Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis
Open accessAbstract
New evidence demonstrates that aging and dyslipidemia are closely associated with oxidative stress, DNA damage and apoptosis in some cells and extravascular tissues. However, in monocytes, which are naturally involved in progression and/or resolution of plaque in atherosclerosis, this concurrence has not yet been fully investigated. In this study, we evaluated the influence of aging and hypercholesterolemia on serum pro-inflammatory cytokines, oxidative stress, DNA damage and apoptosis in monocytes from apolipoprotein E-deficient (apoE −/− ) mice compared with age-matched wild-type C57BL/6 (WT) mice. Experiments were performed in young (2-months) and in old (18-months) male wild-type (WT) and apoE −/− mice. Besides the expected differences in serum lipid profile and plaque formation, we observed that atherosclerotic mice exhibited a significant increase in monocytosis and in serum levels of pro-inflammatory cytokines compared to WT mice. Moreover, it was observed that the overproduction of ROS, led to an increased DNA fragmentation and, consequently, apoptosis in monocytes from normocholesterolemic old mice, which was aggravated in age-matched atherosclerotic mice. In this study, we demonstrate that a pro-inflammatory systemic status is associated with an impairment of functionality of monocytes during aging and that these parameters are fundamental extra-arterial contributors to the aggravation of atherosclerosis. The present data open new avenues for the development of future strategies with the purpose of treating atherosclerosis.
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Progressive and irreversible oxidative damage accumulates with age and diminishes critical aspects of cell physiology.
“Progressive and irreversible oxidative damage accumulates with age and diminishes critical aspects of cell physiology [57,201,202].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [202]
Aging is associated with impaired activity of the proteasome and mitochondrial Lon proteases and reduced capacity for macromolecule repair.
“aging is associated with impaired activity of the proteasome and mitochondrial Lon proteases [203,204,205] and reduced capacity for macromolecule repair [201,202].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [202]
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Research works printed but not linked: 3
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- Authors
- Jacinto, T. A., Meireles, G. S., Dias, A. T., Aires, R., Porto, M. L., Gava, A. L., Vasquez, E. C., Pereira, T. M. C., Campagnaro, B. P., & Meyrelles, S. S.
- Affiliations
- Universidade Federal do Espírito Santo (BR)
- Universidade Vila Velha (BR)
- Instituto Federal do Espírito Santo (BR)
- Corresponding author
- Campagnaro, Bianca P.
- Venue
- Biological Research
- Published
- 2018-09-05
- Volume
- 51
- Issue
- 1
- Pages
- 33-33
- ISSN
- 0716-9760 (ISSN-L)
- 0717-6287
- PMC
- PMC6123971
- OpenAlex
- W2891747209
- Cited by
- 86
- References
- 90
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 15 · 2023: 8 · 2022: 10 · 2021: 19 · 2020: 13 · 2019: 9
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biological Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (307584/2015-1, 303001/2015-1, 445080/2014-0, 445736/2014-3)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- aging, atherosclerosis, monocytes, reactive oxygen species, oxidative stress, DNA damage, apoptosis, hypercholesterolemia, inflammatory cytokines, monocytosis, ApoE-deficient mice, dyslipidemia, biomarkers
- MeSH terms
- Aging, Animals, Disease Models, Animal, DNA Damage, Hyperlipidemias, Male, Mice, Inbred C57BL, Monocytes, Biomarkers, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Atherosclerosis, Mice, Plaque, Atherosclerotic
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