The DOI matches its Crossref record; 369 of the 369 references it cites were found in a registry or an index.
Basic Mechanisms of Diabetic Heart Disease
Open accessAbstract
Diabetes mellitus predisposes affected individuals to a significant spectrum of cardiovascular complications, one of the most debilitating in terms of prognosis is heart failure. Indeed, the increasing global prevalence of diabetes mellitus and an aging population has given rise to an epidemic of diabetes mellitus–induced heart failure. Despite the significant research attention this phenomenon, termed diabetic cardiomyopathy, has received over several decades, understanding of the full spectrum of potential contributing mechanisms, and their relative contribution to this heart failure phenotype in the specific context of diabetes mellitus, has not yet been fully resolved. Key recent preclinical discoveries that comprise the current state-of-the-art understanding of the basic mechanisms of the complex phenotype, that is, the diabetic heart, form the basis of this review. Abnormalities in each of cardiac metabolism, physiological and pathophysiological signaling, and the mitochondrial compartment, in addition to oxidative stress, inflammation, myocardial cell death pathways, and neurohumoral mechanisms, are addressed. Further, the interactions between each of these contributing mechanisms and how they align to the functional, morphological, and structural impairments that characterize the diabetic heart are considered in light of the clinical context: from the disease burden, its current management in the clinic, and where the knowledge gaps remain. The need for continued interrogation of these mechanisms (both known and those yet to be identified) is essential to not only decipher the how and why of diabetes mellitus–induced heart failure but also to facilitate improved inroads into the clinical management of this pervasive clinical challenge.
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1 retracted
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Cited by
Cardiac Energy Metabolism in Heart Failure
Lopaschuk, G. D., Karwi, Q. G., Tian, R., Wende, A. R., & Abel, E. D. (2021) · Circulation Research · doi:10.1161/circresaha.121.318241 · Cited by 1,373
Self-citationDiabetes mellitus—Progress and opportunities in the evolving epidemic
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The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF
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Metadata
- Authors
- Ritchie, R. H., & Abel, E. D.
- Venue
- Circulation Research
- Published
- 2020-05-22
- Volume
- 126
- Issue
- 11
- Pages
- 1501-1525
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W3026907472
- Cited by
- 708
- References
- 369
- FWCI
- 38.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
