Circadian clocks, obesity and cardiometabolic function
Open accessAbstract
Life on earth is governed by the continuous 24‐h cycle of light and dark. Organisms have adapted to this environment with clear diurnal rhythms in their physiology and metabolism, enabling them to anticipate predictable environmental fluctuations over the day and to optimize the timing of relevant biological processes to this cycle. These rhythms are regulated by molecular circadian clocks, and current evidence suggests that interactions between the central and peripheral molecular clocks are important in metabolic and vascular functions. Disrupting this process through mutations in the core clock genes or by interfering with the environmental zeitgebers that entrain the clock appear to modulate the function of cells and tissues, leading to an increased risk for cardiometabolic disease.
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Obesity is an important factor correlating with decreased vaccine-induced immune response, which may affect adaptive immune responses.
“Scott et al. [35] reported that one important factor correlating with decreased vaccine-induced immune response is obesity, which may affect adaptive immune responses.”
From The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly (2016) · cites this paper as [35]
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Cites
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works
Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction
Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884 · see citing works
Mutagenesis and Mapping of a Mouse Gene, <i>Clock</i> , Essential for Circadian Behavior
Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632 · see citing works
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528 · see citing works
Health disorders of shift workers
Knutsson, A. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg048 · Cited by 1,218 · see citing works
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 934 · see citing works
Diabetes and Cardiovascular Disease: The “Common Soil” Hypothesis
Stern, M. P. (1995) · Diabetes · doi:10.2337/diab.44.4.369 · Cited by 739 · see citing works
Rajaratnam, S. M., & Arendt, J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06108-6 · Cited by 711 · see citing works
Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism
Liu, C., Li, S., Liu, T., Borjigin, J., & Lin, J. D. (2007) · Nature · doi:10.1038/nature05767 · Cited by 643 · see citing works
A CLOCK Polymorphism Associated with Human Diurnal Preference
Katzenberg, D. R., Young, T. B., Finn, L. A., Lin, L., King, D. P., Takahashi, J. S., & Mignot, E. J.-M. (1998) · SLEEP · doi:10.1093/sleep/21.6.569 · Cited by 587 · see citing works
Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance
Kelley, D. E., Thaete, F. L., Troost, F., Huwe, T., & Goodpaster, B. H. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.5.e941 · Cited by 538 · see citing works
Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature
McNamara, P., Seo, S., Rudic, R. D., Sehgal, A., Chakravarti, D., & FitzGerald, G. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00401-9 · Cited by 441 · see citing works
Woon, P. Y., Kaisaki, P. J., Bragança, J., Bihoreau, M., Lévy, J., Farrall, M., & Gauguier, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703247104 · Cited by 410 · see citing works
Circadian variation of blood pressure and the vascular response to asynchronous stress
Curtis, A. M., Cheng, Y., Kapoor, S. C., Reilly, D. F., Price, T. S., & FitzGerald, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611680104 · Cited by 401 · see citing works
Bray, M. S., Shaw, C. A., Moore, M. W. S., Garcia, R. A. P., Zanquetta, M. M., Durgan, D. J., Jeong, W. J., Tsai, J.-Y., Bugger, H., Zhang, D., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01291.2007 · Cited by 384 · see citing works
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man
SCOTT, E. M., Carter, A. M., & Grant, P. J. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803778 · Cited by 344 · see citing works
Self-citationMetabolic disturbances in male workers with rotating three-shift work. Results of the WOLF study
Karlsson, B. H., Knutsson, A., Lindahl, B., & Alfredsson, L. S. (2003) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-003-0440-y · Cited by 316 · see citing works
Ando, H., Yanagihara, H., Hayashi, Y., Obi, Y., Tsuruoka, S., Takamura, T., Kaneko, S., & Fujimura, A. (2005) · Endocrinology · doi:10.1210/en.2005-0771 · Cited by 312 · see citing works
Vascular Disease in Mice With a Dysfunctional Circadian Clock
