Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications

Atrial Fibrillation Begets Atrial Fibrillation

WIJFFELS, M. C. E. F., Kirchhof, C. J. H. J., Dorland, R., & Allessie, M. A. (1995) · Circulation · doi:10.1161/01.cir.92.7.1954 · Cited by 3,500

Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study

Heeringa, J., van der Kuip, D. A. M., Hofman, A., Kors, J. A., van Herpen, G., Stricker, B. H. C., Stijnen, T., Lip, G. Y. H., & Witteman, J. C. M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi825 · Cited by 1,939

New ideas about atrial fibrillation 50 years on

Nattel, S. (2002) · Nature · doi:10.1038/415219a · Cited by 1,481

Promotion of Atrial Fibrillation by Heart Failure in Dogs

Li, D., Fareh, S., Leung, T. K., & Nattel, S. (1999) · Circulation · doi:10.1161/01.cir.100.1.87 · Cited by 1,343

Signal Transduction by the TGF-β Superfamily

Attisano, L., & Wrana, J. L. (2002) · Science · doi:10.1126/science.1071809 · Cited by 1,286

Atrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation

Burstein, B., & Nattel, S. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.064 · Cited by 1,248

Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation.

Yue, L., Feng, J.-L., Gaspo, R., Li, G.-R., Wang, Z.-G., & Nattel, S. (1997) · Circulation Research · doi:10.1161/01.res.81.4.512 · Cited by 884

Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation

Nattel, S., Maguy, A., Bouter, S. L., & Yeh, Y. (2007) · Physiological Reviews · doi:10.1152/physrev.00014.2006 · Cited by 857

Prevention of Atrial Fibrillation With Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers

Healey, J. S., Baranchuk, A., Crystal, E., Morillo, C. A., Garfinkle, M., Yusuf, S., & Connolly, S. J. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.11.070 · Cited by 822

Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing–Induced Congestive Heart Failure

Li, D., Shinagawa, K., Pang, L., Leung, T. K., Cardin, S., Wang, Z., & Nattel, S. (2001) · Circulation · doi:10.1161/hc4601.099402 · Cited by 702

TGF-?1 and angiotensin networking in cardiac remodeling

Rosenkranz, S. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.04.030 · Cited by 682

Trandolapril Reduces the Incidence of Atrial Fibrillation After Acute Myocardial Infarction in Patients With Left Ventricular Dysfunction

Pedersen, O. D., Bagger, H., Køber, L., & Torp-Pedersen, C. T. (1999) · Circulation · doi:10.1161/01.cir.100.4.376 · Cited by 656

Relation between echocardiographically determined left atrial size and atrial fibrillation.

Henry, W. L., Morganroth, J., Pearlman, A. S., Clark, C. E., Redwood, D. R., Itscoitz, S. B., & Epstein, S. E. (1976) · Circulation · doi:10.1161/01.cir.53.2.273 · Cited by 641

Enalapril Decreases the Incidence of Atrial Fibrillation in Patients With Left Ventricular Dysfunction

Vermès, E., Tardif, J., Bourassa, M. G., Racine, N., Lévesque, S., White, M., Guerra, P. G., & Ducharme, A. (2003) · Circulation · doi:10.1161/01.cir.0000072793.81076.d4 · Cited by 575

Is atrial fibrillation an inflammatory disorder?

Boos, C. J., Anderson, R. A., & Lip, G. Y. H. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi645 · Cited by 552

Increased Vulnerability to Atrial Fibrillation in Transgenic Mice With Selective Atrial Fibrosis Caused by Overexpression of TGF-β1

Verheule, S., Sato, T., Everett, T. H., Engle, S. K., Otten, D., Rubart, M., Nakajima, H. O., Nakajima, H., Field, L. J., & Olgin, J. E. (2004) · Circulation Research · doi:10.1161/01.res.0000129579.59664.9d · Cited by 551

Somatic Mutations in the Connexin 40 Gene ( GJA5 ) in Atrial Fibrillation

Gollob, M. H., Jones, D. L., Krahn, A. D., Danis, L., Gong, X., Shao, Q., Liu, X., Veinot, J. P., Tang, A., Stewart, A. F. R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052800 · Cited by 543

