The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke
Open accessAbstract
The consequences of cerebrovascular disease are among the leading health issues worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the vascular component of other forms of neurological dysfunction and degeneration. Both forms of vascular disease are driven by diverse risk factors, with hypertension as the leading contributor. Despite the importance of neurovascular disease and subsequent injury after ischemic events, fundamental knowledge in these areas lag behind our current understanding of neuroprotection and vascular biology in general. The goal of this review is to address select key structural and functional changes in the vasculature that promote hypoperfusion and ischemia, while also affecting the extent of injury and effectiveness of therapy. In addition, as damage to the blood–brain barrier is one of the major consequences of ischemia, we discuss cellular and molecular mechanisms underlying ischemia-induced changes in blood–brain barrier integrity and function, including alterations in endothelial cells and the contribution of pericytes, immune cells, and matrix metalloproteinases. Identification of cell types, pathways, and molecules that control vascular changes before and after ischemia may result in novel approaches to slow the progression of cerebrovascular disease and lessen both the frequency and impact of ischemic events.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596
Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
Feigin, V. L., Forouzanfar, M. H., Krishnamurthi, R., Mensah, G. A., Connor, M., Bennett, D. A., Moran, A. E., Sacco, R. L., Anderson, L., Truelsen, T., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61953-4 · Cited by 3,899
Capillary pericytes regulate cerebral blood flow in health and disease
Hall, C. N., Reynell, C., Gesslein, B., Hamilton, N. B., Mishra, A., Sutherland, B. A., O’Farrell, F. M., Buchan, A. M., Lauritzen, M., & Attwell, D. (2014) · Nature · doi:10.1038/nature13165 · Cited by 1,870
The Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857
Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging
Wardlaw, J. M., Smith, C., & Dichgans, M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70060-7 · Cited by 1,657
Rapsomaniki, E., Timmis, A., George, J., Pujades-Rodriguez, M., Shah, A. D., Denaxas, S., White, I. R., Caulfield, M. J., Deanfield, J. E., Smeeth, L., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60685-1 · Cited by 1,643 · cited 1×
“continues to be a leading risk factor for vascular disease and ischemic and hemorrhagic stroke.(1,38,40,41) For reasons that are”
BackgroundBell, R. D., Winkler, E. A., Sagare, A. P., Singh, I., LaRue, B., Deane, R., & Zlokovic, B. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.043 · Cited by 1,448
Pericytes of the neurovascular unit: key functions and signaling pathways
Sweeney, M. D., Ayyadurai, S., & Zlokovic, B. V. (2016) · Nature Neuroscience · doi:10.1038/nn.4288 · Cited by 1,125
Recent insights into the cellular biology of atherosclerosis
Tabas, I., García-Cardeña, G., & Owens, G. K. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412052 · Cited by 1,016 · cited 3×
“of monocytes, and other inflammatory cells, along with phenotypic switching of vascular muscle.(15) Atherosclerosis is primarily a disease of large arteries,(97) but can extend into smaller vessels with the addition of hypertension,(98) and perhaps other”
Background
Research works printed but not linked: 292
- 10.1038/nrneurol.2015.61 · DOI
- 10.1017/CBO9781139382694 · DOI
- 10.1016/j.pneurobio.2015.09.008 · DOI · Paper page
- 10.1016/j.arr.2016.09.006 · DOI · Paper page
- 10.1002/ana.23648 · DOI · Paper page
- 10.1083/jcb.201412147 · DOI · Paper page
- 10.1111/joim.12296 · DOI · Paper page
- Greyling A, Hopman M.T, Thijssen D.H.J. Endothelial function in health and disease. , Berbari AMG, ed. In: Arterial Disorders: Definition, Clinical Manisfestations, Mechanisms and Therapeutic Approaches. Switzerland: Springer International; 2015:161–173. · DOI
- 10.1016/j.atherosclerosis.2014.09.001 · DOI · Paper page
- 10.1161/CIRCRESAHA.116.306531 · DOI · Paper page
- 10.1152/ajpheart.01310.2010 · DOI · Paper page
- Cipolla MJ. The Cerebral Circulation. 2nd Ed. San Rafael, CA: Morgan & Claypool Life Sciences; 2016:1–80.