Anea, C. B., Zhang, M., Stepp, D. W., Simkins, G. B., Reed, G. L., Fulton, D. J., & Rudic, R. D. (2009) · Circulation · doi:10.1161/circulationaha.108.827477 · Cited by 292 · see citing works
Verdecchia, P., Schillaci, G., Gatteschi, C., Zampi, I., Battistelli, M., Bartoccini, C., & Porcellati, C. (1993) · Circulation · doi:10.1161/01.cir.88.3.986 · Cited by 276 · see citing works
Early Morning Attenuation of Endothelial Function in Healthy Humans
Otto, M. E., Svatikova, A., Barretto, R. B. D. M., Santos, S., Hoffmann, M., Khandheria, B., & Somers, V. (2004) · Circulation · doi:10.1161/01.cir.0000128207.26863.c4 · Cited by 273 · see citing works
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Castaño, G. O., & Pirola, C. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1606 · Cited by 262 · see citing works
Young, M. E., Razeghi, P., & Taegtmeyer, H. (2001) · Circulation Research · doi:10.1161/hh1101.091190 · Cited by 251 · see citing works
Mutation of the Circadian Clock Gene Per2 Alters Vascular Endothelial Function
Viswambharan, H., Carvas, J. M., Antic, V., Marecic, A., Jud, C., Zaugg, C. E., Ming, X., Montani, J., Albrecht, U., & Yang, Z. (2007) · Circulation · doi:10.1161/circulationaha.106.653303 · Cited by 242 · see citing works
Histone Acetyltransferase-dependent Chromatin Remodeling and the Vascular Clock
Curtis, A. M., Seo, S., Westgate, E. J., Rudic, R. D., Smyth, E. M., Chakravarti, D., FitzGerald, G. A., & McNamara, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311973200 · Cited by 208 · see citing works
Nakano, S., Fukuda, M., HOTTA, F., Ito, T., Ishii, T., Kitazawa, M., NISHIZAWA, M., Kigoshi, T., & Uchida, K. (1998) · Diabetes · doi:10.2337/diabetes.47.9.1501 · Cited by 194 · see citing works
Impaired Diurnal Blood Pressure Variation and All-cause Mortality
Brotman, D. J., Davidson, M., Boumitri, M., & Vidt, D. G. (2007) · American Journal of Hypertension · doi:10.1038/ajh.2007.7 · Cited by 186 · see citing works
Nonaka, H., Emoto, N., Ikeda, K., Fukuya, H., Rohman, M. S., Raharjo, S. B., Yagita, K., Okamura, H., & Yokoyama, M. (2001) · Circulation · doi:10.1161/hc4001.098048 · Cited by 183 · see citing works
The Network of Time: Understanding the Molecular Circadian System
Roenneberg, T., & Merrow, M. W. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00124-6 · Cited by 180 · see citing works
When the Clock stops ticking, metabolic syndrome explodes
Staels, B. (2006) · Nature Medicine · doi:10.1038/nm0106-54 · Cited by 167 · see citing works
Durgan, D. J., Trexler, N., Egbejimi, O., McElfresh, T. A., Suk, H. Y., Petterson, L. E., Shaw, C. A., Hardin, P. E., Bray, M. S., Chandler, M. P., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601704200 · Cited by 164 · see citing works
Clock genes are implicated in the human metabolic syndrome
Gómez-Abellán, P., Morante, J. J. H., Luján, J., Madrid, J. A., & Garaulet, M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803689 · Cited by 160 · see citing works
Development of dilated cardiomyopathy in<i>Bmal1</i>-deficient mice
Lefta, M., Campbell, K. S., Feng, H.-Z., Jin, J.-P., & Esser, K. A. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00238.2012 · Cited by 158 · see citing works
Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta
Rudic, R. D., McNamara, P., Reilly, D., Grosser, T., Curtis, A.-M., Price, T. S., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2005) · Circulation · doi:10.1161/circulationaha.105.568626 · Cited by 157 · see citing works
Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo
Westgate, E. J., Cheng, Y., Reilly, D. F., Price, T. S., Walisser, J. A., Bradfield, C. A., & FitzGerald, G. A. (2008) · Circulation · doi:10.1161/circulationaha.107.739227 · Cited by 155 · see citing works
Circadian Clocks Are Resounding in Peripheral Tissues
Ptitsyn, A. A., Zvonic, S., Conrad, S. A., Scott, L. K., Mynatt, R. L., & Gimble, J. M. (2006) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020016 · Cited by 145 · see citing works
Metabolic homeostasis in mice with disruptedClockgene expression in peripheral tissues
Kennaway, D. J., Owens, J. A., Voultsios, A., Boden, M. J., & Varcoe, T. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00018.2007 · Cited by 140 · see citing works
Thrombomodulin Is a Clock-controlled Gene in Vascular Endothelial Cells
Takeda, N., Maemura, K., Horie, S., Oishi, K., Imai, Y., Harada, T., Saito, T., Shiga, T., Amiya, E., Manabe, I., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705692200 · Cited by 129 · see citing works
