Global Burden of Stroke

Katan, Mira; Luft, Andreas

doi:10.1055/s-0038-1649503

Cited by 2,137Acute Ischemic Stroke ManagementCardiovascular Health and Risk FactorsGlobal Health and Epidemiology

Global Burden of Stroke

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Katan, Mira, Luft, Andreas·2018·Seminars in Neurology

DOI 10.1055/s-0038-1649503

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Abstract

Stroke is the second leading cause of death and a major cause of disability worldwide. Its incidence is increasing because the population ages. In addition, more young people are affected by stroke in low- and middle-income countries. Ischemic stroke is more frequent but hemorrhagic stroke is responsible for more deaths and disability-adjusted life-years lost. Incidence and mortality of stroke differ between countries, geographical regions, and ethnic groups. In high-income countries mainly, improvements in prevention, acute treatment, and neurorehabilitation have led to a substantial decrease in the burden of stroke over the past 30 years. This article reviews the epidemiological and clinical data concerning stroke incidence and burden around the globe.

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Robotic-assisted gait rehabilitation following stroke: a systematic review of current guidelines and practical clinical recommendations
Calabrò, R. S., (CICERONE), O. B. O. I. C. C. O. R. I. N., Sorrentino, G., Cassio, A., Mazzoli, D., Andrenelli, E., Bizzarini, E., Campanini, I., Carmignano, S. M., Cerulli, S., et al. (2021) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.21.06887-8 · Cited by 131 · see citing works
Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases
Tsai, K., Chen, Y., Chiou, T. T., Chu, T., Li, L., Ng, H., Lee, W., & Lee, C. (2021) · Antioxidants · doi:10.3390/antiox10081166 · Cited by 135 · see citing works
Stroke Rehabilitation in Low- and Middle-Income Countries
Kayola, G., Mataa, M., Asukile, M. T., Chishimba, L., Chomba, M., Mortel, D., Nutakki, A., Zimba, S., & Saylor, D. R. (2023) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000002128 · Cited by 143 · see citing works
A DNA Nanostructure-Based Neuroprotectant against Neuronal Apoptosis via Inhibiting Toll-like Receptor 2 Signaling Pathway in Acute Ischemic Stroke
Zhou, M., Zhang, T., Zhang, B., Zhang, X., Gao, S., Zhang, T., Li, S., Cai, X., & Lin, Y. (2021) · ACS Nano · doi:10.1021/acsnano.1c09626 · Cited by 130 · see citing works
Machine learning methods for functional recovery prediction and prognosis in post-stroke rehabilitation: a systematic review
Campagnini, S., Arienti, C., Patrini, M., Liuzzi, P., Mannini, A., & Carrozza, M. C. (2022) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-022-01032-4 · Cited by 128 · see citing works
“Background Vascular problems in nature are the leading cause of death, and stroke is ranked second in worldwide mortality [1].”
Background
Change of mortality of patients with acute ischemic stroke before and after 2015
Park, S., Lee, J. Y., Heo, N. H., Han, J. J., Lee, E. C., Hong, D.-Y., Lee, D. H., Lee, B. C., Lim, Y. W., Kim, G. O., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.947992 · Cited by 128 · see citing works
“Stroke is the leading cause of death, which is the second most common cause of death and disability worldwide (1, 2).”
