Cardiac Fibrosis: The Fibroblast Awakens

Wound repair and regeneration

Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542

Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association

Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797

Myofibroblasts and mechano-regulation of connective tissue remodelling

Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290

A perivascular origin for mesenchymal stem cells in multiple human organs

Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991

Regulation of type I interferon responses

Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

Molkentin, J. D., Lu, J., Antos, C. L., Markham, B. E., Richardson, J. A., Robbins, J. M., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

Ieda, M., Fu, J.-D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B. G., & Srivastava, D. (2010) · Cell · doi:10.1016/j.cell.2010.07.002 · Cited by 2,454

TGF-β signaling and the fibrotic response

Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

Zeisberg, E. M., Tarnavski, O., Zeisberg, M., Dorfman, A. L., McMullen, J. R., Gustafsson, E., Chandraker, A. K., Yuan, X., Pu, W. T., Roberts, A. B., et al. (2007) · Nature Medicine · doi:10.1038/nm1613 · Cited by 2,251

Silver nanoparticles induced hepatoxicity via the apoptotic/antiapoptotic pathway with activation of TGFβ-1 and α-SMA triggered liver fibrosis in Sprague Dawley rats

Assar, D. H., Mokhbatly, A.-A. A., Ghazy, E., Elbialy, Z. I., Gaber, A. A., Hassan, A., Nabil, A., & Asa, S. A. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-21388-3 · Cited by 36

Substrate stiffness modulates cardiac fibroblast activation, senescence and proinflammatory secretory phenotype

Felisbino, M. B., Rubino, M., Travers, J. G., Schuetze, K. B., Lemieux, M. E., Anseth, K. S., Aguado, B. A., & McKinsey, T. A. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00483.2023 · Cited by 40

Myocardial Fibrosis: Emerging Target for Cardiac Molecular Imaging and Opportunity for Image-Guided Therapy

Bengel, F. M., Diekmann, J., Hess, A., & Jerosch‐Herold, M. (2023) · Journal of Nuclear Medicine · doi:10.2967/jnumed.122.264867 · Cited by 36

Cardiac and perivascular myofibroblasts, matrifibrocytes, and immune fibrocytes in hypertension; commonalities and differences with other cardiovascular diseases

Torimoto, K., Elliott, K., Nakayama, Y., Yanagisawa, H., & Eguchi, S. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae044 · Cited by 38

The Non-cardiomyocyte Cells of the Heart. Their Possible Roles in Exercise-Induced Cardiac Regeneration and Remodeling

Varga, I., Kyselovič, J., Gálfiová, P., & Danišovič, Ľ. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4307-9_8 · Cited by 36

Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor

Zhang, W., Bai, F., Wang, J., Zheng, R., Yang, L., James, E. A., & Zhao, Z. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s144807 · Cited by 36

Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction

Fang, W., He, A., Xiang, M., Lin, Y., Wang, Y., Li, J., Yang, C., Zhang, X., Liu, C.-L., Sukhova, G. K., et al. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.11.010 · Cited by 36

Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activation

Walker, M., Godin, M., & Pelling, A. E. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa015 · Cited by 39

Role of sphingosine 1-phosphate signalling in tissue fibrosis

Donati, C., Cencetti, F., Bernacchioni, C., Vannuzzi, V., & Bruni, P. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109861 · Cited by 36

Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling

Li, H., Wang, Y., Liu, J., Chen, X., Duan, Y., Wang, X., Shen, Y., Kuang, Y., Zhuang, T., Tomlinson, B., et al. (2020) · Theranostics · doi:10.7150/thno.48153 · Cited by 36

Potential clinical biomarkers and perspectives in diabetic cardiomyopathy

Deng, J., Fang, Y., Tian, J., Qiao, A., & Yan, D. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-00998-y · Cited by 39

Up‐regulation of paired‐related homeobox 2 promotes cardiac fibrosis in mice following myocardial infarction by targeting of Wnt5a

Bai, W., Tang, Z., Shan, T., Jing, X., Li, P., Qin, W., Song, P., Wang, B., Xu, J. C., Liu, Z., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14914 · Cited by 36

Transcription Factors Involved in the Development and Prognosis of Cardiac Remodeling

Hong, J., & Zhang, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.828549 · Cited by 35

Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise

Hastings, M. H., Castro, C., Freeman, R., Kadir, A. A., Lerchenmüller, C., Li, H., Rhee, J., Roh, J. D., Roh, K., Singh, A. P., et al. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.07.011 · Cited by 36

