Mortality Among Patients Hospitalized With Heart Failure and Diabetes Mellitus: Results From the National Inpatient Sample 2000 to 2010
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BACKGROUND: Case fatality and hospitalization rates for US patients with heart failure (HF) have steadily decreased during the past several decades. Diabetes mellitus (DM), a risk factor for, and frequent coexisting condition with, HF continues to increase in the general population. METHODS AND RESULTS: We used the National Inpatient Sample to estimate overall as well as age-, sex-, and race/ethnicity-specific trends in HF hospitalizations, DM prevalence, and in-hospital mortality among 2.5 million discharge records from 2000 to 2010 with HF as primary discharge diagnosis. Multivariable logistic and Poisson regression were used to assess the impact of the above demographic characteristics on in-hospital mortality. Age-standardized hospitalizations decreased significantly in HF overall and in HF with DM. Age-standardized in-hospital mortality with HF declined from 2000 to 2010 (4.57% to 3.09%, Ptrend<0.0001), whereas DM prevalence in HF increased (38.9% to 41.9%, Ptrend<0.0001) as did comorbidity burden. Age-standardized in-hospital mortality in HF with DM also decreased significantly (3.53% to 2.27%, Ptrend<0.0001). After adjusting for year, age, and comorbid burden, males remained at 17% increased risk versus females, non-Hispanics remained at 12% increased risk versus Hispanics, and whites had a 30% higher mortality versus non-white minorities. Absolute mortality rates were lower in younger versus older patients, although the rate of decline was attenuated in younger patients. CONCLUSIONS: In-hospital mortality in HF patients with DM significantly decreased during the past decade, despite increases in DM prevalence and comorbid conditions. Mortality rate decreases among younger patients were significantly attenuated, and mortality disparities remain among important demographic subgroups.
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A slight increase in T2DM prevalence was reported in North America over time.
“and a slight increase in the prevalence was reported in North America over time.49,52”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [52]
In registries of hospitalized HF patients in North America and Europe, the prevalence of T2DM is around 40-45%.
“In registries of hospitalized HF patients in North America and Europe, the prevalence of T2DM is around 40-45%, 49 -52”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [52]
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National trends in the endovascular and surgical treatment of idiopathic intracranial hypertension
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Complications and Comorbidities in Individuals >80 Years with Diabetes: A Scoping Review
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Diabetic Heart Failure: Epidemiology and Prognosis
Bamba-Kamagaté, D., Yves-Cédric, K. M., Stéphane, K. K. G., Florent, K., Matokoma, D. M., Ehouman, E., & Jean-Baptiste, A.-K. (2026) · Journal of Cardiac Critical Care TSS · doi:10.25259/jccc_67_2025
- Authors
- Win, T. T., Davis, H. T., & Laskey, W. K.
- Affiliations
- University of New Mexico (US)
- Venue
- Circulation Heart Failure
- Published
- 2016-05
- Volume
- 9
- Issue
- 5
- Pages
- e003023-e003023
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- PMC
- PMC4860283
- OpenAlex
- W2547932276
- Cited by
- 43
- References
- 44
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 2
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR001449)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Keywords
- heart failure, diabetes mellitus, in-hospital mortality, hospitalization trends, comorbidity burden, racial and ethnic disparities, sex differences, age differences, mortality decline, diabetes prevalence
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Asian, Black or African American, Cross-Sectional Studies, Diabetes Mellitus, Female, Heart Failure, Hispanic or Latino, Hospitalization, Humans, Male, Middle Aged, Risk Factors, Sex Factors, Time Factors, United States, Comorbidity, Prevalence, Multivariate Analysis, Chi-Square Distribution, Linear Models, Logistic Models, Databases, Factual, Hospital Mortality, Risk Assessment, White People
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