Pleiotropic AT1 Receptor Signaling Pathways Mediating Physiological and Pathogenic Actions of Angiotensin II

Hunyady, L., & Catt, K. J. (2006) · Molecular Endocrinology · doi:10.1210/me.2004-0536 · Cited by 541

Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation

Issac, T. T., Dokainish, H., & Lakkis, N. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.06.054 · Cited by 525

Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation

Kumagai, K., Nakashima, H., Urata, H., Gondo, N., Arakawa, K., & Saku, K. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00464-9 · Cited by 472

The G Protein–Gated Potassium Current I K,ACh Is Constitutively Active in Patients With Chronic Atrial Fibrillation

Dobrev, D., Friedrich, A., Voigt, N., Jost, N., Wettwer, E., Christ, T., Knaut, M., & Ravens, U. (2005) · Circulation · doi:10.1161/circulationaha.105.575332 · Cited by 463

CTGF Expression is Induced by TGF- β in Cardiac Fibroblasts and Cardiac Myocytes: a Potential Role in Heart Fibrosis

Chen, M. M., Lam, A., Abraham, J. A., Schreiner, G. F., & Joly, A. H. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1215 · Cited by 443

A Myocardial Nox2 Containing NAD(P)H Oxidase Contributes to Oxidative Stress in Human Atrial Fibrillation

Kim, Y. M., Guzik, T. J., Zhang, Y. H., Zhang, Y. H., Kattach, H., Ratnatunga, C., Pillai, R. G., Channon, K. M., & Casadei, B. (2005) · Circulation Research · doi:10.1161/01.res.0000183735.09871.61 · Cited by 407

Effects of experimental heart failure on atrial cellular and ionic electrophysiology.

Li, D.-S., Melnyk, P., Feng, J.-L., Wang, Z.-G., Petrecca, K., Shrier, A., & Nattel, S. (2000) · Circulation · doi:10.1161/01.cir.101.22.2631 · Cited by 384

Atrial Fibrillation Increases Production of Superoxide by the Left Atrium and Left Atrial Appendage

Dudley, S. C., Hoch, N. E., McCann, L. A., Honeycutt, C., Diamandopoulos, L., Fukai, T., Harrison, D. G., Dikalov, S., & Langberg, J. J. (2005) · Circulation · doi:10.1161/circulationaha.105.538108 · Cited by 375

Molecular Mechanisms Underlying Ionic Remodeling in a Dog Model of Atrial Fibrillation

Yue, L., Melnyk, P. M., Gaspo, R., Wang, Z., & Nattel, S. (1999) · Circulation Research · doi:10.1161/01.res.84.7.776 · Cited by 357

Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation

Vest, J. A., Wehrens, X. H. T., Reiken, S. R., Lehnart, S. E., Dobrev, D., Chandra, P., Danilo, P., Ravens, U., Rosen, M. R., & Marks, A. R. (2005) · Circulation · doi:10.1161/01.cir.0000162461.67140.4c · Cited by 352

Atrial fibrosis and the mechanisms of atrial fibrillation

Everett, T. H., & Olgin, J. E. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.12.040 · Cited by 338

Endothelin-1–Induced Arrhythmogenic Ca 2+ Signaling Is Abolished in Atrial Myocytes of Inositol-1,4,5-Trisphosphate(IP 3 )–Receptor Type 2–Deficient Mice

Li, X., Zima, A. V., Sheikh, F., Blatter, L. A., & Chen, J. (2005) · Circulation Research · doi:10.1161/01.res.0000172556.05576.4c · Cited by 333

Molecular Basis of Downregulation of G-Protein–Coupled Inward Rectifying K+Current (IK,ACh) in Chronic Human Atrial Fibrillation

Dobrev, D., Graf, E., Wettwer, E., Himmel, H. M., Hála, O., Doerfel, C., Christ, T., Schüler, S., & Ravens, U. (2001) · Circulation · doi:10.1161/hc4601.099466 · Cited by 320

Reinduction of Atrial Fibrillation Immediately After Termination of the Arrhythmia Is Mediated by Late Phase 3 Early Afterdepolarization–Induced Triggered Activity

