Coronary Syndrome
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