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Cited by 204Cardiovascular Disease and AdiposityCardiovascular Function and Risk FactorsAdipokines, Inflammation, and Metabolic Diseases

Adipocyte Fatty Acid–Binding Protein Suppresses Cardiomyocyte Contraction: A New Link Between Obesity and Heart Disease

Lamounier-Zepter, Valéria, Look, Christiane, Alvarez, Julio, Christ, Torsten, Ravens, Ursula, Schunck, Wolf-Hagen, Ehrhart-Bornstein, Monika, Bornstein, Stefan R. +1 more·2009·Circulation Research
DOI 10.1161/circresaha.109.200501
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Abstract

RATIONALE: Adipocyte fatty acid-binding protein (FABP4) is a member of the intracellular lipid-binding protein family and is predominantly expressed in adipose tissue. Emerging evidence suggests that FABP4 plays a role in some aspects of the metabolic syndrome including the development of type 2 diabetes and atherosclerosis. We have recently reported that secretory products from human adipocytes directly and acutely depressed cardiac contractile function. OBJECTIVE: The purpose of this study was to identify this adipocyte-derived cardiodepressant factor. METHODS AND RESULTS: Through mass spectrometry and immunoblotting, we have identified this cardiodepressant factor as FABP4. FABP4 represents 1.8% to 8.1% of total protein secreted by adipocytes in extracellular medium. FABP4 acutely depressed shortening amplitude as well as intracellular systolic peak Ca(2+) in a dose-dependent manner in isolated rat cardiomyocytes. Heart-specific FABP isoform (FABP3) revealed a similar cardiodepressant effect. The N-terminal amino acids 1 to 20 of FABP4 could be identified as the most effective cardiodepressive domain. We could exclude any effect of FABP4 on action potential duration and L-type Ca(2+) current, suggesting a reduced excitation-contraction gain caused by FABP4 as the main inhibitory mechanism. CONCLUSION: We conclude that the release of FABP4 from adipocytes may be involved in the development of cardiac contractile dysfunction of obese subjects.

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Crossref · 10.1161/circresaha.109.200501

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31 of 31 references verified0 citation errors · 0 not checkable

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  • Increased body weight switches the substrate of the heart from fatty acid to sugar, resulting in fat accumulation around the heart and eventually inducing cardiac impairment and increasing the risk of MI.

    “Increased body weight switches the substrate of the heart from fatty acid to sugar, resulting in fat accumulation around the heart and eventually inducing cardiac impairment and increasing the risk of MI [264,265].”

    From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [265]

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Authors
Lamounier-Zepter, V., Look, C., Alvarez, J., Christ, T., Ravens, U., Schunck, W.-H., Ehrhart-Bornstein, M., Bornstein, S. R., & Morano, I.
Affiliations
  • From the Medical Clinic III (V.L.-Z., C.L., M.E.-B., S.R.B.), Dresden University of Technology, Germany; Institute of Cardiology (J.A.), La Habana, Cuba; Department of Pharmacology and Toxicology (T.C., U.R.), Dresden University of Technology, Germany; Max-Delbrueck-Center for Molecular Medicine (W.-H.S., I.M.), Berlin-Buch, Germany; and University Medicine Charité (I.M.), Berlin, Germany.
  • Max Delbrück Center (DE)
ORCID
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-08-14
Volume
105
Issue
4
Pages
326-334
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/circresaha.109.200501
OpenAlex
W2169507034
Cited by
203
References
32
Citations by year
2026: 2 · 2025: 12 · 2024: 15 · 2023: 8 · 2022: 5 · 2021: 13 · 2020: 11 · 2019: 12 · 2018: 7 · 2017: 13 · 2016: 16 · 2015: 14 · 2014: 16 · 2013: 21 · 2012: 15
FWCI
7.99
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • Site cant be reached (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
adipocyte fatty acid-binding protein, FABP4, FABP3, cardiomyocyte contraction, cardiac contractile dysfunction, adipocyte secretome, excitation-contraction coupling, intracellular calcium, obesity, metabolic syndrome
MeSH terms
Action Potentials, Adult, Aged, Animals, Calcium, Cells, Cultured, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Myocardial Contraction, Obesity, Rats, Wistar, Adipocytes, Calcium Signaling, Metabolic Syndrome, Myocytes, Cardiac, Atherosclerosis, Fatty Acid-Binding Proteins, Rats

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