Targeting Interactions between Fibroblasts and Macrophages to Treat Cardiac Fibrosis

Yang, B., Qiao, Y., Dong, Y., & Meng, Q. (2024) · Cells · doi:10.3390/cells13090764 · Cited by 39

Ginsenoside compound-Mc1 attenuates oxidative stress and apoptosis in cardiomyocytes through an AMP-activated protein kinase–dependent mechanism

Hong, S., Hwang, H., Kim, J. W., Kim, J. A., Lee, Y., Roh, E., Choi, K. M., Baik, S. H., & Yoo, H. J. (2019) · Journal of Ginseng Research · doi:10.1016/j.jgr.2019.08.006 · Cited by 35

Sphingosine-1-Phosphate Receptor Modulator, FTY720, Improves Diastolic Dysfunction and Partially Reverses Atrial Remodeling in a Tm-E180G Mouse Model Linked to Hypertrophic Cardiomyopathy

Ryba, D. M., Warren, C. M., Karam, C. N., Davis, R. T., Chowdhury, S. A. K., Alvarez, M. G., McCann, M. A., Liew, C. W., Wieczorek, D. F., Varga, P., et al. (2019) · Circulation Heart Failure · doi:10.1161/circheartfailure.118.005835 · Cited by 35

Mapping signalling perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources

Kuzmanov, U., Wang, E. Y., Vanderlaan, R. D., Kim, D. H., Lee, S., Hadipour‐Lakmehsari, S., Guo, H., Zhao, Y., McFadden, M. J., Sharma, P., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-020-0585-y · Cited by 35

Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution

Edwards, S., Zhao, G., Tran, J., Patten, K. T., Valenzuela, A. E., Wallis, C., Bein, K. J., Wexler, A. S., Lein, P. J., & Rao, X. (2020) · Environmental Health Perspectives · doi:10.1289/ehp7045 · Cited by 35

Cardioprotective Effect of Decorin in Type 2 Diabetes

Chen, F., Lai, J., Zhu, Y. P., He, M., Hou, H., Wang, J., Chen, C., Wang, D. W., & Tang, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.479258 · Cited by 35

Fibroblast Growth Factor 23 Stimulates Cardiac Fibroblast Activity through Phospholipase C-Mediated Calcium Signaling

Lee, T., Chung, C., Lee, T.-I., Lin, Y., Kao, Y., & Chen, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010166 · Cited by 36

Natural AMPK Activators in Cardiovascular Disease Prevention

Moghaddam, R. H., Samimi, Z., Asgary, S., Mohammadi, P., Hozeifi, S., Hoseinzadeh‐Chahkandak, F., Xu, S., & Farzaei, M. H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.738420 · Cited by 39

Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload

Shinde, A. V., Su, Y., Palanski, B. A., Fujikura, K., Garcia, M. J., & Frangogiannis, N. G. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.02.016 · Cited by 35

Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism

Li, Y., Wang, L., Dong, Z., Wang, S., Qi, L., Cho, K., Zhang, Z., Li, N., Hu, Y., & Jiang, B. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.12.040 · Cited by 35

CCAAT/Enhancer-Binding Proteins in Fibrosis: Complex Roles Beyond Conventional Understanding

Wang, L., Feng, J., Deng, Y., Yang, Q., Wei, Q., Ye, D., Rong, X., & Guo, J. (2022) · Research · doi:10.34133/2022/9891689 · Cited by 35

p53 and Myofibroblast Apoptosis in Organ Fibrosis

McElhinney, K., Irnaten, M., & O'Brien, C. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076737 · Cited by 37

Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition

Wu, Q., Xiao, Y., Jiang, X., Yuan, Y., Yang, Z., Chang, W., Bian, Z., & Tang, Q. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-2956-6 · Cited by 34

Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction

Shibamoto, M., Higo, T., Naito, A. T., Nakagawa, A., Sumida, T. S., Okada, K., Sakai, T., Kuramoto, Y., Yamaguchi, T., Ito, M., et al. (2019) · International Heart Journal · doi:10.1536/ihj.18-701 · Cited by 36

Genomics of Human Fibrotic Diseases: Disordered Wound Healing Response

Stone, R. C., Chen, V., Burgess, J. L., Pannu, S., & Tomic‐Canic, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228590 · Cited by 35