Background
The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury
Huang, J., Chen, L., Yao, Z., Sun, X., Tong, X., & Dong, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114671 · Cited by 128 · see citing works
Global Burden of Ischemic Stroke in Young Adults in 204 Countries and Territories
Zhang, R., Liu, H., Pu, L., Zhao, T., Zhang, S., Han, K., & Han, L. (2022) · Neurology · doi:10.1212/wnl.0000000000201467 · Cited by 127 · see citing works
Fugl-Meyer Assessment Scores Are Related With Kinematic Measures in People with Chronic Hemiparesis after Stroke
Rech, K. D., Salazar, A. P., Marchese, R. R., Schifino, G. P., Cimolin, V., & Pagnussat, A. S. (2019) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2019.104463 · Cited by 122 · see citing works
Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke
Xu, Q., Zhao, B., Ye, Y., Li, Y., Zhang, Y., Xiong, X., & Gu, L. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02137-8 · Cited by 118 · see citing works
DNA-sensing inflammasomes cause recurrent atherosclerotic stroke
Cao, J., Roth, S., Zhang, S., Kopczak, A., Mami, S., Asare, Y., Georgakis, M. K., Messerer, D., Horn, A., Shemer, R., et al. (2024) · Nature · doi:10.1038/s41586-024-07803-4 · Cited by 118 · see citing works
“Stroke is the second-leading cause of death worldwide 3 and a leading cause of long-term disability, with incidence rates rising due to demographic ageing 4 .”
“Caregiving is a full‐time job” impacting stroke caregivers' health and well‐being: A qualitative meta‐synthesis
Kokorelias, K. M., Lu, F. K. T., Santos, J. R., Xu, Y., Leung, R., & Cameron, J. I. (2019) · Health & Social Care in the Community · doi:10.1111/hsc.12895 · Cited by 122 · see citing works
Atrial Fibrillation and Ischemic Stroke: A Clinical Review
Migdady, I., Russman, A., & Buletko, A. B. (2021) · Seminars in Neurology · doi:10.1055/s-0041-1726332 · Cited by 121 · see citing works
Mediation of Systemic Inflammation on Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke
Jin, A., Wang, S., Li, J., Wang, M., Lin, J., Li, H., Meng, X., Wang, Y., & Pan, Y. (2023) · Stroke · doi:10.1161/strokeaha.122.039542 · Cited by 114 · see citing works
Perspective of SGLT2 Inhibition in Treatment of Conditions Connected to Neuronal Loss: Focus on Alzheimer’s Disease and Ischemia-Related Brain Injury
Wiciński, M., Wódkiewicz, E., Górski, K. M., Walczak, M., & Malinowski, B. (2020) · Pharmaceuticals · doi:10.3390/ph13110379 · Cited by 110 · see citing works
“Cerebral ischemic stroke is one of the leading causes of death and long-term disability in the world [40].”
Background
Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis
Wang, Y., Guan, X., Gao, C., Ruan, W., Zhao, S., Kai, G., Li, F., & Pang, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105640 · Cited by 110 · see citing works
Ultrasound Controlled Anti‐Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy
Li, Y., Teng, X., Yang, C., Wang, Y., Wang, L., Dai, Y., Sun, H., & Li, J. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202010391 · Cited by 108 · see citing works
Screening for aspiration risk associated with dysphagia in acute stroke
Boaden, E., Burnell, J., Hives, L., Dey, P., Clegg, A. J., Lyons, M., Lightbody, C. E., Hurley, M. A., Roddam, H., McInnes, E., et al. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012679.pub2 · Cited by 108 · see citing works
ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery
Schulz, J., Hartz, A. M. S., & Bauer, B. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000025 · Cited by 109 · see citing works
Automated Stroke Prediction Using Machine Learning: An Explainable and Exploratory Study With a Web Application for Early Intervention
Mridha, K., Ghimire, S., Shin, J., Aran, A., Uddin, M. M., & Mridha, M. F. (2023) · IEEE Access · doi:10.1109/access.2023.3278273 · Cited by 103 · see citing works
Systematic review of the evidence for stroke family caregiver and dyad interventions
Bakas, T., McCarthy, M. J., & Miller, E. L. (2022) · Stroke · doi:10.1161/strokeaha.121.034090 · Cited by 109 · see citing works
Momordica charantia Exosome-Like Nanoparticles Exert Neuroprotective Effects Against Ischemic Brain Injury via Inhibiting Matrix Metalloproteinase 9 and Activating the AKT/GSK3β Signaling Pathway
Cai, H., Huang, L., Hong, R., Song, J., Guo, X., Zhou, W., Hu, Z., Wang, W., Wang, Y., Shen, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.908830 · Cited by 103 · see citing works
A Low-Cost Lower-Limb Brain-Machine Interface Triggered by Pedaling Motor Imagery for Post-Stroke Patients Rehabilitation
Romero-Laiseca, M. A., Delisle-Rodríguez, D., Cardoso, V. F., Gurve, D., Loterio, F. A., Nascimento, J. H. P., Krishnan, S., Frizera, A., & Bastos-Filho, T. (2020) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2020.2974056 · Cited by 101 · see citing works
Anti-inflammatory and Neuroprotective Agents in Clinical Trials for CNS Disease and Injury: Where Do We Go From Here?
