Short-Term Disruption of Diurnal Rhythms After Murine Myocardial Infarction Adversely Affects Long-Term Myocardial Structure and Function
Abstract
Rationale: Patients in intensive care units are disconnected from their natural environment. Synchrony between environmental diurnal rhythms and intracellular circadian rhythms is essential for normal organ biology; disruption causes pathology. Whether disturbing rhythms after myocardial infarction (MI) exacerbates long-term myocardial dysfunction is not known. Objective: Short-term diurnal rhythm disruption immediately after MI impairs remodeling and adversely affects long-term cardiac structure and function in a murine model. Methods and Results: Mice were infarcted by left anterior descending coronary artery ligation (MI model) within a 3-hour time window, randomized to either a normal diurnal or disrupted environment for 5 days, and then maintained under normal diurnal conditions. Initial infarct size was identical. Short-term diurnal disruption adversely affected body metabolism and altered early innate immune responses. In the first 5 days, crucial for scar formation, there were significant differences in cardiac myeloperoxidase, cytokines, neutrophil, and macrophage infiltration. Homozygous clock mutant mice exhibited altered infiltration after MI, consistent with circadian mechanisms underlying innate immune responses crucial for scar formation. In the proliferative phase, 1 week after MI, this led to significantly less blood vessel formation in the infarct region of disrupted mice; by day 14, echocardiography showed increased left ventricular dilation and infarct expansion. These differences continued to evolve with worse cardiac structure and function by 8 weeks after MI. Conclusions: Diurnal rhythm disruption immediately after MI impaired healing and exacerbated maladaptive cardiac remodeling. These preclinical findings suggest that disrupted diurnal rhythms such as found in modern intensive care unit environments may adversely affect long-term patient outcome.
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Recovery from experimentally induced myocardial ischemia is impaired in mice by rapidly shifting light/dark cycles, suggesting that sleep and circadian rhythm disruption that occurs in intensive care units may compromise recovery.
“For instance, recovery from experimentally induced myocardial ischemia is impaired in mice by rapidly shifting light/dark cycles, suggesting that sleep and circadian rhythm disruption that occurs in intensive care units may compromise recovery (145).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [145]
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Ruben, M. D., Francey, L. J., Guo, Y., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909557116 · Cited by 62 · see citing works
Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure
Eckle, T. D. L. G., Bertazzo, J., Khatua, T. N., Tabatabaei, S. R. F., Bakhtiari, N. M., Walker, L. A., & Martino, T. A. (2024) · Circulation Research · doi:10.1161/circresaha.123.323522 · Cited by 55 · see citing works
“83 Studies using these mice have revealed that the circadian factor CLOCK is pivotal in cardiovascular health and disease, such as through the regulation of inflammatory pathways.”
BackgroundSelf-citationKenig, A., Kolben, Y., Asleh, R., Amir, O., & Ilan, Y. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.695547 · Cited by 53 · see citing works
“Clock mutant mice showed changed infiltration after MI, which is linked to the innate immune responses required for scar formation and associated with reduced blood vessel formation in the infarct region, increased left ventricular dilation, and infarct expansion (44).”
BackgroundReitz, C. J., & Martino, T. A. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150706105926 · Cited by 53 · see citing works
Self-citationFemale ClockΔ19/Δ19 mice are protected from the development of age-dependent cardiomyopathy
Alibhai, F. J., Reitz, C. J., Peppler, W. T., Basu, P., Sheppard, P. A. S., Choleris, E., Bakovic, M., & Martino, T. A. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx185 · Cited by 55 · see citing works
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“In mice, clock mutants exhibit altered immune cell infiltration after AMI alongside decreased blood vessel formation one week post-MI in the proliferative phase and worsened outcomes (2).”
BackgroundCircadian rhythms in cardiovascular (dys)function: approaches for future therapeutics
Lecacheur, M., Ammerlaan, D. J. M., & Dierickx, P. (2024) · npj Cardiovascular Health · doi:10.1038/s44325-024-00024-8 · Cited by 50 · see citing works
“In addition, disruption of the circadian clock fi vedaysafteraninducedinfarctioninmiceleadstochangesinimmunecell in fi ltration (less neutrophils and more macrophages) compared to non-disrupted mice 101 .”