- 10.1093/eurheartj/eht544 · DOI
- 10.1161/CIRCRESAHA.116.309686 · DOI
- 10.1007/s00018-013-1488-9 · DOI
- 10.1007/s10571-015-0308-1 · DOI
- 10.4414/smw.2010.13122 · DOI
- 10.1146/annurev-neuro-071013-014111 · DOI · Paper page
- 10.1161/JAHA.114.000787 · DOI
- 10.1038/nn2003 · DOI · Paper page
- 10.1083/jcb.201212032 · DOI
- 10.1016/j.neuron.2015.06.001 · DOI · Paper page
- 10.1038/nature17965 · DOI
- 10.1016/j.neuron.2016.07.016 · DOI
- 10.1161/01.RES.66.1.8 · DOI · Paper page
- 10.1161/STROKEAHA.108.535435 · DOI
- 10.1152/ajpheart.00490.2012 · DOI · Paper page
- 10.1161/01.STR.27.12.2287 · DOI
- 10.1016/S0140-6736(05)67702-1 · DOI · Paper page
- 10.1038/nrneurol.2016.107 · DOI · Paper page
- 10.1093/eurheartj/ehq472 · DOI
- 10.1016/S1474-4422(16)30073-4 · DOI · Paper page
- 10.1161/STROKEAHA.113.002878 · DOI
- De Silva TM, Pena Silva R.A, Faraci F.M. Endothelium, the blood-brain barrier, and hypertension. , Girouard H, ed. In: Arterial Hypertension and Brain as an End-Organ Target. Switzerland: Springer; 2016:155–180.
- 10.1371/journal.ppat.1002982 · DOI
- 10.1007/s00429-016-1267-0 · DOI
- 10.1161/STROKEAHA.114.005888 · DOI
- 10.1152/japplphysiol.00253.2014 · DOI
- 10.1161/HYPERTENSIONAHA.114.04541 · DOI
- 10.1161/HYPERTENSIONAHA.116.07430 · DOI
- 10.1161/01.STR.0000227236.84546.5a · DOI
- 10.1161/01.hyp.0000042427.05390.5c · DOI
- 10.1161/01.RES.0000146279.11923.14 · DOI
- 10.1161/CIRCRESAHA.108.176339 · DOI
- 10.1161/01.HYP.37.6.1388 · DOI
- 10.1161/01.HYP.30.5.1097 · DOI
- Kontos HA, Wei EP, Navari RM, Levasseur JE, Rosenblum WI, Patterson JL. Responses of cerebral arteries and arterioles to acute hypotension and hypertension. Am J Physiol. 1978;234:H371–H383.
- Wei EP, Kontos HA, Patterson JL. Dependence of pial arteriolar response to hypercapnia on vessel size. Am J Physiol. 1980;238:697–703.
- 10.1152/jn.1997.78.2.651 · DOI
- 10.1161/01.RES.69.3.697 · DOI
- Fogal B, Pober J.S. Vascular endothelial cells as immunological targets in atherosclerosis. , Wick G, Grundtman C., ed. In: Inflammation and Atherosclerosis. Wien: Springer; 2012:87–114. · DOI
- 10.1111/micc.12193 · DOI
- 10.3389/fimmu.2015.00098 · DOI
- 10.1038/srep28447 · DOI
- 10.1126/scisignal.aaf6240 · DOI
- 10.1038/nrd3358 · DOI
- 10.1186/s13024-015-0020-0 · DOI
- 10.1016/j.tem.2014.06.012 · DOI · Paper page
- De Silva TM, Faraci F.M. Reactive oxygen species and the regulation of cerebral vascular tone. , Rodriguez-Porcel M, Miller J.D., ed. In: Oxidative Stress in Vascular Disease. Springer; 2016.
- 10.1161/CIRCULATIONAHA105.562223 · DOI
- 10.1161/01.ATV.0000253885.41509.25 · DOI
- 10.1016/j.brainres.2008.03.020 · DOI
- 10.1001/jama.287.19.2570 · DOI · Paper page
- 10.1111/eci.12401 · DOI
- 10.1161/01.CIR.0000150540.54220.C4 · DOI · Paper page
- 10.1124/pr.114.010454 · DOI · Paper page
- 10.1007/s11886-012-0275-9 · DOI
- 10.1152/ajpheart.00679.2010 · DOI · Paper page
- 10.1161/01.ATV.0000205849.22807.6e · DOI
- 10.1161/HYPERTENSIONAHA.111.00299 · DOI · Paper page
- 10.1124/pr.115.011106 · DOI · Paper page
- 10.1161/HYPERTENSIONAHA.116.07418 · DOI
- 10.1097/HJH.0000000000000259 · DOI
- 10.1161/HYPERTENSIONAHA.113.01274 · DOI · Paper page
- 10.1161/HYPERTENSIONAHA.114.03935 · DOI
- 10.1161/STROKEAHA.107.490631 · DOI
- Faraci FM, Brian JE, Heistad DD. Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase. Am J Physiol. 1995;269:H1522–H1527.
