The DOI matches its Crossref record; 253 of the 253 references it cites were found in a registry or an index.
Autophagy in Cardiovascular Aging
Abstract
Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life- and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Autophagy, a catabolic process that removes and digests damaged proteins and organelles, protects the cell against aging and disease.”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [128]
In the citing paper
“Because autophagy can remove damaged cell components that are associated with aging, this process, and particularly macrophagy, plays an important role in retarding aging and aging-related disease [128,129,130,131,132,133,134].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [128]
Citations
Cites
Items 201–253 of 253
Effects of calorie restriction on cardioprotection and cardiovascular health
Ahmet, I., Tae, H., de Cabo, R., Lakatta, E. G., & Talan, M. I. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.04.015 · Cited by 90
Dietary spermidine for lowering high blood pressure
Eisenberg, T., Abdellatif, M., Zimmermann, A., Schroeder, S., Pendl, T., Harger, A., Stekovic, S., Schipke, J., Magnes, C., Schmidt, A. G., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1280225 · Cited by 87
Self-citationMortality, oxidative stress and tau accumulation during ageing in parkin null mice
Rodríguez‐Navarro, J. A., Casarejos, M. J., Menéndez, J., Solano, R. M., Rodal, I., Gómez, A., de Yébenes, J. G., & Mena, M. A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04762.x · Cited by 85
Kaplon, R. E., Hill, S. D., Bispham, N. Z., Santos‐Parker, J. R., Nowlan, M. J., Snyder, L. L., Chonchol, M., LaRocca, T. J., McQueen, M. B., & Seals, D. R. (2016) · Aging · doi:10.18632/aging.100962 · Cited by 84
Herraiz‐Martínez, A., Garcia, J. A., Llach, A., Molina, C. E., Fernandes, J., Ferrero‐Gregori, A., Rodrı́guez, C., Vallmitjana, A., Benítez, R., Padró, J. M., et al. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv046 · Cited by 80
Evidence for the hallmarks of human aging in replicatively aging yeast
Janssens, G. E., & Veenhoff, L. M. (2016) · Microbial Cell · doi:10.15698/mic2016.07.510 · Cited by 80
Hsieh, P. N., Zhou, G., Yuan, Y., Zhang, R., Prosdocimo, D. A., Sangwung, P., Borton, A. H., Boriushkin, E., Hamik, A., Fujioka, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00899-5 · Cited by 78
Hemodynamic forces in endothelial dysfunction and vascular aging
Collins, C., & Tzima, E. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.010 · Cited by 74
Sung, J. Y., Lee, K. Y., Kim, J., & Choi, H. C. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.08.001 · Cited by 72
Life-long caloric restriction elicits pronounced protection of the aged myocardium: A role for AMPK
Edwards, A. G., Donato, A. J., Lesniewski, L. A., Gioscia‐Ryan, R. A., Seals, D. R., & Moore, R. L. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.09.007 · Cited by 69
Nilsson, P. M., Khalili, P., & Franklin, S. S. (2013) · Blood Pressure · doi:10.3109/08037051.2013.796142 · Cited by 68
Coffee induces autophagy in vivo
Pietrocola, F., Malik, S. A., Mariño, G., Vacchelli, E., Senovilla, L., Chaba, K., Niso‐Santano, M., Maiuri, M. C., Madeo, F., & Kroemer, G. (2014) · Cell Cycle · doi:10.4161/cc.28929 · Cited by 68
Self-citationLi, Q., & Ren, J. T. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00343.x · Cited by 68
Li, Q., Ceylan‐Isik, A. F., Li, J., & Ren, J. T. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0717 · Cited by 67
van der Spoel, E., Rozing, M. P., Houwing‐Duistermaat, J. J., Slagboom, P. E., Beekman, M., de Craen, A. J. M., Westendorp, R. G. J., & van Heemst, D. (2015) · Aging · doi:10.18632/aging.100841 · Cited by 67
Takemoto, K. A., Bernstein, L., Lopez, J. F., MARSHAK, D. W., Rahimtoola, S. H., & Chandraratna, P. A. N. (1992) · American Heart Journal · doi:10.1016/0002-8703(92)90932-l · Cited by 64
