Cardiac Fibrosis: The Fibroblast Awakens

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A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

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New Insights into IGF-1 Signaling in the Heart

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Spike Protein of SARS-CoV-2 Activates Cardiac Fibrogenesis through NLRP3 Inflammasomes and NF-κB Signaling

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Naringenin inhibits transforming growth factor‑β1‑induced cardiac fibroblast proliferation and collagen synthesis via G0/G1 arrest

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The role of mechanotransduction in heart failure pathobiology—a concise review

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Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a β-Adrenoreceptor-Dependent Mechanism

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X-ray diffraction and second harmonic imaging reveal new insights into structural alterations caused by pressure-overload in murine hearts

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E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-β1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene

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Cardiac Applications of Fibroblast Activation Protein Imaging

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Low-dose ethanol intake prevents high-fat diet-induced adverse cardiovascular events in mice

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Functions of Mesenchymal Stem Cells in Cardiac Repair

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miR-33 regulation of adaptive fibrotic response in cardiac remodeling

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Tanshinone I alleviates post-ischemic myocardial injury by targeting TGFBR1 and modulating the TGF-β signaling pathway

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Loureirin B alleviates cardiac fibrosis by suppressing Pin1/TGF-β1 signaling

Cheng, M., Yang, Z., Li, R., Wu, G., & Zhang, C. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174791 · Cited by 13

Risk Scores for Prediction of Major Cardiovascular Events in Non-Alcoholic Fatty Liver Disease: A No Man’s Land?

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6-Shogaol, an Active Component of Ginger, Inhibits p300 Histone Acetyltransferase Activity and Attenuates the Development of Pressure-Overload-Induced Heart Failure

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The immunology of heart failure with preserved ejection fraction

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Application of polyglycolic acid sheets and basic fibroblast growth factor to prevent esophageal stricture after endoscopic submucosal dissection in pigs

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CAR‐T cell therapeutic avenue for fighting cardiac fibrosis: Roadblocks and perspectives

Abdalla, A. M. E., Yu, M., Ahmed, A. I. M., Meng, N., & Ouyang, C. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3955 · Cited by 16

The influence of endurance exercise training on myocardial fibrosis and arrhythmogenesis in a coxsackievirus B3 myocarditis mouse model

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Apigenin inhibits proliferation and differentiation of cardiac fibroblasts through AKT/GSK3β signaling pathway

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The potential therapeutic value of the natural plant compounds matrine and oxymatrine in cardiovascular diseases

Chen, S., WU, S. M., & Lin, B. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1417672 · Cited by 14

Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response

Rath, S. K., Nyamsuren, G., Tampe, B., Yu, D. S., Hulshoff, M. S., Schlösser, D., Maamari, S., Zeisberg, M., & Zeisberg, E. M. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01719-6 · Cited by 14

Epigenetic Regulation in Myocardial Fibroblasts and Its Impact on Cardiovascular Diseases

Komal, S., Gao, Y., Wang, Z., Yu, Q., Wang, P., Zhang, L., & Han, S. (2024) · Pharmaceuticals · doi:10.3390/ph17101353 · Cited by 14

Harnessing the regenerative potential of interleukin11 to enhance heart repair

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Epigenetic regulation of mitochondrial fission and cardiac fibrosis via sFRP3 promoter methylation

Jiang, S.-X., Zhou, Z., Tu, B., Song, K., Lin, L.-C., Liu, Z., Cao, W., Zhao, J., & Tao, H. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05516-5 · Cited by 13

Myofibroblast-Targeting Extracellular Vesicles: A Promising Platform for Cardiac Fibrosis Drug Delivery

Wang, Y., Jiang, H., Chen, Q., Guo, F., Zhang, B., Hu, L., Huang, X., Shen, W., Gao, J., Chen, W., et al. (2025) · Biomaterials Research · doi:10.34133/bmr.0179 · Cited by 14

Emerging Epigenetic Therapies for the Treatment of Cardiac Fibrosis

Garitano, N., Aguado‐Alvaro, L. P., & Pelacho, B. (2025) · Biomedicines · doi:10.3390/biomedicines13051170 · Cited by 13

Integrative approaches in cardiac tissue engineering: Bridging cellular complexity to create accurate physiological models

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Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control