- 10.1161/HYPERTENSIONAHA.110.152959 · DOI
- 10.1161/HYPERTENSIONAHA.108.116731 · DOI
- 10.1161/STROKEAHA.112.661702 · DOI
- 10.1161/CIRCRESAHA.115.306532 · DOI · Paper page
- 10.1161/HYPERTENSIONAHA.113.01761 · DOI
- 10.1177/1747493016647736 · DOI
- 10.1161/CIRCULATIONAHA.114.011147 · DOI
- 10.1161/STROKEAHA.115.011292 · DOI
- 10.1016/j.pcad.2007.04.001 · DOI
- 10.1161/01.STR.24.8.1218 · DOI
- 10.1161/01.CIR.99.15.2003 · DOI · Paper page
- 10.1016/S1474-4422(16)30029-1 · DOI · Paper page
- 10.1161/hs1101.098520 · DOI · Paper page
- 10.1161/01.ATV.0000095973.42032.44 · DOI · Paper page
- 10.3389/fnagi.2015.00115 · DOI
- 10.1161/01.CIR.0000023921.93743.89 · DOI · Paper page
- 10.1016/j.cell.2015.11.055 · DOI · Paper page
- 10.1161/CIRCULATIONAHA.116.023513 · DOI
- 10.1016/j.cell.2016.02.011 · DOI · Paper page
- 10.1161/ATVBAHA.112.249516 · DOI
- 10.1038/srep12059 · DOI
- 10.3171/jns.1989.70.5.0793 · DOI
- 10.1111/j.1440-1681.1994.tb02658.x · DOI
- 10.1042/cs0800119 · DOI
- 10.1161/01.STR.28.11.2266 · DOI
- 10.1161/01.STR.32.3.761 · DOI
- 10.1161/STROKEAHA.109.575365 · DOI
- 10.1038/jcbfm.2013.38 · DOI
- 10.1038/jcbfm.2010.34 · DOI
- 10.1161/STROKEAHA.107.481879 · DOI · Paper page
- 10.1038/bjp.2008.116 · DOI
- 10.1161/01.RES.63.3.604 · DOI
- 10.1007/BF01744604 · DOI
- Heistad DD, Marcus ML, Piegors DJ, Armstrong ML. Regulation of cerebral blood flow in atherosclerotic monkeys. Am J Physiol. 1980;239:H539–H544.
- 10.1161/01.RES.0000111524.05779.60 · DOI
- 10.1161/ATVBAHA.112.300749 · DOI
- 10.1152/ajpheart.01237.2010 · DOI
- 10.1161/HYPERTENSIONAHA.107.103648 · DOI
- 10.1152/physiolgenomics.00087.2015 · DOI
- 10.12659/MSM.881849 · DOI
- 10.1152/ajpregu.00607.2012 · DOI
- 10.1161/01.STR.27.5.927 · DOI
- 10.1007/s11011-015-9722-9 · DOI
- 10.1016/S0047-6374(01)00234-2 · DOI
- 10.1007/s00401-004-0845-z · DOI
- 10.1177/1747493015607485 · DOI
- 10.1007/s00401-016-1560-2 · DOI
- Pleşea IE, Cameniţă A, Georgescu CC, Enache SD, Zaharia B, Georgescu CV, Tenovici M. Study of cerebral vascular structures in hypertensive intracerebral haemorrhage. Rom J Morphol Embryol. 2005;46:249–256.
- Hajdu MA, Baumbach GL. Mechanics of large and small cerebral arteries in chronic hypertension. Am J Physiol. 1994;266:H1027–H1033.
- 10.1161/01.hyp.21.6.816 · DOI
- 10.1161/01.hyp.12.2.89 · DOI
- 10.1161/01.hyp.13.6.968 · DOI · Paper page
- 10.3389/fphys.2013.00133 · DOI
- 10.1155/2013/793630 · DOI
- 10.1161/01.res.0000041408.64867.1d · DOI
- 10.1016/j.cmet.2007.12.008 · DOI
- 10.1111/j.1748-1716.2010.02230.x · DOI
- 10.1161/01.RES.66.6.1747 · DOI
- 10.1001/jamaneurol.2016.1388 · DOI
- Mulvany MJ, Baumbach GL, Aalkjaer C, Heagerty AM, Korsgaard N, Schiffrin EL, Heistad DD. Vascular remodeling. Hypertension. 1996;28:505–506.
- 10.1111/j.1742-7843.2011.00758.x · DOI
- 10.1161/01.hyp.9.6_pt_2.iii101 · DOI
- 10.1161/HYPERTENSIONAHA.114.04794 · DOI
- 10.1161/HYPERTENSIONAHA.115.06565 · DOI
- 10.1096/fj.13-230797 · DOI
- 10.1152/ajpheart.00168.2015 · DOI
- 10.1097/HJH.0b013e32832401ea · DOI
- 10.1007/s40292-015-0086-3 · DOI
- 10.1007/s00234-014-1423-2 · DOI
- 10.1210/endo.142.7.8272 · DOI
- 10.1146/annurev-pharmtox-070115-095427 · DOI
- 10.1161/CIRCULATIONAHA.111.041806 · DOI
- 10.1161/01.HYP.27.3.794 · DOI
- 10.1038/ajh.2011.20 · DOI
- 10.1161/CIRCRESAHA.115.307722 · DOI
- 10.1007/s10439-006-9186-5 · DOI
- 10.1161/HYPERTENSIONAHA.116.08015 · DOI
- 10.1016/0026-2862(85)90032-9 · DOI
- 10.1161/ATVBAHA.111.227314 · DOI
- 10.1093/brain/awt246 · DOI
- 10.1007/s10456-015-9465-6 · DOI
- 10.1161/STROKEAHA.116.013392 · DOI
- Clavier N, Kirsch JR, Hurn PD, Traystman RJ. Effect of postischemic hypoperfusion on vasodilatory mechanisms in cats. Am J Physiol. 1994;267:H2012–H2018.