Opposing effects on cardiac function by calorie restriction in different‐aged mice
Sheng, Y., Lv, S., Huang, M., Lv, Y., Yu, J., Liu, J., Tang, T., Qi, H., Di, W., & Ding, G. (2017) · Aging Cell · doi:10.1111/acel.12652 · Cited by 59
Lesniewski, L. A., Zigler, M. C., Durrant, J., Donato, A. J., & Seals, D. R. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.03.011 · Cited by 58
Taneike, M., Nishida, K., Omiya, S., Zarrinpashneh, E., Misaka, T., Kitazume-Taneike, R., Austin, R., Takaoka, M., Yamaguchi, O., Gambello, M. J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0152628 · Cited by 57
Michiels, C. F., Fransen, P. F., Munck, D. G. D., Meyer, G. R. Y. D., & Martinet, W. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00659.2014 · Cited by 56
Ben‐Avraham, D., Govindaraju, D. R., Budagov, T., Fradin, D., Durda, P., Liu, B., Ott, S., Gutman, D., Sharvit, L. E., Kaplan, R. C., et al. (2017) · Science Advances · doi:10.1126/sciadv.1602025 · Cited by 56
Yang, S., Long, L., Li, D., Zhang, J., Jin, S., Wang, F., & Chen, J. (2015) · Aging Cell · doi:10.1111/acel.12371 · Cited by 55
Calorie restriction protects against age‐related rat aorta sclerosis
Castello, L., Froio, T., Cavallini, G., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2864fje · Cited by 55
Radovits, T., Seres, L., Gerő, D., Lin, L., Beller, C. J., CHEN, S., Zotkina, J., Berger, I., Groves, J. T., & Szabó, C. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.09.005 · Cited by 53
Late Na+ current and protracted electrical recovery are critical determinants of the aging myopathy
Signore, S., Sorrentino, A., Borghetti, G., Cannata', A., Meo, M., Zhou, Y., Kannappan, R., Pasqualini, F., O'Malley, H. A., Sundman, M. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms9803 · Cited by 53
Metformin increases degradation of phospholamban via autophagy in cardiomyocytes
Teng, A. C. T., Miyake, T., Yokoe, S., Zhang, L., Rezende, L. M., Sharma, P., MacLennan, D. H., Liu, P. P., & Gramolini, A. O. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508815112 · Cited by 51
Schroeder, S., Pendl, T., Zimmermann, A., Eisenberg, T., Carmona‐Gutiérrez, D., Ruckenstuhl, C., Mariño, G., Pietrocola, F., Harger, A., Magnes, C., et al. (2014) · Autophagy · doi:10.4161/auto.28919 · Cited by 51
Self-citationThe integrated stress response in budding yeast lifespan extension
Postnikoff, S. D. L., Johnson, J. E., & Tyler, J. K. (2017) · Microbial Cell · doi:10.15698/mic2017.11.597 · Cited by 51
Cardiac aging — Getting to the stem of the problem
Hariharan, N., & Sussman, M. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.008 · Cited by 48
Calorie restriction can reverse, as well as prevent, aging cardiomyopathy
Yan, L., Gao, S., Ho, D. W. T., Park, M., Ge, H., Wang, C., Tian, Y., Lai, L., Lorenzo, M. S. D., Vatner, D. E., et al. (2013) · AGE · doi:10.1007/s11357-012-9508-5 · Cited by 47
Chen, K., Shi, W., Xin, Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077315 · Cited by 45
Wang, Q., Wu, S., Zhu, H., Ding, Y., Dai, X., Ouyang, C., Han, Y.-M., Xie, Z., & Zou, M.-H. (2017) · Autophagy · doi:10.1080/15548627.2016.1263776 · Cited by 45
Bottillo, I., Giordano, C., Cerbelli, B., D’Angelantonio, D., Lipari, M., Polidori, T., Majore, S., Bertini, E., D’Amico, A., Giannarelli, D., et al. (2016) · Cardiovascular Pathology · doi:10.1016/j.carpath.2016.07.005 · Cited by 44
How do yeast sense mitochondrial dysfunction?
Кнорре, Д. А., Соколов, С. С., Zyrina, A. N., & Severin, F. F. (2016) · Microbial Cell · doi:10.15698/mic2016.11.537 · Cited by 39
Gorza, L., Vettore, S., Tessaro, A., et al. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0346 · Cited by 35
Ahmet, I., Wan, R., Mattson, M. P., Lakatta, E. G., & Talan, M. I. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.05.007 · Cited by 35
Cellular aging--postreplicative cells. A review (Part II).