Coleman, J. L. J., Mouat, M. A., Wu, J., Jancovski, N., Bassi, J. K., Chan, A. Y., Humphreys, D. T., Mrad, N., Yu, Z., Ngo, T., et al. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0173-y · Cited by 12

Role of Extracellular Matrix in Cardiac Cellular Therapies

Hematti, P. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-97421-7_9 · Cited by 13

Acetaldehyde dehydrogenase 2 deficiency exacerbates cardiac fibrosis by promoting mobilization and homing of bone marrow fibroblast progenitor cells

Li, X., Weng, X., Shi, H., Gao, R., Wang, P., Jia, D., Zhang, S., Dong, Z., Sun, X., Yang, J., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.10.006 · Cited by 13

Interactions Among Regulatory Non-coding RNAs Involved in Cardiovascular Diseases

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MicroRNAs in organ fibrosis: From molecular mechanisms to potential therapeutic targets

Zhao, H., Feng, Y., Liu, T., Wang, J., & Yu, J. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153588 · Cited by 13

A Dual Role for Death Receptor 5 in Regulating Cardiac Fibroblast Function

Tanner, M. A., & Grisanti, L. A. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.699102 · Cited by 13

Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1

D’Alessandro, E., Scaf, B., Munts, C., van Hunnik, A., Trevelyan, C. J., Verheule, S., Spronk, H. M. H., Turner, N. A., Cate, H. T., Schotten, U., et al. (2021) · Cells · doi:10.3390/cells10112958 · Cited by 13

Class I HDAC modulates angiotensin II–induced fibroblast migration and mitochondrial overactivity

Huynh, T. V., Rethi, L., Chung, C., Yeh, Y., Kao, Y., & Chen, Y. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13712 · Cited by 13

Heart development and regeneration—a multi‐organ effort

Filosa, A., & Sawamiphak, S. (2021) · FEBS Journal · doi:10.1111/febs.16319 · Cited by 13

PRMT5 up-regulation improves myocardial hypertrophy by mediating E2F-1/NF-κB/NLRP3 pathway

Zhang, L., Wang, H. H., & Li, W. (2023) · Preventive Medicine · doi:10.1016/j.ypmed.2023.107553 · Cited by 13

E2F6 protein levels modulate drug induced apoptosis in cardiomyocytes

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Construction and Analysis of a ceRNA Network in Cardiac Fibroblast During Fibrosis Based on in vivo and in vitro Data

Gao, Q., Zhang, H., Chen, Z.-T., Li, Y., Wang, S., Wen, Z., Xie, Y., Mai, J., Wang, J., & Chen, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.503256 · Cited by 15

Anti-IL-20 Antibody Protects against Ischemia/Reperfusion-Impaired Myocardial Function through Modulation of Oxidative Injuries, Inflammation and Cardiac Remodeling

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Tissue fibrosis in cardiorenal syndrome: crosstalk between heart and kidneys

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Nonischemic Septal Fibrosis in Functional Tricuspid Regurgitation Provides Incremental Stratification of Adverse Remodeling and Prognosis

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Lithium Treatment Improves Cardiac Dysfunction in Rats Deprived of Rapid Eye Movement Sleep

Chen, P., Chung, C., Liu, S.-H., Kao, Y., & Chen, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911226 · Cited by 12

The Carthamus tinctorius L. and Lepidium apetalum Willd. Drug Pair Inhibits EndMT through the TGF β 1/Snail Signaling Pathway in the Treatment of Myocardial Fibrosis

Zhou, Z., Ma, D., Zhou, Y., Zhang, K., Liu, Y., Wang, Z., & Wang, Y. (2023) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2023/6018375 · Cited by 12

Doxorubicin Interaction with Lipid Monolayers Leads to Decreased Membrane Stiffness when Experiencing Compression–Expansion Dynamics

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Epigenetic Regulation of EMP/EMT-Dependent Fibrosis

Sisto, M., & Lisi, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052775 · Cited by 13

The detrimental role of galectin‐3 and endoplasmic reticulum stress in the cardiac consequences of myocardial ischemia in the context of obesity

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Baricitinib alleviates cardiac fibrosis and inflammation induced by chronic sympathetic activation