Burashnikov, A., & Antzelevitch, C. (2003) · Circulation · doi:10.1161/01.cir.0000065578.00869.7c · Cited by 312

Tarantula peptide inhibits atrial fibrillation

Bode, F., Sachs, F., & Franz, M. R. (2001) · Nature · doi:10.1038/35051165 · Cited by 306

L-Type Ca 2+ Current Downregulation in Chronic Human Atrial Fibrillation Is Associated With Increased Activity of Protein Phosphatases

Christ, T., Boknı́k, P., Wöhrl, S., Wettwer, E., Graf, E., BOSCH, R. F., Knaut, M., Schmitz, W. L., Ravens, U., & Dobrev, D. (2004) · Circulation · doi:10.1161/01.cir.0000145659.80212.6a · Cited by 291

Relationship between C-reactive protein concentrations during glucocorticoid therapy and recurrent atrial fibrillation

Dernellis, J. M. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.04.025 · Cited by 290

Effects of Rapid Atrial Pacing on the Arrhythmogenic Activity of Single Cardiomyocytes From Pulmonary Veins

Chen, Y., Chen, S.-A., Chen, Y., Yeh, H., Chan, P., Chang, M.-S., & Lin, C. (2001) · Circulation · doi:10.1161/hc4801.099736 · Cited by 289

Calcium-Handling Abnormalities Underlying Atrial Arrhythmogenesis and Contractile Dysfunction in Dogs With Congestive Heart Failure

Yeh, Y.-H., Wakili, R., Qi, X., Chartier, D., Boknı́k, P., Kääb, S., Ravens, U., Coutu, P., Dobrev, D., & Nattel, S. (2008) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.107.754788 · Cited by 289

Cholinergic Atrial Fibrillation in a Computer Model of a Two-Dimensional Sheet of Canine Atrial Cells With Realistic Ionic Properties

Kneller, J., Zou, R., Vigmond, E. J., Wang, Z., Leon, L. J., & Nattel, S. (2002) · Circulation Research · doi:10.1161/01.res.0000019783.88094.ba · Cited by 288

Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: insights from a mathematical model

Courtemanche, M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00034-6 · Cited by 284

Dilated Cardiomyopathy and Sudden Death Resulting From Constitutive Activation of Protein Kinase A

Antos, C. L., Frey, N., Marx, S. O., Reiken, S. R., Gaburjáková, M., Richardson, J. A., Marks, A. R., & Olson, E. N. (2001) · Circulation Research · doi:10.1161/hh2301.100003 · Cited by 279

Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure

HANNA, N. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.026 · Cited by 275

Effect of Simvastatin and Antioxidant Vitamins on Atrial Fibrillation Promotion by Atrial-Tachycardia Remodeling in Dogs

Shiroshita-Takeshita, A., Schram, G., Lavoie, J., & Nattel, S. (2004) · Circulation · doi:10.1161/01.cir.0000145163.56529.d1 · Cited by 274

Molecular Determinants of Altered Ca 2+ Handling in Human Chronic Atrial Fibrillation

El‐Armouche, A., Boknı́k, P., Thomas Eschenhagen, A., Carrier, L., Knaut, M., Ravens, U., & Dobrev, D. (2006) · Circulation · doi:10.1161/circulationaha.106.636845 · Cited by 274

Mice with Cardiac-Restricted Angiotensin-Converting Enzyme (ACE) Have Atrial Enlargement, Cardiac Arrhythmia, and Sudden Death

Xiao, H., Fuchs, S., Campbell, D. J., Lewis, W., Dudley, S. C., Kasi, V. S., Hoit, B. D., Keshelava, G., Zhao, H., Capecchi, M. R., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63363-9 · Cited by 270

Differential Behaviors of Atrial Versus Ventricular Fibroblasts

Burstein, B., Libby, E., Calderone, A., & Nattel, S. (2008) · Circulation · doi:10.1161/circulationaha.107.748053 · Cited by 269

Tachycardia-Induced Changes in Na+Current in a Chronic Dog Model of Atrial Fibrillation

Gaspo, R., BOSCH, R. F., Bou‐Abboud, E., & Nattel, S. (1997) · Circulation Research · doi:10.1161/01.res.81.6.1045 · Cited by 256

Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways

Cardin, S. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.08.014 · Cited by 255

Ion Channel Remodeling Is Related to Intraoperative Atrial Effective Refractory Periods in Patients With Paroxysmal and Persistent Atrial Fibrillation

Brundel, B. J. J. M., Gelder, I. C. V., Henning, R. H., Tieleman, R. G., Tuinenburg, A. E., Wietses, M., Grandjean, J. G., van Gilst, W. H., & Crijns, H. J. G. M. (2001) · Circulation · doi:10.1161/01.cir.103.5.684 · Cited by 250

Gap junctional remodeling in relation to stabilization of atrial fibrillation in the goat

van der Velden, H. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00026-2 · Cited by 250

Human Atrial Ion Channel and Transporter Subunit Gene-Expression Remodeling Associated With Valvular Heart Disease and Atrial Fibrillation

Gaborit, N., Steenman, M., Lamirault, G., Meur, N. L., Bouter, S. L., Lande, G., Leger, J. J., Charpentier, F., Christ, T., Dobrev, D., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.506857 · Cited by 249

Dynamic Nature of Atrial Fibrillation Substrate During Development and Reversal of Heart Failure in Dogs

Shinagawa, K., Shi, Y., Tardif, J., Leung, T. K., & Nattel, S. (2002) · Circulation · doi:10.1161/01.cir.0000016826.62813.f5 · Cited by 240

Enhancement of Cardiac Function and Suppression of Heart Failure Progression By Inhibition of Protein Phosphatase 1

Pathak, A., del Monte, F., Zhao, W., Schultz, J.-E., Lorenz, J. N., Bódi, I., Weiser, D., Hahn, H. S., Carr, A. N., Syed, F. M., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000161256.85833.fa · Cited by 229

Pirfenidone Prevents the Development of a Vulnerable Substrate for Atrial Fibrillation in a Canine Model of Heart Failure

Lee, K. W., Everett, T. H., Rahmutula, D., Palmero, M. J. G., Wilson, E., Ding, C., & Olgin, J. E. (2006) · Circulation · doi:10.1161/circulationaha.106.624320 · Cited by 224

Oxidative Stress Markers Are Associated with Persistent Atrial Fibrillation

Neuman, R. B., Bloom, H. L., Shukrullah, I., Darrow, L. A., Kleinbaum, D. G., Jones, D. P., & Dudley, S. C. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.083923 · Cited by 218

β-Adrenergic Stimulation Modulates Ryanodine Receptor Ca 2+ Release During Diastolic Depolarization to Accelerate Pacemaker Activity in Rabbit Sinoatrial Nodal Cells

Vinogradova, T. M., Bogdanov, K. Y., & Lakatta, E. G. (2002) · Circulation Research · doi:10.1161/hh0102.102271 · Cited by 215

Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+channels

Brundel, B. J. J. M., Gelder, I. C. V., Henning, R. H., Tuinenburg, A. E., Wietses, M., Grandjean, J. G., Wilde, A. A. M., van Gilst, W. H., & Crijns, H. J. G. M. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01195-5 · Cited by 211

Frequency-Dependent Breakdown of Wave Propagation Into Fibrillatory Conduction Across the Pectinate Muscle Network in the Isolated Sheep Right Atrium

Berenfeld, O., Зайцев, А. В., Mironov, S. F., Pertsov, A. M., & Jalife, J. (2002) · Circulation Research · doi:10.1161/01.res.0000022854.95998.5c · Cited by 208

Spironolactone reduces fibrosis of dilated atria during heart failure in rats with myocardial infarction

Milliez, P., DeAngelis, N., Rücker‐Martin, C., Leenhardt, A., Vicaut, É., Robidel, E., Beaufils, P., Delcayre, C., & Hatem, S. N. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi478 · Cited by 204

Cellular Mechanisms of Atrial Contractile Dysfunction Caused by Sustained Atrial Tachycardia

Sun, H. Q., Gaspo, R., Leblanc, N., & Nattel, S. (1998) · Circulation · doi:10.1161/01.cir.98.7.719 · Cited by 202

Inositol‐1,4,5‐trisphosphate‐dependent Ca2+ signalling in cat atrial excitation–contraction coupling and arrhythmias

