The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Circulating MicroRNAs: Novel Biomarkers and Extracellular Communicators in Cardiovascular Disease?
Open accessAbstract
In the past few years, the crucial role of different micro-RNAs (miRNAs) in the cardiovascular system has been widely recognized. Recently, it was discovered that extracellular miRNAs circulate in the bloodstream and that such circulating miRNAs are remarkably stable. This has raised the possibility that miRNAs may be probed in the circulation and can serve as novel diagnostic markers. Although the precise cellular release mechanisms of miRNAs remain largely unknown, the first studies revealed that these circulating miRNAs may be delivered to recipient cells, where they can regulate translation of target genes. In this review, we will discuss the nature of the stability of miRNAs that circulate in the bloodstream and discuss the available evidence regarding the possible function of these circulating miRNAs in distant cell-to-cell communication. Furthermore, we summarize and discuss the usefulness of circulating miRNAs as biomarkers for a wide range of cardiovascular diseases such as myocardial infarction, heart failure, atherosclerosis, hypertension, and type 2 diabetes mellitus.
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MicroRNAs in metabolism and metabolic disorders
Rottiers, V., & Näär, A. M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3313 · Cited by 1,156
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
Okugawa, Y., Grady, W. M., & Goel, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.011 · Cited by 782
The host shapes the gut microbiota via fecal microRNA
Liu, S., da Cunha, A. P., Rezende, R. M., Cialic, R., Wei, Z., Bry, L., Comstock, L. E., Gandhi, R., & Weiner, H. L. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2015.12.005 · Cited by 808
Metadata
- Authors
- Creemers, E. E., Tijsen, A. J., & Pinto, Y. M.
- Venue
- Circulation Research
- Published
- 2012-02-03
- Volume
- 110
- Issue
- 3
- Pages
- 483-495
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2093478617
- Cited by
- 1,009
- References
- 8
- FWCI
- 27.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Creemers, E. E., Tijsen, A. J., & Pinto, Y. M. (2012). Circulating MicroRNAs: Novel Biomarkers and Extracellular Communicators in Cardiovascular Disease? Circulation Research. https://doi.org/10.1161/circresaha.111.247452
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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