Li, W., Liu, J., Jiao, R., Liu, Z., Zhang, T., Chai, D., Meng, L., Yang, Z., Liu, Y., Gu, X., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112894 · Cited by 12

iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases

Germena, G., & Hinkel, R. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11060529 · Cited by 12

Ca2+/calmodulin kinase II–dependent regulation of βIV-spectrin modulates cardiac fibroblast gene expression, proliferation, and contractility

Nassal, D. M., Patel, N., Unudurthi, S. D., Shaheen, R., Yu, J., Mohler, P. J., & Hund, T. J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100893 · Cited by 12

Anti-fibrotic effects of p53 activation induced by RNA polymerase I inhibitor in primary cardiac fibroblasts

Pang, S., Chen, Y., Dai, C., Liu, T., Zhang, W., Wang, J., Cui, X., Guo, X., & Jiang, F. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174303 · Cited by 12

Antagonizing the CX3CR1 Receptor Markedly Reduces Development of Cardiac Hypertrophy After Transverse Aortic Constriction in Mice

Nemska, S., Gassmann, M., Bang, M.-L., Frossard, N., & Tavakoli, R. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001130 · Cited by 12

PI3K(p110α) as a determinant and gene therapy for atrial enlargement in atrial fibrillation

Ezeani, M., & Prabhu, S. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04526-w · Cited by 11

Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction

Wang, B., Tan, Y. C., Zhou, W., Yang, J., Jiang, Y., Liu, X., & Zhan, Z. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.08.010 · Cited by 12

Mechanism of myocardial fibrosis regulation by IGF-1R in atrial fibrillation through the PI3K/Akt/FoxO3a pathway

Zhang, P., Li, H., Zhang, A., Wang, X., Song, Q., Li, Z., Wang, W., Xu, J., Hou, Y., & Zhang, Y. (2023) · Biochemistry and Cell Biology · doi:10.1139/bcb-2022-0199 · Cited by 12

Role of angiogenic transdifferentiation in vascular recovery

Cooke, J. P., & Lai, L. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1155835 · Cited by 12

Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction

Murtha, L. A., Hardy, S. A., Mabotuwana, N. S., Bigland, M. J., Bailey, T., Raguram, K., Liu, S., Ngo, D. T. M., Sverdlov, A. L., Tomin, T., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-41894-9 · Cited by 12

Asiatic acid protects against pressure overload-induced heart failure in mice by inhibiting mitochondria-dependent apoptosis

Du, J., Yu, D., Li, J., Si, L., Zhu, D., Li, B., Gao, Y., Sun, L., Wang, X., & Wang, X. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.09.015 · Cited by 15

Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injury

Long, H., Steimle, J. D., Canozo, F. J. G., Kim, J. H., Li, X., Morikawa, Y., Park, M., Turaga, D., Adachi, I., Wythe, J. D., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202201870 · Cited by 14

Reducing Cardiac Fibrosis: Na/K-ATPase Signaling Complex as a Novel Target

Fan, X., Xie, J., & Tian, J. (2017) · Cardiovascular Pharmacology Open Access · doi:10.4172/2329-6607.1000204 · Cited by 12

Celastrol protects TGF-β1-induced endothelial-mesenchymal transition

Gong, F., Zhao, F., & Gan, X. (2017) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-017-1713-0 · Cited by 12

Cardiac support device (ASD) delivers bone marrow stem cells repetitively to epicardium has promising curative effects in advanced heart failure

Yue, S., Naveed, M., Wang, G., Chen, D., Wang, Z., Yu, F., & Zhou, X. (2018) · Biomedical Microdevices · doi:10.1007/s10544-018-0282-8 · Cited by 12

Huoxin Pill inhibits isoproterenol-induced transdifferentiation and collagen synthesis in cardiac fibroblasts through the TGF-β/Smads pathway

Peng, M., Yang, M., Lu, Y., Lin, S., Gao, H., Xie, L., Huang, B., Chen, D., Shen, A., Shen, Z., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114061 · Cited by 12

Immunomodulatory Nanomedicine

Bartneck, M. (2017) · Macromolecular Bioscience · doi:10.1002/mabi.201700021 · Cited by 12

Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney?

