Cited by 94Atrial Fibrillation Management and OutcomesCardiac electrophysiology and arrhythmiasCardiac Arrhythmias and Treatments

Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins

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Pinho-Gomes, Ana Catarina, Reilly, Svetlana, Brandes, Ralf P., Casadei, Barbara·2014·Antioxidants & Redox Signaling

Abstract

SIGNIFICANCE: Atrial fibrillation (AF) is a burgeoning health-care problem, and the currently available therapeutic armamentarium is barely efficient. Experimental and clinical evidence implicates inflammation and myocardial oxidative stress in the pathogenesis of AF. RECENT ADVANCES: Local and systemic inflammation has been found to both precede and follow the new onset of AF, and NOX2-dependent generation of reactive oxygen species in human right atrial samples has been independently associated with the occurrence of AF in the postoperative period in patients undergoing cardiac surgery. Anti-inflammatory and antioxidant agents can prevent atrial electrical remodeling in animal models of atrial tachypacing and the new onset of AF after cardiac surgery, suggesting a causal relationship between inflammation/oxidative stress and the atrial substrate that supports AF. CRITICAL ISSUES: Statin therapy, by redressing the myocardial nitroso-redox balance and reducing inflammation, has emerged as a potentially effective strategy for the prevention of AF. Evidence indicates that statins prevent AF-induced electrical remodeling in animal models of atrial tachypacing and may reduce the new onset of AF after cardiac surgery. However, whether statins have antiarrhythmic properties in humans has yet to be conclusively demonstrated, as data from randomized controlled trials specifically addressing the relevance of statin therapy for the primary and secondary prevention of AF remain scanty. FUTURE DIRECTIONS: A better understanding of the mechanisms underpinning the putative antiarrhythmic effects of statins may afford tailoring AF treatment to specific clinical settings and patient's subgroups. Large-scale randomized clinical trials are needed to support the indication of statin therapy solely on the basis of AF prevention.

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Crossref · 10.1089/ars.2013.5542

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Authors
Pinho-Gomes, A. C., Reilly, S., Brandes, R. P., & Casadei, B.
Affiliations
  • University of Oxford
  • John Radcliffe Hospital (GB)
  • Goethe University Frankfurt (DE)
Corresponding author
Casadei, Barbara
Venue
Antioxidants & Redox Signaling
Published
2014-03
Volume
20
Issue
8
Pages
1268-1285
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
OpenAlex
W2059738180
Cited by
94
References
183
Citations by year
2025: 9 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 13 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 15 · 2015: 4 · 2014: 9
FWCI
1.59
Type
journal article
Language
en
Open access
Locations
  • Antioxidants and Redox Signaling (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust (090532)
  • British Heart Foundation (RG/11/15/29375)
  • European Commission (261057)
  • Fondation Leducq
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords
atrial fibrillation, statins, HMG-CoA reductase inhibition, inflammation, oxidative stress, reactive oxygen species, NOX2, atrial electrical remodeling, cardiac surgery, antiarrhythmic effect, atrial tachypacing
MeSH terms
Animals, Anti-Inflammatory Agents, Atrial Fibrillation, Humans, Hydroxymethylglutaryl CoA Reductases, NADH, NADPH Oxidoreductases, Reactive Oxygen Species, Oxidative Stress, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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