Disturbed diurnal rhythm alters gene expression and exacerbates cardiovascular disease with rescue by resynchronization
Abstract
Day/night rhythms are recognized as important to normal cardiovascular physiology and timing of adverse cardiovascular events; however, their significance in disease has not been determined. We demonstrate that day/night rhythms play a critical role in compensatory remodeling of cardiovascular tissue, and disruption exacerbates disease pathophysiology. We use a murine model of pressure overload cardiac hypertrophy (transverse aortic constriction) in a rhythm-disruptive 20-hour versus 24-hour environment. Echocardiography reveals increased left ventricular end-systolic and -diastolic dimensions and reduced contractility in rhythm-disturbed transverse aortic constriction animals. Furthermore, cardiomyocytes and vascular smooth muscle cells exhibit reduced hypertrophy, despite increased pressure load. Microarray and real-time PCR demonstrate altered gene cycling in transverse aortic constriction myocardium and hypothalamic suprachiasmatic nucleus. With rhythm disturbance, there is a consequent altered cellular clock mechanism (per2 and bmal), whereas key genes in hypertrophic pathways (ANF, BNP, ACE, and collagen) are downregulated paradoxical to the increased pressure. Phenotypic rescue, including reversal/attenuation of abnormal pathology and genes, only occurs when the external rhythm is allowed to correspond with the animals' innate 24-hour internal rhythm. Our study establishes the importance of diurnal rhythm as a vital determinant in heart disease. Disrupted rhythms contribute to progression of organ dysfunction; restoration of normal diurnal schedules appears to be important for effective treatment of disease.
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Mice with surgically induced heart disease that live on an abnormal light/dark (10:10 h) cycle after surgery show impaired compensatory cardiac and vascular remodeling, reduced ventricular contractile strength, and increased blood pressure compared with animals on a normal light/dark (12:12 h) cycle.
“mice with surgically induced heart disease (cardiac hypertrophy through transverse aortic constriction) that live on an abnormal light/dark (10:10 h) cycle following surgery show impaired compensatory cardiac and vascular remodeling, reduced ventricular contractile strength, and increased blood pressure as compared to animals that live on a normal light/dark (12:12 h) cycle”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Martino et al., 2007
Phenotypic rescue, including reversal or attenuation of abnormal pathology and genes, only occurs when the external rhythm is allowed to correspond with the animals' innate 24-h internal rhythm.
“Phenotypic rescue, including reversal/attenuation of abnormal pathology and genes, only occurs when the external rhythm is allowed to correspond with the animals’ innate 24-h internal rhythm.”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Martino et al., 2007
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Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
Self-citationResetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works
Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction
Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884 · see citing works
Transplanted Suprachiasmatic Nucleus Determines Circadian Period
Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853 · see citing works
Self-citationOrchestrated Transcription of Key Pathways in <i>Arabidopsis</i> by the Circadian Clock
Harmer, S. L., Hogenesch, J. B., Straume, M., Chang, H.-S., Han, B., Zhu, T., Wang, X., Kreps, J. A., & Kay, S. A. (2000) · Science · doi:10.1126/science.290.5499.2110 · Cited by 1,640 · see citing works
Self-citationExtensive and divergent circadian gene expression in liver and heart
Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509 · see citing works
Circadian rhythms from multiple oscillators: lessons from diverse organisms
Bell‐Pedersen, D., Cassone, V. M., Earnest, D. J., Golden, S. S., Hardin, P. E., Thomas, T. L., & Zoran, M. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1633 · Cited by 1,481 · see citing works
Circadian variation and triggers of onset of acute cardiovascular disease.