Bennardo, M., Alibhai, F. J., Tsimakouridze, E. V., Chinnappareddy, N., Podobed, P. S., Reitz, C. J., Pyle, W. G., Simpson, J. A., & Martino, T. A. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00200.2016 · Cited by 48 · see citing works
Self-citationYoung, M. E. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.03.024 · Cited by 47 · see citing works
Circadian influences on myocardial infarction
Virag, J. A. I., & Lust, R. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00422 · Cited by 46 · see citing works
“Alibhai et al. recently demonstrated that post-MI remodeling is worsened by circadian rhythm disruption (Alibhai et al., 2014).”
BackgroundVasculature on the clock: Circadian rhythm and vascular dysfunction
Crnko, S., Cour, M., Laake, L. W. V., & Lecour, S. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.05.003 · Cited by 46 · see citing works
Cardiac Clocks and Preclinical Translation
Mistry, P., Duong, A., Kirshenbaum, L. A., & Martino, T. A. (2017) · Heart Failure Clinics · doi:10.1016/j.hfc.2017.05.002 · Cited by 45 · see citing works
“Recent successes include optimizing the timing of cardiovascular medications to improve drug efficacy and maintaining circadian rhythms and sleep to benefit outcomes after MI. Upcoming areas for preclinical translation include targeting the circadian mechanism to reduce cardiac aging, targeting circadiandriven bioener…”
BackgroundInfluentialSelf-citationCardiac System during the Aging Process
Fernandes-Ribeiro, A. S., Zerolo, B. E., López‐Espuela, F., Sanchez, R., & Fernandes, V. S. (2023) · Aging and Disease · doi:10.14336/ad.2023.0115 · Cited by 50 · see citing works
Association between circadian disruption and diseases: A narrative review
Hou, Y., Liu, L.-M., Chen, X., Li, Q., & Li, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118512 · Cited by 45 · see citing works
Podobed, P. S., Alibhai, F. J., Chow, C.-W., & Martino, T. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104907 · Cited by 41 · see citing works
“Further evidence for molecular circadian control of the sarcomere comes from studies that demonstrated that cAMP-dependent protein kinase (PKA) exhibited rhythmic mRNA expression [48], that diurnal disruption altered myofilament protein phosphorylation by PKA in a murine myocardial infarction model [49], and we and ot…”
BackgroundSelf-citationComplexities in cardiovascular rhythmicity: perspectives on circadian normality, ageing and disease
Monfredi, O., & Lakatta, E. G. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz112 · Cited by 40 · see citing works
Circadian influence on inflammatory response during cardiovascular disease
Aziz, I. S., McMahon, A. M., Friedman, D., Rabinovich-Nikitin, I., Kirshenbaum, L. A., & Martino, T. A. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.11.007 · Cited by 39 · see citing works
Self-citationWang, Y., Jiang, W., Hu, C., Zhou, H., Liu, Z., Liu, Z., Liu, Z., Zhou, Y., Zhou, X., Yu, L., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.668387 · Cited by 39 · see citing works
“It has been reported that aggravating the postMI disruption by altering environmental light-dark cycle could worsen cardiac remodeling (8), whereas the beneficial effects of improving this disruption have also been shown (9, 10).”
BackgroundCircadian influence on the microbiome improves heart failure outcomes
Mistry, P., Reitz, C. J., Khatua, T. N., Rasouli, M., Oliphant, K., Young, M. E., Allen‐Vercoe, E., & Martino, T. A. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.09.006 · Cited by 36 · see citing works
Self-citationMelatonin Treatment in Kidney Diseases
Markowska, M., Niemczyk, S., & Romejko, K. (2023) · Cells · doi:10.3390/cells12060838 · Cited by 38 · see citing works
Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health
Festus, I. D., Spilberg, J., Young, M. E., Cain, S. W., Khoshnevis, S., Smolensky, M. H., Zaheer, F., Descalzi, G., & Martino, T. A. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.02.011 · Cited by 35 · see citing works
“The body ’ s circadian mechanism in fl uences immune cell recruitment to the infarcted heart post MI, essential for outcomes [83].”
