The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Molecular Basis of Cardioprotection: Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning
Open accessAbstract
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that by timely reperfusion is needed to reduce infarct size and improve the prognosis of patients with acute myocardial infarction. The conditioning phenomena provide such cardioprotection, insofar as brief episodes of coronary occlusion/reperfusion preceding (ischemic preconditioning) or following (ischemic postconditioning) sustained myocardial ischemia with reperfusion reduce infarct size. Even ischemia/reperfusion in organs remote from the heart provides cardioprotection (remote ischemic conditioning). The present review characterizes the signal transduction underlying the conditioning phenomena, including their physical and chemical triggers, intracellular signal transduction, and effector mechanisms, notably in the mitochondria. Cardioprotective signal transduction appears as a highly concerted spatiotemporal program. Although the translation of ischemic postconditioning and remote ischemic conditioning protocols to patients with acute myocardial infarction has been fairly successful, the pharmacological recruitment of cardioprotective signaling has been largely disappointing to date.
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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
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Preconditioning the myocardium: from cellular physiology to clinical cardiology
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Function of Mitochondrial Stat3 in Cellular Respiration
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Protein Kinase G Transmits the Cardioprotective Signal From Cytosol to Mitochondria
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Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury
Davidson, S. M., Ferdinandy, P., Andreadou, I., Bøtker, H. E., Heusch, G., Ibáñez, B., Ovize, M., Schulz, R., Yellon, D. M., Hausenloy, D. J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.086 · Cited by 699
Self-citationGuidelines for experimental models of myocardial ischemia and infarction
Lindsey, M. L., Bolli, R., Canty, J. M., Du, X.-J., Frangogiannis, N. G., Frantz, S., Gourdie, R. G., Holmes, J. W., Jones, S. P., Kloner, R. A., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00335.2017 · Cited by 526
Self-citationBerberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465
Metadata
- Authors
- Heusch, G.
- Venue
- Circulation Research
- Published
- 2015-02-13
- Volume
- 116
- Issue
- 4
- Pages
- 674-699
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2129462206
- Cited by
- 811
- References
- 17
- FWCI
- 77.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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