Cited by 332Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Adipocyte/macrophage fatty acid–binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice

Open access
Furuhashi, Masato, Fucho, Raquel, Görgün, Cem Z., Tuncman, Gürol, Cao, Haiming, Hotamisligil, Gökhan S.·2008·Journal of Clinical Investigation

Abstract

Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose inflammation to systemic metabolic consequences are not fully understood. In this study, we have taken advantage of the highly restricted coexpression of adipocyte/macrophage fatty acid-binding proteins (FABPs) aP2 (FABP4) and mal1 (FABP5) to examine the contribution of these lipid chaperones in macrophages and adipocytes to local and systemic inflammation and metabolic homeostasis in mice. Deletion of FABPs in adipocytes resulted in reduced expression of inflammatory cytokines in macrophages, whereas the same deletion in macrophages led to enhanced insulin signaling and glucose uptake in adipocytes. Using radiation chimerism through bone marrow transplantation, we generated mice with FABP deficiency in bone marrow and stroma-derived elements in vivo and studied the impact of each cellular target on local and systemic insulin action and glucose metabolism in dietary obesity. The results of these experiments indicated that neither macrophages nor adipocytes individually could account for the total impact of FABPs on systemic metabolism and suggest that interactions between these 2 cell types, particularly in adipose tissue, are critical for the inflammatory basis of metabolic deterioration.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci34750

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Furuhashi, M., Fucho, R., Görgün, C. Z., Tuncman, G., Cao, H., & Hotamisligil, G. S.
Affiliations
Harvard University (US)
Venue
Journal of Clinical Investigation
Published
2008-06-01
Volume
118
Issue
7
Pages
2640-50
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2025059877
Cited by
332
References
34
Citations by year
2025: 12 · 2024: 18 · 2023: 14 · 2022: 23 · 2021: 15 · 2020: 17 · 2019: 19 · 2018: 15 · 2017: 18 · 2016: 23 · 2015: 17 · 2014: 18 · 2013: 29 · 2012: 19
FWCI
18.07
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Diabetes Association
  • Iacocca Family Foundation
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL065405, HL 65405)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK52540, R90DK071507, P30DK040561, DK71507-04)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
fatty acid binding protein, FABP4, FABP5, adipose tissue inflammation, obesity, macrophages, adipocytes, insulin signaling, glucose uptake, inflammatory cytokines, bone marrow chimerism, metabolic homeostasis
MeSH terms
Adipose Tissue, Animals, Blood Glucose, Cell Communication, Glucose, Inflammation, Insulin, Liver, Macrophages, Male, Mice, Inbred C57BL, Mice, Transgenic, Neoplasm Proteins, Obesity, Receptor, Insulin, Tumor Necrosis Factor-alpha, Bone Marrow Transplantation, Adipocytes, Mice, Knockout, Chemokine CCL2, Fatty Acid-Binding Proteins, Proto-Oncogene Proteins c-akt, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review