Zima, A. V., & Blatter, L. A. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058529 · Cited by 190

Kir3-Based Inward Rectifier Potassium Current

Cha, T., Ehrlich, J. R., Chartier, D., Qi, X., Xiao, L., & Nattel, S. (2006) · Circulation · doi:10.1161/circulationaha.105.561738 · Cited by 183

Association of Human Connexin40 Gene Polymorphisms With Atrial Vulnerability as a Risk Factor for Idiopathic Atrial Fibrillation

Firouzi, M., Ramanna, H., Kok, B., Jongsma, H. J., Koeleman, B. P. C., Doevendans, P. A., Groenewegen, W. A., & Hauer, R. N. W. (2004) · Circulation Research · doi:10.1161/01.res.0000141134.64811.0a · Cited by 180

Transient outward and delayed rectifier currents in canine atrium: properties and role of isolation methods.

Yue, L.-X., Feng, J.-L., Li, G.-R., & Nattel, S. (1996) · American Journal of Physiology · doi:10.1152/ajpheart.1996.270.6.h2157 · Cited by 176

Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model

Zicha, S., Fernández‐Velasco, M., Lonardo, G., L’Heureux, N., & Nattel, S. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.011 · Cited by 171

Role of Rac1 GTPase Activation in Atrial Fibrillation

Adam, O., Frost, G., Custodis, F., Sussman, M. A., Schäfers, H., Böhm, M., & Laufs, U. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.03.041 · Cited by 165

Characterization of a hyperpolarization‐activated time‐dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium

Ehrlich, J. R., Cha, T., Zhang, L., Chartier, D., Villeneuve, L. R., Hébert, T. E., & Nattel, S. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.061119 · Cited by 161

Effects of Antiarrhythmic Drugs on Fibrillation in the Remodeled Atrium

Shinagawa, K., Shiroshita-Takeshita, A., Schram, G., & Nattel, S. (2003) · Circulation · doi:10.1161/01.cir.0000055316.35552.74 · Cited by 160

Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation

Nakano, Y., Niida, S., Dote, K., Takenaka, S., Hirao, H., Miura, F., Ishida, M., Shingu, T., Sueda, T., Yoshizumi, M., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.08.060 · Cited by 153

The T-Type Ca2+Channel Blocker Mibefradil Prevents the Development of a Substrate for Atrial Fibrillation by Tachycardia-Induced Atrial Remodeling in Dogs

Fareh, S., Benardeau, A. M., Thibault, B., & Nattel, S. (1999) · Circulation · doi:10.1161/01.cir.100.21.2191 · Cited by 152

Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: A novel consideration in atrial remodeling☆

Burstein, B., Qi, X., Yeh, Y., Calderone, A., & Nattel, S. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.07.013 · Cited by 152

Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation

Brundel, B. J. J. M. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00289-4 · Cited by 152

Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation

Nattel, S. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00022-x · Cited by 151

Connective tissue growth factor—a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats

Ahmed, M. S. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2003.12.004 · Cited by 149

Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure☆

Shiroshita-Takeshita, A., Brundel, B. J. J. M., Burstein, B., Leung, T. K., Mitamura, H., Ogawa, S., & Nattel, S. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.01.002 · Cited by 149

Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation

Voigt, N., Friedrich, A., Bock, M., Wettwer, E., Christ, T., Knaut, M., Strasser, R. H., Ravens, U., & Dobrev, D. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.02.009 · Cited by 142

Omega-3 Polyunsaturated Fatty Acids Prevent Atrial Fibrillation Associated With Heart Failure but Not Atrial Tachycardia Remodeling

Sakabe, M., Shiroshita-Takeshita, A., Maguy, A., Dumesnil, C., Nigam, A., Leung, T. K., & Nattel, S. (2007) · Circulation · doi:10.1161/circulationaha.107.704759 · Cited by 138

Atrial Glutathione Content, Calcium Current, and Contractility

Carnes, C. A., Janssen, P. M. L., Ruehr, M. L., Nakayama, H., Nakayama, T., Haase, H., Bauer, J. A., Chung, M. K., Fearon, I. M., Gillinov, A. M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704893200 · Cited by 130