Mallah, K., Couch, C., Borucki, D. M., Toutonji, A., Alshareef, M., & Tomlinson, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02021 · Cited by 103 · see citing works
“Stroke is the second leading cause of death disability worldwide (32).”
Background
Design and testing of a soft parallel robot based on pneumatic artificial muscles for wrist rehabilitation
Wang, Y., & Xu, Q. (2021) · Scientific Reports · doi:10.1038/s41598-020-80411-0 · Cited by 98 · see citing works
SNHG12 Promotes Angiogenesis Following Ischemic Stroke via Regulating miR-150/VEGF Pathway
Zhao, M., Wang, J., Xi, X., Tan, N., & Zhang, L. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.08.029 · Cited by 97 · see citing works
Diabetes As an Independent Risk Factor for Stroke Recurrence in Ischemic Stroke Patients: An Updated Meta-Analysis
Zhang, L., Li, X., Wolfe, C. D. A., O’Connell, M. D. L., & Wang, Y. (2021) · Neuroepidemiology · doi:10.1159/000519327 · Cited by 97 · see citing works
Glial Cells as Therapeutic Approaches in Brain Ischemia-Reperfusion Injury
Hernández, I. H., Villa-González, M., Martín-López, G., Soto, M. S., & Pérez-Álvarez, M. J. (2021) · Cells · doi:10.3390/cells10071639 · Cited by 94 · see citing works
Empagliflozin alleviates neuronal apoptosis induced by cerebral ischemia/reperfusion injury through HIF-1α/VEGF signaling pathway
Abdel-latif, R. G., Rifaai, R. A., & Amin, E. F. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01237-y · Cited by 92 · see citing works
Neutrophil extracellular traps: A novel target for the treatment of stroke
Zhao, Z., Pan, Z., Zhang, S., Ma, G., Zhang, W., Song, J., Wang, Y., Kong, L., & Du, G. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108328 · Cited by 95 · see citing works
Intra- and inter-rater reliability of Fugl-Meyer Assessment of Lower Extremity early after stroke
Hernández-Álvarez, E. D., Forero, S. M., Galeano, C. P., Barbosa, N. E., Sunnerhagen, K. S., & Murphy, M. A. (2020) · Brazilian Journal of Physical Therapy · doi:10.1016/j.bjpt.2020.12.002 · Cited by 92 · see citing works
Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation
Lin, Y., Li, Q., Wang, L., Guo, Q., Liu, S., Zhu, S., Sun, Y., Fan, Y., Sun, Y. Y., Li, H., et al. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00199-9 · Cited by 93 · see citing works
“It has high morbidity and mortality and is a global health burden.(178) tFNAs have been applied in both diseases to explore whether they can positively influence neurological inflammation.”
Background
Intrathecal Administration of Nanoclusters for Protecting Neurons against Oxidative Stress in Cerebral Ischemia/Reperfusion Injury
Li, S., Jiang, D., Ehlerding, E. B., Rosenkrans, Z. T., Engle, J. W., Wang, Y., Liu, H., Ni, D., & Cai, W. (2019) · ACS Nano · doi:10.1021/acsnano.9b06780 · Cited by 89 · see citing works
Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
Li, C., Sui, C., Wang, W., Yan, J., Deng, N., Du, X., Cheng, F., Ma, X., Wang, X., & Wang, Q. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.599543 · Cited by 89 · see citing works
“Stroke is a predominant cause of permanent disability and death worldwide (Katan and Luft 2018).”
