Cardiac Fibrosis: The Fibroblast Awakens

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GHSR deficiency exacerbates cardiac fibrosis: role in macrophage inflammasome activation and myofibroblast differentiation

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Sickle cell disease: at the crossroads of pulmonary hypertension and diastolic heart failure

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6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway

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Cardiac pericytes mediate the remodeling response to myocardial infarction

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Heart Failure in Patients with Chronic Kidney Disease

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Bile acid metabolism in health and ageing-related diseases

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Perivascular fibrosis and the microvasculature of the heart. Still hidden secrets of pathophysiology?

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Serelaxin inhibits the profibrotic TGF‐β1/IL‐1β axis by targeting TLR‐4 and the NLRP3 inflammasome in cardiac myofibroblasts

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Hydrogen Sulfide as a Potential Alternative for the Treatment of Myocardial Fibrosis

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Gene therapy targeting cardiac phosphoinositide 3-kinase (p110α) attenuates cardiac remodeling in type 2 diabetes

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Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis

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IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting αSMA

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The role of Wnt signaling in the healing myocardium: a focus on cell specificity

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Atrial Cardiomyopathy in Atrial Fibrillation: Mechanistic Pathways and Emerging Treatment Concepts

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Stachydrine Ameliorates Cardiac Fibrosis Through Inhibition of Angiotensin II/Transformation Growth Factor β1 Fibrogenic Axis

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Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats

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Lack of Thy1 defines a pathogenic fraction of cardiac fibroblasts in heart failure

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MicroRNA-99b-3p promotes angiotensin II-induced cardiac fibrosis in mice by targeting GSK-3β

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Exosomes derived from human amniotic fluid mesenchymal stem cells alleviate cardiac fibrosis via enhancing angiogenesis in vivo and in vitro

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Molecular Approaches and Echocardiographic Deformation Imaging in Detecting Myocardial Fibrosis

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Therapeutic effects of icariin and icariside II on diabetes mellitus and its complications

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The heterocellular heart: identities, interactions, and implications for cardiology

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Formononetin ameliorates isoproterenol induced cardiac fibrosis through improving mitochondrial dysfunction

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α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension

Vang, A., Bós, D. D. S. G., Fernández-Nicolas, A., Zhang, P., Morrison, A., Mancini, T. J., Clements, R., Polina, I. A., Cypress, M. W., Jhun, B. S., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.142945 · Cited by 45

Crossing Into the Next Frontier of Cardiac Extracellular Matrix Research

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Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload

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Targeting fatty acid metabolism for fibrotic disorders

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The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis

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Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy

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The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives

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Pathological cardiac remodeling occurs early in CKD mice from unilateral urinary obstruction, and is attenuated by Enalapril

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Cardioprotective effects of miR-34a silencing in a rat model of doxorubicin toxicity

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Stimulation of Sigma‐1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment

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Metformin accelerates zebrafish heart regeneration by inducing autophagy

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Taohong siwu decoction attenuates myocardial fibrosis by inhibiting fibrosis proliferation and collagen deposition via TGFBR1 signaling pathway

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Regulation and functions of NLRP3 inflammasome in cardiac fibrosis: Current knowledge and clinical significance

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Macrophage and fibroblast trajectory inference and crosstalk analysis during myocardial infarction using integrated single-cell transcriptomic datasets

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The cardiac fibroblast: Origin, identity and role in homeostasis and disease

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Myocardial Tissue Engineering for Regenerative Applications

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Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death

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Resveratrol Attenuates Pressure Overload‐Induced Cardiac Fibrosis and Diastolic Dysfunction via PTEN/AKT/Smad2/3 and NF‐κB Signaling Pathways

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Leukocyte-Dependent Regulation of Cardiac Fibrosis

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The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling

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Molecular imaging of fibroblast activation protein after myocardial infarction using the novel radiotracer [68Ga]MHLL1

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Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration

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Mitochondrial-derived peptides in cardiovascular disease: Novel insights and therapeutic opportunities

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Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload

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TRIM72 contributes to cardiac fibrosis via regulating STAT3/Notch‐1 signaling

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The crosstalk between the cardiovascular and the immune system

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The role of Smad2 and Smad3 in regulating homeostatic functions of fibroblasts in vitro and in adult mice

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Inhibition of the canonical Wnt signaling pathway by a β-catenin/CBP inhibitor prevents heart failure by ameliorating cardiac hypertrophy and fibrosis

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Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis

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Stachydrine, a potential drug for the treatment of cardiovascular system and central nervous system diseases

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Neuronal nitric oxide synthase in hypertension – an update

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Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure

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Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing

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Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells

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β2-Adrenergic Receptors Increase Cardiac Fibroblast Proliferation Through the Gαs/ERK1/2-Dependent Secretion of Interleukin-6

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Chronically infused angiotensin II induces depressive-like behavior via microglia activation

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Inhibition of HSP90 S‐nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway

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AGEs–RAGE axis mediates myocardial fibrosis via activation of cardiac fibroblasts induced by autophagy in heart failure

Liang, B., Zhou, Z., Yang, Z., Liu, J., Zhang, L., He, J., Li, H., Huang, Y., Yang, Q., Xian, S., et al. (2022) · Experimental Physiology · doi:10.1113/ep090042 · Cited by 40

Roles of Epigenetics in Cardiac Fibroblast Activation and Fibrosis

Shao, J., Liu, J., & Zuo, S. (2022) · Cells · doi:10.3390/cells11152347 · Cited by 41

Single-nuclear transcriptome profiling identifies persistent fibroblast activation in hypertrophic and failing human hearts of patients with longstanding disease

Kattih, B., Boeckling, F., Shumliakivska, M., Tombor, L., Rasper, T., Schmitz, K., Hoffmann, J., Nicin, L., Abplanalp, W. T., Carstens, D. C., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad140 · Cited by 42

Hypertension and left ventricular hypertrophy

Djordjevic, D. B., Koracevic, G. P., Đorđević, A. D., & Lović, D. B. (2024) · Journal of Hypertension · doi:10.1097/hjh.0000000000003774 · Cited by 47

Andrographolide Protects against Aortic Banding-Induced Experimental Cardiac Hypertrophy by Inhibiting MAPKs Signaling

Wu, Q., Ni, J., Zhang, N., Liao, H. H., Tang, Q., & Deng, W. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00808 · Cited by 40

A three-dimensional in vitro dynamic micro-tissue model of cardiac scar formation

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Pharmacological inhibition of SUMO-1 with ginkgolic acid alleviates cardiac fibrosis induced by myocardial infarction in mice

Qiu, F., Dong, C., Liu, Y., Shao, X., Huang, D., Han, Y., Wang, B., Liu, Y., Huo, R., Paulo, P., et al. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.03.006 · Cited by 40

Do platelets promote cardiac recovery after myocardial infarction: roles beyond occlusive ischemic damage

Walsh, T. G., & Poole, A. W. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00134.2018 · Cited by 41

Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways

Narikawa, M., Umemura, M., Tanaka, R., Hikichi, M., Nagasako, A., Fujita, T., Yokoyama, U., Ishigami, T., Kimura, K., Tamura, K., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221940 · Cited by 40

Nur77 deficiency exacerbates cardiac fibrosis after myocardial infarction by promoting endothelial‐to‐mesenchymal transition

Chen, J., Jia, J., Ma, L., Li, B., Qin, Q., Qian, J., & Ge, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29877 · Cited by 40

Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis

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VCAM1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium

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YAP/TAZ as mechanobiological signaling pathway in cardiovascular physiological regulation and pathogenesis

Islam, R. M., & Hong, Z. (2024) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2024.100085 · Cited by 44

The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling

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Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model

Wang, L.-X., Yang, X., Yuan, Y., Fan, T., Hou, J., Chen, G., Liang, M., & Wu, Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178619 · Cited by 39

A Human Study to Evaluate Safety, Tolerability, and Cyclic GMP Activating Properties of Cenderitide in Subjects With Stable Chronic Heart Failure

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Angiotensin Converting Enzyme Inhibitors (ACEIs) Decrease the Progression of Cardiac Fibrosis in Rheumatic Heart Disease Through the Inhibition of IL-33/sST2

Ambari, A. M., Setianto, B., Santoso, A., Radi, B., Dwiputra, B., Susilowati, E., Tulrahmi, F., Doevendans, P. A., & Cramer, M. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00115 · Cited by 39

Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway

Shu, J., Hu, L., Wu, Y., Chen, L., Huang, K., Wang, Z., & Liang, M. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174805 · Cited by 39

Combined role for YAP-TEAD and YAP-RUNX2 signalling in substrate-stiffness regulation of cardiac fibroblast proliferation

Ebrahimighaei, R., Sala‐Newby, G. B., Hudson, C. A., Kimura, T. E., Hathway, T., Hawkins, J., McNeill, M. C., Richardson, R. J., Newby, A. C., & Bond, M. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119329 · Cited by 41

Fibroblast Activation Protein Inhibitor Imaging in Nonmalignant Diseases: A New Perspective for Molecular Imaging

Schmidkonz, C., Kuwert, T., Atzinger, A., Cordes, M., Schett, G. A., Ramming, A., & Götz, T. (2022) · Journal of Nuclear Medicine · doi:10.2967/jnumed.122.264205 · Cited by 40

Progress on role of ion channels of cardiac fibroblasts in fibrosis

Xing, C., Bao, L., Li, W., & Fan, H. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1138306 · Cited by 41

The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity

Gutiérrez-Tenorio, J., Marín‐Royo, G., Martínez‐Martínez, E., Martín, R., Miana, M., López‐Andrés, N., Jurado-López, R., Gallardo, I., Luaces, M., Román, J. A. S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17103-9 · Cited by 38

Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome

Kelly, A., Salerno, S., Connolly, A. J., Bishop, M. J., Charpentier, F., Stølen, T., & Smith, G. L. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx244 · Cited by 38

Salvianolic Acid B-Alleviated Angiotensin II Induces Cardiac Fibrosis by Suppressing NF-κB Pathway In Vitro

Wang, C., Luo, H., Xu, Y., Tao, L., Chang, C., & Shen, X. (2018) · Medical Science Monitor · doi:10.12659/msm.908936 · Cited by 38

Periostin Reexpression in Heart Disease Contributes to Cardiac Interstitial Remodeling by Supporting the Cardiac Myofibroblast Phenotype

Dixon, I., Landry, N. M., & Rattan, S. G. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-6657-4_4 · Cited by 37

New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies

Zhao, Y., Du, D., Chen, S., Chen, Z., & Zhao, J. (2022) · Genes · doi:10.3390/genes13081390 · Cited by 38

Sigma-1 Receptor Signaling: In Search of New Therapeutic Alternatives for Cardiovascular and Renal Diseases

Munguía-Galaviz, F. J., Miranda‐Díaz, A. G., Cárdenas-Sosa, M. A., & Echavarría, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031997 · Cited by 40

Integrin beta-like 1 mediates fibroblast–cardiomyocyte crosstalk to promote cardiac fibrosis and hypertrophy

Chen, X., Li, X., Wu, X., Ding, Y., Li, Y., Zhou, G., Wei, Y. X., Chen, S., Lu, X., Xu, J., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad104 · Cited by 37

Redox homeostasis in cardiac fibrosis: Focus on metal ion metabolism

Liu, Z., Liu, Z., Lin, L.-C., Song, K., Tu, B., Ye, Z., Yang, J., Zhao, J., & Tao, H. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103109 · Cited by 40

Targeting cardiac fibrosis with chimeric antigen receptor macrophages

Gao, Z., Yan, L., Meng, J., Lu, Z., Ge, K., Jiang, Z., Feng, T., Wang, H., Liu, C., Tang, J., et al. (2024) · Cell Discovery · doi:10.1038/s41421-024-00718-4 · Cited by 38

Roselle is cardioprotective in diet-induced obesity rat model with myocardial infarction

Si, L.-Y.-N., Ali, S. A. M., Latip, J., Fauzi, N. M., Budin, S. B., & Zainalabidin, S. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.10.030 · Cited by 38

Human Immunodeficiency Virus Increases the Risk of Incident Heart Failure

Yen, Y., Ko, M.-C., Yen, M., Hu, B.-S., Wang, T.-H., Chuang, P., Lai, H.-H., Chen, C.-C., & Deng, C.-Y. (2018) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001917 · Cited by 38

Differential Gender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes in Aging Mice

Achkar, A., Saliba, Y., & Farès, N. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8282157 · Cited by 37

The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis

Seidenberg, J., Stellato, M., Hukara, A., Ludewig, B., Klingel, K., Distler, O., Błyszczuk, P., & Kania, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041861 · Cited by 37

Role of the microRNA-29 family in myocardial fibrosis

Li, C., Wang, N., Rao, P., Wang, L., Lu, D., & Sun, L. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00814-z · Cited by 38

Epicardial and endothelial cell activation concurs with extracellular matrix remodeling in atrial fibrillation

van den Berg, N. W. E., Kawasaki, M., Fabrizi, B., Nariswari, F. A., Verduijn, A. C., Neefs, J., Wesselink, R., Al‐Shama, R., van der Wal, A. C., de Boer, O. J., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.558 · Cited by 37

Myocardial fibrosis by T1 mapping magnetic resonance imaging predicts incident cardiovascular events and all-cause mortality: the Multi-Ethnic Study of Atherosclerosis

Marques, M. D., Weinberg, R., Kapoor, S., Ostovaneh, M. R., Kato, Y., Liu, C. Y., Shea, S., McClelland, R. L., Post, W. S., Bluemke, D. A., et al. (2022) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeac010 · Cited by 36

Cardiac fibroblasts in myocardial injury and heart failure

Linthout, S. V., Matz, I., González, A., & Davis, J. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf902 · Cited by 38

Cardiac fibrosis: Pathobiology and therapeutic targets

Czubryt, M. P., & Hale, T. M. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110066 · Cited by 74

Pathophysiology of cardiac fibroblasts and impacts on the severity of the cardiac disease

Duttaroy, A. K., & Mallick, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99570-2.00016-3

Characteristics and Regulation of Cardiac Fibroblasts

Ying-bing, X. (2011) · Advances in Cardiovascular Diseases

The Janus face of myofibroblasts in the remodeling heart

Hermans, K. C. M., Daskalopoulos, E. P., & Blankesteijn, W. M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.017 · Cited by 33