Pharmacological response of quinidine induced early afterdepolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms

Nattel, S., & Quantz, M. (1988) · Cardiovascular Research · doi:10.1093/cvr/22.11.808 · Cited by 127

Characterization of Sustained Atrial Tachycardia in Dogs with Rapid Ventricular Pacing‐Induced Heart Failure

Stambler, B., Fenelon, G., Shepard, R., Clemo, H., & Guiraudon, C. (2003) · Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2003.02519.x · Cited by 123

Remodeling of atrial dimensions and emptying function in canine models of atrial fibrillation

Shi, Y. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00377-7 · Cited by 116

Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces ICa,Land Itoin rapid atrial pacing in rabbits

BOSCH, R. F., Scherer, C. R., Rüb, N., Wöhrl, S., Steinmeyer, K., Haase, H., Busch, A. E., Seipel, L., & Kühlkamp, V. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02922-4 · Cited by 114

Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium

Zou, R., Kneller, J., Leon, L. J., & Nattel, S. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00252.2005 · Cited by 113

Changes in IK,ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes

Voigt, N., Maguy, A., Yeh, Y., Qi, X., Ravens, U., Dobrev, D., & Nattel, S. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm051 · Cited by 109

Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs

Shiroshita-Takeshita, A., Brundel, B. J. J. M., Lavoie, J., & Nattel, S. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.11.028 · Cited by 108

Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction

Lopes, S. M. C. D. S., Feijen, A., Korving, J., Korchynskyi, O., Larsson, J., Karlsson, S., ten Dijke, P., Lyons, K. M., Goldschmeding, R., Doevendans, P. A., et al. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20162 · Cited by 97

Selective Induction of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Atrial and Ventricular Myocardium in Patients With Atrial Fibrillation

Mukherjee, R. D., Herron, A. R., Lowry, A. S., Stroud, R. E., Stroud, M. R., Wharton, J. M., Ikonomidis, J. S., Crumbley, A. J., Spinale, F. G., & Gold, M. R. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.08.073 · Cited by 94

Contrasting Gene Expression Profiles in Two Canine Models of Atrial Fibrillation

Cardin, S., Libby, E., Pelletier, P., Bouter, S. L., Shiroshita-Takeshita, A., Meur, N. L., Leger, J. J., Demolombe, S., Ponton, A., Glass, L., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000258428.09589.1a · Cited by 93

Cesium‐Induced Atrial Tachycardia Degenerating into Atrial Fibrillation in Dogs: Atrial Torsades de Pointes?

SATOH, T., & Zipes, D. P. (1998) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1998.tb00137.x · Cited by 91

Calpains and cytokines in fibrillating human atria

Goette, A., Arndt, M., Röcken, C., Staack, T., Bechtloff, R., Reinhold, D., Huth, C., Ansorge, S., Klein, H., & Lendeckel, U. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00505.2001 · Cited by 91

Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism

NUNEZ, L., Vaquero, L. M., Gómez, R. J., Caballero, R., Mateos‐Cáceres, P. J., Macaya, C., Iriepa, I., Galvez‐Ruano, E., López-Farré, A. J., & Tamargo, J. L. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.021 · Cited by 88

Expression of connexins 40 and 43 in human left atrium in atrial fibrillation of different aetiologies

Wetzel, U., Boldt, A., Lauschke, J., Weigl, J., Schirdewahn, P., Dorszewski, A., Doll, N., Hindricks, G., Dhein, S., & Kottkamp, H. (2005) · Heart · doi:10.1136/hrt.2003.024216 · Cited by 84

Selective Aldosterone Blockade Suppresses Atrial Tachyarrhythmias in Heart Failure

Shroff, S. C., Ryu, K., MARTOVITZ, N. L., Hoit, B. D., & Stambler, B. S. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00372.x · Cited by 82

Activation of the calcineurin signaling pathway induces atrial hypertrophy during atrial fibrillation

Bukowska, A., Lendeckel, U., Hirte, D., Wolke, C., Striggow, F., Röhnert, P., Huth, C., Klein, H., & Goette, A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5353-3 · Cited by 78

Differential Calcineurin/NFATc3 Activity Contributes to the I to Transmural Gradient in the Mouse Heart