Background
The AIM2 inflammasome: A novel biomarker and target in cardiovascular disease
Du, L., Wang, X., Chen, S., & Guo, X. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106533 · Cited by 86 · see citing works
Low‐Field MRI of Stroke: Challenges and Opportunities
Bhat, S. S., Fernandes, T., Poojar, P., Ferreira, M. D. S., Padma, C. R., Hanumantharaju, M. C., Ogbole, G. I., Nunes, R. G., & Geethanath, S. (2020) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27324 · Cited by 85 · see citing works
“Pathophysiology of Stroke Stroke is a cerebrovascular disease and a leading cause of death worldwide after ischemic heart disease.(2) Stroke is broadly classified into two types: ischemic or hemorrhagic.”
Background
Sex, Age, and Socioeconomic Differences in Nonfatal Stroke Incidence and Subsequent Major Adverse Outcomes
Akyea, R. K., Vinogradova, Y., Qureshi, N., Patel, R. S., Kontopantelis, E., Ntaios, G., Asselbergs, F. W., Kai, J., & Weng, S. F. (2021) · Stroke · doi:10.1161/strokeaha.120.031659 · Cited by 85 · see citing works
Examining the effect of virtual reality therapy on cognition post-stroke: a systematic review and meta-analysis
Wiley, E., Khattab, S., & Tang, A. (2020) · Disability and Rehabilitation Assistive Technology · doi:10.1080/17483107.2020.1755376 · Cited by 84 · see citing works
“Introduction With over 80 million individuals globally living with stroke, stroke is the second leading cause of disability and death worldwide [1,2].”
Background
Effects of Genetically Determined Iron Status on Risk of Venous Thromboembolism and Carotid Atherosclerotic Disease: A Mendelian Randomization Study
Gill, D., Brewer, C. F., Monori, G., Trégouët, D., Franceschini, N., Giambartolomei, C., Tzoulaki, I., & Dehghan, A. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012994 · Cited by 81 · see citing works
Metformin: A Potential Candidate for Targeting Aging Mechanisms
Hu, D., Xie, F., Xiao, Y., Chen, L., Zhong, J., Huang, D., Chen, J., Wei, J., Jiang, Y., & Zhong, T. (2021) · Aging and Disease · doi:10.14336/ad.2020.0702 · Cited by 79 · see citing works
Towards Transforming Neurorehabilitation: The Impact of Artificial Intelligence on Diagnosis and Treatment of Neurological Disorders
Calderone, A., Latella, D., Bonanno, M., Quartarone, A., Mojdehdehbaher, S., Celesti, A., & Calabrò, R. S. (2024) · Biomedicines · doi:10.3390/biomedicines12102415 · Cited by 78 · see citing works
Prediction of Long-Term Stroke Recurrence Using Machine Learning Models
Abedi, V., Avula, V., Chaudhary, D. P., Shahjouei, S., Khan, A., Griessenauer, C. J., Li, J., & Zand, R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061286 · Cited by 77 · see citing works
Oral and Laryngeal Diadochokinesis Across the Life Span: A Scoping Review of Methods, Reference Data, and Clinical Applications
Kent, R. D., Kim, Y., & Chen, L.-M. (2021) · Journal of Speech Language and Hearing Research · doi:10.1044/2021_jslhr-21-00396 · Cited by 77 · see citing works
Deep learning-based behavioral profiling of rodent stroke recovery
Weber, R., Mulders, G., Kaiser, J., Tackenberg, C., & Rust, R. (2022) · BMC Biology · doi:10.1186/s12915-022-01434-9 · Cited by 77 · see citing works
“42 The following scoring was applied; (0) no observable deficit; (1) forelimb flexion; (2) forelimb flexion and decreased resistance to lateral push; (3) circling; (4) circling and spinning around the cranial-caudal axis; (5) no spontaneous movement/ death.”