The Diagnostic and Therapeutic Value of Multimarker Analysis in Heart Failure. An Approach to Biomarker-Targeted Therapy

Topf, A., Mirna, M., Ohnewein, B., Jirak, P., Kopp, K. L., Fejzic, D., Haslinger, M., Motloch, L. J., Hoppe, U. C., Berezin, A. Е., et al. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.579567 · Cited by 34

Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies

Chen, Y., Gao, Y., Zhou, Y., Li, X., Wang, H., Polonsky, T. S., Vermund, S. H., Qian, H., & Qian, F. (2021) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002629 · Cited by 34

Engineering Human Cardiac Muscle Patch Constructs for Prevention of Post-infarction LV Remodeling

Wang, L., Serpooshan, V., & Zhang, J. J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.621781 · Cited by 35

Cardiac regenerative capacity: an evolutionary afterthought?

Nguyen, P. D., de Bakker, D. E. M., & Bakkers, J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03831-9 · Cited by 36

Exploring the Communal Pathogenesis, Ferroptosis Mechanism, and Potential Therapeutic Targets of Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy via a Microarray Data Analysis

Wang, Z., Xia, Q., Su, W., Cao, M., Sun, Y., Zhang, M., Chen, W., & Jiang, T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.824756 · Cited by 34

MiR‐154 directly suppresses DKK2 to activate Wnt signaling pathway and enhance activation of cardiac fibroblasts

Sun, L., Bie, Z., Zhang, C., Li, H., Liudong, L., & Yang, J. (2016) · Cell Biology International · doi:10.1002/cbin.10655 · Cited by 34

Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts

Jana, S., Zhang, H., Lopaschuk, G. D., Freed, D. H., Sergi, C. M., Kantor, P. F., Oudit, G. Y., & Kassiri, Z. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.010427 · Cited by 34

Developmental Pathways of Cardiac FibroblastsPreprint

Tallquist, M. D. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037184 · Cited by 34

Immunometabolism changes in fibrosis: from mechanisms to therapeutic strategies

Feng, L., Chen, X., Huang, Y., Zhang, X., Zheng, S., & Xie, N. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1243675 · Cited by 35

Arrhythmogenic Substrates for Atrial Fibrillation in Obesity

Lubbers, E. R., Price, M. V., & Mohler, P. J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01482 · Cited by 36

New Noonan Syndrome Model Mice with RIT1 Mutation Exhibit Cardiac Hypertrophy and Susceptibility to β-adrenergic Stimulation-Induced Cardiac Fibrosis

Takahara, S., Inoue, S., Miyagawa‐Tomita, S., Matsuura, K., Nakashima, Y., Niihori, T., Matsubara, Y., Saiki, Y., & Aoki, Y. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.014 · Cited by 33

Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis

Stewart, R. M., Rodriguez, E. C., & King, M. C. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-07-0438 · Cited by 31

The Role of NLRP3 Inflammasome in Radiation-Induced Cardiovascular Injury

Huang, S., Che, J., Chu, Q., & Zhang, P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00140 · Cited by 33

Application of Animal Models in Diabetic Cardiomyopathy

Lee, W. S., & Kim, J. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0285 · Cited by 34

Preclinical rodent models of cardiac fibrosis

Wang, Y., Wang, M., Samuel, C. S., & Widdop, R. E. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15450 · Cited by 33

Myocardial fibrosis

Espeland, T., Lunde, I. G., Amundsen, B. H., Gullestad, L. L., & Aakhus, S. (2018) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.17.1027 · Cited by 33

Advances in three-dimensional bioprinted stem cell-based tissue engineering for cardiovascular regeneration

Khanna, A., Ayan, B., Undieh, A. A., Yang, Y., & Huang, N. F. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.04.017 · Cited by 38

Dengzhan Shengmai capsule attenuates cardiac fibrosis in post-myocardial infarction rats by regulating LTBP2 and TGF-β1/Smad3 pathway

Wang, M., Wang, M., Zhao, J., Xu, H., Xi, Y., & Yang, H. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154849 · Cited by 32

Can Myocardial Fibrosis Be Reversed?