InfluentialSelf-citationCsoma, B., & Bikov, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814145 · Cited by 33 · see citing works
“Alibhai et al. demonstrated that short-term disturbance to the circadian rhythm following an MI negatively affects the long-term cardiac function in mice [79].”
BackgroundLin, J., Kuang, H., Jiang, J., Zhou, H., Li, P., Xu, Y., & Kuang, J. (2023) · Medical Science Monitor · doi:10.12659/msm.942215 · Cited by 32 · see citing works
“…rhythm after MI impaired healing and exacerbated maladaptive cardiac remodelling, demonstrating that the short-term rhythm disruptions interfered with an early inflammatory phase of LV remodelling, adversely affecting the innate immune infiltration, and adversely affecting scar formation [97].”
BackgroundCircadian toxicity of environmental pollution. Inhalation of polluted air to give a precedent
Haberzettl, P. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.05.002 · Cited by 29 · see citing works
Basu, P., Alibhai, F. J., Tsimakouridze, E. V., Singh, R. K., Paglialunga, S., Holloway, G. P., Martino, T. A., & Bakovic, M. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00380-15 · Cited by 29 · see citing works
Self-citationPyle, W. G., & Martino, T. A. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.05.003 · Cited by 28 · see citing works
Self-citationHuang, Y., Zhang, C., Xu, Z.-Q. J., Shen, J., Zhang, X., Du, H., Zhang, K., & Zhang, D. (2017) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2017.01.004 · Cited by 28 · see citing works
Circadian Effects on Vascular Immunopathologies
Zeng, Q., Oliva, V. M., Moro, M. Á., & Scheiermann, C. (2024) · Circulation Research · doi:10.1161/circresaha.123.323619 · Cited by 27 · see citing works
Lecour, S., du Pré, B. C., Bøtker, H. E., Brundel, B. J. J. M., Daiber, A., Davidson, S. M., Ferdinandy, P., Girão, H., Gollmann‐Tepeköylü, C., Gyöngyösi, M., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab293 · Cited by 28 · see citing works
Light Exposure at Night and Cardiovascular Disease Incidence
Windred, D. P., Burns, A. C., Rutter, M. K., Lane, J. M., Saxena, R., Scheer, F. A. J. L., Cain, S. W., & Phillips, A. J. K. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.39031 · Cited by 28 · see citing works
Circadian clocks, obesity and cardiometabolic function
Scott, E. M. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12518 · Cited by 25 · see citing works
Jiao, L., Wang, Y., Zhang, S., Wang, Y., Liu, Z., Liu, Z., Zhou, Y., Zhou, H., Xu, X., Li, Z., et al. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12829 · Cited by 24 · see citing works
“It was first proposed by Alibhai et al.9 that light disruption induced metabolism and immune disorder, which further worsen cardiac structure and function remodeling.”
MethodCircadian mutant mice with obesity and metabolic syndrome are resilient to cardiovascular disease
Reitz, C. J., Alibhai, F. J., Seolin, B. G. D. L., Nemec-Bakk, A. S., Khaper, N., & Martino, T. A. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00462.2020 · Cited by 23 · see citing works
“CLOCK is a key component of this molecular 76 mechanism (63) and has been demonstrated to regulate rhythms in cardiac metabolism (8), gene 77 and protein expression (45), and play a role in heart disease outcomes, including age-related 78 cardiovascular dysfunction (1, 2) and healing responses following myocardial inf…”
BackgroundMethodInfluentialSelf-citationLiang, Q. L., Xu, H., Liu, M., Lei, Q., Yan, J., Yang, G., & Chen, L. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.025021 · Cited by 23 · see citing works
Duong, A., Reitz, C. J., Louth, E. L., Creighton, S. D., Rasouli, M., Zwaiman, A., Kroetsch, J. T., Bolz, S., Winters, B. D., Bailey, C. D. C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41469-7 · Cited by 21 · see citing works
Self-citationChe, Y., Shimizu, Y., Hayashi, T., Suzuki, J., Pu, Z., Tsuzuki, K., Narita, S., Shibata, R., & Murohara, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-61710-2 · Cited by 20 · see citing works
“In animal models, circadian disruption were reported to lead to cardiovascular disease 22,23 .”