Rossow, C. F., Dilly, K. W., & Santana, L. F. (2006) · Circulation Research · doi:10.1161/01.res.0000222028.92993.10 · Cited by 73

Pharmacological evidence for altered src kinase regulation of I Ca,L in patients with chronic atrial fibrillation

Greiser, M., Halaszovich, C. R., Frechen, D., Boknı́k, P., Ravens, U., Dobrev, D., Lückhoff, A., & Schotten, U. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0174-6 · Cited by 72

The L-type Ca2+-channel subunits α1C and β2 are not downregulated in atrial myocardium of patients with chronic atrial fibrillation

Schotten, U. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00012-9 · Cited by 64

Steady-state and nonsteady-state action potentials in fibrillating canine atrium: abnormal rate adaptation and its possible mechanisms

Hara, M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00044-9 · Cited by 64

Spontaneous episodes of atrial fibrillation after implantation of the Metrix Atrioverter: observations on treated and nontreated episodes

Timmermans, C. C., Lévy, S., Ayers, G. M., Jung, W., Jordaens, L. J. L. M., Rosenqvist, M., Thibault, B., Camm, J. A., Rodriguez, L., & Wellens, H. J. J. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00579-9 · Cited by 62

Measurement of Funny Current (If) Channel mRNA in Human Atrial Tissue: Correlation with Left Atrial Filling Pressure and Atrial Fibrillation

Lai, L., Su, M., Lin, J.-L., TSAI, C., Lin, F., Chen, Y., Hwang, J., Huang, S. K. S., Tseng, Y.-Z., & Lien, W.-P. (1999) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1999.tb01265.x · Cited by 61

Down‐regulation of sarcolipin mRNA expression in chronic atrial fibrillation

Uemura, N., Ohkusa, T., Hamano, K., Nakagome, M., Hori, H., Shimizu, M., Matsuzaki, M., Mochizuki, S., Minamisawa, S., & Ishikawa, Y. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01422.x · Cited by 59

Consequences of atrial electrical remodeling for the anti-arrhythmic action of class IC and class III drugs

Duytschaever, M. F., Blaauw, Y., & Allessie, M. A. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.019 · Cited by 58

Decreased ATP-sensitive K+ current density during chronic human atrial fibrillation

Balana, B. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00246-3 · Cited by 49

Bepridil Reverses Atrial Electrical Remodeling and L‐Type Calcium Channel Downregulation in a Canine Model of Persistent Atrial Tachycardia

Nishida, K., Fujiki, A., Sakamoto, T., Iwamoto, J., Mizumaki, K., Hashimoto, N., & Inoue, H. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00833.x · Cited by 48

Remodeling of Ca2+-handling by atrial tachycardia: evidence for a role in loss of rate-adaptation

Kneller, J. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00274-2 · Cited by 46

Crosstalk between L-type calcium channels and ZnT-1, a new player in rate-dependent cardiac electrical remodeling

Beharier, O., Etzion, Y., Katz, A., Friedman, H., Tenbosh, N., Zacharish, S., Bereza, S., Goshen, U., & Moran, A. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.11.007 · Cited by 45

Comparison of Ca2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes.

Coutu, P., Chartier, D., & Nattel, S. (2006) · American Journal of Physiology. Heart and Circulatory Physiology · doi:10.1152/ajpheart.00730.2005 · Cited by 45

Effect of the Implantable Atrial Defibrillator on the Natural History of Atrial Fibrillation

Tse, H., Lau, C., Yu, C., Lee, K. L., Michaud, G. F., Knight, B. P., Morady, F., & Strickberger, S. A. (1999) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1999.tb00296.x · Cited by 45

Novel targets for treating heart and muscle disease – stabilizing ryanodine receptors and preventing intracellular calcium leak

Lehnart, S. E. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.09.010 · Cited by 43

Clinical Evaluation of a Policy of Early Repeated Internal Cardioversion for Recurrence of Atrial Fibrillation

Fynn, S. P., TODD, D. M., Hobbs, W. J., Armstrong, K. L., Fitzpatrick, A. P., & Garratt, C. J. (2002) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2002.00135.x · Cited by 34

Does flecainide regain its antiarrhythmic activity after electrical cardioversion of persistent atrial fibrillation?