Muller, J. E., Tofler, G. H., & Stone, P. H. (1989) · Circulation · doi:10.1161/01.cir.79.4.733 · Cited by 1,426 · see citing works
Tofler, G. H., Brezinski, D., Schafer, A. I., Czeisler, C. A., Rutherford, J. D., Willich, S. N., Gleason, R. E., Williams, G. H., & Muller, J. E. (1987) · New England Journal of Medicine · doi:10.1056/nejm198706113162405 · Cited by 1,072 · see citing works
Sleep Apnea and Cardiovascular Disease
Leung, R. S. T., & Bradley, T. D. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.12.2107045 · Cited by 645 · see citing works
Circadian Variation in the Timing of Stroke Onset: A Meta-analysis
Elliott, W. J. (1998) · Stroke · doi:10.1161/01.str.29.5.992 · Cited by 638 · see citing works
Nuclear Receptor Rev-erbα Is a Critical Lithium-Sensitive Component of the Circadian Clock
Yin, L., Wang, J., Klein, P. S., & Lazar, M. A. (2006) · Science · doi:10.1126/science.1121613 · Cited by 556 · see citing works
Bradley, T. D., & Floras, J. S. (2003) · Circulation · doi:10.1161/01.cir.0000061758.05044.64 · Cited by 518 · see citing works
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Antos, C. L., McKinsey, T. A., Frey, N., Kutschke, W. J., McAnally, J., Shelton, J. M., Richardson, J. A., Hill, J. A., & Olson, E. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231619298 · Cited by 477 · see citing works
Sleep is of the brain, by the brain and for the brain
Hobson, J. A. (2005) · Nature · doi:10.1038/nature04283 · Cited by 440 · see citing works
A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock
Iitaka, C., Miyazaki, K., Akaike, T., & Ishida, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503526200 · Cited by 373 · see citing works
Increased onset of sudden cardiac death in the first three hours after awakening
Willich, S. N., Goldberg, R. J., Maclure, M., Perriello, L. M., & Muller, J. E. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)91391-g · Cited by 282 · see citing works
Intrinsic Diurnal Variations in Cardiac Metabolism and Contractile Function
Young, M. E., Razeghi, P., Cedars, A. M., Guthrie, P. H., & Taegtmeyer, H. (2001) · Circulation Research · doi:10.1161/hh2401.100741 · Cited by 204 · see citing works
Circadian rhythm in the cardiovascular system: chronocardiology
Guo, Y., & Stein, P. K. (2003) · American Heart Journal · doi:10.1016/s0002-8703(02)94797-6 · Cited by 190 · see citing works
Henriques, J. P. S., Haasdijk, A., & Zijlstra, F. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00461-3 · Cited by 168 · see citing works
Kassiri, Z., Oudit, G. Y., Sanchez, O. H., Dawood, F., Mohammed, F. F., Nuttall, R. K., Edwards, D. R., Liu, P. P., Backx, P. H., & Khokha, R. (2005) · Circulation Research · doi:10.1161/01.res.0000178789.16929.cf · Cited by 162 · see citing works
Self-citationModifications of Cardiac Autonomic Profile Associated With a Shift Schedule of Work
Furlan, R., Barbic, F., Piazza, S., Tinelli, M., Seghizzi, P., & Malliani, A. (2000) · Circulation · doi:10.1161/01.cir.102.16.1912 · Cited by 151 · see citing works
Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior
Hu, K., Ivanov, P. C., Hilton, M. F., Chen, Z., Ayers, R. T., Stanley, H. E., & Shea, S. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408243101 · Cited by 141 · see citing works
Aldosterone release during the sleep–wake cycle in humans
Charloux, A., Gronfier, C., Lonsdorfer-Wolf, E., Piquard, F., & Brandenberger, G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e43 · Cited by 138 · see citing works
Day/night rhythms in gene expression of the normal murine heart
Martino, T. A., Arab, S., Straume, M., Belsham, D. D., Tata, N., Cai, F., Liu, P. X., Trivieri, M. G., Ralph, M. R., & Sole, M. J. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0520-1 · Cited by 137 · see citing works