Law, G. R., Ellison, G. T. H., Secher, A. L., Damm, P., Mathiesen, E. R., Temple, R., Murphy, H. R., & SCOTT, E. M. (2015) · Diabetes Care · doi:10.2337/dc15-0070 · Cited by 128 · see citing works
Self-citationIt’s All in the Timing: Many Clocks, Many Outputs
Panda, S., & Hogenesch, J. B. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730404269008 · Cited by 125 · see citing works
Obesity alters circadian expressions of molecular clock genes in the brainstem
Kaneko, K., Yamada, T., Tsukita, S., Takahashi, K., Ishigaki, Y., Oka, Y., & Katagiri, H. (2009) · Brain Research · doi:10.1016/j.brainres.2008.12.071 · Cited by 123 · see citing works
Alibhai, F. J., Tsimakouridze, E. V., Chinnappareddy, N., Wright, D. C., Billia, F., O’Sullivan, M. L., Pyle, W. G., Sole, M. J., & Martino, T. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302995 · Cited by 122 · see citing works
Increased Superoxide and Endothelial NO Synthase Uncoupling in Blood Vessels of Bmal1-Knockout Mice
Anea, C. B., Cheng, B., Sharma, S., Kumar, S., Caldwell, R. W., Yao, L., Ali, M. I., Merloiu, A. M., Stepp, D. W., Black, S. M., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.261750 · Cited by 122 · see citing works
Perciaccante, A., Fiorentini, A., Paris, A., Serra, P., & Tubani, L. (2006) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-6-19 · Cited by 118 · see citing works
Sookoian, S. C. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i31.4242 · Cited by 111 · see citing works
Otway, D. T., Mäntele, S., Bretschneider, S., Wright, J., Trayhurn, P., Skene, D. J., Robertson, M. D., & Johnston, J. D. (2011) · Diabetes · doi:10.2337/db10-1098 · Cited by 106 · see citing works
Brachial artery endothelial function in residents and fellows working night shifts
Amir, O., Alroy, S., Schliamser, J. E., Asmir, I., Shiran, A., Flugelman, M. Y., Halon, D. A., & Lewis, B. S. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.12.032 · Cited by 92 · see citing works
Diurnal Variation in Endothelium-Dependent Vasodilatation Is Not Apparent in Coronary Artery Disease
Shaw, J. A., Chin-Dusting, J. P. F., Kingwell, B. A., & Dart, A. M. (2001) · Circulation · doi:10.1161/01.cir.103.6.806 · Cited by 82 · see citing works
Oishi, K., Ohkura, N., Wakabayashi, M., Shirai, H., SATO, K., Matsuda, J., Atsumi, G., & Ishida, N. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02032.x · Cited by 78 · see citing works
Molecular clocks, type 2 diabetes and cardiovascular disease
Prasai, M., George, J. T., & SCOTT, E. M. (2008) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2008.015 · Cited by 76 · see citing works
Self-citationVisceral Fat and Cardiovascular Risk Factors in Chinese NIDDM Patients
Anderson, P. J., Chan, J. C. N., Chan, Y. L., Tomlinson, B., Young, R. P., Lee, Z. S. K., Lee, K. K. C., Metreweli, C., Cockram, C. S., & Critchley, J. (1997) · Diabetes Care · doi:10.2337/diacare.20.12.1854 · Cited by 70 · see citing works
Further Observations on the Diurnal Variation in Oral Glucose Tolerance
Jarrett, R. J., & KEEN, H. (1970) · BMJ · doi:10.1136/bmj.4.5731.334 · Cited by 69 · see citing works
Chen, J., Jen, S.-L., Lee, W.-L., et al. (1998) · Diabetes Care · doi:10.2337/diacare.21.10.1743 · Cited by 65 · see citing works
Peripheral Circadian Clock Rhythmicity Is Retained in the Absence of Adrenergic Signaling
Reilly, D. F., Curtis, A. M., Cheng, Y., Westgate, E. J., Rudic, R. D., Paschos, G. K., Morris, J., Ouyang, M., THOMAS, S. A., & FitzGerald, G. A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.152538 · Cited by 64 · see citing works
Circadian rhythms, insulin action, and glucose homeostasis
Tan, E., & SCOTT, E. M. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000061 · Cited by 58 · see citing works
Self-citationDigital Signal Processing Reveals Circadian Baseline Oscillation in Majority of Mammalian Genes
Ptitsyn, A. A., Zvonic, S., & Gimble, J. M. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030120 · Cited by 58 · see citing works
Ohkura, N., Oishi, K., FUKUSHIMA, N., Kasamatsu, M., ATSUMI, G., ISHIDA, N., Horie, S., & Matsuda, J. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02210.x · Cited by 54 · see citing works
Attenuation of myocardial injury in mice with functional deletion of the circadian rhythm gene mPer2
Virag, J. A. I., Dries, J. L., Easton, P., et al. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01280.2008 · Cited by 53 · see citing works
Diurnal variations in myocardial metabolism
Bray, M. S., & Young, M. E. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn054 · Cited by 52 · see citing works
Absence of circadian variation in the onset of acute myocardial infarction in diabetic subjects.