Method
Ischemic Stroke Genetics: What Is New and How to Apply It in Clinical Practice?
Ekkert, A., Šliachtenko, A., Grigaitė, J., Burnytė, B., Utkus, A., & Jatužis, D. (2021) · Genes · doi:10.3390/genes13010048 · Cited by 76 · see citing works
“Stroke is a frequent medical emergency, the burden of which is rising annually [1].”
Background
Molecular Pathways of Vulnerable Carotid Plaques at Risk of Ischemic Stroke: A Narrative Review
Miceli, G., Basso, M. G., Pintus, C., Pennacchio, A. R., Cocciola, E., Cuffaro, M., Profita, M., Rizzo, G., & Tuttolomondo, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084351 · Cited by 79 · see citing works
“Stroke represents one of the leading causes of death and disability worldwide, with carotid artery atherosclerosis being a primary risk factor for its development [1].”
Background
RETRACTED ARTICLE: Predictive modelling and identification of key risk factors for stroke using machine learning
Hassan, A., Ahmad, S. G., Munir, E. U., Khan, I., & Ramzan, N. (2024) · Scientific Reports · doi:10.1038/s41598-024-61665-4 · Cited by 86 · see citing works
Retracted
Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels
Bogorad, M. I., DeStefano, J. G., Linville, R. M., Wong, A. D., & Searson, P. C. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19855875 · Cited by 72 · see citing works
Machine learning to predict mortality after rehabilitation among patients with severe stroke
Scrutinio, D., Ricciardi, C., Donisi, L., Losavio, E., Battista, P., Guida, P., Cesarelli, M., Pagano, G., & D’Addio, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-77243-3 · Cited by 75 · see citing works
Effectiveness and safety of virtual reality rehabilitation after stroke: an overview of systematic reviews
Bargeri, S., Scalea, S., Agosta, F., Banfi, G., Corbetta, D., Filippi, M., Sarasso, E., Turolla, A., Castellini, G., & Gianola, S. (2023) · EClinicalMedicine · doi:10.1016/j.eclinm.2023.102220 · Cited by 82 · see citing works
Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders
Olloquequi, J., Cano, A. C., Sánchez‐López, E., Carrasco, M., Verdaguer, E., Fortuna, A. C., Folch, J., Bulló, M., Auladell, C., Camins, A., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113709 · Cited by 72 · see citing works
“Currently, strokes are the second leading cause of death worldwide [165].”
Background
Review of imaging biomarkers for the vulnerable carotid plaque
Saba, L., Agarwal, N., Cau, R., Gerosa, C., Sanfilippo, R., Porcu, M., Montisci, R., Cerrone, G., Yang, Q., Balestrieri, A., et al. (2021) · JVS Vascular Science · doi:10.1016/j.jvssci.2021.03.001 · Cited by 70 · see citing works
“The current incidence of stroke in Europe and the USA is approximately 200 per 100,000 population per year of which 80% of strokes are ischemic.(1,2) Severe carotid artery stenosis is a wellestablished risk factor and accounts for approximately 20% of all ischemic strokes.”
Background
The Role of NF-κB Triggered Inflammation in Cerebral Ischemia
Jover‐Mengual, T., Hwang, J.-Y., Byun, H.-R., Court-Vazquez, B. L., Centeno, J. M., Burguete, M. C., & Zukin, R. S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.633610 · Cited by 69 · see citing works
Cardamonin attenuates cerebral ischemia/reperfusion injury by activating the HIF ‐1α/ VEGFA pathway
Ni, H., Li, J., Zheng, J., & Zhou, B. (2022) · Phytotherapy Research · doi:10.1002/ptr.7409 · Cited by 68 · see citing works
Liquid Biopsy in Neurological Diseases
Malhotra, S., Miras, M. C. M., Pappolla, A., Montalbán, X., & Comabella, M. (2023) · Cells · doi:10.3390/cells12141911 · Cited by 69 · see citing works
“Stroke is the second leading cause of death and a significant cause of disability worldwide [79].”