Tieleman, R. G., Gelder, I. C. V., Bosker, H. A., Kingma, T., Wilde, A. A. M., Kirchhof, C. J. H. J., Bennekers, J. H., Bracke, F. A. L. E., Veeger, N. J. G. M., Haaksma, J., et al. (2005) · Heart Rhythm · doi:10.1016/j.hrthm.2004.11.014 · Cited by 34

Inositol-1,4,5-Trisphosphate and Ryanodine-Dependent Ca2+ Signaling in a Chronic Dog Model of Atrial Fibrillation

Zhao, Z.-H., Zhang, H.-C., Xu, Y., Zhang, P., Li, X., Liu, Y., & Guo, J. (2006) · Cardiology · doi:10.1159/000095517 · Cited by 31

Vagal Atrial Fibrillation

Yeh, Y., Lemola, K., & Nattel, S. (2007) · Zhōnghuá mínguó xīnzàngxué huì zázhì · Cited by 28

Correlation Between Atrial ZnT‐1 Expression and Atrial Fibrillation in Humans: A Pilot Study

Etzion, Y., Ganiel, A., Beharier, O., Shaleṿ, A., Novack, V., Volvich, L., Abrahamov, D., Matsa, M., Sahar, G., Moran, A., et al. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.01008.x · Cited by 27

Proliferative Signaling and Disease Progression in Heart Failure.

Katz, A. M. (2002) · Circulation Journal · doi:10.1253/circj.66.225 · Cited by 24

Changes of IK, ATP current density and allosteric modulation during chronic atrial fibrillation.

Wu, G., Huang, C.-X., Tang, Y., Jiang, H. X., Wan, J., Chen, H., Xie, Q., & Huang, Z. (2005) · PubMed · Cited by 21

Time course of recovery of left atrial mechanical dysfunction after cardioversion of spontaneous atrial fibrillation with the implantable atrial defibrillator

Tse, H., Wang, Q., Yu, C., Ayers, G. M., & Lau, C. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01143-7 · Cited by 14

Ion channel remodelling in relation to intra-operative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation

Brundel, B. J. J. M., Gelder, I. C. V., Henning, R. J., Tieleman, R. G., van Gilst, W. H., & Crijns, H. (2000) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 8

Abstract 1237: Heat Shock Protein Induction Attenuates Atrial Remodeling and Atrial Fibrillation Promotion in Dogs with Ventricular Tachycardiomyopathy

Shiroshita-Takeshita, A., Sakabe, M., Maguy, A., Cardin, S., Brundel, B. J. J. M., & Nattel, S. (2007) · Circulation · Cited by 4

Pharmacological Cardioversion of Long-Lasting Atrial Fibrillation

Fujiki, A., & Inoue, H. (2007) · Circulation Journal · doi:10.1253/circj.71.a69 · Cited by 4

2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation

January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,145

2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation

January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.022 · Cited by 2,955

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.012 · Cited by 2,794

The Clinical Profile and Pathophysiology of Atrial Fibrillation

Andrade, J. G., Khairy, P., Dobrev, D., & Nattel, S. (2014) · Circulation Research · doi:10.1161/circresaha.114.303211 · Cited by 1,232

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · EP Europace · doi:10.1093/europace/eux274 · Cited by 1,203

Left Atrial Anatomic Remodeling in Atrial Fibrillation

Cosío, F. G., & Castillo, E. A. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00701.x · Cited by 7

Atrial Remodeling And Atrial Fibrillation: Mechanistic Interactions And Clinical Implications

Hassan, W., & Al-Ghamdi, B. S. (2009) · Journal of Atrial Fibrillation · doi:10.4022/jafib.v1i7.537 · Cited by 22

Exercise Capacity and Atrial Remodeling in Atrial Fibrillation

Lambrakos, L. K., & Goldberger, J. J. (2016) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2016.05.016

Electrophysiologic Remodeling of the Atrium in Patients With Atrial Fibrillation

Tse, H. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)88224-1

Atrial Remodeling Induced by Exercise: a Model(s) for Atrial Fibrillation

Backx, & Peter, H. H. (2016)