Fava, S., Azzopardi, J., Muscat, H. A., & Fenech, F. F. (1995) · Heart · doi:10.1136/hrt.74.4.370 · Cited by 47 · see citing works
Diurnal Variation in Vascular and Metabolic Function in Diet-Induced Obesity
Prasai, M., Mughal, R. S., Wheatcroft, S. B., Kearney, M. T., Grant, P. J., & SCOTT, E. M. (2013) · Diabetes · doi:10.2337/db11-1740 · Cited by 47 · see citing works
Self-citationNeel revisited: the adipocyte, seasonality and type 2 diabetes
SCOTT, E. M., & Grant, P. J. (2006) · Diabetologia · doi:10.1007/s00125-006-0280-x · Cited by 43 · see citing works
Self-citationNakano, S., Ogihara, M., Tamura, C., et al. (1999) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(99)00049-5 · Cited by 37 · see citing works
An Endocrinologist's Guide to the Clock
Prasai, M., Pernicova, I., Grant, P. J., & SCOTT, E. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2449 · Cited by 34 · see citing works
Self-citationRunning a Clock Requires Quality Time Together
Dunlap, J. (2006) · Science · doi:10.1126/science.1122839 · Cited by 24 · see citing works
Nakano, S., Kitazawa, M., Tsuda, S.-I., Himeno, M., Makiishi, H., Nakagawa, A., Kigoshi, T., & Uchida, K. (2002) · Clinical and Experimental Hypertension · doi:10.1081/ceh-100108716 · Cited by 22 · see citing works
Inter-subject differences in constitutive expression levels of the clock gene in man
Balmforth, A. J., Grant, P. J., SCOTT, E. M., Wheatcroft, S. B., Kearney, M. T., Staels, B., & Marx, N. (2007) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2007.004 · Cited by 15 · see citing works
Self-citationOverweight Influence on Circadian Variations of Ambulatory Blood Pressure in Chinese Adolescents
Li, A., Zhao, Z., Zhang, L.-L., et al. (2005) · Clinical and Experimental Hypertension · doi:10.1081/ceh-48777 · Cited by 12 · see citing works
Pernicova, I., Akıncı, B., Prasai, M. J., et al. (2012) · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Kennaway DJ, Owens JA, Voultsios A, Boden MJ, Varcoe TJ. Metabolic home- ostasis in mice with disrupted Clock gene expression in peripheral tissues. Am J Physiol Regul Integr Comp Physiol 2007; 293: R1528-R1537.
- Anea CB, Cheng B, Sharma S et al. Increased superoxide an endothelial NO synthetase uncoupling in blood vessels of Bmal1-knowkcout mice. Circ Res 2012; 111: 1157-1165.
- Scott EM, Carter AM, George JT, Prasai MJ, Day C, Grant PJ. The 3111T/C polymorphism of the Clock gene is associated with waist circumference in subjects with non alcoholic fatty liver disease (NAFLD). Diabetes 2008; 57: A488.
- Gomez-Abellan P, Hernandez-Morante JJ, Lujan JA, Madrid JA, Garaulet M. Clock genes are implicated in the human metabolic syndrome. Int J Obes (Lond) 2008; 32: 121-128.
Cited by
Sorted by citations
Park, H.-J., & Lee, H.-S. (2016) · Nutrition Research and Practice · doi:10.4162/nrp.2016.10.4.418 · Cited by 34 · see citing works
- Authors
- Scott, E. M.
- Affiliations
- University of Leeds (GB)
- Corresponding author
- Scott, E. M.
- ORCID
- Scott, E. M.
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2015-09
- Volume
- 17
- Issue
- S1
- Pages
- 84-89
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W1933442998
- Cited by
- 25
- References
- 72
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 2
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- circadian clock, obesity, cardiometabolic disease, diurnal cycle, core clock genes, peripheral clocks, zeitgebers, circadian rhythm disruption, metabolic function, vascular function
- MeSH terms
- Cardiovascular Diseases, Circadian Rhythm, Humans, Lighting, Metabolic Diseases, Obesity, Chronobiology Disorders, Circadian Clocks
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