Cardiac Fibrosis: The Fibroblast Awakens

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MiR-574–5p promotes the differentiation of human cardiac fibroblasts via regulating ARID3A

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Global analysis of histone modifications and long-range chromatin interactions revealed the differential cistrome changes and novel transcriptional players in human dilated cardiomyopathy

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Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation

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Left Ventricular Remodeling in Degenerative Aortic Valve Stenosis

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Human cardiosphere-derived stromal cells exposed to SARS-CoV-2 evolve into hyper-inflammatory/ pro -fibrotic phenotype and produce infective viral particles depending on the levels of ACE2 receptor expression

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A Brief Review on the Biology and Effects of Cellular and Circulating microRNAs on Cardiac Remodeling after Infarction

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Fibroblast-specific IKK-β deficiency ameliorates angiotensin II–induced adverse cardiac remodeling in mice

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Cytokine-Mediated Alterations of Human Cardiac Fibroblast’s Secretome

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CREB1 transcription-activated lncRNA PVT1 promotes cardiac fibrosis via miR-145/HCN1 axis

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Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats

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Renewal of embryonic and neonatal-derived cardiac-resident macrophages in response to environmental cues abrogated their potential to promote cardiomyocyte proliferation via Jagged-1–Notch1

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Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress

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Emerging role of m6A modification in fibrotic diseases and its potential therapeutic effect

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The role of deubiquitinases in cardiac disease

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Ultrasonic Cavitation-Enabled Treatment for Therapy of Hypertrophic Cardiomyopathy: Proof of Principle

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Leukocyte immunoglobulin-like receptor B4 (LILRB4) negatively mediates the pathological cardiac hypertrophy by suppressing fibrosis, inflammation and apoptosis via the activation of NF-κB signaling

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Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation

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Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

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Expression of xylosyltransferases I and II and their role in the pathogenesis of arthrofibrosis

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Integrating Measures of Myocardial Fibrosis in the Transition from Hypertensive Heart Disease to Heart Failure

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Comprehensive Mapping and Dynamics of Site-Specific Prolyl-Hydroxylation, Lysyl-Hydroxylation and Lysyl O-Glycosylation of Collagens Deposited in ECM During Zebrafish Heart Regeneration

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PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repairPreprint

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An injectable hydrogel containing versatile nanoparticles with antioxidant and antifibrotic properties for myocardial infarction treatment

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Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure

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Pro-fibrotic effect of oxidized LDL in cardiac myofibroblasts

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A strategic expression method of miR-29b and its anti-fibrotic effect based on RNA-sequencing analysis

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UCHL1 inhibition attenuates cardiac fibrosis via modulation of nuclear factor-κB signaling in fibroblasts

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Xinyang Tablet inhibits MLK3-mediated pyroptosis to attenuate inflammation and cardiac dysfunction in pressure overload

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Circle the Cardiac Remodeling With circRNAs

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New insights into the roles of glucocorticoid signaling dysregulation in pathological cardiac hypertrophy

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MicroRNAs—The Heart of Post-Myocardial Infarction Remodeling

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Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects

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Tripartite motif 38 attenuates cardiac fibrosis after myocardial infarction by suppressing TAK1 activation via TAB2/3 degradation

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Role of long noncoding RNAs in pathological cardiac remodeling after myocardial infarction: An emerging insight into molecular mechanisms and therapeutic potential

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Protective transcriptional mechanisms in cardiomyocytes and cardiac fibroblasts

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Effects of emodin, a plant‐derived anthraquinone, on TGF‐β1‐induced cardiac fibroblast activation and function

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Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice

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Doxorubicin-induced modulation of TGF-β signaling cascade in mouse fibroblasts: insights into cardiotoxicity mechanisms

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Emerging therapeutic targets for cardiac arrhythmias: role of STAT3 in regulating cardiac fibroblast function

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Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization

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Methyl Ferulic Acid Attenuates Human Cardiac Fibroblasts Differentiation and Myocardial Fibrosis by Suppressing pRB-E2F1/CCNE2 and RhoA/ROCK2 Pathway

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miR ‐486 improves fibrotic activity in myocardial infarction by targeting SRSF3 / p21‐Mediated cardiac myofibroblast senescence

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Single-cell RNA-seq reveals cellular heterogeneity from deep fascia in patients with acute compartment syndrome

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Protection against cancer therapy-induced cardiovascular injury by planed-derived polyphenols and nanomaterials

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PPAR-γ is involved in the protective effect of 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucoside against cardiac fibrosis in pressure-overloaded rats

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Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-β expression in cardiac myocytes

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Disease-Inspired Tissue Engineering: Investigation of Cardiovascular Pathologies

Simon, L. R., & Masters, K. S. B. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01067 · Cited by 21

Circular RNAs as potential theranostics in the cardiac fibrosis

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Role of carotenoids and retinoids during heart development

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Targeting peroxisome proliferator-activated receptors: A new strategy for the treatment of cardiac fibrosis

Lu, Q., Guo, P., Guo, J., Arés, I., López-Torres, B., Martínez‐Larrañaga, M., Wang, X., Anadón, A., & Martínez, M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107702 · Cited by 21

TUG1 knockdown suppresses cardiac fibrosis after myocardial infarction

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Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell‐derived cardiomyocytes