Frangogiannis, N. G. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.10.094 · Cited by 33

Beyond cardiomyocytes: Cellular diversity in the heart's response to exercise

Trager, L. E., Lyons, M., Kuznetsov, A., Sheffield, C., Roh, K., Freeman, R., Rhee, J., Guseh, J. S., Li, H., & Rosenzweig, A. (2022) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.12.011 · Cited by 35

Molecular mechanisms and targets of right ventricular fibrosis in pulmonary hypertension

Bekedam, F. T., Goumans, M., Bogaard, H. J., de Man, F. S., & Valldeperas, A. L. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108389 · Cited by 33

Review: Acetylation mechanisms and targeted therapies in cardiac fibrosis

Liu, W., Yuan, Q., Cao, S., Wang, G., Liu, X., Xia, Y., Bian, Y., Xu, F., & Chen, Y. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106815 · Cited by 33

Pericytes in the Heart

Lee, L. L., & Chintalgattu, V. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-11093-2_11 · Cited by 33

Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition

Yin, Y., Zhang, Q., Zhao, Q., Ding, G., Wei, C., Chang, L., Li, H., Bei, H., Wang, H., Liang, J., et al. (2019) · BioMed Research International · doi:10.1155/2019/6595437 · Cited by 32

Ginsenoside Re inhibits myocardial fibrosis by regulating miR-489/myd88/NF-κB pathway

Sun, J., Wang, R., Chao, T., Peng, J., Wang, C., & Chen, K. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.11.009 · Cited by 32

Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease

Zhao, F., Satyanarayana, G., Zhang, Z., Zhao, J., Ma, X., & Wang, Y. (2022) · Cells · doi:10.3390/cells11132081 · Cited by 35

Scutellarin Attenuates Doxorubicin‐Induced Cardiotoxicity by Inhibiting Myocardial Fibrosis, Apoptosis and Autophagy in Rats

Sun, X., Zhou, L., Han, Y., Yang, Q., Li, X., Xin, B., Chi, M., Wang, Y., & Guo, C. (2022) · Chemistry & Biodiversity · doi:10.1002/cbdv.202200450 · Cited by 32

Multifaceted TGF‐β signaling, a master regulator: From bench‐to‐bedside, intricacies, and complexities

Ahuja, S., & Zaheer, S. (2023) · Cell Biology International · doi:10.1002/cbin.12097 · Cited by 33

Understanding the role of mammalian sterile 20-like kinase 1 (MST1) in cardiovascular disorders

Yang, Y., Wang, H., Ma, Z., Hu, W., & Sun, D. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.11.010 · Cited by 32

Epigallocatechingallate attenuates myocardial injury in a mouse model of heart failure through TGF‑β1/Smad3 signaling pathway

Chen, K., Chen, W., Liu, S. L., Wu, T. S., Yu, K., Qi, J., Wang, Y., Yao, H., Huang, X. Y., Han, Y., et al. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8825 · Cited by 32

The Potential of Fibroblast Activation Protein-Targeted Imaging as a Biomarker of Cardiac Remodeling and Injury

Fernández‐Mayola, M., & Thackeray, J. T. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01869-8 · Cited by 33

Successful treatment of established heart failure in mice with recombinant HDL (Milano)

Aboumsallem, J. P., Mishra, M., Amin, R., Muthuramu, I., Kempen, H. J. M., & Geest, B. D. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14463 · Cited by 31

Bisdemethoxycurcumin protects against renal fibrosis via activation of fibroblast apoptosis

Jin, F., Jin, Y. H., Du, J., Jiang, L., Zhang, Y., Zhao, Z., Yang, B., Luo, P., & He, Q. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.01.012 · Cited by 31

Limited Regeneration Potential with Minimal Epicardial Progenitor Conversions in the Neonatal Mouse Heart after Injury

Cai, W., Tan, J. H., Yan, J., Zhang, L., Cai, X., Wang, H., Liu, F., Ye, M., & Cai, C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.003 · Cited by 31

Efferocytosis of vascular cells in cardiovascular disease

Cabrera, J. T. O., & Makino, A. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107919 · Cited by 32

Clinical and Molecular Implications of Osteopontin in Heart Failure

Mamazhakypov, A., Sartmyrzaeva, M., Шогаибович, С. А., SCHERMULY, R. T., & Sydykov, A. S. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44080245 · Cited by 30

Investigating the NF-κB signaling pathway in heart failure: Exploring potential therapeutic approaches

Ghiasi, M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40812 · Cited by 30

Advances in cardiac organoid research: implications for cardiovascular disease treatment

Huang, Z., Jia, K., Tan, Y., Yang, Y. P., Xiao, W., Zhou, X., Yi, J., & Zhang, C. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02598-8 · Cited by 30

