The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Endothelial Cell Metabolism in Normal and Diseased Vasculature
Open accessAbstract
Higher organisms rely on a closed cardiovascular circulatory system with blood vessels supplying vital nutrients and oxygen to distant tissues. Not surprisingly, vascular pathologies rank among the most life-threatening diseases. At the crux of most of these vascular pathologies are (dysfunctional) endothelial cells (ECs), the cells lining the blood vessel lumen. ECs display the remarkable capability to switch rapidly from a quiescent state to a highly migratory and proliferative state during vessel sprouting. This angiogenic switch has long been considered to be dictated by angiogenic growth factors (eg, vascular endothelial growth factor) and other signals (eg, Notch) alone, but recent findings show that it is also driven by a metabolic switch in ECs. Furthermore, these changes in metabolism may even override signals inducing vessel sprouting. Here, we review how EC metabolism differs between the normal and dysfunctional/diseased vasculature and how it relates to or affects the metabolism of other cell types contributing to the pathology. We focus on the biology of ECs in tumor blood vessel and diabetic ECs in atherosclerosis as examples of the role of endothelial metabolism in key pathological processes. Finally, current as well as unexplored EC metabolism-centric therapeutic avenues are discussed.
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Cites
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Cited by
Human blood vessel organoids as a model of diabetic vasculopathy
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Zhou, H., Wang, S., Zhu, P., Hu, S., Chen, Y., & Ren, J. (2018) · Redox Biology · doi:10.1016/j.redox.2017.12.019 · Cited by 550
“Therefore, the hunt for means to protect the cardiac microvasculature against hyperglycemic damage is essential to retard or alleviate diabetic macrovascular complications [4].”
BackgroundIntegrated Single-Cell Atlas of Endothelial Cells of the Human Lung
Schupp, J. C., Adams, T. S., Cosme, C., Raredon, M. S. B., Yuan, Y., Omote, N., Poli, S., Chioccioli, M., Rose, K.-A., Manning, E. P., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.052318 · Cited by 453
Endothelial Dysfunction in Hypertension: Current Concepts and Clinical Implications
Gallo, G., Volpe, M., & Savoia, C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.798958 · Cited by 446
Angiogenesis in the atherosclerotic plaque
Camaré, C., Pucelle, M., Nègre-Salvayre, A., & Salvayre, R. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.007 · Cited by 401
Metadata
- Authors
- Eelen, G., de Zeeuw, P., Simons, M., & Carmeliet, P.
- Venue
- Circulation Research
- Published
- 2015-03-27
- Volume
- 116
- Issue
- 7
- Pages
- 1231-1244
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W1966971152
- Cited by
- 627
- References
- 29
- FWCI
- 19.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Eelen, G., de Zeeuw, P., Simons, M., & Carmeliet, P. (2015). Endothelial Cell Metabolism in Normal and Diseased Vasculature. Circulation Research. https://doi.org/10.1161/circresaha.116.302855
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