Self-citationTofler, G. H., Gebara, O., Mittleman, M. A., Taylor, P., Siegel, W., Venditti, F. J., Rasmussen, C. A. F., Muller, J. E., & for the CPI Investigators (1995) · Circulation · doi:10.1161/01.cir.92.5.1203 · Cited by 129 · see citing works
Cellular Senescence Impairs Circadian Expression of Clock Genes In Vitro and In Vivo
Kunieda, T., Minamino, T., Katsuno, T., Tateno, K., Nishi, J.-I., Miyauchi, H., Orimo, M., Okada, S., & Komuro, I. (2006) · Circulation Research · doi:10.1161/01.res.0000204504.25798.a8 · Cited by 129 · see citing works
Cardiovascular Tissues Contain Independent Circadian Clocks
Davidson, A. J., London, B., Block, G. D., & Menaker, M. (2005) · Clinical and Experimental Hypertension · doi:10.1081/ceh-48933 · Cited by 117 · see citing works
Chronobiology of rupture and dissection of aortic aneurysms
Manfredini, R., Boari, B., Gallerani, M., Salmi, R., Bossone, E., Distante, A., Eagle, K. A., & Mehta, R. H. (2004) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2004.04.019 · Cited by 106 · see citing works
Hermida, R. C., Ayala, D. E., & Calvo, C. (2005) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000174144.07174.74 · Cited by 72 · see citing works
Increased risk of congestive heart failure among infarctions with nighttime onset
Mukamal, K. J., Muller, J. E., Maclure, M., Sherwood, J. B., & Mittleman, M. A. (2000) · American Heart Journal · doi:10.1067/mhj.2000.108830 · Cited by 62 · see citing works
European Survey on Circadian Variation of Angina Pectoris (ESCVA) in Treated Patients
Willich, S. N., Kulig, M., & Müller‐Nordhorn, J. (2004) · Herz · doi:10.1007/s00059-004-2536-x · Cited by 10 · see citing works
Laskey, W. K., Selzer, F., Holmes, D. R., Wilensky, R. L., Cohen, H. A., Williams, D. O., Kip, K. E., & Detre, K. M. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.10.003 · Cited by 4 · see citing works
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Disruption of circadian clocks has ramifications for metabolism, brain, and behavior
Karatsoreos, I. N., Bhagat, S., Bloss, E. B., Morrison, J. H., & McEwen, B. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018375108 · Cited by 547 · see citing works
Circadian rhythms and the molecular clock in cardiovascular biology and disease
Crnko, S., Du Pré, B. C., Sluijter, J. P. G., & Van Laake, L. W. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0167-4 · Cited by 499 · see citing works
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
Circadian disruption: what do we actually mean?
Vetter, C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14255 · Cited by 333 · see citing works
Impact of Circadian Disruption on Cardiovascular Function and Disease
Chellappa, S. L., Vujović, N., Williams, J. S., & Scheer, F. A. J. L. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.008 · Cited by 333 · see citing works
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters
Martino, T. A., Oudit, G. Y., Herzenberg, A. M., Tata, N., Koletar, M. M., Kabir, G. M., Belsham, D. D., Backx, P. H., Ralph, M. R., & Sole, M. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00829.2007 · Cited by 317 · see citing works
Self-citationCircadian rhythms and cardiovascular health
Portaluppi, F., Tiseo, R., Smolensky, M. H., Hermida, R. C., Ayala, D. E., & Fabbian, F. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.04.003 · Cited by 310 · see citing works
Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy
Dallmann, R., Okyar, A., & Lévi, F. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.03.004 · Cited by 295 · see citing works
The Cardiomyocyte Circadian Clock: Emerging Roles in Health and Disease
Durgan, D. J., & Young, M. E. (2010) · Circulation Research · doi:10.1161/circresaha.109.209957 · Cited by 277 · see citing works
Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System
Azmi, N. A. S. M., Juliana, N., Azmani, S., Effendy, N. M., Abu, I. F., Teng, N. I. M. F., & Das, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18020676 · Cited by 235 · see citing works
Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
Yu, E. A., & Weaver, D. R. (2011) · Aging · doi:10.18632/aging.100323 · Cited by 228 · see citing works
The impact of the circadian timing system on cardiovascular and metabolic function
Morris, C. J., Yang, J. N., & Scheer, F. A. J. L. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00019-8 · Cited by 215 · see citing works
When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis
Teichman, E. M., O’Riordan, K. J., Gahan, C. G. M., Dinan, T. G., & Cryan, J. F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.008 · Cited by 198 · see citing works
Circadian Clocks and Vascular Function
Paschos, G. K., & FitzGerald, G. A. (2010) · Circulation Research · doi:10.1161/circresaha.109.211706 · Cited by 190 · see citing works
Circadian clock and cardiovascular disease
Takeda, N., & Maemura, K. (2011) · Journal of Cardiology · doi:10.1016/j.jjcc.2011.02.006 · Cited by 171 · see citing works
Eastman, C. I., & Smith (2012) · Nature and Science of Sleep · doi:10.2147/nss.s10372 · Cited by 171 · see citing works
The Circadian System: A Regulatory Feedback Network of Periphery and Brain
Buijs, F. N., Mercado, L. L., Guzmán‐Ruiz, M. A., Guerrero‐Vargas, N. N., Romo‐Nava, F., & Buijs, R. M. (2016) · Physiology · doi:10.1152/physiol.00037.2015 · Cited by 158 · see citing works
Recent advances in circadian rhythms in cardiovascular system
Chen, L., & Yang, G. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00071 · Cited by 157 · see citing works
Mechanism of the circadian clock in physiology
Richards, J., & Gumz, M. L. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00066.2013 · Cited by 153 · see citing works
The cardiomyocyte molecular clock, regulation of <i>Scn5a</i> , and arrhythmia susceptibility
Schroder, E. A., Lefta, M., Zhang, X., Bartos, D. C., Feng, H.-Z., Zhao, Y., Patwardhan, A., Jin, J.-P., Esser, K. A., & Delisle, B. P. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00383.2012 · Cited by 147 · see citing works
Adverse effects of chronic circadian desynchronization in animals in a “challenging” environment
Preuss, F., Tang, Y., Laposky, A. D., Arble, D. M., Keshavarzian, A., & Turek, F. W. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00118.2008 · Cited by 140 · see citing works
Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology
Martino, T. A., & Young, M. E. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415575246 · Cited by 133 · see citing works
Self-citationMartino, T. A., & Sole, M. J. (2009) · Circulation Research · doi:10.1161/circresaha.109.206201 · Cited by 124 · see citing works
Self-citationDisrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease
Alibhai, F. J., LaMarre, J., Reitz, C. J., Tsimakouridze, E. V., Kroetsch, J. T., Bolz, S., Shulman, A., Steinberg, S., Burris, T. P., Oudit, G. Y., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.01.008 · Cited by 123 · see citing works
Self-citationAlibhai, F. J., Tsimakouridze, E. V., Chinnappareddy, N., Wright, D. C., Billia, F., O’Sullivan, M. L., Pyle, W. G., Sole, M. J., & Martino, T. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302995 · Cited by 122 · see citing works
Self-citationInteractions between metabolism and circadian clocks: reciprocal disturbances
Delezie, J., & Challet, É. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06246.x · Cited by 118 · see citing works
Circadian desynchrony and metabolic dysfunction; did light pollution make us fat?