Background
Immersive VR for upper-extremity rehabilitation in patients with neurological disorders: a scoping review
Ceradini, M., Losanno, E., Micera, S., Bandini, A., & Orlandi, S. (2024) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-024-01367-0 · Cited by 76 · see citing works
“Given the global prevalence of stroke [28], stroke survivors have naturally emerged as primary candidates for immersive VR-based rehabilitation programs (Fig.”
Background
Role of vitamin B12 deficiency in ischemic stroke risk and outcome
Yahn, G. B., Abato, J. E., & Jadavji, N. M. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.291381 · Cited by 68 · see citing works
Effects of peer support interventions on physical and psychosocial outcomes among stroke survivors: A systematic review and meta-analysis.
Wan, X.-J., Chau, J., Mou, H.-Y., & Liu, X. (2021) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2021.104001 · Cited by 65 · see citing works
Targeting PI3K/Akt in Cerebral Ischemia Reperfusion Injury Alleviation: From Signaling Networks to Targeted Therapy
Zheng, T., Jiang, T., Ma, H., Zhu, Y., & Wang, M. Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04039-1 · Cited by 68 · see citing works
“Ischemic stroke is a prevalent acute cerebrovascular ailment, capable of causing profound neurological dysfunction and, in severe cases, fatalities [1].”
Current status of ischemic stroke treatment: From thrombolysis to potential regenerative medicine
Hurd, M. D., Goel, I., Sakai, Y., & Teramura, Y. (2021) · Regenerative Therapy · doi:10.1016/j.reth.2021.09.009 · Cited by 66 · see citing works
“Stroke is the secondmost common cause of death and amajor cause of disability globally [5].”
Background
Professionals' Views and Experiences of Using Rehabilitation Robotics With Stroke Survivors: A Mixed Methods Survey
Li, L., Tyson, S. F., & Weightman, A. (2021) · Frontiers in Medical Technology · doi:10.3389/fmedt.2021.780090 · Cited by 66 · see citing works
“We categorized groups based on following characteristics: (1) participants’ occupation (OT, occupational therapists; PT, physiotherapists); (2) career stage (<1 year, 1–5 years, 6–10 years, and >10 years); and (3) rehabilitation robot type (end-effector and exoskeleton).”
BackgroundMethod
Quality of life of stroke survivors in Africa: a systematic review and meta-analysis
Bello, U. M., Chutiyami, M., Salihu, D., Abdu, S. I., Tafida, B. A., Jabbo, A. A., Gamawa, A., Umar, L., Lawan, A., Miller, T., et al. (2021) · Quality of Life Research · doi:10.1007/s11136-020-02591-6 · Cited by 64 · see citing works
“Globally, stroke survivors report low QoL for reasons related to the cost of optimal medical services, lifestyle factors, low medical literacy, environmental and socioeconomic factors and inadequate adherence to interventions [41, 42].”
Background
Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
Zhang, W., Dong, X. Y., & Huang, R. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01096-3 · Cited by 66 · see citing works
“Among new cases, 26% recovered with the ability to conduct basic daily activities only, and 50% suffered declined mobility due to hemiparesis [2].”
Background
Virtual and Augmented Reality in Post-stroke Rehabilitation: A Narrative Review
Khokale, R. V., Mathew, G. S., Ahmed, S., Maheen, S., Fawad, M., Bandaru, P., Zerin, A., Nazir, Z., Khawaja, I., Sharif, I., et al. (2023) · Cureus · doi:10.7759/cureus.37559 · Cited by 63 · see citing works
“Hemorrhagic strokes are less common than ischemic strokes, but they cause more severe outcomes, leading to death and disability-adjusted life-years (DALYs) lost [4,11].”