- Mayhan WG, Amundsen SM, Faraci FM, Heistad DD. Responses of cerebral arteries after ischemia and reperfusion in cats. Am J Physiol. 1988;255:H879–H884.
- Nelson CW, Wei EP, Povlishock JT, Kontos HA, Moskowitz MA. Oxygen radicals in cerebral ischemia. Am J Physiol. 1992;263:H1356–H1362.
- 10.1007/s12975-016-0468-4 · DOI
- 10.1161/01.STR.31.4.940 · DOI
- 10.1371/journal.pone.0028393 · DOI
- 10.1523/JNEUROSCI.1645-07.2007 · DOI
- 10.1161/01.str.0000033132.85123.6a · DOI
- 10.1080/10739680801986742 · DOI
- 10.1038/jcbfm.2012.137 · DOI
- 10.1038/sj.jcbfm.9600132 · DOI
- 10.1038/jcbfm.1988.89 · DOI
- 10.1038/jcbfm.1989.51 · DOI
- 10.1177/0271678X16638350 · DOI
- 10.1161/01.str.0000020712.84444.8d · DOI
- 10.1152/ajpheart.00800.2006 · DOI
- 10.1161/01.STR.29.7.1469 · DOI
- 10.1161/01.STR.32.7.1658 · DOI
- 10.1161/01.STR.0000252157.93998.47 · DOI
- 10.1161/01.STR.17.6.1309 · DOI
- 10.1038/jcbfm.1990.61 · DOI
- 10.1046/j.1460-9568.2000.00880.x · DOI
- 10.1161/CIRCRESAHA.116.308022 · DOI · Paper page
- 10.1197/aemj.9.9.933 · DOI
- 10.1016/j.neuroscience.2008.02.012 · DOI · Paper page
- 10.1016/j.expneurol.2009.06.002 · DOI
- 10.1016/j.mvr.2007.06.004 · DOI
- 10.2174/1871527311312030004 · DOI
- 10.1093/cvr/cvq090 · DOI
- 10.1016/j.nbd.2009.07.030 · DOI · Paper page
- 10.1038/jcbfm.2008.2 · DOI
- 10.4161/tisb.24180 · DOI
- 10.1016/j.mvr.2008.09.012 · DOI · Paper page
- 10.1080/10739680600556944 · DOI
- 10.1007/s11010-012-1415-7 · DOI
- 10.1161/STROKEAHA.109.574939 · DOI
- 10.1196/annals.1420.016 · DOI · Paper page
- 10.1083/jcb.200210135 · DOI · Paper page
- 10.1038/sj.jcbfm.9600055 · DOI · Paper page
- 10.1242/jcs.018473 · DOI · Paper page
- 10.1016/j.molcel.2006.08.006 · DOI · Paper page
200 of 292 shown
Cited by
Brain-to-cervical lymph node signaling after stroke.
Esposito, E., Ahn, B. J., Shi, J., Nakamura, Y., Park, J. H., Mandeville, E. T., Yu, Z., Chan, S. J., Desai, R., Hayakawa, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13324-w · Cited by 123
CNS border-associated macrophages in the homeostatic and ischaemic brain
Gerganova, G., Riddell, A., & Miller, A. A. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108220 · Cited by 72
Disease Highlights the Cellular Diversity of Neurovascular Units: Sign in Stranger
Faraci, F. M. (2017) · Circulation Research · doi:10.1161/circresaha.117.311386 · Cited by 4
Self-citation
Metadata
- Authors
- Hu, X., De Silva, T. M., Chen, J., & Faraci, F. M.
- Venue
- Circulation Research
- Published
- 2017-02-03
- Volume
- 120
- Issue
- 3
- Pages
- 449-471
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2584646669
- Cited by
- 441
- References
- 29
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke. https://app.cochat.ai/papers/10.1161/circresaha.116.308427
- The paper
- Hu, X., De Silva, T. M., Chen, J., & Faraci, F. M. (2017). Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke. Circulation Research. https://doi.org/10.1161/circresaha.116.308427
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