BackgroundA Tissue-Specific Rhythmic Recruitment Pattern of Leukocyte Subsets
Yuan, Y., Wu, S., Li, W., & He, W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00102 · Cited by 20 · see citing works
“The influence of the circadian system on MI is further demonstrated by the homozygous clock mutant mice(Clockdelta19), which leads to more infiltrations of neutrophils and macrophages to infarcted myocardium, and worse cardiac structure, suggesting that abolishment of circadian rhythm can adversely affected the cardia…”
BackgroundSager, H. B., Hüsser, O., Steffens, S., Laugwitz, K., Schunkert, H., Kastrati, A., Ndrepepa, G., & Kessler, T. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1934-z · Cited by 20 · see citing works
Tan, C., Saito, N., Miyawaki, I., & Shiotani, H. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1764012 · Cited by 19 · see citing works
Dim light at night exacerbates stroke outcome
Weil, Z. M., Fonken, L. K., Walker, W. H., Bumgarner, J. R., Liu, J. A., Meléndez‐Fernández, O. H., Zhang, N., DeVries, A. C., & Nelson, R. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14915 · Cited by 19 · see citing works
Nuclear Receptors and Clock Components in Cardiovascular Diseases
Pourcet, B., & Duez, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189721 · Cited by 16 · see citing works
Circadian Dependence of the Acute Immune Response to Myocardial Infarction
Kilgallen, A. B., van den Akker, F., Feyen, D. A. M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.869512 · Cited by 16 · see citing works
“Hence, it is reasonable to speculate that reducing environmental stressors, by implementing circadian lights in hospitals, could promote an improved healing of the myocardium after MI (Alibhai et al., 2014).”
BackgroundThe Impact of Sex, Circadian Disruption, and the ClockΔ19/Δ19 Genotype on Alcohol Drinking in Mice
Rizk, A. A., Jenkins, B. W., Al-Sabagh, Y., Hamidullah, S., Reitz, C. J., Rasouli, M., Martino, T. A., & Khokhar, J. Y. (2022) · Genes · doi:10.3390/genes13040701 · Cited by 16 · see citing works
“All experiments were approved by the University of Guelph Institutional Animal Care and Use Committee and performed in accordance with the guidelines set forth by the Canadian Council on Animal Care (1993).”
MethodSelf-citationKroetsch, J. T., Lidington, D., Alibhai, F. J., Reitz, C. J., Zhang, H., Dinh, D. D., Hanchard, J., Khatua, T. N., Heximer, S. P., Martino, T. A., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac174 · Cited by 15 · see citing works
Self-citationCircadian medicine: a critical strategy for cardiac care
Sole, M. J., & Martino, T. A. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00925-8 · Cited by 15 · see citing works
Self-citationSheng, M., Chen, X., Yu, Y., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1102567 · Cited by 14 · see citing works
“The mean arterial pressure and heart rate circadian phase of clock mutant mice were significantly delayed (Alibhai et al., 2014).”
BackgroundCircadian Disruption and the Molecular Clock in Atherosclerosis and Hypertension
Costello, H. M., Sharma, R. K., McKee, A. R., & Gumz, M. L. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.06.416 · Cited by 15 · see citing works
Giles, A. V., Sun, J., Femnou, A. N., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00493.2018 · Cited by 14 · see citing works
Xue, G., Yang, X., Zhan, G., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.988408 · Cited by 14 · see citing works
“C57BL/6 mice underwent MI, as described previously (Alibhai et al., 2014).”