Huethorst, E., Mortensen, P., Simitev, R. D., Gao, H., Pohjolainen, L., Talman, V., Ruskoaho, H., Burton, F. L., Gadegaard, N., & Smith, G. L. (2021) · The Journal of Physiology · doi:10.1113/jp282228 · Cited by 21

Advances in Intercellular Communication Mediated by Exosomal ncRNAs in Cardiovascular Disease

Zhang, X., Sun, S., Ren, G., Liu, W., & Chen, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216197 · Cited by 20

Metabolic Adaptations and Therapies in Cardiac Hypoxia

Li, H., Xiao, F., Zhou, C., Zhu, T., & Wang, S. (2025) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.12.008 · Cited by 20

Promoting Cardiac Regeneration and Repair Using Acellular Biomaterials

Vasanthan, V., Hassanabad, A. F., Pattar, S. S., Niklewski, P., Wagner, K. T., & Fedak, P. W. M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00291 · Cited by 21

Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering

Garoffolo, G., Ferrari, S., Rizzi, S., Barbuto, M., Bernava, G., & Pesce, M. (2020) · Biomolecules · doi:10.3390/biom10101419 · Cited by 18

Cardiac fibrosis: emerging agents in preclinical and clinical development

Spoladore, R., Falasconi, G., Fiore, G., Maio, S. D., Preda, A., Slavich, M., Margonato, A., & Fragasso, G. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2021.1868432 · Cited by 19

Epigenetic Repression of Chloride Channel Accessory 2 Transcription in Cardiac Fibroblast: Implication in Cardiac Fibrosis

Shao, T., Xue, Y., & Fang, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.771466 · Cited by 19

Tanshinone IIA fromSalvia miltiorrhizaexerts anti‐fibrotic effects on cardiac fibroblasts and rat heart tissues by suppressing the levels of pro‐fibrotic factors: The key role of miR‐618

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Activation of PPARα Ameliorates Cardiac Fibrosis in Dsg2-Deficient Arrhythmogenic Cardiomyopathy

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Proteomic Insights into Cardiac Fibrosis: From Pathophysiological Mechanisms to Therapeutic Opportunities

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microRNAs as Biomarkers of Endothelial Dysfunction and Therapeutic Target in the Pathogenesis of Atrial Fibrillation

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Epigallocatechin-3-Gallate Attenuates Myocardial Dysfunction via Inhibition of Endothelial-to-Mesenchymal Transition

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Insulin‐Like Growth Factor 1 Receptor Deficiency Alleviates Angiotensin II–Induced Cardiac Fibrosis Through the Protein Kinase B/Extracellular Signal‐Regulated Kinase/Nuclear Factor‐κB Pathway

Zhu, J., Li, Q., Sun, Y., Zhang, S., Pan, R., Xie, Y., Chen, J., Shi, L., Chen, Y., Sun, Z., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.029631 · Cited by 19

Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts

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Association of Coronary Microvascular Rarefaction and Myocardial Fibrosis With Coronary Artery Disease

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The Functional Pluralism of Fibroblasts in the Infarcted Myocardium

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Human Atrial Fibroblast Adaptation to Heterogeneities in Substrate Stiffness

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Paired box 6 inhibits cardiac fibroblast differentiation

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Recapturing embryonic potential in the adult epicardium: Prospects for cardiac repair

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Fibroblast and Myofibroblast Subtypes: Single Cell Sequencing

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In vivo reprogramming as a new approach to cardiac regenerative therapy

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Histone methyltransferase DOT1L mediates the TGF-β1/Smad3 signaling pathway through epigenetic modification of SYK in myocardial infarction

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HTRA1-driven detachment of type I collagen from endoplasmic reticulum contributes to myocardial fibrosis in dilated cardiomyopathy

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Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation

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Activation of Imprinted Gene PW1 Promotes Cardiac Fibrosis After Ischemic Injury

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Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction

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SNRK: a metabolic regulator with multifaceted role in development and disease

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An Investigation of Fibulin-2 in Hypertrophic Cardiomyopathy

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Micro- and nanoscale biophysical cues for cardiovascular disease therapy

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Cardiorenal Syndrome: Emerging Role of Medical Imaging for Clinical Diagnosis and Management

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Hypertrophic Cardiomyopathy and Atrial Fibrillation: A Review

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Cardiac Remodeling in Hypertension: Clinical Impact on Brain, Heart, and Kidney Function

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Role of m6A Methylation in the Occurrence and Development of Heart Failure

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Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis

Moita, M. R., Silva, M. M., Diniz, C., Serra, M., Hoet, R., Barbas, A., & Simão, D. F. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1015473 · Cited by 20

Ghrelin attenuates myocardial fibrosis after acute myocardial infarction via inhibiting endothelial-to mesenchymal transition in rat model

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Nanoyttria Attenuates isoproterenol-induced Cardiac Injury

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Atorvastatin attenuates TGF‑β1‑induced fibrogenesis by inhibiting Smad3 and MAPK signaling in human ventricular fibroblasts

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Cardiac fibroblasts in myocardial injury and heart failure

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Cardiac fibrosis: Pathobiology and therapeutic targets

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Pathophysiology of cardiac fibroblasts and impacts on the severity of the cardiac disease

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Characteristics and Regulation of Cardiac Fibroblasts

Ying-bing, X. (2011) · Advances in Cardiovascular Diseases

The Janus face of myofibroblasts in the remodeling heart

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