Wyse, C. A., Selman, C., Page, M. M., Coogan, A. N., & Hazlerigg, D. G. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.09.023 · Cited by 115 · see citing works
Durgan, D. J., Tsai, J.-Y., Grenett, M. H., Pat, B., Ratcliffe, W. F., Villegas‐Montoya, C., Garvey, M. E., Nagendran, J., Dyck, J. R. B., Bray, M. S., et al. (2011) · Chronobiology International · doi:10.3109/07420528.2010.550406 · Cited by 114 · see citing works
OSA and Cardiovascular Risk in Pediatrics
Smith, D. F., & Amin, R. S. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.02.011 · Cited by 111 · see citing works
Circadian Clocks, Food Intake, and Metabolism
Challet, É. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396971-2.00005-1 · Cited by 97 · see citing works
Daylight saving time: an American Academy of Sleep Medicine position statement
Rishi, M. A., Ahmed, O., Perez, J. H. B., Berneking, M., Dombrowsky, J. W., Flynn‐Evans, E. E., Santiago, V., Sullivan, S. S., Upender, R. P., Yuen, K., et al. (2020) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.8780 · Cited by 96 · see citing works
Martino, T. A., Tata, N., Simpson, J. A., Vanderlaan, R., Dawood, F., Kabir, M. G., Khaper, N., Cifelli, C., Podobed, P., Liu, P. P., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.11.022 · Cited by 94 · see citing works
Self-citationSynchrony and desynchrony in circadian clocks: impacts on learning and memoryPreprint
Krishnan, H. C., & Lyons, L. C. (2015) · Learning & Memory · doi:10.1101/lm.038877.115 · Cited by 89 · see citing works
Consequences of Circadian and Sleep Disturbances for the Cardiovascular System
Alibhai, F. J., Tsimakouridze, E. V., Reitz, C. J., Pyle, W. G., & Martino, T. A. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.01.015 · Cited by 86 · see citing works
Self-citationCircadian networks in human embryonic stem cell‐derived cardiomyocytes
Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., Geijsen, N., & Laake, L. W. V. (2017) · EMBO Reports · doi:10.15252/embr.201743897 · Cited by 85 · see citing works
Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine
Pourcet, B., & Duez, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01630 · Cited by 84 · see citing works
The day/night proteome in the murine heart
Podobed, P. S., Pyle, W. G., Ackloo, S. Z., Alibhai, F. J., Tsimakouridze, E. V., Ratcliffe, W. F., Mackay, A., Simpson, J. A., Wright, D. C., Kirby, G. M., et al. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00011.2014 · Cited by 84 · see citing works
Self-citationShanware, N. P., Hutchinson, J. A., Kim, S. H., Zhan, L., Bowler, M. J., & Tibbetts, R. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.224014 · Cited by 83 · see citing works
Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms
Vukolic, A., Antic, V., Vliet, B. N. V., Yang, Z., Albrecht, U., & Montani, J. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00404.2009 · Cited by 81 · see citing works
The Multiple Facets of Per2Preprint
Albrecht, U., Bordon, A., Schmutz, I., & Ripperger, J. A. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.001 · Cited by 77 · see citing works
Assembly and maintenance of the sarcomere night and day
Boateng, S. Y., & Goldspink, P. H. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm048 · Cited by 72 · see citing works
Vascular circadian rhythms in a mouse vascular smooth muscle cell line (Movas-1)
Chalmers, J. A., Martino, T. A., Tata, N., Ralph, M. R., Sole, M. J., & Belsham, D. D. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90572.2008 · Cited by 72 · see citing works
Self-citationWang, Q., Maillard, M. P., Schibler, U., Burnier, M., & Gachon, F. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00241.2010 · Cited by 70 · see citing works
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Khaper, N., Bailey, C. D. C., Ghugre, N. R., Reitz, C. J., Awosanmi, Z., Waines, R., & Martino, T. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.006 · Cited by 66 · see citing works
Self-citationSole, M. J., & Martino, T. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00426.2009 · Cited by 64 · see citing works