Upadhya, B., Amjad, A., & Stacey, R. B. (2019) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2019.11.018 · Cited by 12

Sympathetic overactivation and catecholamine toxicity: mechanisms and therapeutic strategies for neurogenic heart injury following acute ischemic stroke

Guo, W., Li, H., Li, H., Nie, Q.-W., Wang, Z., Li, J., & Tang, Q. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1632704 · Cited by 14

Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis

Wang, Z., Zhang, Z., Ping, Z., Yang, S., Li, Y., Jiang, T., Zheng, X., Zhang, Q., Liu, Z., Zhang, X., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09337-5 · Cited by 11

Imaging Early Life Cardiovascular Phenotype

Varadarajan, V., Gidding, S. S., Wu, C. O., Carr, J. J., & Lima, J. A. C. (2023) · Circulation Research · doi:10.1161/circresaha.123.322054 · Cited by 11

ONX0914 inhibition of immunoproteasome subunit LMP7 ameliorates diabetic cardiomyopathy via restraining endothelial–mesenchymal transition

Wang, M., Liu, Y., Dai, L., Zhong, X., Zhang, W., Xie, Y., Zeng, H., & Wang, H. (2023) · Clinical Science · doi:10.1042/cs20230732 · Cited by 11

Analysis of immunoinfiltration and EndoMT based on TGF-β signaling pathway-related genes in acute myocardial infarction

Shen, J., Liang, J., Rejiepu, M., Ma, Z., Zhao, J., Li, J., Zhang, L., Yuan, P., Wang, J., & Tang, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-55613-5 · Cited by 11

On‐Demand Bioactivation of Inert Materials With Plasma‐Polymerized Nanoparticles

Santos, M., Michael, P. L., Mitchell, T. C., Lam, Y. T., Robinson, T. M., Moore, M. J., Tan, R. P., Rnjak‐Kovacina, J., Lim, K. S., & Wise, S. G. (2024) · Advanced Materials · doi:10.1002/adma.202311313 · Cited by 11

Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function

Chen, P., Ye, C., Huang, Y., Xu, B., Wu, T., Dong, Y., Jin, Y., Zhao, L., Hu, C., Mao, J., et al. (2024) · Biological Research · doi:10.1186/s40659-024-00492-3 · Cited by 13

Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction

Wang, X., Zhao, Y., Zhang, Q.-Y., Zhao, J.-X., Yin, D. Z., Zhang, Z.-Z., Jin, X., Li, S.-N., Ji, H.-Y., Chen, H.-Y., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01306-8 · Cited by 11

Discovery of 1,2,4-Triazole-3-thione Derivatives as Potent and Selective DCN1 Inhibitors for Pathological Cardiac Fibrosis and Remodeling

He, Z., Gao, G., Qiao, H., Dong, G., Dan, Z., Li, Y., Qi, Y., Zhang, Q., Yuan, S., Liu, H., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00713 · Cited by 11

Therapeutic potential of agents targeting cannabinoid type 2 receptors in organ fibrosis

Eddin, L. B., Meeran, M. F. N., Subramanya, S. B., Jha, N. K., & Ojha, S. K. (2024) · Pharmacology Research & Perspectives · doi:10.1002/prp2.1219 · Cited by 11

The synergistic protective effects of paeoniflorin and β-ecdysterone against cardiac hypertrophy through suppressing oxidative stress and ferroptosis

Yan, P., Li, X., He, Y., Zhang, Y., Wang, Y., Liu, J., Ren, S., Wu, D., Zhao, Y., Ding, L., et al. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111509 · Cited by 11

Miglustat ameliorates isoproterenol-induced cardiac fibrosis via targeting UGCG

Liu, J., Li, W., Jiao, R., Liu, Z., Zhang, T., Chai, D., Meng, L., Yang, Z., Liu, Y., Wu, H., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01093-w · Cited by 11

Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)

Ran, Y., Guo, Z.-L., Zhang, L., Li, H., Zhang, X.-Y., Guan, X.-M., Cui, X.-D., Chen, H., & Cheng, M. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13492 · Cited by 11

Nanocatalytic antioxidation synergizes cardioprotection and antifibrosis in cardiac injury

He, R., Yang, B., & Shi, J. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102820 · Cited by 10

RASSF1‐AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice

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Divergent Effects of Resveratrol on Rat Cardiac Fibroblasts and Cardiomyocytes

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