Background
Efficacy of Robot-Assisted Training on Rehabilitation of Upper Limb Function in Patients With Stroke: A Systematic Review and Meta-analysis
Yang, X., Shi, X., Xue, X., & Deng, Z. (2023) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2023.02.004 · Cited by 62 · see citing works
Characterization of the Blood Brain Barrier Disruption in the Photothrombotic Stroke Model
Weber, R., Grönnert, L., Mulders, G., Maurer, M., Tackenberg, C., Schwab, M. E., & Rust, R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.586226 · Cited by 61 · see citing works
Heart Rate Variability: A Measure of Cardiovascular Health and Possible Therapeutic Target in Dysautonomic Mental and Neurological Disorders
Siepmann, M., Weidner, K., Petrowski, K., & Siepmann, T. (2022) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-022-09572-0 · Cited by 61 · see citing works
“…cause of death and a major cause of lasting disability in adults worldwide and more than three quarters of stroke survivors display symptoms due to compromised regulation of the cardiovascular system and other organs by the autonomic nervous system (Katan & Luft, 2018; Xiong et al., 2012, 2014).”
Background
A Review of Risk Factors and Predictors for Hemorrhagic Transformation in Patients with Acute Ischemic Stroke
Thomas, S., Plumber, N., Venkatapathappa, P., & Gorantla, V. R. (2021) · International Journal of Vascular Medicine · doi:10.1155/2021/4244267 · Cited by 59 · see citing works
Effects of Virtual Reality Cognitive Training on Neuroplasticity: A Quasi-Randomized Clinical Trial in Patients with Stroke
Gangemi, A., Luca, R. D., Fabio, R. A., Lauria, P., Rifici, C., Pollicino, P., Marra, A., Olivo, A., Quartarone, A., & Calabrò, R. S. (2023) · Biomedicines · doi:10.3390/biomedicines11123225 · Cited by 58 · see citing works
“Survivors of stroke face immediate challenges in coping with long-term sensory-motor and cognitive impairments [1,2].”
Background
Integrating AI-driven wearable devices and biometric data into stroke risk assessment: A review of opportunities and challenges
Olawade, D. B., Aderinto, N., David-Olawade, A. C., Egbon, E., Adereni, T., Popoola, M. R., & Tiwari, R. (2024) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2024.108689 · Cited by 58 · see citing works
Systematic review of guidelines to identify recommendations for upper limb robotic rehabilitation after stroke
Morone, G., Neurorehabilitation, O. B. O. ". I. C. C. O. R. I., Palomba, A., Cinnera, A. M., Agostini, M., Aprile, I. G., Arienti, C., Paci, M., Casanova, E., MARINO, D., et al. (2021) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.21.06625-9 · Cited by 57 · see citing works
Relationship of sleep duration with the risk of stroke incidence and stroke mortality: an updated systematic review and dose–response meta-analysis of prospective cohort studies
Wang, H., Sun, J., Sun, M., Liu, N., & Wang, M. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.11.001 · Cited by 57 · see citing works
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Authors: Katan, M., & Luft, A.
Affiliations: Department of Neurology, Stroke Center, University Hospital of Zurich, Zurich, Switzerland
University Hospital Zurich (CH)
Corresponding author: Luft, Andreas
ORCID: Luft, Andreas
Venue: Seminars in Neurology
Publisher: Georg Thieme Verlag KG
Published: 2018-04
Volume: 38
Issue: 02
Pages: 208-211
ISSN: 0271-8235 (ISSN-L)
1098-9021
DOI: 10.1055/s-0038-1649503
OpenAlex: W2803306216
Cited by: 2,137
References: 57
Citations by year: 2026: 164 · 2025: 350 · 2024: 361 · 2023: 387 · 2022: 376 · 2021: 276 · 2020: 159 · 2019: 55 · 2018: 7 · 2017: 1 · 2013: 1
FWCI: 17.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Seminars in Neurology (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Topics: Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Health Professions › Health Information Management › Global Health and Epidemiology
Keywords: stroke, global burden of disease, stroke incidence, stroke mortality, ischemic stroke, hemorrhagic stroke, disability-adjusted life years, population aging, young adults, low- and middle-income countries, ethnic disparities, stroke prevention, neurorehabilitation
MeSH terms: Humans, Sex Factors, Global Health, Disease Management, Stroke

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