Self-citationVerwey, M., Dhir, S. K., & Amir, S. (2016) · F1000Research · doi:10.12688/f1000research.9180.1 · Cited by 62 · see citing works
Miyazaki, M., Schroder, E. A., Edelmann, S. E., Hughes, M. E., Kornacker, K., Balke, C. W., & Esser, K. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027168 · Cited by 58 · see citing works
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Circadian clock and vascular disease
Takeda, N., & Maemura, K. (2010) · Hypertension Research · doi:10.1038/hr.2010.68 · Cited by 56 · see citing works
Circadian rhythms in skin and other elastic tissues
Sherratt, M. J., Hopkinson, L., Naven, M. A., Hibbert, S. A., Ozols, M., Eckersley, A., Newton, V. L., Bell, M., & Meng, Q. (2019) · Matrix Biology · doi:10.1016/j.matbio.2019.08.004 · Cited by 53 · see citing works
Daiber, A., Frenis, K., Kuntić, M., Li, H., Wolf, E., Kilgallen, A. B., Lecour, S., Laake, L. W. V., Schulz, R., Hahad, O., et al. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0272 · Cited by 54 · see citing works
Interactions between Gut Microbiota, Host Circadian Rhythms, and Metabolic Diseases
Zhang, M., Zhou, C., Li, X., Li, H., Han, Q., Chen, Z., Tang, W., & Yin, J. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100416 · Cited by 53 · see citing works
Reitz, C. J., & Martino, T. A. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150706105926 · Cited by 53 · see citing works
Self-citationFemale ClockΔ19/Δ19 mice are protected from the development of age-dependent cardiomyopathy
Alibhai, F. J., Reitz, C. J., Peppler, W. T., Basu, P., Sheppard, P. A. S., Choleris, E., Bakovic, M., & Martino, T. A. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx185 · Cited by 55 · see citing works
Self-citationSleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria
Abdel‐Rahman, E. A., Hosseiny, S., Aaliya, A., Adel, M., Yasseen, B. A., AlOkda, A., Radwan, Y., Saber, S. H., Elkholy, N., Elhanafy, E., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.01.006 · Cited by 51 · see citing works
Endotoxin Disrupts Circadian Rhythms in Macrophages via Reactive Oxygen Species
Wang, Y., Pati, P., Xu, Y., Chen, F., Stepp, D. W., Huo, Y., Rudic, R. D., & Fulton, D. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155075 · Cited by 51 · see citing works
Oyama, Y., Bartman, C. M., Bonney, S. K., Lee, J. S., Walker, L. A., Han, J., Borchers, C. H., Buttrick, P. M., Aherne, C. M., Clendenen, N., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.020 · Cited by 48 · see citing works
Bennardo, M., Alibhai, F. J., Tsimakouridze, E. V., Chinnappareddy, N., Podobed, P. S., Reitz, C. J., Pyle, W. G., Simpson, J. A., & Martino, T. A. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00200.2016 · Cited by 48 · see citing works
Self-citationTsimakouridze, E. V., Straume, M., Podobed, P. S., Chin, H., LaMarre, J., Johnson, R., Antenos, M., Kirby, G. M., Mackay, A., Huether, P., et al. (2012) · Chronobiology International · doi:10.3109/07420528.2012.691145 · Cited by 46 · see citing works
Self-citationCircadian influences on myocardial infarction
Virag, J. A. I., & Lust, R. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00422 · Cited by 46 · see citing works
Cardiac Clocks and Preclinical Translation
Mistry, P., Duong, A., Kirshenbaum, L. A., & Martino, T. A. (2017) · Heart Failure Clinics · doi:10.1016/j.hfc.2017.05.002 · Cited by 45 · see citing works
Self-citationAltered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride
Chen, P., Kakan, X., & Zhang, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.03.019 · Cited by 43 · see citing works
The significance of circadian rhythms and dysrhythmias in critical illness
McKenna, H., Reiss, I. K. M., & Martín, D. (2017) · Journal of the Intensive Care Society · doi:10.1177/1751143717692603 · Cited by 44 · see citing works
REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
Lee, S.-H., Hadipour-Lakmehsari, S., Murthy, H. R., Gibb, N., Miyake, T., Teng, A. C. T., Cosme, J., Yu, J. C., Moon, M., Lim, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14143-9 · Cited by 42 · see citing works
Self-citationNatriuretic peptides in the control of lipid metabolism and insulin sensitivity