Gm, M. (1977) · PubMed · Cited by 34
Muscle-specificity of age-related changes in markers of autophagy and sphingolipid metabolism
Russ, D. W., Boyd, I. M., McCoy, K. M., & McCorkle, K. W. (2015) · Biogerontology · doi:10.1007/s10522-015-9598-4 · Cited by 34
Zheng, Q., Zhao, K., Han, X., Huff, A. F., Cui, Q., Babcock, S. A., Yu, S., & Zhang, Y. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.04.023 · Cited by 34
Castello, L., Maina, M., Testa, G., Cavallini, G., Biasi, F., Donati, A., Leonarduzzi, G., Bergamini, E., Poli, G., & Chiarpotto, E. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.06.006 · Cited by 34
signaling in cardiac myocyte excitation- transcription coupling
Wu, X., Zhang, T., Bossuyt, J. B., et al. (2006) · Cited by 34
Xu, X.-J., Zhao, W., Feng, S., Sun, C., Chen, Q., Ni, B., & Hu, H. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7533 · Cited by 34
Regulation of autophagy in cardiomyocytes by Ins(1,4,5)P3 and IP3-receptors
Wong, A., Grubb, D. R., Cooley, N., Luo, J., & Woodcock, E. A. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.10.014 · Cited by 28
Integrative metabolomics as emerging tool to study autophagy regulation
Stryeck, S., Birner‐Gruenberger, R., & Madl, T. (2017) · Microbial Cell · doi:10.15698/mic2017.08.584 · Cited by 28
Wang, J., Song, Y., Li, H., Shen, Q., Shen, J., An, X., Wu, J., Zhang, J., Wu, Y., Xiao, H., et al. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12622 · Cited by 22
Pursnani, S. K., Diener‐West, M., & Sharrett, A. R. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.12.046 · Cited by 21
Age-related accumulation of lipofuscin in myocardium of Japanese monkey (Macaca fuscata)
Nakano, M., Mizuno, T., Katoh, H., et al. (1989) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(89)90066-3 · Cited by 18
Yuldasheva, N. Y., Rashid, S. T., Haywood, N. J., Cordell, P. A., Mughal, R. S., Viswambharan, H., Imrie, H., Sukumar, P., Cubbon, R. M., Aziz, A., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304121 · Cited by 18
Balanced CoQ6 biosynthesis is required for lifespan and mitophagy in yeast
González‐Mariscal, I., Martín‐Montalvo, A., Ojeda-Gonzalez, C., Rodríguez‐Eguren, A., Gutierrez-Ríos, P., Navas, P., & Santos‐Ocaña, C. (2017) · Microbial Cell · doi:10.15698/mic2017.02.556 · Cited by 17
Regulation of cardiomyocyte autophagy by calcium
Shaikh, S., Troncoso, R., Criollo, A., Bravo, R., Garcı́a, L., Morselli, E., Cifuentes, M., Quest, A. F. G., Hill, J. A., & Lavandero, S. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00374.2015 · Cited by 16
Cardiovascular effects of long-term caffeine administration in aged rats
Agaty, S. M. E., & Seif, A. A. (2014) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-014-1098-z · Cited by 13
Young Little Mice Express a Premature Cardiovascular Aging Phenotype
Reddy, A. K., Hartley, C. J., Pham, T. T. T., Darlington, G., Entman, M. L., & Taffet, G. E. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt055 · Cited by 11
Activin Signaling Regulates Autophagy and Cardiac Aging through mTORC2Preprint
Chang, K., Kang, P., Liu, Y., Huang, K., Taylor, E., Sagona, A. P., Nezis, I. P., Bodmer, R., Ocorr, K. A., & Bai, H. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/139360 · Cited by 4
Flagged first, then by citations
Research works printed but not linked: 2
- Khavjou, O, Dunbar, SB, Whitsel, L, Nelson, S. Projected costs of informal caregiving for cardiovascular disease: 2015 – 2035 [abstract 16715]. Circulation. 2017;136(suppl 1):A16715 LP–A16715 LP.
- Sciarretta, S, Zhai, P, Volpe, M, Sadoshima, J. Trehalose, a natural dissacharide, reduces cardiac remodeling after myocardial infarction through autophagy activation [abstract 18096]. Circulation. 2012;126(suppl 21):A18096–A18096.
Cited by
Sorted by citations
Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity
Abdellatif, M., Trummer-Herbst, V., Heberle, A. M., Humnig, A., Pendl, T., Durand, S., Cerrato, G., Hofer, S. J., Islam, M., Voglhuber, J., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.059863 · Cited by 108
Self-citationCaloric Restriction Mimetics in Nutrition and Clinical Trials
Hofer, S. J., Davinelli, S., Bergmann, M., Scapagnini, G., & Madeo, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.717343 · Cited by 109
Self-citationThe mitochondrial permeability transition: Nexus of aging, disease and longevity
Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94
Obesity accelerates cardiovascular ageing
Ruperez, C., Madeo, F., de Cabo, R., Kroemer, G., & Abdellatif, M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf216 · Cited by 73
Self-citationRuiz-Meana, M., Bou-Teen, D., Ferdinandy, P., Gyongyosi, M., Pesce, M., Perrino, C., Schulz, R., Sluijter, J. P. G., Tocchetti, C. G., Thum, T., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa132 · Cited by 67
Metadata
- Authors
- Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G.
- Affiliations
- Medical University of Graz (AT)
- BioTechMed Graz, Austria (S.S., D.C.-G., F.M.)
- University of Graz (AT)
- Inserm (FR)
- Venue
- Circulation Research
- Published
- 2018-09-14
- Volume
- 123
- Issue
- 7
- Pages
- 803-824
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2890933287
- Cited by
- 239
- References
- 253
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 24 · 2023: 31 · 2022: 37 · 2021: 37 · 2020: 32 · 2019: 24 · 2018: 3
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-17-CE14-0030, ANR-16-ECVD-0008)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- autophagy, cardiovascular aging, longevity pathways, caloric restriction, caloric restriction mimetics, metformin, spermidine, rapamycin, cardioprotection, vascular health, age-related cardiovascular disease, dietary intervention, genetic models
- MeSH terms
- Age Factors, Aging, Animals, Autophagy, Cardiovascular Diseases, Cardiovascular System, Health Status, Humans, Longevity, Metformin, Risk Factors, Spermidine, Sirolimus, Caloric Restriction, Protective Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