Ghrelin suppresses cardiac fibrosis of post-myocardial infarction heart failure rats by adjusting the activin A-follistatin imbalance

Yang, C., Liu, J., Liu, K., Du, B., Shi, K., Ding, M., Li, B., & Yang, P. C. (2017) · Peptides · doi:10.1016/j.peptides.2017.10.018 · Cited by 30

Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling

Narikawa, M., Umemura, M., Tanaka, R., Fujita, T., Yokoyama, U., Ishigami, T., Kimura, K., Tamura, K., & Ishikawa, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-24749-6 · Cited by 30

Cardiac Stem Cells in the Postnatal Heart: Lessons from Development

Aguilar-Sanchez, C., Michael, M., & Pennings, S. (2018) · Stem Cells International · doi:10.1155/2018/1247857 · Cited by 31

Hypoplastic left heart syndrome: From bedside to bench and back

Saraf, A. P., Book, W., Nelson, T. J., & Xu, C. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.08.005 · Cited by 30

Anisotropic conduction in the myocardium due to fibrosis: the effect of texture on wave propagation

Nezlobinsky, T. V., Solovyova, O. E., & Panfilov, A. V. (2020) · Scientific Reports · doi:10.1038/s41598-020-57449-1 · Cited by 30

Novel roles of immunometabolism and nonmyocyte metabolism in cardiac remodeling and injury

Mouton, A. J., & Hall, J. E. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00188.2020 · Cited by 33

Systematic quantification of histologic ventricular fibrosis in isolated mitral valve prolapse and sudden cardiac death

Han, H., Parsons, S. A., Curl, C. L., Teh, A. W., Raaijmakers, A. J. A., Koshy, A. N., Leong, T. Y.-M., Burrell, L. M., O’Donnell, D., Vohra, J. K., et al. (2020) · Heart Rhythm · doi:10.1016/j.hrthm.2020.12.021 · Cited by 30

Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiomyocytes

Medzikovic, L., Heese, H., van Loenen, P. B., van Roomen, C. P. A. A., Hooijkaas, I. B., Christoffels, V. M., Creemers, E. E., de Vries, C. J. M., & de Waard, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041600 · Cited by 30

Epigenetics and expression of key genes associated with cardiac fibrosis: NLRP3, MMP2, MMP9, CCN2/CTGF and AGT

Chandra, S., Ehrlich, K. C., Lacey, M. R., Baribault, C., & Ehrlich, M. (2021) · Epigenomics · doi:10.2217/epi-2020-0446 · Cited by 30

Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality

Lezoualc’h, F., Badimón, L., Baker, H. E., Bernard, M., Czibik, G., de Boer, R. A., d’Humières, T., Kergoat, M., Kowala, M. C., Rieusset, J., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac152 · Cited by 29

Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart

Rubino, M., Travers, J. G., Headrick, A. L., Enyart, B. T., Lemieux, M. E., Cavasin, M. A., Schwisow, J. A., Hardy, E. J., Kaltenbacher, K. J., Felisbino, M. B., et al. (2022) · Circulation Research · doi:10.1161/circresaha.122.321475 · Cited by 30

Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart

Dhanjal, T., Lellouche, N., von Ruhland, C. J., Abehsira, G., Edwards, D. H., Dubois‐Randé, J., Moschonas, K., Teíger, E., Williams, A. J., & George, C. H. (2017) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2016.11.010 · Cited by 30

Rho kinase signaling and cardiac physiology

Dai, Y., Luo, W., & Chang, J. (2017) · Current Opinion in Physiology · doi:10.1016/j.cophys.2017.07.005 · Cited by 30

Nuclear Localization Leucine-Rich-Repeat Protein 1 Deficiency Protects Against Cardiac Hypertrophy by Pressure Overload

Zong, J., Li, F., Liang, K. H., Dai, R., Zhang, H., Yan, L., Liu, J., Xu, L., & Qian, W. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491664 · Cited by 30

Coupling between cardiac cells—An important determinant of electrical impulse propagation and arrhythmogenesis

Kléber, A. G., & Jin, Q. (2021) · Biophysics Reviews · doi:10.1063/5.0050192 · Cited by 29

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Prieto‐Vila, M., Yoshioka, Y., Kuriyama, N., Okamura, A., Yamamoto, Y., Muranaka, A., & Ochiya, T. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12461 · Cited by 35