MethodCircadian system and aging: where both times interact
Cobarro, C., Soares, L. I., Kutsenko, Y., & Tomás‐Loba, A. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1646794 · Cited by 15 · see citing works
Hao, K., Zhai, Q., Gu, Y., Chen, Y.-Q., Wang, Y., Liu, R., Yan, S.-P., Wang, Y., Shi, Y., Lei, W., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01059-w · Cited by 12 · see citing works
“Despite evidence for the potential adverse effects of chronic disruption of the circadian clock [48, 49, 54, 55], very little is known about the role of the SCN in the response to acute stress including MI.”
BackgroundZhao, T., Liu, J.-J., Zhu, J., Li, H., Wang, Y.-C., Zhao, Y., Shao, S.-J., Guo, H.-D., & Mou, F.-F. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4455183 · Cited by 11 · see citing works
“MI mice were established by ligature of the left anterior descending branch under isoflurane anesthetization [21].”
MethodOne Health: Circadian Medicine Benefits Both Non-human Animals and Humans Alike
Farag, H. I., Murphy, B. A., Templeman, J. R., Hanlon, C., Joshua, J., Koch, T. G., Niel, L., Shoveller, A. K. K., Bédécarrats, G. Y., Ellison, A., et al. (2024) · Journal of Biological Rhythms · doi:10.1177/07487304241228021 · Cited by 10 · see citing works
Self-citationBone Marrow Niche in Cardiometabolic Disease: Mechanisms and Therapeutic Potential
Kohutek, Z. A., Caslin, H. L., Fehrenbach, D. J., Heimlich, J. B., Brown, J. D., Madhur, M. S., Ferrell, P. B., & Doran, A. C. (2025) · Circulation Research · doi:10.1161/circresaha.124.323778 · Cited by 14 · see citing works
Sleep and Circadian Alterations and the Gut Microbiome: Associations or Causality?
Farré, N., Torres, M., Gozal, D., & Farré, R. (2018) · Current Sleep Medicine Reports · doi:10.1007/s40675-018-0100-0 · Cited by 10 · see citing works
The chronobiology of human heart failure: clinical implications and therapeutic opportunities
Gentile, F., Emdin, M., Passino, C., Montuoro, S., Tognini, P., Floras, J. S., O'Neill, J. M., & Giannoni, A. (2024) · Heart Failure Reviews · doi:10.1007/s10741-024-10447-1 · Cited by 9 · see citing works
Identification of the potential biomarkers associated with circadian rhythms in heart failure
Sun, Q., Zhao, J., Liu, L., Wang, X., & Gu, X. (2023) · PeerJ · doi:10.7717/peerj.14734 · Cited by 9 · see citing works
“, 2002), which may also perturb the delicate balance with severe repercussions on HF outcomes (Alibhai et al., 2014; Song et al., 2022).”
BackgroundImplications of Enteral and Parenteral Feeding Times
Rothschild, J. A., & Lagakos, W. (2014) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607114551026 · Cited by 9 · see citing works
Yan, X., Huang, Y., & Wu, J. (2018) · Journal of Computational Biology · doi:10.1089/cmb.2017.0254 · Cited by 8 · see citing works
“Long-term myocardial structure and function are adversely affected by circadian rhythm disorder after murine myocardial infarction (Alibhai et al., 2014).”
Circadian regulation of cardiac muscle function and protein degradation
Yoo, S. H. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1957911 · Cited by 8 · see citing works
“In addition to GSK-3β, several other kinases have also been implicated in sarcomere protein modification and contractile function, including PKA, PKD, CamKII and calcineurin (Alibhai et al. 2014; Bray et al. 2008; Rotter et al. 2014; Sachan et al. 2011).”