Verboven, K., Hansen, D., Jocken, J., & Blaak, E. (2017) · Obesity Reviews · doi:10.1111/obr.12598 · Cited by 34 · see citing works
Podobed, P. S., Alibhai, F. J., Chow, C.-W., & Martino, T. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104907 · Cited by 41 · see citing works
Self-citationComplexities in cardiovascular rhythmicity: perspectives on circadian normality, ageing and disease
Monfredi, O., & Lakatta, E. G. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz112 · Cited by 40 · see citing works
Circadian regulation of cardiovascular function: a role for vasoactive intestinal peptide
Schroeder, A., Loh, D. H., Jordan, M. C., Roos, K. P., & Colwell, C. S. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00190.2010 · Cited by 39 · see citing works
Circadian influence on inflammatory response during cardiovascular disease
Aziz, I. S., McMahon, A. M., Friedman, D., Rabinovich-Nikitin, I., Kirshenbaum, L. A., & Martino, T. A. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.11.007 · Cited by 38 · see citing works
Self-citationWang, Y., Jiang, W., Hu, C., Zhou, H., Liu, Z., Liu, Z., Liu, Z., Zhou, Y., Zhou, X., Yu, L., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.668387 · Cited by 39 · see citing works
Martino, T. A., Tata, N., Bjarnason, G. A., Straume, M., & Sole, M. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00183.2007 · Cited by 38 · see citing works
Self-citationCircadian influence on the microbiome improves heart failure outcomes
Mistry, P., Reitz, C. J., Khatua, T. N., Rasouli, M., Oliphant, K., Young, M. E., Allen‐Vercoe, E., & Martino, T. A. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.09.006 · Cited by 36 · see citing works
Self-citationMatsumura, T., Nakagawa, H., Suzuki, K., Ninomiya, C., & Ishiwata, T. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1105250 · Cited by 37 · see citing works
Circadian MicroRNAs in Cardioprotection
Oyama, Y., Bartman, C. M., Gile, J. J., & Eckle, T. D. L. G. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170707165319 · Cited by 36 · see citing works
Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health
Festus, I. D., Spilberg, J., Young, M. E., Cain, S. W., Khoshnevis, S., Smolensky, M. H., Zaheer, F., Descalzi, G., & Martino, T. A. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.02.011 · Cited by 35 · see citing works
Self-citationHu, K., Scheer, F. A. J. L., Buijs, R. M., & Shea, S. A. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn150 · Cited by 35 · see citing works
Fletcher, E. K., Morgan, J., Kennaway, D. J., Bienvenu, L. A., Rickard, A. J., Delbridge, L. M. D., Fuller, P. J., Clyne, C. D., & Young, M. J. (2017) · Endocrinology · doi:10.1210/en.2016-1911 · Cited by 34 · see citing works
Coordination of cardiac rhythmic output and circadian metabolic regulation in the heart
Hsieh, P. N., Zhang, L., & Jain, M. K. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2606-x · Cited by 34 · see citing works
Chronobiology in Aortic Diseases – “Is This Really a Random Phenomenon?”
Manfredini, R., Fabbian, F., Manfredini, F., Salmi, R., Gallerani, M., & Bossone, E. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.04.001 · Cited by 34 · see citing works
Rishi, M. A., Cheng, J. Y., Strang, A. R., Sexton–Radek, K., Ganguly, G., Licis, A., Flynn‐Evans, E. E., Berneking, M., Bhui, R., Creamer, J. L., et al. (2023) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10898 · Cited by 33 · see citing works
Circadian-Hypoxia Link and its Potential for Treatment of Cardiovascular Disease
Bartman, C. M., & Eckle, T. D. L. G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190516081612 · Cited by 33 · see citing works
Lin, J., Kuang, H., Jiang, J., Zhou, H., Li, P., Xu, Y., & Kuang, J. (2023) · Medical Science Monitor · doi:10.12659/msm.942215 · Cited by 32 · see citing works
Mochel, J. P., & Danhof, M. (2015) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2015_27 · Cited by 32 · see citing works
Hu, K., Scheer, F. A. J. L., Buijs, R. M., & Shea, S. A. (2008) · Journal of Biological Rhythms · doi:10.1177/0748730408316166 · Cited by 32 · see citing works