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Fang, C., Zeng, Z., Ni, B., Wen, X., Fang, Z., Zou, J., & Zhang, G. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1681875 · Cited by 29

A primer on current progress in cardiac fibrosis

Al‐Hattab, D. S., & Czubryt, M. P. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0687 · Cited by 29

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Beermann, J., Kirste, D., Iwanov, K., Lu, D., Kleemiß, F., Kumarswamy, R., Schimmel, K., Bär, C., & Thum, T. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.158 · Cited by 29

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Ezeani, M., Noor, A., Alt, K., Lal, S., Donnelly, P. S., Hagemeyer, C. E., & Niego, B. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.022139 · Cited by 29

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Shi, X., Zhang, L., Li, Y., Xue, J., Liang, F., Ni, H.-W., Wang, X., Cai, Z., Shen, L.-H., Huang, T., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.779225 · Cited by 29

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Li, Z., Gao, J., Sun, D., Jiao, Q., Ma, J., Cui, W., Lou, Y., Xu, F., Li, S., & Li, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1045501 · Cited by 28

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Ma, T., Qiu, F., Gong, Y., Cao, H., Dai, G., Sun, D., Zhu, D., Lei, H., Liu, Z., & Gao, L. (2023) · Theranostics · doi:10.7150/thno.82543 · Cited by 29

Cardiovascular outcome of breast cancer patients with concomitant radiotherapy and chemotherapy: A 10-year multicenter cohort study

Kim, D. Y., Youn, J., Park, M., Lee, S., Choi, S.-W., Ryu, K.-H., Kim, L. S., Shim, M.-S., Lee, J. J., & Han, S. (2019) · Journal of Cardiology · doi:10.1016/j.jjcc.2019.02.001 · Cited by 29

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Matilla, L., Arrieta, V., Jover, E., García-Peña, A., Martínez‐Martínez, E., Sádaba, R., Álvarez, V., Navarro, A., Fernández‐Celis, A., Gainza, A., et al. (2020) · Cells · doi:10.3390/cells9071667 · Cited by 29

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Li, S.-S., Pan, L., Zhang, Z., Zhou, M.-D., Chen, X., Qian, L., Dai, M., Lu, J., Yu, Z.-M., Dang, S., et al. (2024) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0031 · Cited by 30

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Guo, W., Yang, C., Zou, J., Yu, T., Li, M., He, R., Chen, K., Hell, R. C. R., Gross, E. R., Zou, X., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111858 · Cited by 31

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Rolski, F., & Ma̧czewski, M. (2025) · Pharmaceuticals · doi:10.3390/ph18030313 · Cited by 33

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Lee, J., Oh, J. E., Rhee, K., Yoo, B., Eom, Y. W., Park, S. W., Lee, J. H., Son, J., Youn, Y. J., Ahn, M., et al. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03542-7 · Cited by 30

Comparative efficacy of different types of antihypertensive drugs in reversing left ventricular hypertrophy as determined with echocardiography in hypertensive patients: A network meta‐analysis of randomized controlled trials

Chen, J., Pei, Y., Li, C., Li, Y., Wang, Q. Y., & Yu, J. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.14047 · Cited by 28

Novel factors that activate and deactivate cardiac fibroblasts: A new perspective for treatment of cardiac fibrosis

Camargo, R. O., Abual’anaz, B. M., Rattan, S. G., Filomeno, K. L., & Dixon, I. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12947 · Cited by 28

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Zhao, H., Yang, H., Geng, C., Chen, Y., Tang, Y., Li, Z., Pang, J., Shu, T., Nie, Y., Liu, Y., et al. (2021) · Theranostics · doi:10.7150/thno.47845 · Cited by 29

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Linthout, S. V., Matz, I., González, A., & Davis, J. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf902 · Cited by 38

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Czubryt, M. P., & Hale, T. M. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110066 · Cited by 74

Pathophysiology of cardiac fibroblasts and impacts on the severity of the cardiac disease

Duttaroy, A. K., & Mallick, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99570-2.00016-3

Characteristics and Regulation of Cardiac Fibroblasts

Ying-bing, X. (2011) · Advances in Cardiovascular Diseases

The Janus face of myofibroblasts in the remodeling heart

Hermans, K. C. M., Daskalopoulos, E. P., & Blankesteijn, W. M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.017 · Cited by 33