BackgroundKıvrak, A., & Yıldırım, A. (2023) · Kardiologia Polska · doi:10.33963/kp.a2023.0150 · Cited by 8 · see citing works
Cardiovascular research and the arrival of circadian medicine
Martino, T. A., & Delisle, B. P. (2023) · Chronobiology International · doi:10.1080/07420528.2022.2151862 · Cited by 7 · see citing works
“…relevant to clinical cardiology therapies, such as chronotherapy for hypertension, (Mistry et al. 2017) circadian lighting in intensive care units (Alibhai et al. 2014), and can influence morbidity and mortality following surgical procedures such as percutaneous coronary intervention, or…”
BackgroundSelf-citationReitz, C. J., Rasouli, M., Alibhai, F. J., Khatua, T. N., Pyle, W. G., & Martino, T. A. (2022) · JCI Insight · doi:10.1172/jci.insight.164700 · Cited by 7 · see citing works
Self-citationLin, J., Yao, H., Li, J., Hou, C., Song, X., An, K., Tian, S., Li, X., Wang, Y., Guo, Q., et al. (2023) · BMC Public Health · doi:10.1186/s12889-023-17077-6 · Cited by 6 · see citing works
“Recent studies reported that circadian rhythm disorder increases the risk of CHD and other CVDs [34, 35].”
BackgroundEdgar, R. S., O’Donnell, A. J., Zhuang, X. A., et al. (2025) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2023.0336 · Cited by 5 · see citing works
Cheng, S., Wu, J., Pei, Y., Tong, H., Fan, M., Xiang, Q., Ding, Y., Xie, L., Zhang, H., Sun, W., et al. (2023) · Sleep And Breathing · doi:10.1007/s11325-023-02974-2 · Cited by 5 · see citing works
“Previous studies reported that short-term constant light exposure (24 h/day) had effects on cardiac response to ischemia–reperfusion [2] and VR after AMI [3].”
InfluentialZhang, T., Zhang, G., Liu, T., Gu, T., Yu, F., Xu, P., Mi, W., Zhao, X., Guo, Q., Zheng, H., et al. (2026) · Med Research · doi:10.1002/mdr2.70052 · Cited by 4 · see citing works
Effect of KLF15-Mediated Circadian Rhythm on Myocardial Infarction: A Narrative Review
Zhao, J., Chen, Z., Yang, J., Duan, L., Yang, H. Y., Cai, D., & Zhao, Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104831 · Cited by 4 · see citing works
“A similar phenomenon can also affect the recovery of hospitalized patients [32].”
A brief history of circadian time in the heart
Young, M. E., Khanna, V., Metcalfe, M., Rameshkumar, N., Harington, S., Li, L. H., Doost, J. S., Taegtmeyer, H., & Martino, T. A. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.08.005 · Cited by 4 · see citing works
Self-citationMyocardial Repair Around-The-Clock
Sharma, U. C., & Canty, J. M. (2014) · Circulation Research · doi:10.1161/circresaha.114.304102 · Cited by 4 · see citing works
- Authors
- Alibhai, F. J., Tsimakouridze, E. V., Chinnappareddy, N., Wright, D. C., Billia, F., O’Sullivan, M. L., Pyle, W. G., Sole, M. J., & Martino, T. A.
- Affiliations
- University Health Network (CA)
- ORCID
- Venue
- Circulation Research
- Published
- 2014-05-23
- Volume
- 114
- Issue
- 11
- Pages
- 1713-1722
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2129546872
- Semantic Scholar
- 52dc76bbff6a1eb6aeaa8f8ad67a1849f7a682fe
- Cited by
- 122
- References
- 54
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 18 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 11 · 2018: 9 · 2017: 10 · 2016: 5 · 2015: 10 · 2014: 6
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- IslandScholar (University of Prince Edward Island) (submittedVersion)
- Funders
- Canadian Institutes of Health Research (MOP119518)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- myocardial infarction, circadian rhythm disruption, diurnal cycle, cardiac remodeling, myocardial fibrosis, innate immune response, macrophage infiltration, neutrophils, myeloperoxidase, infarct healing, coronary artery ligation, ICU environment, left ventricular dilatation, infarct expansion, Clock mutant mice
- MeSH terms
- Animals, Circadian Rhythm, Coronary Vessels, Disease Models, Animal, Heart, Ligation, Male, Mice, Inbred C57BL, Myocardial Infarction, Myocardium, Time Factors, Mice
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