Chalmers, J. A., Lin, S.-Y. J., Martino, T. A., Arab, S., Liu, P. X., Husain, M., Sole, M. J., & Belsham, D. D. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0050 · Cited by 32 · see citing works
Self-citationWang, X., Xue, J., Yang, J., & Xie, M.-L. (2013) · Genes & Nutrition · doi:10.1007/s12263-013-0333-y · Cited by 31 · see citing works
Effects of circadian misalignment on sleep in mice
Hasan, S., Foster, F., Vyazovskiy, V. V., & Peirson, S. N. (2018) · Scientific Reports · doi:10.1038/s41598-018-33480-1 · Cited by 28 · see citing works
Light Exposure at Night and Cardiovascular Disease Incidence
Windred, D. P., Burns, A. C., Rutter, M. K., Lane, J. M., Saxena, R., Scheer, F. A. J. L., Cain, S. W., & Phillips, A. J. K. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.39031 · Cited by 28 · see citing works
Pyle, W. G., & Martino, T. A. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.05.003 · Cited by 28 · see citing works
Self-citationAssociations of Short Sleep and Shift Work Status with Hypertension among Black and White Americans
Ceïde, M. E., Pandey, A. K., Ravenell, J., Donat, M., Ogedegbe, G. G., & Jean‐Louis, G. (2015) · International Journal of Hypertension · doi:10.1155/2015/697275 · Cited by 28 · see citing works
Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease
Li, M., Xin, H., Yuan, Y., Yang, X., Li, H., Tian, D., Zhang, H., Zhang, Z., Han, T.-L., Chen, Q., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.721231 · Cited by 29 · see citing works
Time‐restricted eating for chronodisruption‐related chronic diseases
Cheng, W., Desmet, L., & Depoortere, I. (2023) · Acta Physiologica · doi:10.1111/apha.14027 · Cited by 27 · see citing works
Cardiovascular disease, chronopharmacotherapy, and the molecular clock
Takeda, N., & Maemura, K. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.04.011 · Cited by 25 · see citing works
Preliminary Study on the Effect of a Night Shift on Blood Pressure and Clock Gene Expression
Toffoli, B., Tonon, F., Giudici, F., Ferretti, T., Ghirigato, E., Contessa, M., Francica, M., Candido, R., Puato, M., Grillo, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119309 · Cited by 24 · see citing works
Clock genes in health and diseases
Mongrain, V., & Cermakian, N. (2009) · Journal of Applied Biomedicine · doi:10.32725/jab.2009.002 · Cited by 23 · see citing works
Circadian mutant mice with obesity and metabolic syndrome are resilient to cardiovascular disease
Reitz, C. J., Alibhai, F. J., Seolin, B. G. D. L., Nemec-Bakk, A. S., Khaper, N., & Martino, T. A. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00462.2020 · Cited by 23 · see citing works
Self-citationLiang, Q. L., Xu, H., Liu, M., Lei, Q., Yan, J., Yang, G., & Chen, L. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.025021 · Cited by 23 · see citing works
- Authors
- Martino, T. A., Tata, N., Belsham, D. D., Chalmers, J., Straume, M., Lee, P., Pribiag, H., Khaper, N., Liu, P. P., Dawood, F., Backx, P. H., Ralph, M. R., & Sole, M. J.
- Affiliations
- University Health Network (CA)
- ORCID
- Venue
- Hypertension
- Published
- 2007-05
- Volume
- 49
- Issue
- 5
- Pages
- 1104-1113
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2148332803
- Cited by
- 196
- References
- 34
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 11 · 2023: 10 · 2022: 9 · 2021: 9 · 2020: 16 · 2019: 13 · 2018: 8 · 2017: 16 · 2016: 10 · 2015: 11 · 2014: 9 · 2013: 8 · 2012: 8
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- circadian rhythm, cardiac hypertrophy, pressure overload, transverse aortic constriction, gene expression, suprachiasmatic nucleus, clock genes, Per2, cardiomyocyte hypertrophy, vascular smooth muscle cells, left ventricular remodeling, atrial natriuretic peptide, brain natriuretic peptide, ACE, collagen, cardiovascular disease
- MeSH terms
- Animals, Biological Clocks, Brain, Circadian Rhythm, Echocardiography, Cardiomegaly, Hypertension, Male, Mice, Inbred C57BL, Myocardial Contraction, Myocardium, Severity of Illness Index, Gene Expression, Ventricular Remodeling, Gene Expression Profiling, Microarray Analysis, Mice
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